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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8234

FusionGeneSummary for CPEB4_CEP112

check button Fusion gene summary
Fusion gene informationFusion gene name: CPEB4_CEP112
Fusion gene ID: 8234
HgeneTgene
Gene symbol

CPEB4

CEP112

Gene ID

80315

201134

Gene namecytoplasmic polyadenylation element binding protein 4centrosomal protein 112
SynonymsCPE-BP4|hCPEB-4CCDC46|MACOCO
Cytomap

5q35.2

17q24.1

Type of geneprotein-codingprotein-coding
Descriptioncytoplasmic polyadenylation element-binding protein 4CPE-binding protein 4centrosomal protein of 112 kDacentrosomal protein 112kDacoiled-coil domain-containing protein 46
Modification date2018052320180519
UniProtAcc

Q17RY0

Q8N8E3

Ensembl transtripts involved in fusion geneENST00000265085, ENST00000520867, 
ENST00000334035, ENST00000519835, 
ENST00000522336, ENST00000517880, 
ENST00000519467, 		ENST00000535342, 
ENST00000392769, ENST00000541355, 
ENST00000537949, ENST00000317442, 
ENST00000580482, 
Fusion gene scores* DoF score3 X 2 X 3=1814 X 9 X 6=756
# samples 312
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(12/756*10)=-2.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CPEB4 [Title/Abstract] AND CEP112 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-DX-AB3A-01ACPEB4chr5

173337607

+CEP112chr17

64179425

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000265085ENST00000535342CPEB4chr5

173337607

+CEP112chr17

64179425

-
5CDS-5UTRENST00000265085ENST00000392769CPEB4chr5

173337607

+CEP112chr17

64179425

-
5CDS-intronENST00000265085ENST00000541355CPEB4chr5

173337607

+CEP112chr17

64179425

-
5CDS-5UTRENST00000265085ENST00000537949CPEB4chr5

173337607

+CEP112chr17

64179425

-
5CDS-intronENST00000265085ENST00000317442CPEB4chr5

173337607

+CEP112chr17

64179425

-
5CDS-intronENST00000265085ENST00000580482CPEB4chr5

173337607

+CEP112chr17

64179425

-
5CDS-5UTRENST00000520867ENST00000535342CPEB4chr5

173337607

+CEP112chr17

64179425

-
5CDS-5UTRENST00000520867ENST00000392769CPEB4chr5

173337607

+CEP112chr17

64179425

-
5CDS-intronENST00000520867ENST00000541355CPEB4chr5

173337607

+CEP112chr17

64179425

-
5CDS-5UTRENST00000520867ENST00000537949CPEB4chr5

173337607

+CEP112chr17

64179425

-
5CDS-intronENST00000520867ENST00000317442CPEB4chr5

173337607

+CEP112chr17

64179425

-
5CDS-intronENST00000520867ENST00000580482CPEB4chr5

173337607

+CEP112chr17

64179425

-
5CDS-5UTRENST00000334035ENST00000535342CPEB4chr5

173337607

+CEP112chr17

64179425

-
5CDS-5UTRENST00000334035ENST00000392769CPEB4chr5

173337607

+CEP112chr17

64179425

-
5CDS-intronENST00000334035ENST00000541355CPEB4chr5

173337607

+CEP112chr17

64179425

-
5CDS-5UTRENST00000334035ENST00000537949CPEB4chr5

173337607

+CEP112chr17

64179425

-
5CDS-intronENST00000334035ENST00000317442CPEB4chr5

173337607

+CEP112chr17

64179425

-
5CDS-intronENST00000334035ENST00000580482CPEB4chr5

173337607

+CEP112chr17

64179425

-
5CDS-5UTRENST00000519835ENST00000535342CPEB4chr5

173337607

+CEP112chr17

64179425

-
5CDS-5UTRENST00000519835ENST00000392769CPEB4chr5

173337607

+CEP112chr17

64179425

-
5CDS-intronENST00000519835ENST00000541355CPEB4chr5

173337607

+CEP112chr17

64179425

-
5CDS-5UTRENST00000519835ENST00000537949CPEB4chr5

173337607

+CEP112chr17

64179425

-
5CDS-intronENST00000519835ENST00000317442CPEB4chr5

173337607

+CEP112chr17

64179425

-
5CDS-intronENST00000519835ENST00000580482CPEB4chr5

173337607

+CEP112chr17

64179425

-
5CDS-5UTRENST00000522336ENST00000535342CPEB4chr5

173337607

+CEP112chr17

64179425

-
5CDS-5UTRENST00000522336ENST00000392769CPEB4chr5

173337607

+CEP112chr17

64179425

-
5CDS-intronENST00000522336ENST00000541355CPEB4chr5

173337607

+CEP112chr17

64179425

-
5CDS-5UTRENST00000522336ENST00000537949CPEB4chr5

173337607

+CEP112chr17

64179425

-
5CDS-intronENST00000522336ENST00000317442CPEB4chr5

173337607

+CEP112chr17

64179425

-
5CDS-intronENST00000522336ENST00000580482CPEB4chr5

173337607

+CEP112chr17

64179425

-
5CDS-5UTRENST00000517880ENST00000535342CPEB4chr5

173337607

+CEP112chr17

64179425

-
5CDS-5UTRENST00000517880ENST00000392769CPEB4chr5

173337607

+CEP112chr17

64179425

-
5CDS-intronENST00000517880ENST00000541355CPEB4chr5

173337607

+CEP112chr17

64179425

-
5CDS-5UTRENST00000517880ENST00000537949CPEB4chr5

173337607

+CEP112chr17

64179425

-
5CDS-intronENST00000517880ENST00000317442CPEB4chr5

173337607

+CEP112chr17

64179425

-
5CDS-intronENST00000517880ENST00000580482CPEB4chr5

173337607

+CEP112chr17

64179425

-
intron-5UTRENST00000519467ENST00000535342CPEB4chr5

173337607

+CEP112chr17

64179425

-
intron-5UTRENST00000519467ENST00000392769CPEB4chr5

173337607

+CEP112chr17

64179425

-
intron-intronENST00000519467ENST00000541355CPEB4chr5

173337607

+CEP112chr17

64179425

-
intron-5UTRENST00000519467ENST00000537949CPEB4chr5

173337607

+CEP112chr17

64179425

-
intron-intronENST00000519467ENST00000317442CPEB4chr5

173337607

+CEP112chr17

64179425

-
intron-intronENST00000519467ENST00000580482CPEB4chr5

173337607

+CEP112chr17

64179425

-

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FusionProtFeatures for CPEB4_CEP112


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CPEB4

Q17RY0

CEP112

Q8N8E3

Sequence-specific RNA-binding protein that binds to thecytoplasmic polyadenylation element (CPE), an uridine-richsequence element (consensus sequence 5'-UUUUUAU-3') within themRNA 3'-UTR (PubMed:24990967). RNA binding results in a clearconformational change analogous to the Venus fly trap mechanism(PubMed:24990967). Regulates activation of unfolded proteinresponse (UPR) in the process of adaptation to ER stress in liver,by maintaining translation of CPE-regulated mRNAs in conditions inwhich global protein synthesis is inhibited (By similarity).Required for cell cycle progression, specifically for cytokinesisand chromosomal segregation (PubMed:26398195). Plays a role as anoncogene promoting tumor growth and progression by positivelyregulating translation of t-plasminogen activator/PLAT(PubMed:22138752). Stimulates proliferation of melanocytes(PubMed:27857118). In contrast to CPEB1 and CPEB3, does not playrole in synaptic plasticity, learning and memory (By similarity).{ECO:0000250|UniProtKB:Q7TN98, ECO:0000269|PubMed:22138752,ECO:0000269|PubMed:24990967, ECO:0000269|PubMed:26398195,ECO:0000269|PubMed:27857118}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CPEB4_CEP112


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CPEB4_CEP112


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CPEB4NDST1, UBE3C, SAV1, BMI1CEP112FUS, USP7


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CPEB4_CEP112


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CPEB4_CEP112


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource