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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8190

FusionGeneSummary for COX7B_COX7B

check button Fusion gene summary
Fusion gene informationFusion gene name: COX7B_COX7B
Fusion gene ID: 8190
HgeneTgene
Gene symbol

COX7B

COX7B

Gene ID

1349

1349

Gene namecytochrome c oxidase subunit 7Bcytochrome c oxidase subunit 7B
SynonymsAPLCC|LSDMCA2APLCC|LSDMCA2
Cytomap

Xq21.1

Xq21.1

Type of geneprotein-codingprotein-coding
Descriptioncytochrome c oxidase subunit 7B, mitochondrialcytochrome c oxidase polypeptide VIIbcytochrome c oxidase subunit VIIbcytochrome-c oxidase chain VIIbcytochrome c oxidase subunit 7B, mitochondrialcytochrome c oxidase polypeptide VIIbcytochrome c oxidase subunit VIIbcytochrome-c oxidase chain VIIb
Modification date2018052220180522
UniProtAcc

P24311

P24311

Ensembl transtripts involved in fusion geneENST00000481445, ENST00000475465, 
ENST00000481445, ENST00000475465, 
Fusion gene scores* DoF score1 X 1 X 1=14 X 3 X 4=48
# samples 14
** MAII scorelog2(1/1*10)=3.32192809488736log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: COX7B [Title/Abstract] AND COX7B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CA944777COX7BchrX

77158162

-COX7BchrX

77155023

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000481445ENST00000481445COX7BchrX

77158162

-COX7BchrX

77155023

+
5CDS-3UTRENST00000481445ENST00000475465COX7BchrX

77158162

-COX7BchrX

77155023

+
3UTR-5UTRENST00000475465ENST00000481445COX7BchrX

77158162

-COX7BchrX

77155023

+
3UTR-3UTRENST00000475465ENST00000475465COX7BchrX

77158162

-COX7BchrX

77155023

+

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FusionProtFeatures for COX7B_COX7B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
COX7B

P24311

COX7B

P24311

This protein is one of the nuclear-coded polypeptidechains of cytochrome c oxidase, the terminal oxidase inmitochondrial electron transport. Plays a role in proper centralnervous system (CNS) development in vertebrates.{ECO:0000269|PubMed:23122588}. This protein is one of the nuclear-coded polypeptidechains of cytochrome c oxidase, the terminal oxidase inmitochondrial electron transport. Plays a role in proper centralnervous system (CNS) development in vertebrates.{ECO:0000269|PubMed:23122588}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for COX7B_COX7B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for COX7B_COX7B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for COX7B_COX7B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneCOX7BP24311DB02659Cholic AcidCytochrome c oxidase subunit 7B, mitochondrialsmall moleculeapproved
TgeneCOX7BP24311DB02659Cholic AcidCytochrome c oxidase subunit 7B, mitochondrialsmall moleculeapproved

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RelatedDiseases for COX7B_COX7B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource