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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8251

FusionGeneSummary for CPM_GOLT1B

check button Fusion gene summary
Fusion gene informationFusion gene name: CPM_GOLT1B
Fusion gene ID: 8251
HgeneTgene
Gene symbol

CPM

GOLT1B

Gene ID

1368

51026

Gene namecarboxypeptidase Mgolgi transport 1B
Synonyms-CGI-141|GCT2|GOT1|GOT1B|YMR292W
Cytomap

12q15

12p12.1

Type of geneprotein-codingprotein-coding
Descriptioncarboxypeptidase Mrenal carboxypeptidaseurinary carboxypeptidase Bvesicle transport protein GOT1Bgerm cell tumor 2hGOT1aputative NF-kappa-B-activating protein 470
Modification date2018052320180523
UniProtAcc

P14384

Q9Y3E0

Ensembl transtripts involved in fusion geneENST00000546373, ENST00000551568, 
ENST00000338356, ENST00000549691, 
ENST00000535593, ENST00000542038, 
ENST00000540141, ENST00000229314, 
Fusion gene scores* DoF score12 X 5 X 6=3601 X 1 X 2=2
# samples 122
** MAII scorelog2(12/360*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/2*10)=3.32192809488736
Context

PubMed: CPM [Title/Abstract] AND GOLT1B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVKIRCTCGA-AS-3777-01ACPMchr12

69326458

-GOLT1Bchr12

21659819

+
TCGARVLIHCTCGA-DD-A115-01ACPMchr12

69326458

-GOLT1Bchr12

21659819

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000546373ENST00000535593CPMchr12

69326458

-GOLT1Bchr12

21659819

+
5CDS-intronENST00000546373ENST00000542038CPMchr12

69326458

-GOLT1Bchr12

21659819

+
5CDS-intronENST00000546373ENST00000540141CPMchr12

69326458

-GOLT1Bchr12

21659819

+
5CDS-intronENST00000546373ENST00000229314CPMchr12

69326458

-GOLT1Bchr12

21659819

+
5CDS-intronENST00000551568ENST00000535593CPMchr12

69326458

-GOLT1Bchr12

21659819

+
5CDS-intronENST00000551568ENST00000542038CPMchr12

69326458

-GOLT1Bchr12

21659819

+
5CDS-intronENST00000551568ENST00000540141CPMchr12

69326458

-GOLT1Bchr12

21659819

+
5CDS-intronENST00000551568ENST00000229314CPMchr12

69326458

-GOLT1Bchr12

21659819

+
5CDS-intronENST00000338356ENST00000535593CPMchr12

69326458

-GOLT1Bchr12

21659819

+
5CDS-intronENST00000338356ENST00000542038CPMchr12

69326458

-GOLT1Bchr12

21659819

+
5CDS-intronENST00000338356ENST00000540141CPMchr12

69326458

-GOLT1Bchr12

21659819

+
5CDS-intronENST00000338356ENST00000229314CPMchr12

69326458

-GOLT1Bchr12

21659819

+
intron-intronENST00000549691ENST00000535593CPMchr12

69326458

-GOLT1Bchr12

21659819

+
intron-intronENST00000549691ENST00000542038CPMchr12

69326458

-GOLT1Bchr12

21659819

+
intron-intronENST00000549691ENST00000540141CPMchr12

69326458

-GOLT1Bchr12

21659819

+
intron-intronENST00000549691ENST00000229314CPMchr12

69326458

-GOLT1Bchr12

21659819

+

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FusionProtFeatures for CPM_GOLT1B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CPM

P14384

GOLT1B

Q9Y3E0

Specifically removes C-terminal basic residues (Arg orLys) from peptides and proteins. It is believed to play importantroles in the control of peptide hormone and growth factor activityat the cell surface, and in the membrane-localized degradation ofextracellular proteins. {ECO:0000269|PubMed:12457462}. May be involved in fusion of ER-derived transportvesicles with the Golgi complex.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CPM_GOLT1B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CPM_GOLT1B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CPMELAVL1, CAPZA2, DBN1, FLNA, GAK, MYH9, PPP1CC, RAB7A, PDLIM7, ATP6AP2, SYNPO, MAPRE1, GOLT1B, LIMA1, ANLN, MYO19, ZSCAN12, ULBP1, FTH1, TBC1D22B, GTPBP3GOLT1BUNC93B1, ELAVL1, RTN4, TCTN3, TMEM216, ANXA1, ATP1A1, ATP2A2, ATP5A1, ATP5B, ATP5J, ATP6V1A, ATP6V1B2, ATP6V1E1, ATP6V0A1, ATP6AP1, ATP5O, C1QBP, CALU, CAV1, CD59, CD97, CDC42, CLCN7, COX4I1, CPM, CYC1, DSG2, STOM, ETFB, EXTL2, FLOT2, GOLGA2, PDIA3, JUP, KTN1, LBR, LGALS1, LIFR, MAP3K4, RAB8A, MGST3, NDUFA2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFA10, NDUFB1, NDUFB4, NDUFB7, NDUFB8, NDUFS1, NDUFS2, NDUFS3, NDUFV1, NDUFS4, NDUFS5, NDUFS6, NDUFS8, NDUFV2, NDUFV3, DDR2, PCDH7, CHMP1A, PHB, PHKA2, HTRA1, ABCD3, ALDH18A1, RAB5C, RECQL, SNTB2, SOAT1, TFRC, TGFBR1, TPI1, UQCRC1, UQCRC2, UQCRFS1, VDAC1, VDAC2, CXCR4, GPRC5A, ATP6V0D1, HGS, XPR1, VAPB, VAPA, RAB11B, ATP6V1F, COX5A, ABCG2, PTGES, ATP6V1G1, SEC22B, MLEC, PIEZO1, SPCS2, IST1, PDCD6IP, PDCD6, BCAP31, FLOT1, TCIRG1, HYOU1, RABAC1, ERLIN1, CKAP4, IMMT, ERLIN2, PHB2, CHSY1, ENDOD1, SUN2, INTS7, CHMP2B, DHRS7B, LRP10, MYOF, ATP2C1, UQCRQ, GOLIM4, ASTE1, STOML2, ITSN2, REEP5, KATNA1, NABP1, NDUFA13, ATP6V1D, FAM8A1, ATP6V1H, SARAF, SLC38A2, CHPF2, CHCHD3, DNAJC11, PLGRKT, NDUFA12, KIDINS220, NCKAP5L, MRPL14, TMEM237, FUNDC2, VKORC1, TMEM109, MBOAT7, TMEM43, CYBRD1, REEP4, SGPP1, YIPF5, TMUB1, CHCHD6, CCDC115, MCU, TMEM55B, RNF185, ACBD5, MYADM, MMGT1, PRKCDBP, OSBPL8, CHMP4B, TMEM199, PTRF, RABL3, UBAC2, SFT2D2, C6orf120, KIAA1715, TMEM30B, LMNA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CPM_GOLT1B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CPM_GOLT1B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCPMC0014175Endometriosis1CTD_human
HgeneCPMC0037116Silicosis1CTD_human