FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 8384

FusionGeneSummary for CRB1_IGFN1

check button Fusion gene summary
Fusion gene informationFusion gene name: CRB1_IGFN1
Fusion gene ID: 8384
HgeneTgene
Gene symbol

CRB1

IGFN1

Gene ID

23418

91156

Gene namecrumbs 1, cell polarity complex componentimmunoglobulin-like and fibronectin type III domain containing 1
SynonymsLCA8|RP12EEF1A2BP1
Cytomap

1q31.3

1q32.1

Type of geneprotein-codingprotein-coding
Descriptionprotein crumbs homolog 1crumbs family member 1, photoreceptor morphogenesis associatedimmunoglobulin-like and fibronectin type III domain-containing protein 1EEF1A2-binding protein 1KY-interacting protein 1eEF1A2 binding protein
Modification date2018052320180519
UniProtAcc

P82279

Q86VF2

Ensembl transtripts involved in fusion geneENST00000535699, ENST00000538660, 
ENST00000367400, ENST00000367399, 
ENST00000543483, ENST00000544212, 
ENST00000367397, ENST00000476483, 
ENST00000295591, ENST00000335211, 
ENST00000451870, 
Fusion gene scores* DoF score1 X 1 X 1=14 X 4 X 4=64
# samples 14
** MAII scorelog2(1/1*10)=3.32192809488736log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CRB1 [Title/Abstract] AND IGFN1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLGGTCGA-DU-8163-01ACRB1chr1

197237612

+IGFN1chr1

201162375

+
TCGALDLGGTCGA-DU-8163-01ACRB1chr1

197237612

+IGFN1chr1

201163282

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000535699ENST00000295591CRB1chr1

197237612

+IGFN1chr1

201162375

+
intron-5UTRENST00000535699ENST00000335211CRB1chr1

197237612

+IGFN1chr1

201162375

+
intron-5UTRENST00000535699ENST00000451870CRB1chr1

197237612

+IGFN1chr1

201162375

+
5CDS-5UTRENST00000538660ENST00000295591CRB1chr1

197237612

+IGFN1chr1

201162375

+
5CDS-5UTRENST00000538660ENST00000335211CRB1chr1

197237612

+IGFN1chr1

201162375

+
5CDS-5UTRENST00000538660ENST00000451870CRB1chr1

197237612

+IGFN1chr1

201162375

+
5CDS-5UTRENST00000367400ENST00000295591CRB1chr1

197237612

+IGFN1chr1

201162375

+
5CDS-5UTRENST00000367400ENST00000335211CRB1chr1

197237612

+IGFN1chr1

201162375

+
5CDS-5UTRENST00000367400ENST00000451870CRB1chr1

197237612

+IGFN1chr1

201162375

+
5CDS-5UTRENST00000367399ENST00000295591CRB1chr1

197237612

+IGFN1chr1

201162375

+
5CDS-5UTRENST00000367399ENST00000335211CRB1chr1

197237612

+IGFN1chr1

201162375

+
5CDS-5UTRENST00000367399ENST00000451870CRB1chr1

197237612

+IGFN1chr1

201162375

+
intron-5UTRENST00000543483ENST00000295591CRB1chr1

197237612

+IGFN1chr1

201162375

+
intron-5UTRENST00000543483ENST00000335211CRB1chr1

197237612

+IGFN1chr1

201162375

+
intron-5UTRENST00000543483ENST00000451870CRB1chr1

197237612

+IGFN1chr1

201162375

+
intron-5UTRENST00000544212ENST00000295591CRB1chr1

197237612

+IGFN1chr1

201162375

+
intron-5UTRENST00000544212ENST00000335211CRB1chr1

197237612

+IGFN1chr1

201162375

+
intron-5UTRENST00000544212ENST00000451870CRB1chr1

197237612

+IGFN1chr1

201162375

+
intron-5UTRENST00000367397ENST00000295591CRB1chr1

197237612

+IGFN1chr1

201162375

+
intron-5UTRENST00000367397ENST00000335211CRB1chr1

197237612

+IGFN1chr1

201162375

+
intron-5UTRENST00000367397ENST00000451870CRB1chr1

197237612

+IGFN1chr1

201162375

+
intron-5UTRENST00000476483ENST00000295591CRB1chr1

197237612

+IGFN1chr1

201162375

+
intron-5UTRENST00000476483ENST00000335211CRB1chr1

197237612

+IGFN1chr1

201162375

+
intron-5UTRENST00000476483ENST00000451870CRB1chr1

197237612

+IGFN1chr1

201162375

+
intron-5UTRENST00000535699ENST00000295591CRB1chr1

197237612

+IGFN1chr1

201163282

+
intron-5UTRENST00000535699ENST00000335211CRB1chr1

197237612

+IGFN1chr1

201163282

+
intron-5UTRENST00000535699ENST00000451870CRB1chr1

197237612

+IGFN1chr1

201163282

+
5CDS-5UTRENST00000538660ENST00000295591CRB1chr1

197237612

+IGFN1chr1

201163282

+
5CDS-5UTRENST00000538660ENST00000335211CRB1chr1

197237612

+IGFN1chr1

201163282

+
5CDS-5UTRENST00000538660ENST00000451870CRB1chr1

197237612

+IGFN1chr1

201163282

+
5CDS-5UTRENST00000367400ENST00000295591CRB1chr1

197237612

+IGFN1chr1

201163282

+
5CDS-5UTRENST00000367400ENST00000335211CRB1chr1

197237612

+IGFN1chr1

201163282

+
5CDS-5UTRENST00000367400ENST00000451870CRB1chr1

197237612

+IGFN1chr1

201163282

+
5CDS-5UTRENST00000367399ENST00000295591CRB1chr1

197237612

+IGFN1chr1

201163282

+
5CDS-5UTRENST00000367399ENST00000335211CRB1chr1

197237612

+IGFN1chr1

201163282

+
5CDS-5UTRENST00000367399ENST00000451870CRB1chr1

197237612

+IGFN1chr1

201163282

+
intron-5UTRENST00000543483ENST00000295591CRB1chr1

197237612

+IGFN1chr1

201163282

+
intron-5UTRENST00000543483ENST00000335211CRB1chr1

197237612

+IGFN1chr1

201163282

+
intron-5UTRENST00000543483ENST00000451870CRB1chr1

197237612

+IGFN1chr1

201163282

+
intron-5UTRENST00000544212ENST00000295591CRB1chr1

197237612

+IGFN1chr1

201163282

+
intron-5UTRENST00000544212ENST00000335211CRB1chr1

197237612

+IGFN1chr1

201163282

+
intron-5UTRENST00000544212ENST00000451870CRB1chr1

197237612

+IGFN1chr1

201163282

+
intron-5UTRENST00000367397ENST00000295591CRB1chr1

197237612

+IGFN1chr1

201163282

+
intron-5UTRENST00000367397ENST00000335211CRB1chr1

197237612

+IGFN1chr1

201163282

+
intron-5UTRENST00000367397ENST00000451870CRB1chr1

197237612

+IGFN1chr1

201163282

+
intron-5UTRENST00000476483ENST00000295591CRB1chr1

197237612

+IGFN1chr1

201163282

+
intron-5UTRENST00000476483ENST00000335211CRB1chr1

197237612

+IGFN1chr1

201163282

+
intron-5UTRENST00000476483ENST00000451870CRB1chr1

197237612

+IGFN1chr1

201163282

+

Top

FusionProtFeatures for CRB1_IGFN1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CRB1

P82279

IGFN1

Q86VF2


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for CRB1_IGFN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for CRB1_IGFN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CRB1PSMD13, EXT2, ALBIGFN1MEOX2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for CRB1_IGFN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for CRB1_IGFN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCRB1C1838647RETINITIS PIGMENTOSA 12 (disorder)21CTD_human;UNIPROT
HgeneCRB1C3151202LEBER CONGENITAL AMAUROSIS 819UNIPROT
HgeneCRB1C0035334Retinitis Pigmentosa3CTD_human;HPO;ORPHANET
HgeneCRB1C0035305Retinal Detachment1CTD_human
HgeneCRB1C0154832Exudative retinopathy1CTD_human
HgeneCRB1C0339527Leber Congenital Amaurosis1CTD_human;ORPHANET
HgeneCRB1C1868310Pigmented Paravenous Chorioretinal Atrophy1CTD_human;ORPHANET;UNIPROT