|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 8114 |
FusionGeneSummary for COPZ1_PPP1R1A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: COPZ1_PPP1R1A | Fusion gene ID: 8114 | Hgene | Tgene | Gene symbol | COPZ1 | PPP1R1A | Gene ID | 22818 | 5502 |
| Gene name | coatomer protein complex subunit zeta 1 | protein phosphatase 1 regulatory inhibitor subunit 1A | |
| Synonyms | CGI-120|COPZ|HSPC181|zeta-COP|zeta1-COP | I1|IPP1 | |
| Cytomap | 12q13.13 | 12q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | coatomer subunit zeta-1coatomer protein complex, subunit zetazeta-1 COPzeta-1-coat protein | protein phosphatase 1 regulatory subunit 1AI-1IPP-1inhibitor-1protein phosphatase inhibitor-1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P61923 | Q13522 | |
| Ensembl transtripts involved in fusion gene | ENST00000262061, ENST00000549043, ENST00000552218, ENST00000553231, ENST00000552362, ENST00000455864, ENST00000416254, ENST00000549116, ENST00000551779, ENST00000548281, ENST00000548753, | ENST00000547431, ENST00000257905, | |
| Fusion gene scores | * DoF score | 8 X 3 X 7=168 | 1 X 1 X 1=1 |
| # samples | 8 | 1 | |
| ** MAII score | log2(8/168*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: COPZ1 [Title/Abstract] AND PPP1R1A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | COPZ1 | GO:0006891 | intra-Golgi vesicle-mediated transport | 11056392 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LGG | TCGA-E1-5304-01A | COPZ1 | chr12 | 54718965 | + | PPP1R1A | chr12 | 54974834 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000262061 | ENST00000547431 | COPZ1 | chr12 | 54718965 | + | PPP1R1A | chr12 | 54974834 | - |
| Frame-shift | ENST00000262061 | ENST00000257905 | COPZ1 | chr12 | 54718965 | + | PPP1R1A | chr12 | 54974834 | - |
| 5UTR-3CDS | ENST00000549043 | ENST00000547431 | COPZ1 | chr12 | 54718965 | + | PPP1R1A | chr12 | 54974834 | - |
| 5UTR-3CDS | ENST00000549043 | ENST00000257905 | COPZ1 | chr12 | 54718965 | + | PPP1R1A | chr12 | 54974834 | - |
| In-frame | ENST00000552218 | ENST00000547431 | COPZ1 | chr12 | 54718965 | + | PPP1R1A | chr12 | 54974834 | - |
| Frame-shift | ENST00000552218 | ENST00000257905 | COPZ1 | chr12 | 54718965 | + | PPP1R1A | chr12 | 54974834 | - |
| In-frame | ENST00000553231 | ENST00000547431 | COPZ1 | chr12 | 54718965 | + | PPP1R1A | chr12 | 54974834 | - |
| Frame-shift | ENST00000553231 | ENST00000257905 | COPZ1 | chr12 | 54718965 | + | PPP1R1A | chr12 | 54974834 | - |
| In-frame | ENST00000552362 | ENST00000547431 | COPZ1 | chr12 | 54718965 | + | PPP1R1A | chr12 | 54974834 | - |
| Frame-shift | ENST00000552362 | ENST00000257905 | COPZ1 | chr12 | 54718965 | + | PPP1R1A | chr12 | 54974834 | - |
| In-frame | ENST00000455864 | ENST00000547431 | COPZ1 | chr12 | 54718965 | + | PPP1R1A | chr12 | 54974834 | - |
| Frame-shift | ENST00000455864 | ENST00000257905 | COPZ1 | chr12 | 54718965 | + | PPP1R1A | chr12 | 54974834 | - |
| 5UTR-3CDS | ENST00000416254 | ENST00000547431 | COPZ1 | chr12 | 54718965 | + | PPP1R1A | chr12 | 54974834 | - |
| 5UTR-3CDS | ENST00000416254 | ENST00000257905 | COPZ1 | chr12 | 54718965 | + | PPP1R1A | chr12 | 54974834 | - |
| In-frame | ENST00000549116 | ENST00000547431 | COPZ1 | chr12 | 54718965 | + | PPP1R1A | chr12 | 54974834 | - |
| Frame-shift | ENST00000549116 | ENST00000257905 | COPZ1 | chr12 | 54718965 | + | PPP1R1A | chr12 | 54974834 | - |
| In-frame | ENST00000551779 | ENST00000547431 | COPZ1 | chr12 | 54718965 | + | PPP1R1A | chr12 | 54974834 | - |
| Frame-shift | ENST00000551779 | ENST00000257905 | COPZ1 | chr12 | 54718965 | + | PPP1R1A | chr12 | 54974834 | - |
| intron-3CDS | ENST00000548281 | ENST00000547431 | COPZ1 | chr12 | 54718965 | + | PPP1R1A | chr12 | 54974834 | - |
| intron-3CDS | ENST00000548281 | ENST00000257905 | COPZ1 | chr12 | 54718965 | + | PPP1R1A | chr12 | 54974834 | - |
| intron-3CDS | ENST00000548753 | ENST00000547431 | COPZ1 | chr12 | 54718965 | + | PPP1R1A | chr12 | 54974834 | - |
| intron-3CDS | ENST00000548753 | ENST00000257905 | COPZ1 | chr12 | 54718965 | + | PPP1R1A | chr12 | 54974834 | - |
Top |
FusionProtFeatures for COPZ1_PPP1R1A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| COPZ1 | PPP1R1A |
| The coatomer is a cytosolic protein complex that bindsto dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosyntheticprotein transport from the ER, via the Golgi up to the trans Golginetwork. Coatomer complex is required for budding from Golgimembranes, and is essential for the retrograde Golgi-to-ERtransport of dilysine-tagged proteins. In mammals, the coatomercan only be recruited by membranes associated to ADP-ribosylationfactors (ARFs), which are small GTP-binding proteins; the complexalso influences the Golgi structural integrity, as well as theprocessing, activity, and endocytic recycling of LDL receptors (Bysimilarity). {ECO:0000250}. The zeta subunit may be involved in regulating the coatassembly and, hence, the rate of biosynthetic protein transportdue to its association-dissociation properties with the coatomercomplex. | Inhibitor of protein-phosphatase 1. This protein may beimportant in hormonal control of glycogen metabolism. Hormonesthat elevate intracellular cAMP increase I-1 activity in manytissues. I-1 activation may impose cAMP control over proteins thatare not directly phosphorylated by PKA. Following a rise inintracellular calcium, I-1 is inactivated by calcineurin (orPP2B). Does not inhibit type-2 phosphatases. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | PPP1R1A | chr12:54718965 | chr12:54974834 | ENST00000257905 | - | 4 | 7 | 42_54 | 134 | 172 | Region | Essential for activity |
| Tgene | PPP1R1A | chr12:54718965 | chr12:54974834 | ENST00000257905 | - | 4 | 7 | 9_12 | 134 | 172 | Region | Note=Essential for activity |
Top |
FusionGeneSequence for COPZ1_PPP1R1A |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_COPZ1_ENST00000262061_chr12_54718965_+_PPP1R1A_ENST00000547431_chr12_54974834_-_99aa MEALILKLQNASLKLTREAVRNPAQKNPQPIYHHWIPREPTRSERGGGTGGQKSVGGFPCSTHTLAPFYVFTRSILLLKRGERMSHPLEP >In-frame_COPZ1_ENST00000552218_chr12_54718965_+_PPP1R1A_ENST00000547431_chr12_54974834_-_99aa MEALILKLQNASLKLTREAVRNPAQKNPQPIYHHWIPREPTRSERGGGTGGQKSVGGFPCSTHTLAPFYVFTRSILLLKRGERMSHPLEP >In-frame_COPZ1_ENST00000553231_chr12_54718965_+_PPP1R1A_ENST00000547431_chr12_54974834_-_99aa MEALILKLQNASLKLTREAVRNPAQKNPQPIYHHWIPREPTRSERGGGTGGQKSVGGFPCSTHTLAPFYVFTRSILLLKRGERMSHPLEP >In-frame_COPZ1_ENST00000552362_chr12_54718965_+_PPP1R1A_ENST00000547431_chr12_54974834_-_99aa MEALILKLQNASLKLTREAVRNPAQKNPQPIYHHWIPREPTRSERGGGTGGQKSVGGFPCSTHTLAPFYVFTRSILLLKRGERMSHPLEP >In-frame_COPZ1_ENST00000455864_chr12_54718965_+_PPP1R1A_ENST00000547431_chr12_54974834_-_99aa MEALILKLQNASLKLTREAVRNPAQKNPQPIYHHWIPREPTRSERGGGTGGQKSVGGFPCSTHTLAPFYVFTRSILLLKRGERMSHPLEP >In-frame_COPZ1_ENST00000549116_chr12_54718965_+_PPP1R1A_ENST00000547431_chr12_54974834_-_99aa MEALILKLQNASLKLTREAVRNPAQKNPQPIYHHWIPREPTRSERGGGTGGQKSVGGFPCSTHTLAPFYVFTRSILLLKRGERMSHPLEP >In-frame_COPZ1_ENST00000551779_chr12_54718965_+_PPP1R1A_ENST00000547431_chr12_54974834_-_99aa MEALILKLQNASLKLTREAVRNPAQKNPQPIYHHWIPREPTRSERGGGTGGQKSVGGFPCSTHTLAPFYVFTRSILLLKRGERMSHPLEP |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_COPZ1_ENST00000262061_chr12_54718965_+_PPP1R1A_ENST00000547431_chr12_54974834_-_297nt ATGGAGGCGCTGATTTTGAAACTGCAGAATGCATCCCTAAAACTCACGAGAGAGGCAGTAAGGAACCCAGCACAAAAGAACCCTCAACCC ATATACCACCACTGGATTCCAAGGGAGCCAACTCGGTCTGAGAGAGGAGGAGGGACTGGGGGACAGAAGAGCGTGGGAGGATTTCCCTGC TCCACCCACACTTTGGCTCCATTCTATGTCTTCACTCGCTCCATTTTACTGCTCAAAAGGGGAGAGAGAATGTCGCATCCACTGGAGCCC >In-frame_COPZ1_ENST00000552218_chr12_54718965_+_PPP1R1A_ENST00000547431_chr12_54974834_-_297nt ATGGAGGCGCTGATTTTGAAACTGCAGAATGCATCCCTAAAACTCACGAGAGAGGCAGTAAGGAACCCAGCACAAAAGAACCCTCAACCC ATATACCACCACTGGATTCCAAGGGAGCCAACTCGGTCTGAGAGAGGAGGAGGGACTGGGGGACAGAAGAGCGTGGGAGGATTTCCCTGC TCCACCCACACTTTGGCTCCATTCTATGTCTTCACTCGCTCCATTTTACTGCTCAAAAGGGGAGAGAGAATGTCGCATCCACTGGAGCCC >In-frame_COPZ1_ENST00000553231_chr12_54718965_+_PPP1R1A_ENST00000547431_chr12_54974834_-_297nt ATGGAGGCGCTGATTTTGAAACTGCAGAATGCATCCCTAAAACTCACGAGAGAGGCAGTAAGGAACCCAGCACAAAAGAACCCTCAACCC ATATACCACCACTGGATTCCAAGGGAGCCAACTCGGTCTGAGAGAGGAGGAGGGACTGGGGGACAGAAGAGCGTGGGAGGATTTCCCTGC TCCACCCACACTTTGGCTCCATTCTATGTCTTCACTCGCTCCATTTTACTGCTCAAAAGGGGAGAGAGAATGTCGCATCCACTGGAGCCC >In-frame_COPZ1_ENST00000552362_chr12_54718965_+_PPP1R1A_ENST00000547431_chr12_54974834_-_297nt ATGGAGGCGCTGATTTTGAAACTGCAGAATGCATCCCTAAAACTCACGAGAGAGGCAGTAAGGAACCCAGCACAAAAGAACCCTCAACCC ATATACCACCACTGGATTCCAAGGGAGCCAACTCGGTCTGAGAGAGGAGGAGGGACTGGGGGACAGAAGAGCGTGGGAGGATTTCCCTGC TCCACCCACACTTTGGCTCCATTCTATGTCTTCACTCGCTCCATTTTACTGCTCAAAAGGGGAGAGAGAATGTCGCATCCACTGGAGCCC >In-frame_COPZ1_ENST00000455864_chr12_54718965_+_PPP1R1A_ENST00000547431_chr12_54974834_-_297nt ATGGAGGCGCTGATTTTGAAACTGCAGAATGCATCCCTAAAACTCACGAGAGAGGCAGTAAGGAACCCAGCACAAAAGAACCCTCAACCC ATATACCACCACTGGATTCCAAGGGAGCCAACTCGGTCTGAGAGAGGAGGAGGGACTGGGGGACAGAAGAGCGTGGGAGGATTTCCCTGC TCCACCCACACTTTGGCTCCATTCTATGTCTTCACTCGCTCCATTTTACTGCTCAAAAGGGGAGAGAGAATGTCGCATCCACTGGAGCCC >In-frame_COPZ1_ENST00000549116_chr12_54718965_+_PPP1R1A_ENST00000547431_chr12_54974834_-_297nt ATGGAGGCGCTGATTTTGAAACTGCAGAATGCATCCCTAAAACTCACGAGAGAGGCAGTAAGGAACCCAGCACAAAAGAACCCTCAACCC ATATACCACCACTGGATTCCAAGGGAGCCAACTCGGTCTGAGAGAGGAGGAGGGACTGGGGGACAGAAGAGCGTGGGAGGATTTCCCTGC TCCACCCACACTTTGGCTCCATTCTATGTCTTCACTCGCTCCATTTTACTGCTCAAAAGGGGAGAGAGAATGTCGCATCCACTGGAGCCC >In-frame_COPZ1_ENST00000551779_chr12_54718965_+_PPP1R1A_ENST00000547431_chr12_54974834_-_297nt ATGGAGGCGCTGATTTTGAAACTGCAGAATGCATCCCTAAAACTCACGAGAGAGGCAGTAAGGAACCCAGCACAAAAGAACCCTCAACCC ATATACCACCACTGGATTCCAAGGGAGCCAACTCGGTCTGAGAGAGGAGGAGGGACTGGGGGACAGAAGAGCGTGGGAGGATTTCCCTGC TCCACCCACACTTTGGCTCCATTCTATGTCTTCACTCGCTCCATTTTACTGCTCAAAAGGGGAGAGAGAATGTCGCATCCACTGGAGCCC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_COPZ1_ENST00000262061_chr12_54718965_+_PPP1R1A_ENST00000547431_chr12_54974834_-_2335nt TTTTGCGGCTCCACGTCGGCACCAGCTGCGGGGCAAGATGGAGGCGCTGATTTTGAAACTGCAGAATGCATCCCTAAAACTCACGAGAGA GGCAGTAAGGAACCCAGCACAAAAGAACCCTCAACCCATATACCACCACTGGATTCCAAGGGAGCCAACTCGGTCTGAGAGAGGAGGAGG GACTGGGGGACAGAAGAGCGTGGGAGGATTTCCCTGCTCCACCCACACTTTGGCTCCATTCTATGTCTTCACTCGCTCCATTTTACTGCT CAAAAGGGGAGAGAGAATGTCGCATCCACTGGAGCCCAGAGACGACCCAACAAAGATGCCATGATAGACACCAGCTCTCCTACACCCTCC ACCACAACAGGCTCACCTGGGCCAGCCCCAGGGCTAATCCAGATTCCCATTCTGGTTGTGTTCATCTTCGGCAGGGGATGGGGGGGCCTC TTCTTCACAGGGGGACAGCTCGTCAATGGACATCTGGTTGGTGATGCCTGTAGAGGAGCATAAAGGAGGCTGAGCTTAGGCCAAGAAGTA TTCTTCCCCAGAACCCAAGGAGTATGTGGAGACATGTAAGGGATTCTCATCCATCAACCTGCCTTCAAGCTGAACTACATTCAACCCATC CCCACTTGGGAAGAGCCTCTCCAGCCTTGCTAAAACTCAGAACCCTCAACACCACCCTACCACCCCCTCACACAGGAAGAGATTTCCCAG CCAGGGCCACCAAATTAGCCAAATCTACAGGGGCACCATTTACAGGGACCACAGTGTGCACAGGGACCCTTGGGTTGTGGAATATCTGAC TGTCTCTATCATCTCTACGGCCCCCATTCTTAGAACATTCCAGGCCACTCAGCCAGTCTTTCCTGTGATCTAACTGGTCTGATCAGCTCC ACTCCCAAATCAAGGAGTCCGGCAAAGGGTTTCCCCAGGGGCTTAAGAAAAATGGACCTCCTAGTGCTCCATGATCCACCCACACAAGTT CTCACCCCTGCCCTCTGCCATGGTACCCACCACTTGCTGCCCGTTCCTTCCATTTCTGCTTATTCTCCTGAATGCGCTTGACCCAGGTGG AACGAAAGCTGACCACATCAGGGTTGGGGTCTCCCACTTCCACATCCAGAGAGGGCTGGCGCCACTGAAAGCTAGAAGCAGAACCCCCAA AAGCCGCAAGAGGTAAGCCCCAGCCCACTCCAGAACCACCTTAGCCCTGGGAGTGCAGGACATGGAAGACCAGGAGAAGGTTCAGGGAAC TTCATCTTCCTCTTTTCCTCTACTAGATATTCCCCAAGTCCCTGTCCCTCTCCCCCTCATTTCACCCCTCCCTCTCCACATCTTCCCTCC TGGTAGAAGGAAAATTAAAACAAGATTAGCCAGAAGGCAGAAAGACAGCTAATGGAAGAAACAAAAATATGGTGAAGGGGAGCATAGGTA CAGGTCACACCCTTCTGATCCCATCCTTCTGTCCCTGACGGCAGAGGGACTCCCAAGCTTGAAGCAGTCTGCCTCCCCACCACCCCACCA TGGCTGTGAGTCGGTCCTCTCTGTGAGTCCAAATCCCTCCCTACCACTGCCTTCCTGAACCAAGATATCTGGCTACCCCAGCCACCCTCA CCTGGGCTGGTTTTTAGACTTGGAGTCCTCATCCGCCAGGGGCTGAACACTCTTCTCTGCCACGTCAGTCAGCACAGAGAATGTGGGCTC CACAATGAAGTCGATGAACCCTGCAGTGGAGGAGCAATGCCGTAGAGATGTCTTACTATTATCTGGAGGGCTAGGCAGAGCATGCAGCTG GCATGGCCAGGACCCCTGGCTGCTTATGAAAGAGGATGGAGAGGTAACCTGGGGCTGAAAACTTCCCAATGCAGGGCAGGCTTTGGGATG ATGTCTTGGTGCCCCAGAGAGCTCCTTCCTGCCATTGCAGCCCCCTGGCCTCCTAACCCAGGACCCCATGCTCTAGCACAGTAGGCTTTC CTCTACAGGAAGAATGGTTTGGGGGGATTGAGGACTTGGAGCAATCCTGACCCAGGCAGCATCTTTTCCCCCTCCCAGTCCTCCCCTTCC TGCAGGAGAGGACACTCACCTATCTGAGACTGTGCCACTAGAGTGGAAGTGCGGTCACAGAGTGGAGAAAAGGGCAGGCCCAACTCTGCC TCCTTGTCACCCTAGAGGAGGGAACAGGGTAGGAAAGCTGGAGAGGATACCTCAGACCTACCAGATCTGGGGTACAGGTGGCAAGTGGTG >In-frame_COPZ1_ENST00000552218_chr12_54718965_+_PPP1R1A_ENST00000547431_chr12_54974834_-_2331nt GCGGCTCCACGTCGGCACCAGCTGCGGGGCAAGATGGAGGCGCTGATTTTGAAACTGCAGAATGCATCCCTAAAACTCACGAGAGAGGCA GTAAGGAACCCAGCACAAAAGAACCCTCAACCCATATACCACCACTGGATTCCAAGGGAGCCAACTCGGTCTGAGAGAGGAGGAGGGACT GGGGGACAGAAGAGCGTGGGAGGATTTCCCTGCTCCACCCACACTTTGGCTCCATTCTATGTCTTCACTCGCTCCATTTTACTGCTCAAA AGGGGAGAGAGAATGTCGCATCCACTGGAGCCCAGAGACGACCCAACAAAGATGCCATGATAGACACCAGCTCTCCTACACCCTCCACCA CAACAGGCTCACCTGGGCCAGCCCCAGGGCTAATCCAGATTCCCATTCTGGTTGTGTTCATCTTCGGCAGGGGATGGGGGGGCCTCTTCT TCACAGGGGGACAGCTCGTCAATGGACATCTGGTTGGTGATGCCTGTAGAGGAGCATAAAGGAGGCTGAGCTTAGGCCAAGAAGTATTCT TCCCCAGAACCCAAGGAGTATGTGGAGACATGTAAGGGATTCTCATCCATCAACCTGCCTTCAAGCTGAACTACATTCAACCCATCCCCA CTTGGGAAGAGCCTCTCCAGCCTTGCTAAAACTCAGAACCCTCAACACCACCCTACCACCCCCTCACACAGGAAGAGATTTCCCAGCCAG GGCCACCAAATTAGCCAAATCTACAGGGGCACCATTTACAGGGACCACAGTGTGCACAGGGACCCTTGGGTTGTGGAATATCTGACTGTC TCTATCATCTCTACGGCCCCCATTCTTAGAACATTCCAGGCCACTCAGCCAGTCTTTCCTGTGATCTAACTGGTCTGATCAGCTCCACTC CCAAATCAAGGAGTCCGGCAAAGGGTTTCCCCAGGGGCTTAAGAAAAATGGACCTCCTAGTGCTCCATGATCCACCCACACAAGTTCTCA CCCCTGCCCTCTGCCATGGTACCCACCACTTGCTGCCCGTTCCTTCCATTTCTGCTTATTCTCCTGAATGCGCTTGACCCAGGTGGAACG AAAGCTGACCACATCAGGGTTGGGGTCTCCCACTTCCACATCCAGAGAGGGCTGGCGCCACTGAAAGCTAGAAGCAGAACCCCCAAAAGC CGCAAGAGGTAAGCCCCAGCCCACTCCAGAACCACCTTAGCCCTGGGAGTGCAGGACATGGAAGACCAGGAGAAGGTTCAGGGAACTTCA TCTTCCTCTTTTCCTCTACTAGATATTCCCCAAGTCCCTGTCCCTCTCCCCCTCATTTCACCCCTCCCTCTCCACATCTTCCCTCCTGGT AGAAGGAAAATTAAAACAAGATTAGCCAGAAGGCAGAAAGACAGCTAATGGAAGAAACAAAAATATGGTGAAGGGGAGCATAGGTACAGG TCACACCCTTCTGATCCCATCCTTCTGTCCCTGACGGCAGAGGGACTCCCAAGCTTGAAGCAGTCTGCCTCCCCACCACCCCACCATGGC TGTGAGTCGGTCCTCTCTGTGAGTCCAAATCCCTCCCTACCACTGCCTTCCTGAACCAAGATATCTGGCTACCCCAGCCACCCTCACCTG GGCTGGTTTTTAGACTTGGAGTCCTCATCCGCCAGGGGCTGAACACTCTTCTCTGCCACGTCAGTCAGCACAGAGAATGTGGGCTCCACA ATGAAGTCGATGAACCCTGCAGTGGAGGAGCAATGCCGTAGAGATGTCTTACTATTATCTGGAGGGCTAGGCAGAGCATGCAGCTGGCAT GGCCAGGACCCCTGGCTGCTTATGAAAGAGGATGGAGAGGTAACCTGGGGCTGAAAACTTCCCAATGCAGGGCAGGCTTTGGGATGATGT CTTGGTGCCCCAGAGAGCTCCTTCCTGCCATTGCAGCCCCCTGGCCTCCTAACCCAGGACCCCATGCTCTAGCACAGTAGGCTTTCCTCT ACAGGAAGAATGGTTTGGGGGGATTGAGGACTTGGAGCAATCCTGACCCAGGCAGCATCTTTTCCCCCTCCCAGTCCTCCCCTTCCTGCA GGAGAGGACACTCACCTATCTGAGACTGTGCCACTAGAGTGGAAGTGCGGTCACAGAGTGGAGAAAAGGGCAGGCCCAACTCTGCCTCCT TGTCACCCTAGAGGAGGGAACAGGGTAGGAAAGCTGGAGAGGATACCTCAGACCTACCAGATCTGGGGTACAGGTGGCAAGTGGTGGGGG >In-frame_COPZ1_ENST00000553231_chr12_54718965_+_PPP1R1A_ENST00000547431_chr12_54974834_-_2323nt ACGTCGGCACCAGCTGCGGGGCAAGATGGAGGCGCTGATTTTGAAACTGCAGAATGCATCCCTAAAACTCACGAGAGAGGCAGTAAGGAA CCCAGCACAAAAGAACCCTCAACCCATATACCACCACTGGATTCCAAGGGAGCCAACTCGGTCTGAGAGAGGAGGAGGGACTGGGGGACA GAAGAGCGTGGGAGGATTTCCCTGCTCCACCCACACTTTGGCTCCATTCTATGTCTTCACTCGCTCCATTTTACTGCTCAAAAGGGGAGA GAGAATGTCGCATCCACTGGAGCCCAGAGACGACCCAACAAAGATGCCATGATAGACACCAGCTCTCCTACACCCTCCACCACAACAGGC TCACCTGGGCCAGCCCCAGGGCTAATCCAGATTCCCATTCTGGTTGTGTTCATCTTCGGCAGGGGATGGGGGGGCCTCTTCTTCACAGGG GGACAGCTCGTCAATGGACATCTGGTTGGTGATGCCTGTAGAGGAGCATAAAGGAGGCTGAGCTTAGGCCAAGAAGTATTCTTCCCCAGA ACCCAAGGAGTATGTGGAGACATGTAAGGGATTCTCATCCATCAACCTGCCTTCAAGCTGAACTACATTCAACCCATCCCCACTTGGGAA GAGCCTCTCCAGCCTTGCTAAAACTCAGAACCCTCAACACCACCCTACCACCCCCTCACACAGGAAGAGATTTCCCAGCCAGGGCCACCA AATTAGCCAAATCTACAGGGGCACCATTTACAGGGACCACAGTGTGCACAGGGACCCTTGGGTTGTGGAATATCTGACTGTCTCTATCAT CTCTACGGCCCCCATTCTTAGAACATTCCAGGCCACTCAGCCAGTCTTTCCTGTGATCTAACTGGTCTGATCAGCTCCACTCCCAAATCA AGGAGTCCGGCAAAGGGTTTCCCCAGGGGCTTAAGAAAAATGGACCTCCTAGTGCTCCATGATCCACCCACACAAGTTCTCACCCCTGCC CTCTGCCATGGTACCCACCACTTGCTGCCCGTTCCTTCCATTTCTGCTTATTCTCCTGAATGCGCTTGACCCAGGTGGAACGAAAGCTGA CCACATCAGGGTTGGGGTCTCCCACTTCCACATCCAGAGAGGGCTGGCGCCACTGAAAGCTAGAAGCAGAACCCCCAAAAGCCGCAAGAG GTAAGCCCCAGCCCACTCCAGAACCACCTTAGCCCTGGGAGTGCAGGACATGGAAGACCAGGAGAAGGTTCAGGGAACTTCATCTTCCTC TTTTCCTCTACTAGATATTCCCCAAGTCCCTGTCCCTCTCCCCCTCATTTCACCCCTCCCTCTCCACATCTTCCCTCCTGGTAGAAGGAA AATTAAAACAAGATTAGCCAGAAGGCAGAAAGACAGCTAATGGAAGAAACAAAAATATGGTGAAGGGGAGCATAGGTACAGGTCACACCC TTCTGATCCCATCCTTCTGTCCCTGACGGCAGAGGGACTCCCAAGCTTGAAGCAGTCTGCCTCCCCACCACCCCACCATGGCTGTGAGTC GGTCCTCTCTGTGAGTCCAAATCCCTCCCTACCACTGCCTTCCTGAACCAAGATATCTGGCTACCCCAGCCACCCTCACCTGGGCTGGTT TTTAGACTTGGAGTCCTCATCCGCCAGGGGCTGAACACTCTTCTCTGCCACGTCAGTCAGCACAGAGAATGTGGGCTCCACAATGAAGTC GATGAACCCTGCAGTGGAGGAGCAATGCCGTAGAGATGTCTTACTATTATCTGGAGGGCTAGGCAGAGCATGCAGCTGGCATGGCCAGGA CCCCTGGCTGCTTATGAAAGAGGATGGAGAGGTAACCTGGGGCTGAAAACTTCCCAATGCAGGGCAGGCTTTGGGATGATGTCTTGGTGC CCCAGAGAGCTCCTTCCTGCCATTGCAGCCCCCTGGCCTCCTAACCCAGGACCCCATGCTCTAGCACAGTAGGCTTTCCTCTACAGGAAG AATGGTTTGGGGGGATTGAGGACTTGGAGCAATCCTGACCCAGGCAGCATCTTTTCCCCCTCCCAGTCCTCCCCTTCCTGCAGGAGAGGA CACTCACCTATCTGAGACTGTGCCACTAGAGTGGAAGTGCGGTCACAGAGTGGAGAAAAGGGCAGGCCCAACTCTGCCTCCTTGTCACCC TAGAGGAGGGAACAGGGTAGGAAAGCTGGAGAGGATACCTCAGACCTACCAGATCTGGGGTACAGGTGGCAAGTGGTGGGGGTGGGGGGT >In-frame_COPZ1_ENST00000552362_chr12_54718965_+_PPP1R1A_ENST00000547431_chr12_54974834_-_2323nt ACGTCGGCACCAGCTGCGGGGCAAGATGGAGGCGCTGATTTTGAAACTGCAGAATGCATCCCTAAAACTCACGAGAGAGGCAGTAAGGAA CCCAGCACAAAAGAACCCTCAACCCATATACCACCACTGGATTCCAAGGGAGCCAACTCGGTCTGAGAGAGGAGGAGGGACTGGGGGACA GAAGAGCGTGGGAGGATTTCCCTGCTCCACCCACACTTTGGCTCCATTCTATGTCTTCACTCGCTCCATTTTACTGCTCAAAAGGGGAGA GAGAATGTCGCATCCACTGGAGCCCAGAGACGACCCAACAAAGATGCCATGATAGACACCAGCTCTCCTACACCCTCCACCACAACAGGC TCACCTGGGCCAGCCCCAGGGCTAATCCAGATTCCCATTCTGGTTGTGTTCATCTTCGGCAGGGGATGGGGGGGCCTCTTCTTCACAGGG GGACAGCTCGTCAATGGACATCTGGTTGGTGATGCCTGTAGAGGAGCATAAAGGAGGCTGAGCTTAGGCCAAGAAGTATTCTTCCCCAGA ACCCAAGGAGTATGTGGAGACATGTAAGGGATTCTCATCCATCAACCTGCCTTCAAGCTGAACTACATTCAACCCATCCCCACTTGGGAA GAGCCTCTCCAGCCTTGCTAAAACTCAGAACCCTCAACACCACCCTACCACCCCCTCACACAGGAAGAGATTTCCCAGCCAGGGCCACCA AATTAGCCAAATCTACAGGGGCACCATTTACAGGGACCACAGTGTGCACAGGGACCCTTGGGTTGTGGAATATCTGACTGTCTCTATCAT CTCTACGGCCCCCATTCTTAGAACATTCCAGGCCACTCAGCCAGTCTTTCCTGTGATCTAACTGGTCTGATCAGCTCCACTCCCAAATCA AGGAGTCCGGCAAAGGGTTTCCCCAGGGGCTTAAGAAAAATGGACCTCCTAGTGCTCCATGATCCACCCACACAAGTTCTCACCCCTGCC CTCTGCCATGGTACCCACCACTTGCTGCCCGTTCCTTCCATTTCTGCTTATTCTCCTGAATGCGCTTGACCCAGGTGGAACGAAAGCTGA CCACATCAGGGTTGGGGTCTCCCACTTCCACATCCAGAGAGGGCTGGCGCCACTGAAAGCTAGAAGCAGAACCCCCAAAAGCCGCAAGAG GTAAGCCCCAGCCCACTCCAGAACCACCTTAGCCCTGGGAGTGCAGGACATGGAAGACCAGGAGAAGGTTCAGGGAACTTCATCTTCCTC TTTTCCTCTACTAGATATTCCCCAAGTCCCTGTCCCTCTCCCCCTCATTTCACCCCTCCCTCTCCACATCTTCCCTCCTGGTAGAAGGAA AATTAAAACAAGATTAGCCAGAAGGCAGAAAGACAGCTAATGGAAGAAACAAAAATATGGTGAAGGGGAGCATAGGTACAGGTCACACCC TTCTGATCCCATCCTTCTGTCCCTGACGGCAGAGGGACTCCCAAGCTTGAAGCAGTCTGCCTCCCCACCACCCCACCATGGCTGTGAGTC GGTCCTCTCTGTGAGTCCAAATCCCTCCCTACCACTGCCTTCCTGAACCAAGATATCTGGCTACCCCAGCCACCCTCACCTGGGCTGGTT TTTAGACTTGGAGTCCTCATCCGCCAGGGGCTGAACACTCTTCTCTGCCACGTCAGTCAGCACAGAGAATGTGGGCTCCACAATGAAGTC GATGAACCCTGCAGTGGAGGAGCAATGCCGTAGAGATGTCTTACTATTATCTGGAGGGCTAGGCAGAGCATGCAGCTGGCATGGCCAGGA CCCCTGGCTGCTTATGAAAGAGGATGGAGAGGTAACCTGGGGCTGAAAACTTCCCAATGCAGGGCAGGCTTTGGGATGATGTCTTGGTGC CCCAGAGAGCTCCTTCCTGCCATTGCAGCCCCCTGGCCTCCTAACCCAGGACCCCATGCTCTAGCACAGTAGGCTTTCCTCTACAGGAAG AATGGTTTGGGGGGATTGAGGACTTGGAGCAATCCTGACCCAGGCAGCATCTTTTCCCCCTCCCAGTCCTCCCCTTCCTGCAGGAGAGGA CACTCACCTATCTGAGACTGTGCCACTAGAGTGGAAGTGCGGTCACAGAGTGGAGAAAAGGGCAGGCCCAACTCTGCCTCCTTGTCACCC TAGAGGAGGGAACAGGGTAGGAAAGCTGGAGAGGATACCTCAGACCTACCAGATCTGGGGTACAGGTGGCAAGTGGTGGGGGTGGGGGGT >In-frame_COPZ1_ENST00000455864_chr12_54718965_+_PPP1R1A_ENST00000547431_chr12_54974834_-_2323nt ACGTCGGCACCAGCTGCGGGGCAAGATGGAGGCGCTGATTTTGAAACTGCAGAATGCATCCCTAAAACTCACGAGAGAGGCAGTAAGGAA CCCAGCACAAAAGAACCCTCAACCCATATACCACCACTGGATTCCAAGGGAGCCAACTCGGTCTGAGAGAGGAGGAGGGACTGGGGGACA GAAGAGCGTGGGAGGATTTCCCTGCTCCACCCACACTTTGGCTCCATTCTATGTCTTCACTCGCTCCATTTTACTGCTCAAAAGGGGAGA GAGAATGTCGCATCCACTGGAGCCCAGAGACGACCCAACAAAGATGCCATGATAGACACCAGCTCTCCTACACCCTCCACCACAACAGGC TCACCTGGGCCAGCCCCAGGGCTAATCCAGATTCCCATTCTGGTTGTGTTCATCTTCGGCAGGGGATGGGGGGGCCTCTTCTTCACAGGG GGACAGCTCGTCAATGGACATCTGGTTGGTGATGCCTGTAGAGGAGCATAAAGGAGGCTGAGCTTAGGCCAAGAAGTATTCTTCCCCAGA ACCCAAGGAGTATGTGGAGACATGTAAGGGATTCTCATCCATCAACCTGCCTTCAAGCTGAACTACATTCAACCCATCCCCACTTGGGAA GAGCCTCTCCAGCCTTGCTAAAACTCAGAACCCTCAACACCACCCTACCACCCCCTCACACAGGAAGAGATTTCCCAGCCAGGGCCACCA AATTAGCCAAATCTACAGGGGCACCATTTACAGGGACCACAGTGTGCACAGGGACCCTTGGGTTGTGGAATATCTGACTGTCTCTATCAT CTCTACGGCCCCCATTCTTAGAACATTCCAGGCCACTCAGCCAGTCTTTCCTGTGATCTAACTGGTCTGATCAGCTCCACTCCCAAATCA AGGAGTCCGGCAAAGGGTTTCCCCAGGGGCTTAAGAAAAATGGACCTCCTAGTGCTCCATGATCCACCCACACAAGTTCTCACCCCTGCC CTCTGCCATGGTACCCACCACTTGCTGCCCGTTCCTTCCATTTCTGCTTATTCTCCTGAATGCGCTTGACCCAGGTGGAACGAAAGCTGA CCACATCAGGGTTGGGGTCTCCCACTTCCACATCCAGAGAGGGCTGGCGCCACTGAAAGCTAGAAGCAGAACCCCCAAAAGCCGCAAGAG GTAAGCCCCAGCCCACTCCAGAACCACCTTAGCCCTGGGAGTGCAGGACATGGAAGACCAGGAGAAGGTTCAGGGAACTTCATCTTCCTC TTTTCCTCTACTAGATATTCCCCAAGTCCCTGTCCCTCTCCCCCTCATTTCACCCCTCCCTCTCCACATCTTCCCTCCTGGTAGAAGGAA AATTAAAACAAGATTAGCCAGAAGGCAGAAAGACAGCTAATGGAAGAAACAAAAATATGGTGAAGGGGAGCATAGGTACAGGTCACACCC TTCTGATCCCATCCTTCTGTCCCTGACGGCAGAGGGACTCCCAAGCTTGAAGCAGTCTGCCTCCCCACCACCCCACCATGGCTGTGAGTC GGTCCTCTCTGTGAGTCCAAATCCCTCCCTACCACTGCCTTCCTGAACCAAGATATCTGGCTACCCCAGCCACCCTCACCTGGGCTGGTT TTTAGACTTGGAGTCCTCATCCGCCAGGGGCTGAACACTCTTCTCTGCCACGTCAGTCAGCACAGAGAATGTGGGCTCCACAATGAAGTC GATGAACCCTGCAGTGGAGGAGCAATGCCGTAGAGATGTCTTACTATTATCTGGAGGGCTAGGCAGAGCATGCAGCTGGCATGGCCAGGA CCCCTGGCTGCTTATGAAAGAGGATGGAGAGGTAACCTGGGGCTGAAAACTTCCCAATGCAGGGCAGGCTTTGGGATGATGTCTTGGTGC CCCAGAGAGCTCCTTCCTGCCATTGCAGCCCCCTGGCCTCCTAACCCAGGACCCCATGCTCTAGCACAGTAGGCTTTCCTCTACAGGAAG AATGGTTTGGGGGGATTGAGGACTTGGAGCAATCCTGACCCAGGCAGCATCTTTTCCCCCTCCCAGTCCTCCCCTTCCTGCAGGAGAGGA CACTCACCTATCTGAGACTGTGCCACTAGAGTGGAAGTGCGGTCACAGAGTGGAGAAAAGGGCAGGCCCAACTCTGCCTCCTTGTCACCC TAGAGGAGGGAACAGGGTAGGAAAGCTGGAGAGGATACCTCAGACCTACCAGATCTGGGGTACAGGTGGCAAGTGGTGGGGGTGGGGGGT >In-frame_COPZ1_ENST00000549116_chr12_54718965_+_PPP1R1A_ENST00000547431_chr12_54974834_-_2318nt GGCACCAGCTGCGGGGCAAGATGGAGGCGCTGATTTTGAAACTGCAGAATGCATCCCTAAAACTCACGAGAGAGGCAGTAAGGAACCCAG CACAAAAGAACCCTCAACCCATATACCACCACTGGATTCCAAGGGAGCCAACTCGGTCTGAGAGAGGAGGAGGGACTGGGGGACAGAAGA GCGTGGGAGGATTTCCCTGCTCCACCCACACTTTGGCTCCATTCTATGTCTTCACTCGCTCCATTTTACTGCTCAAAAGGGGAGAGAGAA TGTCGCATCCACTGGAGCCCAGAGACGACCCAACAAAGATGCCATGATAGACACCAGCTCTCCTACACCCTCCACCACAACAGGCTCACC TGGGCCAGCCCCAGGGCTAATCCAGATTCCCATTCTGGTTGTGTTCATCTTCGGCAGGGGATGGGGGGGCCTCTTCTTCACAGGGGGACA GCTCGTCAATGGACATCTGGTTGGTGATGCCTGTAGAGGAGCATAAAGGAGGCTGAGCTTAGGCCAAGAAGTATTCTTCCCCAGAACCCA AGGAGTATGTGGAGACATGTAAGGGATTCTCATCCATCAACCTGCCTTCAAGCTGAACTACATTCAACCCATCCCCACTTGGGAAGAGCC TCTCCAGCCTTGCTAAAACTCAGAACCCTCAACACCACCCTACCACCCCCTCACACAGGAAGAGATTTCCCAGCCAGGGCCACCAAATTA GCCAAATCTACAGGGGCACCATTTACAGGGACCACAGTGTGCACAGGGACCCTTGGGTTGTGGAATATCTGACTGTCTCTATCATCTCTA CGGCCCCCATTCTTAGAACATTCCAGGCCACTCAGCCAGTCTTTCCTGTGATCTAACTGGTCTGATCAGCTCCACTCCCAAATCAAGGAG TCCGGCAAAGGGTTTCCCCAGGGGCTTAAGAAAAATGGACCTCCTAGTGCTCCATGATCCACCCACACAAGTTCTCACCCCTGCCCTCTG CCATGGTACCCACCACTTGCTGCCCGTTCCTTCCATTTCTGCTTATTCTCCTGAATGCGCTTGACCCAGGTGGAACGAAAGCTGACCACA TCAGGGTTGGGGTCTCCCACTTCCACATCCAGAGAGGGCTGGCGCCACTGAAAGCTAGAAGCAGAACCCCCAAAAGCCGCAAGAGGTAAG CCCCAGCCCACTCCAGAACCACCTTAGCCCTGGGAGTGCAGGACATGGAAGACCAGGAGAAGGTTCAGGGAACTTCATCTTCCTCTTTTC CTCTACTAGATATTCCCCAAGTCCCTGTCCCTCTCCCCCTCATTTCACCCCTCCCTCTCCACATCTTCCCTCCTGGTAGAAGGAAAATTA AAACAAGATTAGCCAGAAGGCAGAAAGACAGCTAATGGAAGAAACAAAAATATGGTGAAGGGGAGCATAGGTACAGGTCACACCCTTCTG ATCCCATCCTTCTGTCCCTGACGGCAGAGGGACTCCCAAGCTTGAAGCAGTCTGCCTCCCCACCACCCCACCATGGCTGTGAGTCGGTCC TCTCTGTGAGTCCAAATCCCTCCCTACCACTGCCTTCCTGAACCAAGATATCTGGCTACCCCAGCCACCCTCACCTGGGCTGGTTTTTAG ACTTGGAGTCCTCATCCGCCAGGGGCTGAACACTCTTCTCTGCCACGTCAGTCAGCACAGAGAATGTGGGCTCCACAATGAAGTCGATGA ACCCTGCAGTGGAGGAGCAATGCCGTAGAGATGTCTTACTATTATCTGGAGGGCTAGGCAGAGCATGCAGCTGGCATGGCCAGGACCCCT GGCTGCTTATGAAAGAGGATGGAGAGGTAACCTGGGGCTGAAAACTTCCCAATGCAGGGCAGGCTTTGGGATGATGTCTTGGTGCCCCAG AGAGCTCCTTCCTGCCATTGCAGCCCCCTGGCCTCCTAACCCAGGACCCCATGCTCTAGCACAGTAGGCTTTCCTCTACAGGAAGAATGG TTTGGGGGGATTGAGGACTTGGAGCAATCCTGACCCAGGCAGCATCTTTTCCCCCTCCCAGTCCTCCCCTTCCTGCAGGAGAGGACACTC ACCTATCTGAGACTGTGCCACTAGAGTGGAAGTGCGGTCACAGAGTGGAGAAAAGGGCAGGCCCAACTCTGCCTCCTTGTCACCCTAGAG GAGGGAACAGGGTAGGAAAGCTGGAGAGGATACCTCAGACCTACCAGATCTGGGGTACAGGTGGCAAGTGGTGGGGGTGGGGGGTTGTTG >In-frame_COPZ1_ENST00000551779_chr12_54718965_+_PPP1R1A_ENST00000547431_chr12_54974834_-_2311nt GCTGCGGGGCAAGATGGAGGCGCTGATTTTGAAACTGCAGAATGCATCCCTAAAACTCACGAGAGAGGCAGTAAGGAACCCAGCACAAAA GAACCCTCAACCCATATACCACCACTGGATTCCAAGGGAGCCAACTCGGTCTGAGAGAGGAGGAGGGACTGGGGGACAGAAGAGCGTGGG AGGATTTCCCTGCTCCACCCACACTTTGGCTCCATTCTATGTCTTCACTCGCTCCATTTTACTGCTCAAAAGGGGAGAGAGAATGTCGCA TCCACTGGAGCCCAGAGACGACCCAACAAAGATGCCATGATAGACACCAGCTCTCCTACACCCTCCACCACAACAGGCTCACCTGGGCCA GCCCCAGGGCTAATCCAGATTCCCATTCTGGTTGTGTTCATCTTCGGCAGGGGATGGGGGGGCCTCTTCTTCACAGGGGGACAGCTCGTC AATGGACATCTGGTTGGTGATGCCTGTAGAGGAGCATAAAGGAGGCTGAGCTTAGGCCAAGAAGTATTCTTCCCCAGAACCCAAGGAGTA TGTGGAGACATGTAAGGGATTCTCATCCATCAACCTGCCTTCAAGCTGAACTACATTCAACCCATCCCCACTTGGGAAGAGCCTCTCCAG CCTTGCTAAAACTCAGAACCCTCAACACCACCCTACCACCCCCTCACACAGGAAGAGATTTCCCAGCCAGGGCCACCAAATTAGCCAAAT CTACAGGGGCACCATTTACAGGGACCACAGTGTGCACAGGGACCCTTGGGTTGTGGAATATCTGACTGTCTCTATCATCTCTACGGCCCC CATTCTTAGAACATTCCAGGCCACTCAGCCAGTCTTTCCTGTGATCTAACTGGTCTGATCAGCTCCACTCCCAAATCAAGGAGTCCGGCA AAGGGTTTCCCCAGGGGCTTAAGAAAAATGGACCTCCTAGTGCTCCATGATCCACCCACACAAGTTCTCACCCCTGCCCTCTGCCATGGT ACCCACCACTTGCTGCCCGTTCCTTCCATTTCTGCTTATTCTCCTGAATGCGCTTGACCCAGGTGGAACGAAAGCTGACCACATCAGGGT TGGGGTCTCCCACTTCCACATCCAGAGAGGGCTGGCGCCACTGAAAGCTAGAAGCAGAACCCCCAAAAGCCGCAAGAGGTAAGCCCCAGC CCACTCCAGAACCACCTTAGCCCTGGGAGTGCAGGACATGGAAGACCAGGAGAAGGTTCAGGGAACTTCATCTTCCTCTTTTCCTCTACT AGATATTCCCCAAGTCCCTGTCCCTCTCCCCCTCATTTCACCCCTCCCTCTCCACATCTTCCCTCCTGGTAGAAGGAAAATTAAAACAAG ATTAGCCAGAAGGCAGAAAGACAGCTAATGGAAGAAACAAAAATATGGTGAAGGGGAGCATAGGTACAGGTCACACCCTTCTGATCCCAT CCTTCTGTCCCTGACGGCAGAGGGACTCCCAAGCTTGAAGCAGTCTGCCTCCCCACCACCCCACCATGGCTGTGAGTCGGTCCTCTCTGT GAGTCCAAATCCCTCCCTACCACTGCCTTCCTGAACCAAGATATCTGGCTACCCCAGCCACCCTCACCTGGGCTGGTTTTTAGACTTGGA GTCCTCATCCGCCAGGGGCTGAACACTCTTCTCTGCCACGTCAGTCAGCACAGAGAATGTGGGCTCCACAATGAAGTCGATGAACCCTGC AGTGGAGGAGCAATGCCGTAGAGATGTCTTACTATTATCTGGAGGGCTAGGCAGAGCATGCAGCTGGCATGGCCAGGACCCCTGGCTGCT TATGAAAGAGGATGGAGAGGTAACCTGGGGCTGAAAACTTCCCAATGCAGGGCAGGCTTTGGGATGATGTCTTGGTGCCCCAGAGAGCTC CTTCCTGCCATTGCAGCCCCCTGGCCTCCTAACCCAGGACCCCATGCTCTAGCACAGTAGGCTTTCCTCTACAGGAAGAATGGTTTGGGG GGATTGAGGACTTGGAGCAATCCTGACCCAGGCAGCATCTTTTCCCCCTCCCAGTCCTCCCCTTCCTGCAGGAGAGGACACTCACCTATC TGAGACTGTGCCACTAGAGTGGAAGTGCGGTCACAGAGTGGAGAAAAGGGCAGGCCCAACTCTGCCTCCTTGTCACCCTAGAGGAGGGAA CAGGGTAGGAAAGCTGGAGAGGATACCTCAGACCTACCAGATCTGGGGTACAGGTGGCAAGTGGTGGGGGTGGGGGGTTGTTGTGTGAAA |
Top |
FusionGenePPI for COPZ1_PPP1R1A |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| COPZ1 | COPG1, TMED10, COPA, COPB1, COPZ1, APP, ARCN1, COPB2, COPG2, GOPC, TMED9, UGT1A1, BAG3, TLE3, DIAPH1, KLC1, RUFY1, TTI1, NUDCD1, STAU1, DTNBP1, SF3B1, REV3L, HERC2, MKS1, XPO1, DUSP1, DUSP28, DUSP8, SARNP, SUB1, CHORDC1, DRG1, DIS3, SEPT7, PRCC, CDK5, SH3GLB1, SCYL2, ZC3HAV1, DLD, DLST, TRIM25 | PPP1R1A | PPP1R15A, PRMT6, RRAGA, SLC25A11, SPEM1, ZNF414, ZPBP2, FGL1, ACTA2, ACTA1, JMY |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Tgene | PPP1R1A | chr12:54718965 | chr12:54974834 | ENST00000257905 | - | 4 | 7 | 143_171 | 134 | 172 | PPP1R15A |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for COPZ1_PPP1R1A |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for COPZ1_PPP1R1A |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | PPP1R1A | C0003811 | Cardiac Arrhythmia | 1 | CTD_human |
| Tgene | PPP1R1A | C0018801 | Heart failure | 1 | CTD_human |
| Tgene | PPP1R1A | C0878544 | Cardiomyopathies | 1 | CTD_human |
| Tgene | PPP1R1A | C2239176 | Liver carcinoma | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|