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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8140

FusionGeneSummary for CORO6_CORO6

check button Fusion gene summary
Fusion gene informationFusion gene name: CORO6_CORO6
Fusion gene ID: 8140
HgeneTgene
Gene symbol

CORO6

CORO6

Gene ID

84940

84940

Gene namecoronin 6coronin 6
Synonyms--
Cytomap

17q11.2

17q11.2

Type of geneprotein-codingprotein-coding
Descriptioncoronin-6clipin-Ecoronin, actin binding protein 6coronin-like protein Ecoronin-6clipin-Ecoronin, actin binding protein 6coronin-like protein E
Modification date2018051920180519
UniProtAcc

Q6QEF8

Q6QEF8

Ensembl transtripts involved in fusion geneENST00000445145, ENST00000388767, 
ENST00000345068, ENST00000580212, 
ENST00000456796, ENST00000584969, 
ENST00000577909, 		ENST00000445145, 
ENST00000388767, ENST00000345068, 
ENST00000580212, ENST00000456796, 
ENST00000584969, ENST00000577909, 
Fusion gene scores* DoF score2 X 2 X 2=84 X 4 X 3=48
# samples 24
** MAII scorelog2(2/8*10)=1.32192809488736log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CORO6 [Title/Abstract] AND CORO6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CF454387CORO6chr17

27942721

-CORO6chr17

27942744

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000445145ENST00000445145CORO6chr17

27942721

-CORO6chr17

27942744

+
intron-3UTRENST00000445145ENST00000388767CORO6chr17

27942721

-CORO6chr17

27942744

+
intron-3UTRENST00000445145ENST00000345068CORO6chr17

27942721

-CORO6chr17

27942744

+
intron-3UTRENST00000445145ENST00000580212CORO6chr17

27942721

-CORO6chr17

27942744

+
intron-3UTRENST00000445145ENST00000456796CORO6chr17

27942721

-CORO6chr17

27942744

+
intron-intronENST00000445145ENST00000584969CORO6chr17

27942721

-CORO6chr17

27942744

+
intron-intronENST00000445145ENST00000577909CORO6chr17

27942721

-CORO6chr17

27942744

+
intron-3UTRENST00000388767ENST00000445145CORO6chr17

27942721

-CORO6chr17

27942744

+
intron-3UTRENST00000388767ENST00000388767CORO6chr17

27942721

-CORO6chr17

27942744

+
intron-3UTRENST00000388767ENST00000345068CORO6chr17

27942721

-CORO6chr17

27942744

+
intron-3UTRENST00000388767ENST00000580212CORO6chr17

27942721

-CORO6chr17

27942744

+
intron-3UTRENST00000388767ENST00000456796CORO6chr17

27942721

-CORO6chr17

27942744

+
intron-intronENST00000388767ENST00000584969CORO6chr17

27942721

-CORO6chr17

27942744

+
intron-intronENST00000388767ENST00000577909CORO6chr17

27942721

-CORO6chr17

27942744

+
intron-3UTRENST00000345068ENST00000445145CORO6chr17

27942721

-CORO6chr17

27942744

+
intron-3UTRENST00000345068ENST00000388767CORO6chr17

27942721

-CORO6chr17

27942744

+
intron-3UTRENST00000345068ENST00000345068CORO6chr17

27942721

-CORO6chr17

27942744

+
intron-3UTRENST00000345068ENST00000580212CORO6chr17

27942721

-CORO6chr17

27942744

+
intron-3UTRENST00000345068ENST00000456796CORO6chr17

27942721

-CORO6chr17

27942744

+
intron-intronENST00000345068ENST00000584969CORO6chr17

27942721

-CORO6chr17

27942744

+
intron-intronENST00000345068ENST00000577909CORO6chr17

27942721

-CORO6chr17

27942744

+
intron-3UTRENST00000580212ENST00000445145CORO6chr17

27942721

-CORO6chr17

27942744

+
intron-3UTRENST00000580212ENST00000388767CORO6chr17

27942721

-CORO6chr17

27942744

+
intron-3UTRENST00000580212ENST00000345068CORO6chr17

27942721

-CORO6chr17

27942744

+
intron-3UTRENST00000580212ENST00000580212CORO6chr17

27942721

-CORO6chr17

27942744

+
intron-3UTRENST00000580212ENST00000456796CORO6chr17

27942721

-CORO6chr17

27942744

+
intron-intronENST00000580212ENST00000584969CORO6chr17

27942721

-CORO6chr17

27942744

+
intron-intronENST00000580212ENST00000577909CORO6chr17

27942721

-CORO6chr17

27942744

+
intron-3UTRENST00000456796ENST00000445145CORO6chr17

27942721

-CORO6chr17

27942744

+
intron-3UTRENST00000456796ENST00000388767CORO6chr17

27942721

-CORO6chr17

27942744

+
intron-3UTRENST00000456796ENST00000345068CORO6chr17

27942721

-CORO6chr17

27942744

+
intron-3UTRENST00000456796ENST00000580212CORO6chr17

27942721

-CORO6chr17

27942744

+
intron-3UTRENST00000456796ENST00000456796CORO6chr17

27942721

-CORO6chr17

27942744

+
intron-intronENST00000456796ENST00000584969CORO6chr17

27942721

-CORO6chr17

27942744

+
intron-intronENST00000456796ENST00000577909CORO6chr17

27942721

-CORO6chr17

27942744

+
intron-3UTRENST00000584969ENST00000445145CORO6chr17

27942721

-CORO6chr17

27942744

+
intron-3UTRENST00000584969ENST00000388767CORO6chr17

27942721

-CORO6chr17

27942744

+
intron-3UTRENST00000584969ENST00000345068CORO6chr17

27942721

-CORO6chr17

27942744

+
intron-3UTRENST00000584969ENST00000580212CORO6chr17

27942721

-CORO6chr17

27942744

+
intron-3UTRENST00000584969ENST00000456796CORO6chr17

27942721

-CORO6chr17

27942744

+
intron-intronENST00000584969ENST00000584969CORO6chr17

27942721

-CORO6chr17

27942744

+
intron-intronENST00000584969ENST00000577909CORO6chr17

27942721

-CORO6chr17

27942744

+
intron-3UTRENST00000577909ENST00000445145CORO6chr17

27942721

-CORO6chr17

27942744

+
intron-3UTRENST00000577909ENST00000388767CORO6chr17

27942721

-CORO6chr17

27942744

+
intron-3UTRENST00000577909ENST00000345068CORO6chr17

27942721

-CORO6chr17

27942744

+
intron-3UTRENST00000577909ENST00000580212CORO6chr17

27942721

-CORO6chr17

27942744

+
intron-3UTRENST00000577909ENST00000456796CORO6chr17

27942721

-CORO6chr17

27942744

+
intron-intronENST00000577909ENST00000584969CORO6chr17

27942721

-CORO6chr17

27942744

+
intron-intronENST00000577909ENST00000577909CORO6chr17

27942721

-CORO6chr17

27942744

+

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FusionProtFeatures for CORO6_CORO6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CORO6

Q6QEF8

CORO6

Q6QEF8


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CORO6_CORO6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CORO6_CORO6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for CORO6_CORO6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for CORO6_CORO6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource