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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8301

FusionGeneSummary for CPS1_PRDX3

check button Fusion gene summary
Fusion gene informationFusion gene name: CPS1_PRDX3
Fusion gene ID: 8301
HgeneTgene
Gene symbol

CPS1

PRDX3

Gene ID

1373

10935

Gene namecarbamoyl-phosphate synthase 1peroxiredoxin 3
SynonymsCPSASE1|PHNAOP-1|AOP1|HBC189|MER5|PRO1748|SP-22|prx-III
Cytomap

2q34

10q26.11

Type of geneprotein-codingprotein-coding
Descriptioncarbamoyl-phosphate synthase [ammonia], mitochondrialcarbamoyl-phosphate synthase (ammonia)carbamoyl-phosphate synthase 1, mitochondrialcarbamoylphosphate synthetase Ithioredoxin-dependent peroxide reductase, mitochondrialantioxidant protein 1peroxiredoxin IIIprotein MER5 homolog
Modification date2018052320180519
UniProtAcc

P31327

P30048

Ensembl transtripts involved in fusion geneENST00000430249, ENST00000233072, 
ENST00000451903, ENST00000497121, 
ENST00000356951, ENST00000298510, 
ENST00000494433, 
Fusion gene scores* DoF score7 X 8 X 4=2243 X 3 X 2=18
# samples 83
** MAII scorelog2(8/224*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CPS1 [Title/Abstract] AND PRDX3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCPS1

GO:0032496

response to lipopolysaccharide

15897806

HgeneCPS1

GO:0050667

homocysteine metabolic process

20031578

TgenePRDX3

GO:0008284

positive regulation of cell proliferation

12011429

TgenePRDX3

GO:0018171

peptidyl-cysteine oxidation

21850687

TgenePRDX3

GO:0033673

negative regulation of kinase activity

18205602

TgenePRDX3

GO:0034599

cellular response to oxidative stress

21850687

TgenePRDX3

GO:0042542

response to hydrogen peroxide

17893648

TgenePRDX3

GO:0042744

hydrogen peroxide catabolic process

7733872

TgenePRDX3

GO:0043066

negative regulation of apoptotic process

21850687

TgenePRDX3

GO:0051092

positive regulation of NF-kappaB transcription factor activity

12492477


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AV694689CPS1chr2

211421447

+PRDX3chr10

120931984

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000430249ENST00000356951CPS1chr2

211421447

+PRDX3chr10

120931984

-
intron-3CDSENST00000430249ENST00000298510CPS1chr2

211421447

+PRDX3chr10

120931984

-
intron-intronENST00000430249ENST00000494433CPS1chr2

211421447

+PRDX3chr10

120931984

-
5UTR-3CDSENST00000233072ENST00000356951CPS1chr2

211421447

+PRDX3chr10

120931984

-
5UTR-3CDSENST00000233072ENST00000298510CPS1chr2

211421447

+PRDX3chr10

120931984

-
5UTR-intronENST00000233072ENST00000494433CPS1chr2

211421447

+PRDX3chr10

120931984

-
intron-3CDSENST00000451903ENST00000356951CPS1chr2

211421447

+PRDX3chr10

120931984

-
intron-3CDSENST00000451903ENST00000298510CPS1chr2

211421447

+PRDX3chr10

120931984

-
intron-intronENST00000451903ENST00000494433CPS1chr2

211421447

+PRDX3chr10

120931984

-
intron-3CDSENST00000497121ENST00000356951CPS1chr2

211421447

+PRDX3chr10

120931984

-
intron-3CDSENST00000497121ENST00000298510CPS1chr2

211421447

+PRDX3chr10

120931984

-
intron-intronENST00000497121ENST00000494433CPS1chr2

211421447

+PRDX3chr10

120931984

-

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FusionProtFeatures for CPS1_PRDX3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CPS1

P31327

PRDX3

P30048

Involved in the urea cycle of ureotelic animals wherethe enzyme plays an important role in removing excess ammonia fromthe cell.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CPS1_PRDX3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CPS1_PRDX3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CPS1_PRDX3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneCPS1P31327DB06775Carglumic AcidCarbamoyl-phosphate synthase [ammonia], mitochondrialsmall moleculeapproved

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RelatedDiseases for CPS1_PRDX3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCPS1C4082171Hyperammonemia Due to Carbamoyl Phosphate Synthetase 1 Deficiency10ORPHANET;UNIPROT
HgeneCPS1C0220994Hyperammonemia2CTD_human;HPO
HgeneCPS1C0751753Carbamoyl-Phosphate Synthase I Deficiency Disease2CTD_human;ORPHANET
HgeneCPS1C0009421Comatose1CTD_human;HPO
HgeneCPS1C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneCPS1C0031190Persistent Fetal Circulation Syndrome1CTD_human
HgeneCPS1C0032927Precancerous Conditions1CTD_human
HgeneCPS1C0376618Endotoxemia1CTD_human
TgenePRDX3C0029456Osteoporosis1CTD_human
TgenePRDX3C0079744Diffuse Large B-Cell Lymphoma1CTD_human
TgenePRDX3C0085084Motor Neuron Disease1CTD_human