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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 8327

FusionGeneSummary for CPSF6_MYF6

check button Fusion gene summary
Fusion gene informationFusion gene name: CPSF6_MYF6
Fusion gene ID: 8327
HgeneTgene
Gene symbol

CPSF6

MYF6

Gene ID

11052

4618

Gene namecleavage and polyadenylation specific factor 6myogenic factor 6
SynonymsCFIM|CFIM68|CFIM72|HPBRII-4|HPBRII-7CNM3|MRF4|bHLHc4|myf-6
Cytomap

12q15

12q21.31

Type of geneprotein-codingprotein-coding
Descriptioncleavage and polyadenylation specificity factor subunit 6CPSF 68 kDa subunitcleavage and polyadenylation specific factor 6, 68kDacleavage and polyadenylation specificity factor 68 kDa subunitcleavage factor Im complex 68 kDa subunitpre-mRNA cleavage myogenic factor 6class C basic helix-loop-helix protein 4muscle-specific regulatory factor 4myogenic factor 6 (herculin)
Modification date2018052220180523
UniProtAcc

Q16630

P23409

Ensembl transtripts involved in fusion geneENST00000435070, ENST00000456847, 
ENST00000266679, ENST00000550987, 
ENST00000551516, 
ENST00000228641, 
Fusion gene scores* DoF score23 X 6 X 11=15183 X 1 X 2=6
# samples 263
** MAII scorelog2(26/1518*10)=-2.54558826238701
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/6*10)=2.32192809488736
Context

PubMed: CPSF6 [Title/Abstract] AND MYF6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCPSF6

GO:0006397

mRNA processing

14690600

HgeneCPSF6

GO:0051262

protein tetramerization

20695905

HgeneCPSF6

GO:0051290

protein heterotetramerization

23187700

HgeneCPSF6

GO:1990120

messenger ribonucleoprotein complex assembly

29276085


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-DX-A2J0-01ACPSF6chr12

69633486

+MYF6chr12

81101634

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000435070ENST00000228641CPSF6chr12

69633486

+MYF6chr12

81101634

+
In-frameENST00000456847ENST00000228641CPSF6chr12

69633486

+MYF6chr12

81101634

+
In-frameENST00000266679ENST00000228641CPSF6chr12

69633486

+MYF6chr12

81101634

+
3UTR-3CDSENST00000550987ENST00000228641CPSF6chr12

69633486

+MYF6chr12

81101634

+
In-frameENST00000551516ENST00000228641CPSF6chr12

69633486

+MYF6chr12

81101634

+

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FusionProtFeatures for CPSF6_MYF6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CPSF6

Q16630

MYF6

P23409

Component of the cleavage factor Im (CFIm) complex thatfunctions as an activator of the pre-mRNA 3'-end cleavage andpolyadenylation processing required for the maturation of pre-mRNAinto functional mRNAs (PubMed:9659921, PubMed:8626397,PubMed:14690600, PubMed:29276085). CFIm contributes to therecruitment of multiprotein complexes on specific sequences on thepre-mRNA 3'-end, so called cleavage and polyadenylation signals(pA signals) (PubMed:9659921, PubMed:8626397, PubMed:14690600).Most pre-mRNAs contain multiple pA signals, resulting inalternative cleavage and polyadenylation (APA) producing mRNAswith variable 3'-end formation (PubMed:23187700, PubMed:29276085).The CFIm complex acts as a key regulator of cleavage andpolyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) fora huge number of pre-mRNAs (PubMed:20695905, PubMed:29276085).CPSF6 enhances NUDT21/CPSF5 binding to 5'-UGUA-3' elementslocalized upstream of pA signals and promotes RNA looping, andhence activates directly the mRNA 3'-processing machinery(PubMed:15169763, PubMed:29276085, PubMed:21295486). Plays a rolein mRNA export (PubMed:19864460). {ECO:0000269|PubMed:14690600,ECO:0000269|PubMed:15169763, ECO:0000269|PubMed:19864460,ECO:0000269|PubMed:20695905, ECO:0000269|PubMed:21295486,ECO:0000269|PubMed:23187700, ECO:0000269|PubMed:29276085,ECO:0000269|PubMed:8626397, ECO:0000269|PubMed:9659921}. Involved in muscle differentiation (myogenic factor).Induces fibroblasts to differentiate into myoblasts. Probablesequence specific DNA-binding protein.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMYF6chr12:69633486chr12:81101634ENST00000228641+0393_144-74243DomainbHLH

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCPSF6chr12:69633486chr12:81101634ENST00000266679+111208_39820701Compositional biasNote=Pro-rich
HgeneCPSF6chr12:69633486chr12:81101634ENST00000266679+111490_55120701Compositional biasNote=Arg-rich
HgeneCPSF6chr12:69633486chr12:81101634ENST00000435070+110208_398202111Compositional biasNote=Pro-rich
HgeneCPSF6chr12:69633486chr12:81101634ENST00000435070+110490_551202111Compositional biasNote=Arg-rich
HgeneCPSF6chr12:69633486chr12:81101634ENST00000266679+111202_20620701MotifGAR
HgeneCPSF6chr12:69633486chr12:81101634ENST00000435070+110202_206202111MotifGAR
HgeneCPSF6chr12:69633486chr12:81101634ENST00000266679+111404_55120701RegionSufficient for nuclear speckle localization
HgeneCPSF6chr12:69633486chr12:81101634ENST00000266679+111405_55120701RegionNecessary for RNA-binding
HgeneCPSF6chr12:69633486chr12:81101634ENST00000266679+111510_55120701RegionSufficient for nuclear targeting
HgeneCPSF6chr12:69633486chr12:81101634ENST00000266679+11181_16120701RegionNecessary for nuclear paraspeckles localization
HgeneCPSF6chr12:69633486chr12:81101634ENST00000435070+110404_551202111RegionSufficient for nuclear speckle localization
HgeneCPSF6chr12:69633486chr12:81101634ENST00000435070+110405_551202111RegionNecessary for RNA-binding
HgeneCPSF6chr12:69633486chr12:81101634ENST00000435070+110510_551202111RegionSufficient for nuclear targeting
HgeneCPSF6chr12:69633486chr12:81101634ENST00000435070+11081_161202111RegionNecessary for nuclear paraspeckles localization


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FusionGeneSequence for CPSF6_MYF6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_CPSF6_ENST00000435070_chr12_69633486_+_MYF6_ENST00000228641_chr12_81101634_+_337aa
MADGVDHIDIYADVGEEFNQSFLSNXMFXRALAAITLGDXCSMTAKSWIEFQELLYIKLGRLMSLHXLNAIWVVPLGFXVHHPVQIESEA
KEENMMMDLFETGSYFFYLDGENVTLQPLEVAEGSPLYPGSDGTLSPCQDQMPPEAGSDSSGEEHVLAPPGLQPPHCPGQCLIWACKTCK
RKSAPTDRRKAATLRERRRLKKINEAFEALKRRTVANPNQRLPKVEILRSAISYIERLQDLLHRLDQQEKMQELGVDPFSYRPKQENLEG

>In-frame_CPSF6_ENST00000456847_chr12_69633486_+_MYF6_ENST00000228641_chr12_81101634_+_337aa
MADGVDHIDIYADVGEEFNQSFLSNXMFXRALAAITLGDXCSMTAKSWIEFQELLYIKLGRLMSLHXLNAIWVVPLGFXVHHPVQIESEA
KEENMMMDLFETGSYFFYLDGENVTLQPLEVAEGSPLYPGSDGTLSPCQDQMPPEAGSDSSGEEHVLAPPGLQPPHCPGQCLIWACKTCK
RKSAPTDRRKAATLRERRRLKKINEAFEALKRRTVANPNQRLPKVEILRSAISYIERLQDLLHRLDQQEKMQELGVDPFSYRPKQENLEG

>In-frame_CPSF6_ENST00000266679_chr12_69633486_+_MYF6_ENST00000228641_chr12_81101634_+_337aa
MADGVDHIDIYADVGEEFNQSFLSNXMFXRALAAITLGDXCSMTAKSWIEFQELLYIKLGRLMSLHXLNAIWVVPLGFXVHHPVQIESEA
KEENMMMDLFETGSYFFYLDGENVTLQPLEVAEGSPLYPGSDGTLSPCQDQMPPEAGSDSSGEEHVLAPPGLQPPHCPGQCLIWACKTCK
RKSAPTDRRKAATLRERRRLKKINEAFEALKRRTVANPNQRLPKVEILRSAISYIERLQDLLHRLDQQEKMQELGVDPFSYRPKQENLEG

>In-frame_CPSF6_ENST00000551516_chr12_69633486_+_MYF6_ENST00000228641_chr12_81101634_+_337aa
MADGVDHIDIYADVGEEFNQSFLSNXMFXRALAAITLGDXCSMTAKSWIEFQELLYIKLGRLMSLHXLNAIWVVPLGFXVHHPVQIESEA
KEENMMMDLFETGSYFFYLDGENVTLQPLEVAEGSPLYPGSDGTLSPCQDQMPPEAGSDSSGEEHVLAPPGLQPPHCPGQCLIWACKTCK
RKSAPTDRRKAATLRERRRLKKINEAFEALKRRTVANPNQRLPKVEILRSAISYIERLQDLLHRLDQQEKMQELGVDPFSYRPKQENLEG


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_CPSF6_ENST00000435070_chr12_69633486_+_MYF6_ENST00000228641_chr12_81101634_+_1011nt
ATGGCGGACGGCGTGGACCACATAGACATTTACGCGGATGTCGGCGAAGAGTTCAACCAGAGTTTTCTTTCAAACTAGATGTTCTAGAGA
GCACTAGCTGCAATCACATTGGGAGACTGATGCTCCATGACAGCTAAAAGTTGGATTGAGTTTCAGGAGCTACTATATATAAAGCTGGGT
CGACTTATGTCACTGCACTAATTAAATGCCATCTGGGTGGTTCCTCTGGGTTTTTGAGTCCATCACCCAGTTCAGATCGAGTCAGAGGCC
AAGGAGGAGAACATGATGATGGACCTTTTTGAAACTGGCTCCTATTTCTTCTACTTGGATGGGGAAAATGTTACTCTGCAGCCATTAGAA
GTGGCAGAAGGCTCTCCTTTGTATCCAGGGAGTGATGGTACCTTGTCCCCCTGCCAGGACCAAATGCCCCCGGAAGCGGGGAGCGACAGC
AGCGGAGAGGAACATGTCCTGGCGCCCCCGGGCCTGCAGCCTCCACACTGCCCCGGCCAGTGTCTGATCTGGGCTTGCAAGACCTGCAAG
AGAAAATCTGCCCCCACTGACCGGCGAAAAGCCGCCACCCTGCGCGAAAGGAGGAGGCTAAAGAAAATCAACGAGGCCTTCGAGGCACTG
AAGCGGCGAACTGTGGCCAACCCCAACCAGAGGCTGCCCAAGGTGGAGATTCTGCGGAGCGCCATCAGCTATATTGAGCGGCTGCAGGAC
CTGCTGCACCGGCTGGATCAGCAGGAGAAGATGCAGGAGCTGGGGGTGGACCCCTTCAGCTACAGACCCAAACAAGAAAATCTTGAGGGT
GCGGATTTCCTGCGCACCTGCAGCTCCCAGTGGCCAAGTGTTTCCGATCATTCCAGGGGGCTCGTGATAACGGCTAAGGAAGGAGGAGCA
AGTATTGATTCGTCAGCCTCGAGTAGCCTTCGATGCCTTTCTTCCATCGTGGACAGTATTTCCTCGGAGGAACGCAAACTCCCCTGCGTG

>In-frame_CPSF6_ENST00000456847_chr12_69633486_+_MYF6_ENST00000228641_chr12_81101634_+_1011nt
ATGGCGGACGGCGTGGACCACATAGACATTTACGCGGATGTCGGCGAAGAGTTCAACCAGAGTTTTCTTTCAAACTAGATGTTCTAGAGA
GCACTAGCTGCAATCACATTGGGAGACTGATGCTCCATGACAGCTAAAAGTTGGATTGAGTTTCAGGAGCTACTATATATAAAGCTGGGT
CGACTTATGTCACTGCACTAATTAAATGCCATCTGGGTGGTTCCTCTGGGTTTTTGAGTCCATCACCCAGTTCAGATCGAGTCAGAGGCC
AAGGAGGAGAACATGATGATGGACCTTTTTGAAACTGGCTCCTATTTCTTCTACTTGGATGGGGAAAATGTTACTCTGCAGCCATTAGAA
GTGGCAGAAGGCTCTCCTTTGTATCCAGGGAGTGATGGTACCTTGTCCCCCTGCCAGGACCAAATGCCCCCGGAAGCGGGGAGCGACAGC
AGCGGAGAGGAACATGTCCTGGCGCCCCCGGGCCTGCAGCCTCCACACTGCCCCGGCCAGTGTCTGATCTGGGCTTGCAAGACCTGCAAG
AGAAAATCTGCCCCCACTGACCGGCGAAAAGCCGCCACCCTGCGCGAAAGGAGGAGGCTAAAGAAAATCAACGAGGCCTTCGAGGCACTG
AAGCGGCGAACTGTGGCCAACCCCAACCAGAGGCTGCCCAAGGTGGAGATTCTGCGGAGCGCCATCAGCTATATTGAGCGGCTGCAGGAC
CTGCTGCACCGGCTGGATCAGCAGGAGAAGATGCAGGAGCTGGGGGTGGACCCCTTCAGCTACAGACCCAAACAAGAAAATCTTGAGGGT
GCGGATTTCCTGCGCACCTGCAGCTCCCAGTGGCCAAGTGTTTCCGATCATTCCAGGGGGCTCGTGATAACGGCTAAGGAAGGAGGAGCA
AGTATTGATTCGTCAGCCTCGAGTAGCCTTCGATGCCTTTCTTCCATCGTGGACAGTATTTCCTCGGAGGAACGCAAACTCCCCTGCGTG

>In-frame_CPSF6_ENST00000266679_chr12_69633486_+_MYF6_ENST00000228641_chr12_81101634_+_1011nt
ATGGCGGACGGCGTGGACCACATAGACATTTACGCGGATGTCGGCGAAGAGTTCAACCAGAGTTTTCTTTCAAACTAGATGTTCTAGAGA
GCACTAGCTGCAATCACATTGGGAGACTGATGCTCCATGACAGCTAAAAGTTGGATTGAGTTTCAGGAGCTACTATATATAAAGCTGGGT
CGACTTATGTCACTGCACTAATTAAATGCCATCTGGGTGGTTCCTCTGGGTTTTTGAGTCCATCACCCAGTTCAGATCGAGTCAGAGGCC
AAGGAGGAGAACATGATGATGGACCTTTTTGAAACTGGCTCCTATTTCTTCTACTTGGATGGGGAAAATGTTACTCTGCAGCCATTAGAA
GTGGCAGAAGGCTCTCCTTTGTATCCAGGGAGTGATGGTACCTTGTCCCCCTGCCAGGACCAAATGCCCCCGGAAGCGGGGAGCGACAGC
AGCGGAGAGGAACATGTCCTGGCGCCCCCGGGCCTGCAGCCTCCACACTGCCCCGGCCAGTGTCTGATCTGGGCTTGCAAGACCTGCAAG
AGAAAATCTGCCCCCACTGACCGGCGAAAAGCCGCCACCCTGCGCGAAAGGAGGAGGCTAAAGAAAATCAACGAGGCCTTCGAGGCACTG
AAGCGGCGAACTGTGGCCAACCCCAACCAGAGGCTGCCCAAGGTGGAGATTCTGCGGAGCGCCATCAGCTATATTGAGCGGCTGCAGGAC
CTGCTGCACCGGCTGGATCAGCAGGAGAAGATGCAGGAGCTGGGGGTGGACCCCTTCAGCTACAGACCCAAACAAGAAAATCTTGAGGGT
GCGGATTTCCTGCGCACCTGCAGCTCCCAGTGGCCAAGTGTTTCCGATCATTCCAGGGGGCTCGTGATAACGGCTAAGGAAGGAGGAGCA
AGTATTGATTCGTCAGCCTCGAGTAGCCTTCGATGCCTTTCTTCCATCGTGGACAGTATTTCCTCGGAGGAACGCAAACTCCCCTGCGTG

>In-frame_CPSF6_ENST00000551516_chr12_69633486_+_MYF6_ENST00000228641_chr12_81101634_+_1011nt
ATGGCGGACGGCGTGGACCACATAGACATTTACGCGGATGTCGGCGAAGAGTTCAACCAGAGTTTTCTTTCAAACTAGATGTTCTAGAGA
GCACTAGCTGCAATCACATTGGGAGACTGATGCTCCATGACAGCTAAAAGTTGGATTGAGTTTCAGGAGCTACTATATATAAAGCTGGGT
CGACTTATGTCACTGCACTAATTAAATGCCATCTGGGTGGTTCCTCTGGGTTTTTGAGTCCATCACCCAGTTCAGATCGAGTCAGAGGCC
AAGGAGGAGAACATGATGATGGACCTTTTTGAAACTGGCTCCTATTTCTTCTACTTGGATGGGGAAAATGTTACTCTGCAGCCATTAGAA
GTGGCAGAAGGCTCTCCTTTGTATCCAGGGAGTGATGGTACCTTGTCCCCCTGCCAGGACCAAATGCCCCCGGAAGCGGGGAGCGACAGC
AGCGGAGAGGAACATGTCCTGGCGCCCCCGGGCCTGCAGCCTCCACACTGCCCCGGCCAGTGTCTGATCTGGGCTTGCAAGACCTGCAAG
AGAAAATCTGCCCCCACTGACCGGCGAAAAGCCGCCACCCTGCGCGAAAGGAGGAGGCTAAAGAAAATCAACGAGGCCTTCGAGGCACTG
AAGCGGCGAACTGTGGCCAACCCCAACCAGAGGCTGCCCAAGGTGGAGATTCTGCGGAGCGCCATCAGCTATATTGAGCGGCTGCAGGAC
CTGCTGCACCGGCTGGATCAGCAGGAGAAGATGCAGGAGCTGGGGGTGGACCCCTTCAGCTACAGACCCAAACAAGAAAATCTTGAGGGT
GCGGATTTCCTGCGCACCTGCAGCTCCCAGTGGCCAAGTGTTTCCGATCATTCCAGGGGGCTCGTGATAACGGCTAAGGAAGGAGGAGCA
AGTATTGATTCGTCAGCCTCGAGTAGCCTTCGATGCCTTTCTTCCATCGTGGACAGTATTTCCTCGGAGGAACGCAAACTCCCCTGCGTG


* Fusion transcript sequences (Full-length transcript).
>In-frame_CPSF6_ENST00000435070_chr12_69633486_+_MYF6_ENST00000228641_chr12_81101634_+_1277nt
CTCGGAAGTGACGCAAGCGCCCCCCCACCGCCGCTAGATCCGCTGCTGCTGCCGCGGCGGGCAGACCTGCAGGAGGCGGCGGCGGCGGCG
GCGGCCGAGGCTGAAGGAAGATGGCGGACGGCGTGGACCACATAGACATTTACGCGGATGTCGGCGAAGAGTTCAACCAGACCAAATGCC
CCCGGAAGCGGGGAGCGACAGCAGCGGAGAGGAACATGTCCTGGCGCCCCCGGGCCTGCAGCCTCCACACTGCCCCGGCCAGTGTCTGAT
CTGGGCTTGCAAGACCTGCAAGAGAAAATCTGCCCCCACTGACCGGCGAAAAGCCGCCACCCTGCGCGAAAGGAGGAGGCTAAAGAAAAT
CAACGAGGCCTTCGAGGCACTGAAGCGGCGAACTGTGGCCAACCCCAACCAGAGGCTGCCCAAGGTGGAGATTCTGCGGAGCGCCATCAG
CTATATTGAGCGGCTGCAGGACCTGCTGCACCGGCTGGATCAGCAGGAGAAGATGCAGGAGCTGGGGGTGGACCCCTTCAGCTACAGACC
CAAACAAGAAAATCTTGAGGGTGCGGATTTCCTGCGCACCTGCAGCTCCCAGTGGCCAAGTGTTTCCGATCATTCCAGGGGGCTCGTGAT
AACGGCTAAGGAAGGAGGAGCAAGTATTGATTCGTCAGCCTCGAGTAGCCTTCGATGCCTTTCTTCCATCGTGGACAGTATTTCCTCGGA
GGAACGCAAACTCCCCTGCGTGGAGGAAGTGGTGGAGAAGTAACTGAGCCTGCGCTTGAGACCTTCTCCACGCAGCAGGAAGATCCCACC
GACCCTTCCTGGCCTAATCCTTTAGATTAGGTCACATTACATTAACATTTAGGAACCCAGACCGAAAAGTTGCTGAAAGGGAAGGAGACA
CATTCACAAAGAAACGTTGCGAAAATTGCGAAATCTGTTGTGCATGCTCAAATGAAAACGCCTTTCGGCTTTGGGCTTTTATTTTTTTGG
AACTGCGAGTGGCTTAGGTCTAGCCTCATTTTGTTTTTGTTTGGTTGGTTTTATACTATATTAACTTTTATTACGGTGATCCTTTTGTGC
CATGTTCAAAAGAAGTTCATTCCTGTCTAAAGTGGGAAAGTTGCATTTAATGTTAGGGGTATTTAATGTATTTTTGTAAATAGTTTAACA
CTTTCTTTTTTTACGTAAACCTGAAATATATTTTAAATGTGGAATGATGTATATAAAATGTGCGAGGATCCTGGTATTGTAATATTAAAA

>In-frame_CPSF6_ENST00000456847_chr12_69633486_+_MYF6_ENST00000228641_chr12_81101634_+_1214nt
GACCTGCAGGAGGCGGCGGCGGCGGCGGCGGCCGAGGCTGAAGGAAGATGGCGGACGGCGTGGACCACATAGACATTTACGCGGATGTCG
GCGAAGAGTTCAACCAGACCAAATGCCCCCGGAAGCGGGGAGCGACAGCAGCGGAGAGGAACATGTCCTGGCGCCCCCGGGCCTGCAGCC
TCCACACTGCCCCGGCCAGTGTCTGATCTGGGCTTGCAAGACCTGCAAGAGAAAATCTGCCCCCACTGACCGGCGAAAAGCCGCCACCCT
GCGCGAAAGGAGGAGGCTAAAGAAAATCAACGAGGCCTTCGAGGCACTGAAGCGGCGAACTGTGGCCAACCCCAACCAGAGGCTGCCCAA
GGTGGAGATTCTGCGGAGCGCCATCAGCTATATTGAGCGGCTGCAGGACCTGCTGCACCGGCTGGATCAGCAGGAGAAGATGCAGGAGCT
GGGGGTGGACCCCTTCAGCTACAGACCCAAACAAGAAAATCTTGAGGGTGCGGATTTCCTGCGCACCTGCAGCTCCCAGTGGCCAAGTGT
TTCCGATCATTCCAGGGGGCTCGTGATAACGGCTAAGGAAGGAGGAGCAAGTATTGATTCGTCAGCCTCGAGTAGCCTTCGATGCCTTTC
TTCCATCGTGGACAGTATTTCCTCGGAGGAACGCAAACTCCCCTGCGTGGAGGAAGTGGTGGAGAAGTAACTGAGCCTGCGCTTGAGACC
TTCTCCACGCAGCAGGAAGATCCCACCGACCCTTCCTGGCCTAATCCTTTAGATTAGGTCACATTACATTAACATTTAGGAACCCAGACC
GAAAAGTTGCTGAAAGGGAAGGAGACACATTCACAAAGAAACGTTGCGAAAATTGCGAAATCTGTTGTGCATGCTCAAATGAAAACGCCT
TTCGGCTTTGGGCTTTTATTTTTTTGGAACTGCGAGTGGCTTAGGTCTAGCCTCATTTTGTTTTTGTTTGGTTGGTTTTATACTATATTA
ACTTTTATTACGGTGATCCTTTTGTGCCATGTTCAAAAGAAGTTCATTCCTGTCTAAAGTGGGAAAGTTGCATTTAATGTTAGGGGTATT
TAATGTATTTTTGTAAATAGTTTAACACTTTCTTTTTTTACGTAAACCTGAAATATATTTTAAATGTGGAATGATGTATATAAAATGTGC

>In-frame_CPSF6_ENST00000266679_chr12_69633486_+_MYF6_ENST00000228641_chr12_81101634_+_1198nt
CGGCGGCGGCGGCGGCCGAGGCTGAAGGAAGATGGCGGACGGCGTGGACCACATAGACATTTACGCGGATGTCGGCGAAGAGTTCAACCA
GACCAAATGCCCCCGGAAGCGGGGAGCGACAGCAGCGGAGAGGAACATGTCCTGGCGCCCCCGGGCCTGCAGCCTCCACACTGCCCCGGC
CAGTGTCTGATCTGGGCTTGCAAGACCTGCAAGAGAAAATCTGCCCCCACTGACCGGCGAAAAGCCGCCACCCTGCGCGAAAGGAGGAGG
CTAAAGAAAATCAACGAGGCCTTCGAGGCACTGAAGCGGCGAACTGTGGCCAACCCCAACCAGAGGCTGCCCAAGGTGGAGATTCTGCGG
AGCGCCATCAGCTATATTGAGCGGCTGCAGGACCTGCTGCACCGGCTGGATCAGCAGGAGAAGATGCAGGAGCTGGGGGTGGACCCCTTC
AGCTACAGACCCAAACAAGAAAATCTTGAGGGTGCGGATTTCCTGCGCACCTGCAGCTCCCAGTGGCCAAGTGTTTCCGATCATTCCAGG
GGGCTCGTGATAACGGCTAAGGAAGGAGGAGCAAGTATTGATTCGTCAGCCTCGAGTAGCCTTCGATGCCTTTCTTCCATCGTGGACAGT
ATTTCCTCGGAGGAACGCAAACTCCCCTGCGTGGAGGAAGTGGTGGAGAAGTAACTGAGCCTGCGCTTGAGACCTTCTCCACGCAGCAGG
AAGATCCCACCGACCCTTCCTGGCCTAATCCTTTAGATTAGGTCACATTACATTAACATTTAGGAACCCAGACCGAAAAGTTGCTGAAAG
GGAAGGAGACACATTCACAAAGAAACGTTGCGAAAATTGCGAAATCTGTTGTGCATGCTCAAATGAAAACGCCTTTCGGCTTTGGGCTTT
TATTTTTTTGGAACTGCGAGTGGCTTAGGTCTAGCCTCATTTTGTTTTTGTTTGGTTGGTTTTATACTATATTAACTTTTATTACGGTGA
TCCTTTTGTGCCATGTTCAAAAGAAGTTCATTCCTGTCTAAAGTGGGAAAGTTGCATTTAATGTTAGGGGTATTTAATGTATTTTTGTAA
ATAGTTTAACACTTTCTTTTTTTACGTAAACCTGAAATATATTTTAAATGTGGAATGATGTATATAAAATGTGCGAGGATCCTGGTATTG

>In-frame_CPSF6_ENST00000551516_chr12_69633486_+_MYF6_ENST00000228641_chr12_81101634_+_1172nt
GGAAGATGGCGGACGGCGTGGACCACATAGACATTTACGCGGATGTCGGCGAAGAGTTCAACCAGACCAAATGCCCCCGGAAGCGGGGAG
CGACAGCAGCGGAGAGGAACATGTCCTGGCGCCCCCGGGCCTGCAGCCTCCACACTGCCCCGGCCAGTGTCTGATCTGGGCTTGCAAGAC
CTGCAAGAGAAAATCTGCCCCCACTGACCGGCGAAAAGCCGCCACCCTGCGCGAAAGGAGGAGGCTAAAGAAAATCAACGAGGCCTTCGA
GGCACTGAAGCGGCGAACTGTGGCCAACCCCAACCAGAGGCTGCCCAAGGTGGAGATTCTGCGGAGCGCCATCAGCTATATTGAGCGGCT
GCAGGACCTGCTGCACCGGCTGGATCAGCAGGAGAAGATGCAGGAGCTGGGGGTGGACCCCTTCAGCTACAGACCCAAACAAGAAAATCT
TGAGGGTGCGGATTTCCTGCGCACCTGCAGCTCCCAGTGGCCAAGTGTTTCCGATCATTCCAGGGGGCTCGTGATAACGGCTAAGGAAGG
AGGAGCAAGTATTGATTCGTCAGCCTCGAGTAGCCTTCGATGCCTTTCTTCCATCGTGGACAGTATTTCCTCGGAGGAACGCAAACTCCC
CTGCGTGGAGGAAGTGGTGGAGAAGTAACTGAGCCTGCGCTTGAGACCTTCTCCACGCAGCAGGAAGATCCCACCGACCCTTCCTGGCCT
AATCCTTTAGATTAGGTCACATTACATTAACATTTAGGAACCCAGACCGAAAAGTTGCTGAAAGGGAAGGAGACACATTCACAAAGAAAC
GTTGCGAAAATTGCGAAATCTGTTGTGCATGCTCAAATGAAAACGCCTTTCGGCTTTGGGCTTTTATTTTTTTGGAACTGCGAGTGGCTT
AGGTCTAGCCTCATTTTGTTTTTGTTTGGTTGGTTTTATACTATATTAACTTTTATTACGGTGATCCTTTTGTGCCATGTTCAAAAGAAG
TTCATTCCTGTCTAAAGTGGGAAAGTTGCATTTAATGTTAGGGGTATTTAATGTATTTTTGTAAATAGTTTAACACTTTCTTTTTTTACG
TAAACCTGAAATATATTTTAAATGTGGAATGATGTATATAAAATGTGCGAGGATCCTGGTATTGTAATATTAAAAAGAAGTTTCTATATG


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FusionGenePPI for CPSF6_MYF6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CPSF6PLSCR1, GIN1, WWP1, EWSR1, ARMC7, KLHL12, NUDT21, UBAC1, WWP2, NCK2, RNPS1, CREBBP, PAPOLA, ITCH, NEDD4, WWOX, APBB1, TCERG1, MME, CLP1, ITSN2, HNRNPA1, CUL3, CAND1, UBQLN4, U2AF2, UBAP2L, NONO, WBP11, CPSF7, PUF60, CSTF2, POLR2I, NUP88, TCEA2, ZBTB8B, CSNK1A1, SAFB, MAX, STRN, TBC1D2, TTN, NUP107, BARD1, MDC1, SMURF1, NPM1, FN1, CSNK2A1, TP63, DAB2, CD81, LMNA, SRPK2, PRPF40A, WBP4, FXR2, FUS, PPIL1, TOLLIP, OTUB2, CUL7, OBSL1, CCDC8, EZH2, SUZ12, EED, RSRP1, LUC7L2, DDX17, DDX5, KHSRP, SMARCB1, TXNDC9, PCF11, SMARCC1, SMARCC2, SMEK1, NTRK1, XPO1, VPS26A, NF2, SNW1, JMJD6, RBBP6, PA2G4, TRAP1, SND1, ANXA5, MYL12B, SNRPB2, UBE2N, COQ2, DLD, HSD17B10, PARK7, G3BP1MYF6TCF3, CSRP3, TCF12, TCF4, NES, ID4, MAPK14, IRGC, TBC1D4, DISC1, CSRP2BP, MBIP


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CPSF6_MYF6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CPSF6_MYF6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMYF6C3280703MYOPATHY, CENTRONUCLEAR, 31UNIPROT