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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8229

FusionGeneSummary for CPEB1_CRTC3

check button Fusion gene summary
Fusion gene informationFusion gene name: CPEB1_CRTC3
Fusion gene ID: 8229
HgeneTgene
Gene symbol

CPEB1

CRTC3

Gene ID

64506

64784

Gene namecytoplasmic polyadenylation element binding protein 1CREB regulated transcription coactivator 3
SynonymsCPE-BP1|CPEB|CPEB-1|h-CPEB|hCPEB-1TORC-3|TORC3
Cytomap

15q25.2

15q26.1

Type of geneprotein-codingprotein-coding
Descriptioncytoplasmic polyadenylation element-binding protein 1CPE-binding protein 1CREB-regulated transcription coactivator 3transducer of regulated CREB protein 3transducer of regulated cAMP response element-binding protein (CREB) 3
Modification date2018052320180523
UniProtAcc

Q9BZB8

Q6UUV7

Ensembl transtripts involved in fusion geneENST00000450751, ENST00000563800, 
ENST00000398591, ENST00000562019, 
ENST00000423133, ENST00000568128, 
ENST00000564522, ENST00000261723, 
ENST00000568757, ENST00000398592, 
ENST00000563519, 		ENST00000420329, 
ENST00000560098, ENST00000268184, 
ENST00000558619, 
Fusion gene scores* DoF score1 X 2 X 1=27 X 8 X 4=224
# samples 17
** MAII scorelog2(1/2*10)=2.32192809488736log2(7/224*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CPEB1 [Title/Abstract] AND CRTC3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCPEB1

GO:0032869

cellular response to insulin stimulus

18752464

HgeneCPEB1

GO:0071456

cellular response to hypoxia

18752464


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-WE-A8ZM-06ACPEB1chr15

83316607

-CRTC3chr15

91150610

+
TCGALDSKCMTCGA-WE-A8ZM-06ACPEB1chr15

83315888

-CRTC3chr15

91147617

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000450751ENST00000420329CPEB1chr15

83316607

-CRTC3chr15

91150610

+
intron-intronENST00000450751ENST00000560098CPEB1chr15

83316607

-CRTC3chr15

91150610

+
intron-intronENST00000450751ENST00000268184CPEB1chr15

83316607

-CRTC3chr15

91150610

+
intron-3UTRENST00000450751ENST00000558619CPEB1chr15

83316607

-CRTC3chr15

91150610

+
intron-3CDSENST00000563800ENST00000420329CPEB1chr15

83316607

-CRTC3chr15

91150610

+
intron-intronENST00000563800ENST00000560098CPEB1chr15

83316607

-CRTC3chr15

91150610

+
intron-intronENST00000563800ENST00000268184CPEB1chr15

83316607

-CRTC3chr15

91150610

+
intron-3UTRENST00000563800ENST00000558619CPEB1chr15

83316607

-CRTC3chr15

91150610

+
intron-3CDSENST00000398591ENST00000420329CPEB1chr15

83316607

-CRTC3chr15

91150610

+
intron-intronENST00000398591ENST00000560098CPEB1chr15

83316607

-CRTC3chr15

91150610

+
intron-intronENST00000398591ENST00000268184CPEB1chr15

83316607

-CRTC3chr15

91150610

+
intron-3UTRENST00000398591ENST00000558619CPEB1chr15

83316607

-CRTC3chr15

91150610

+
intron-3CDSENST00000562019ENST00000420329CPEB1chr15

83316607

-CRTC3chr15

91150610

+
intron-intronENST00000562019ENST00000560098CPEB1chr15

83316607

-CRTC3chr15

91150610

+
intron-intronENST00000562019ENST00000268184CPEB1chr15

83316607

-CRTC3chr15

91150610

+
intron-3UTRENST00000562019ENST00000558619CPEB1chr15

83316607

-CRTC3chr15

91150610

+
intron-3CDSENST00000423133ENST00000420329CPEB1chr15

83316607

-CRTC3chr15

91150610

+
intron-intronENST00000423133ENST00000560098CPEB1chr15

83316607

-CRTC3chr15

91150610

+
intron-intronENST00000423133ENST00000268184CPEB1chr15

83316607

-CRTC3chr15

91150610

+
intron-3UTRENST00000423133ENST00000558619CPEB1chr15

83316607

-CRTC3chr15

91150610

+
Frame-shiftENST00000568128ENST00000420329CPEB1chr15

83316607

-CRTC3chr15

91150610

+
5CDS-intronENST00000568128ENST00000560098CPEB1chr15

83316607

-CRTC3chr15

91150610

+
5CDS-intronENST00000568128ENST00000268184CPEB1chr15

83316607

-CRTC3chr15

91150610

+
5CDS-3UTRENST00000568128ENST00000558619CPEB1chr15

83316607

-CRTC3chr15

91150610

+
intron-3CDSENST00000564522ENST00000420329CPEB1chr15

83316607

-CRTC3chr15

91150610

+
intron-intronENST00000564522ENST00000560098CPEB1chr15

83316607

-CRTC3chr15

91150610

+
intron-intronENST00000564522ENST00000268184CPEB1chr15

83316607

-CRTC3chr15

91150610

+
intron-3UTRENST00000564522ENST00000558619CPEB1chr15

83316607

-CRTC3chr15

91150610

+
intron-3CDSENST00000261723ENST00000420329CPEB1chr15

83316607

-CRTC3chr15

91150610

+
intron-intronENST00000261723ENST00000560098CPEB1chr15

83316607

-CRTC3chr15

91150610

+
intron-intronENST00000261723ENST00000268184CPEB1chr15

83316607

-CRTC3chr15

91150610

+
intron-3UTRENST00000261723ENST00000558619CPEB1chr15

83316607

-CRTC3chr15

91150610

+
intron-3CDSENST00000568757ENST00000420329CPEB1chr15

83316607

-CRTC3chr15

91150610

+
intron-intronENST00000568757ENST00000560098CPEB1chr15

83316607

-CRTC3chr15

91150610

+
intron-intronENST00000568757ENST00000268184CPEB1chr15

83316607

-CRTC3chr15

91150610

+
intron-3UTRENST00000568757ENST00000558619CPEB1chr15

83316607

-CRTC3chr15

91150610

+
intron-3CDSENST00000398592ENST00000420329CPEB1chr15

83316607

-CRTC3chr15

91150610

+
intron-intronENST00000398592ENST00000560098CPEB1chr15

83316607

-CRTC3chr15

91150610

+
intron-intronENST00000398592ENST00000268184CPEB1chr15

83316607

-CRTC3chr15

91150610

+
intron-3UTRENST00000398592ENST00000558619CPEB1chr15

83316607

-CRTC3chr15

91150610

+
intron-3CDSENST00000563519ENST00000420329CPEB1chr15

83316607

-CRTC3chr15

91150610

+
intron-intronENST00000563519ENST00000560098CPEB1chr15

83316607

-CRTC3chr15

91150610

+
intron-intronENST00000563519ENST00000268184CPEB1chr15

83316607

-CRTC3chr15

91150610

+
intron-3UTRENST00000563519ENST00000558619CPEB1chr15

83316607

-CRTC3chr15

91150610

+
5UTR-3CDSENST00000450751ENST00000420329CPEB1chr15

83315888

-CRTC3chr15

91147617

+
5UTR-intronENST00000450751ENST00000560098CPEB1chr15

83315888

-CRTC3chr15

91147617

+
5UTR-intronENST00000450751ENST00000268184CPEB1chr15

83315888

-CRTC3chr15

91147617

+
5UTR-3UTRENST00000450751ENST00000558619CPEB1chr15

83315888

-CRTC3chr15

91147617

+
intron-3CDSENST00000563800ENST00000420329CPEB1chr15

83315888

-CRTC3chr15

91147617

+
intron-intronENST00000563800ENST00000560098CPEB1chr15

83315888

-CRTC3chr15

91147617

+
intron-intronENST00000563800ENST00000268184CPEB1chr15

83315888

-CRTC3chr15

91147617

+
intron-3UTRENST00000563800ENST00000558619CPEB1chr15

83315888

-CRTC3chr15

91147617

+
intron-3CDSENST00000398591ENST00000420329CPEB1chr15

83315888

-CRTC3chr15

91147617

+
intron-intronENST00000398591ENST00000560098CPEB1chr15

83315888

-CRTC3chr15

91147617

+
intron-intronENST00000398591ENST00000268184CPEB1chr15

83315888

-CRTC3chr15

91147617

+
intron-3UTRENST00000398591ENST00000558619CPEB1chr15

83315888

-CRTC3chr15

91147617

+
intron-3CDSENST00000562019ENST00000420329CPEB1chr15

83315888

-CRTC3chr15

91147617

+
intron-intronENST00000562019ENST00000560098CPEB1chr15

83315888

-CRTC3chr15

91147617

+
intron-intronENST00000562019ENST00000268184CPEB1chr15

83315888

-CRTC3chr15

91147617

+
intron-3UTRENST00000562019ENST00000558619CPEB1chr15

83315888

-CRTC3chr15

91147617

+
intron-3CDSENST00000423133ENST00000420329CPEB1chr15

83315888

-CRTC3chr15

91147617

+
intron-intronENST00000423133ENST00000560098CPEB1chr15

83315888

-CRTC3chr15

91147617

+
intron-intronENST00000423133ENST00000268184CPEB1chr15

83315888

-CRTC3chr15

91147617

+
intron-3UTRENST00000423133ENST00000558619CPEB1chr15

83315888

-CRTC3chr15

91147617

+
intron-3CDSENST00000568128ENST00000420329CPEB1chr15

83315888

-CRTC3chr15

91147617

+
intron-intronENST00000568128ENST00000560098CPEB1chr15

83315888

-CRTC3chr15

91147617

+
intron-intronENST00000568128ENST00000268184CPEB1chr15

83315888

-CRTC3chr15

91147617

+
intron-3UTRENST00000568128ENST00000558619CPEB1chr15

83315888

-CRTC3chr15

91147617

+
intron-3CDSENST00000564522ENST00000420329CPEB1chr15

83315888

-CRTC3chr15

91147617

+
intron-intronENST00000564522ENST00000560098CPEB1chr15

83315888

-CRTC3chr15

91147617

+
intron-intronENST00000564522ENST00000268184CPEB1chr15

83315888

-CRTC3chr15

91147617

+
intron-3UTRENST00000564522ENST00000558619CPEB1chr15

83315888

-CRTC3chr15

91147617

+
intron-3CDSENST00000261723ENST00000420329CPEB1chr15

83315888

-CRTC3chr15

91147617

+
intron-intronENST00000261723ENST00000560098CPEB1chr15

83315888

-CRTC3chr15

91147617

+
intron-intronENST00000261723ENST00000268184CPEB1chr15

83315888

-CRTC3chr15

91147617

+
intron-3UTRENST00000261723ENST00000558619CPEB1chr15

83315888

-CRTC3chr15

91147617

+
5UTR-3CDSENST00000568757ENST00000420329CPEB1chr15

83315888

-CRTC3chr15

91147617

+
5UTR-intronENST00000568757ENST00000560098CPEB1chr15

83315888

-CRTC3chr15

91147617

+
5UTR-intronENST00000568757ENST00000268184CPEB1chr15

83315888

-CRTC3chr15

91147617

+
5UTR-3UTRENST00000568757ENST00000558619CPEB1chr15

83315888

-CRTC3chr15

91147617

+
intron-3CDSENST00000398592ENST00000420329CPEB1chr15

83315888

-CRTC3chr15

91147617

+
intron-intronENST00000398592ENST00000560098CPEB1chr15

83315888

-CRTC3chr15

91147617

+
intron-intronENST00000398592ENST00000268184CPEB1chr15

83315888

-CRTC3chr15

91147617

+
intron-3UTRENST00000398592ENST00000558619CPEB1chr15

83315888

-CRTC3chr15

91147617

+
intron-3CDSENST00000563519ENST00000420329CPEB1chr15

83315888

-CRTC3chr15

91147617

+
intron-intronENST00000563519ENST00000560098CPEB1chr15

83315888

-CRTC3chr15

91147617

+
intron-intronENST00000563519ENST00000268184CPEB1chr15

83315888

-CRTC3chr15

91147617

+
intron-3UTRENST00000563519ENST00000558619CPEB1chr15

83315888

-CRTC3chr15

91147617

+

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FusionProtFeatures for CPEB1_CRTC3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CPEB1

Q9BZB8

CRTC3

Q6UUV7

Sequence-specific RNA-binding protein that regulatesmRNA cytoplasmic polyadenylation and translation initiation duringoocyte maturation, early development and at postsynapse sites ofneurons. Binds to the cytoplasmic polyadenylation element (CPE),an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. RNA binding results in a clearconformational change analogous to the Venus fly trap mechanism(PubMed:24990967). In absence of phosphorylation and inassociation with TACC3 is also involved as a repressor oftranslation of CPE-containing mRNA; a repression that is relievedby phosphorylation or degradation (By similarity). Involved in thetransport of CPE-containing mRNA to dendrites; those mRNAs may betransported to dendrites in a translationally dormant form andtranslationally activated at synapses (By similarity). Itsinteraction with APLP1 promotes local CPE-containing mRNApolyadenylation and translation activation (By similarity).Induces the assembly of stress granules in the absence of stress.Required for cell cycle progression, specifically for prophaseentry (PubMed:26398195). {ECO:0000250|UniProtKB:P70166,ECO:0000269|PubMed:15731006, ECO:0000269|PubMed:15966895,ECO:0000269|PubMed:24990967, ECO:0000269|PubMed:26398195}. Transcriptional coactivator for CREB1 which activatestranscription through both consensus and variant cAMP responseelement (CRE) sites. Acts as a coactivator, in the SIK/TORCsignaling pathway, being active when dephosphorylated and actsindependently of CREB1 'Ser-133' phosphorylation. Enhances theinteraction of CREB1 with TAF4. Regulates the expression ofspecific CREB-activated genes such as the steroidogenic gene,StAR. Potent coactivator of PPARGC1A and inducer of mitochondrialbiogenesis in muscle cells. Also coactivator for TAX activation ofthe human T-cell leukemia virus type 1 (HTLV-1) long terminalrepeats (LTR). {ECO:0000269|PubMed:14506290,ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:15466468,ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408,ECO:0000269|PubMed:17210223, ECO:0000269|PubMed:17644518}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CPEB1_CRTC3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CPEB1_CRTC3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CPEB1CPEB1, APP, SLC16A7, PIN1, SYMPK, METAP1D, GBP5, APBA3, CSTF2T, GAN, NMD3, CSTF2CRTC3YWHAG, YWHAB, SCYL1, NEDD1, MAGEA10, EWSR1, CENPJ, XPO1, CLTC, HCCS, HSPA5, POLD1, MAPK8, LRP8, GTSE1, PCDHB15, CFAP97, MCM2, DCAF7, KCTD3, KIF13B, CGN, ZBTB21, KSR1, CBY1, MDM2, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CPEB1_CRTC3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CPEB1_CRTC3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCPEB1C0023434Chronic Lymphocytic Leukemia1CTD_human