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Fusion gene ID: 8209 |
FusionGeneSummary for CPB2_ZC3H13 |
Fusion gene summary |
Fusion gene information | Fusion gene name: CPB2_ZC3H13 | Fusion gene ID: 8209 | Hgene | Tgene | Gene symbol | CPB2 | ZC3H13 | Gene ID | 1361 | 23091 |
Gene name | carboxypeptidase B2 | zinc finger CCCH-type containing 13 | |
Synonyms | CPU|PCPB|TAFI | KIAA0853|Xio | |
Cytomap | 13q14.13 | 13q14.13 | |
Type of gene | protein-coding | protein-coding | |
Description | carboxypeptidase B2carboxypeptidase B-like proteincarboxypeptidase B2 (plasma)carboxypeptidase B2 (plasma, carboxypeptidase U)carboxypeptidase Rthrombin-activable fibrinolysis inhibitorthrombin-activatable fibrinolysis inhibitor | zinc finger CCCH domain-containing protein 13 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q96IY4 | Q5T200 | |
Ensembl transtripts involved in fusion gene | ENST00000181383, ENST00000439329, | ENST00000242848, ENST00000378921, ENST00000282007, ENST00000470308, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 6 X 7 X 3=126 |
# samples | 1 | 7 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(7/126*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CPB2 [Title/Abstract] AND ZC3H13 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LIHC | TCGA-G3-A25U-01A | CPB2 | chr13 | 46648008 | - | ZC3H13 | chr13 | 46542163 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000181383 | ENST00000242848 | CPB2 | chr13 | 46648008 | - | ZC3H13 | chr13 | 46542163 | - |
Frame-shift | ENST00000181383 | ENST00000378921 | CPB2 | chr13 | 46648008 | - | ZC3H13 | chr13 | 46542163 | - |
Frame-shift | ENST00000181383 | ENST00000282007 | CPB2 | chr13 | 46648008 | - | ZC3H13 | chr13 | 46542163 | - |
5CDS-intron | ENST00000181383 | ENST00000470308 | CPB2 | chr13 | 46648008 | - | ZC3H13 | chr13 | 46542163 | - |
Frame-shift | ENST00000439329 | ENST00000242848 | CPB2 | chr13 | 46648008 | - | ZC3H13 | chr13 | 46542163 | - |
Frame-shift | ENST00000439329 | ENST00000378921 | CPB2 | chr13 | 46648008 | - | ZC3H13 | chr13 | 46542163 | - |
Frame-shift | ENST00000439329 | ENST00000282007 | CPB2 | chr13 | 46648008 | - | ZC3H13 | chr13 | 46542163 | - |
5CDS-intron | ENST00000439329 | ENST00000470308 | CPB2 | chr13 | 46648008 | - | ZC3H13 | chr13 | 46542163 | - |
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FusionProtFeatures for CPB2_ZC3H13 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
CPB2 | ZC3H13 |
Cleaves C-terminal arginine or lysine residues frombiologically active peptides such as kinins or anaphylatoxins inthe circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues fromfibrin that has already been partially degraded by plasmin.{ECO:0000269|PubMed:10574983}. | Associated component of the WMM complex, a complex thatmediates N6-methyladenosine (m6A) methylation of RNAs, amodification that plays a role in the efficiency of mRNA splicingand RNA processing (PubMed:29507755). Acts as a key regulator ofm6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs)pluripotency via its role in m6A methylation (By similarity). Inthe WMM complex, anchors component of the MACOM subcomplex in thenucleus (By similarity). Also required for bridging WTAP to theRNA-binding component RBM15 (RBM15 or RBM15B) (By similarity).{ECO:0000250|UniProtKB:E9Q784}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CPB2_ZC3H13 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CPB2_ZC3H13 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CPB2 | A2M, F2, PLG, C5, FN1, TINAG | ZC3H13 | CENPA, MED12, MED13, CCNC, MED25, MED16, MED17, MED1, MED28, MED24, MED23, MED4, MED29, MED8, MED15, MED6, MED14, CDK19, MED30, MED26, POLR2A, POLR2B, MED9, MED19, MED27, MED20, MED21, CDK9, TERF2, BAP1, SIRT7, ALYREF, USP15, WBP11, MAGOH, EIF4A3, CSNK2A1, SCHIP1, YWHAQ, SUZ12, BMI1, ZNF645, KIAA1429, WTAP, KRAS, SRPK2, CLK1, CBR1, ID1, THOC1, KIF26B, MZT1, GAN, U2AF2, ZC3H18, CLK3 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CPB2_ZC3H13 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CPB2_ZC3H13 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CPB2 | C0002453 | Amenorrhea | 1 | CTD_human |
Hgene | CPB2 | C0028754 | Obesity | 1 | CTD_human |