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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8109

FusionGeneSummary for COPZ1_HNRNPA1

check button Fusion gene summary
Fusion gene informationFusion gene name: COPZ1_HNRNPA1
Fusion gene ID: 8109
HgeneTgene
Gene symbol

COPZ1

HNRNPA1

Gene ID

22818

3178

Gene namecoatomer protein complex subunit zeta 1heterogeneous nuclear ribonucleoprotein A1
SynonymsCGI-120|COPZ|HSPC181|zeta-COP|zeta1-COPALS19|ALS20|HNRPA1|HNRPA1L3|IBMPFD3|UP 1|hnRNP A1|hnRNP-A1
Cytomap

12q13.13

12q13.13

Type of geneprotein-codingprotein-coding
Descriptioncoatomer subunit zeta-1coatomer protein complex, subunit zetazeta-1 COPzeta-1-coat proteinheterogeneous nuclear ribonucleoprotein A1helix-destabilizing proteinheterogeneous nuclear ribonucleoprotein A1B proteinheterogeneous nuclear ribonucleoprotein B2 proteinheterogeneous nuclear ribonucleoprotein core protein A1hnRNP core protein A1-lik
Modification date2018052320180523
UniProtAcc

P61923

P09651

Ensembl transtripts involved in fusion geneENST00000262061, ENST00000549043, 
ENST00000552218, ENST00000553231, 
ENST00000552362, ENST00000455864, 
ENST00000416254, ENST00000549116, 
ENST00000551779, ENST00000548281, 
ENST00000548753, 
ENST00000546500, 
ENST00000340913, ENST00000330752, 
ENST00000547276, ENST00000551803, 
Fusion gene scores* DoF score8 X 3 X 7=1685 X 5 X 4=100
# samples 85
** MAII scorelog2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: COPZ1 [Title/Abstract] AND HNRNPA1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCOPZ1

GO:0006891

intra-Golgi vesicle-mediated transport

11056392

TgeneHNRNPA1

GO:0032212

positive regulation of telomere maintenance via telomerase

23935072

TgeneHNRNPA1

GO:0051168

nuclear export

8521471

TgeneHNRNPA1

GO:0051170

import into nucleus

8521471

TgeneHNRNPA1

GO:1903936

cellular response to sodium arsenite

27694260


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUADTCGA-MP-A4T8-01ACOPZ1chr12

54737100

+HNRNPA1chr12

54677596

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000262061ENST00000546500COPZ1chr12

54737100

+HNRNPA1chr12

54677596

+
Frame-shitENST00000262061ENST00000340913COPZ1chr12

54737100

+HNRNPA1chr12

54677596

+
Frame-shitENST00000262061ENST00000330752COPZ1chr12

54737100

+HNRNPA1chr12

54677596

+
5CDS-intronENST00000262061ENST00000547276COPZ1chr12

54737100

+HNRNPA1chr12

54677596

+
5CDS-intronENST00000262061ENST00000551803COPZ1chr12

54737100

+HNRNPA1chr12

54677596

+
Frame-shitENST00000549043ENST00000546500COPZ1chr12

54737100

+HNRNPA1chr12

54677596

+
Frame-shitENST00000549043ENST00000340913COPZ1chr12

54737100

+HNRNPA1chr12

54677596

+
Frame-shitENST00000549043ENST00000330752COPZ1chr12

54737100

+HNRNPA1chr12

54677596

+
5CDS-intronENST00000549043ENST00000547276COPZ1chr12

54737100

+HNRNPA1chr12

54677596

+
5CDS-intronENST00000549043ENST00000551803COPZ1chr12

54737100

+HNRNPA1chr12

54677596

+
Frame-shitENST00000552218ENST00000546500COPZ1chr12

54737100

+HNRNPA1chr12

54677596

+
Frame-shitENST00000552218ENST00000340913COPZ1chr12

54737100

+HNRNPA1chr12

54677596

+
Frame-shitENST00000552218ENST00000330752COPZ1chr12

54737100

+HNRNPA1chr12

54677596

+
5CDS-intronENST00000552218ENST00000547276COPZ1chr12

54737100

+HNRNPA1chr12

54677596

+
5CDS-intronENST00000552218ENST00000551803COPZ1chr12

54737100

+HNRNPA1chr12

54677596

+
Frame-shitENST00000553231ENST00000546500COPZ1chr12

54737100

+HNRNPA1chr12

54677596

+
Frame-shitENST00000553231ENST00000340913COPZ1chr12

54737100

+HNRNPA1chr12

54677596

+
Frame-shitENST00000553231ENST00000330752COPZ1chr12

54737100

+HNRNPA1chr12

54677596

+
5CDS-intronENST00000553231ENST00000547276COPZ1chr12

54737100

+HNRNPA1chr12

54677596

+
5CDS-intronENST00000553231ENST00000551803COPZ1chr12

54737100

+HNRNPA1chr12

54677596

+
Frame-shitENST00000552362ENST00000546500COPZ1chr12

54737100

+HNRNPA1chr12

54677596

+
Frame-shitENST00000552362ENST00000340913COPZ1chr12

54737100

+HNRNPA1chr12

54677596

+
Frame-shitENST00000552362ENST00000330752COPZ1chr12

54737100

+HNRNPA1chr12

54677596

+
5CDS-intronENST00000552362ENST00000547276COPZ1chr12

54737100

+HNRNPA1chr12

54677596

+
5CDS-intronENST00000552362ENST00000551803COPZ1chr12

54737100

+HNRNPA1chr12

54677596

+
Frame-shitENST00000455864ENST00000546500COPZ1chr12

54737100

+HNRNPA1chr12

54677596

+
Frame-shitENST00000455864ENST00000340913COPZ1chr12

54737100

+HNRNPA1chr12

54677596

+
Frame-shitENST00000455864ENST00000330752COPZ1chr12

54737100

+HNRNPA1chr12

54677596

+
5CDS-intronENST00000455864ENST00000547276COPZ1chr12

54737100

+HNRNPA1chr12

54677596

+
5CDS-intronENST00000455864ENST00000551803COPZ1chr12

54737100

+HNRNPA1chr12

54677596

+
intron-3CDSENST00000416254ENST00000546500COPZ1chr12

54737100

+HNRNPA1chr12

54677596

+
intron-3CDSENST00000416254ENST00000340913COPZ1chr12

54737100

+HNRNPA1chr12

54677596

+
intron-3CDSENST00000416254ENST00000330752COPZ1chr12

54737100

+HNRNPA1chr12

54677596

+
intron-intronENST00000416254ENST00000547276COPZ1chr12

54737100

+HNRNPA1chr12

54677596

+
intron-intronENST00000416254ENST00000551803COPZ1chr12

54737100

+HNRNPA1chr12

54677596

+
intron-3CDSENST00000549116ENST00000546500COPZ1chr12

54737100

+HNRNPA1chr12

54677596

+
intron-3CDSENST00000549116ENST00000340913COPZ1chr12

54737100

+HNRNPA1chr12

54677596

+
intron-3CDSENST00000549116ENST00000330752COPZ1chr12

54737100

+HNRNPA1chr12

54677596

+
intron-intronENST00000549116ENST00000547276COPZ1chr12

54737100

+HNRNPA1chr12

54677596

+
intron-intronENST00000549116ENST00000551803COPZ1chr12

54737100

+HNRNPA1chr12

54677596

+
Frame-shitENST00000551779ENST00000546500COPZ1chr12

54737100

+HNRNPA1chr12

54677596

+
Frame-shitENST00000551779ENST00000340913COPZ1chr12

54737100

+HNRNPA1chr12

54677596

+
Frame-shitENST00000551779ENST00000330752COPZ1chr12

54737100

+HNRNPA1chr12

54677596

+
5CDS-intronENST00000551779ENST00000547276COPZ1chr12

54737100

+HNRNPA1chr12

54677596

+
5CDS-intronENST00000551779ENST00000551803COPZ1chr12

54737100

+HNRNPA1chr12

54677596

+
intron-3CDSENST00000548281ENST00000546500COPZ1chr12

54737100

+HNRNPA1chr12

54677596

+
intron-3CDSENST00000548281ENST00000340913COPZ1chr12

54737100

+HNRNPA1chr12

54677596

+
intron-3CDSENST00000548281ENST00000330752COPZ1chr12

54737100

+HNRNPA1chr12

54677596

+
intron-intronENST00000548281ENST00000547276COPZ1chr12

54737100

+HNRNPA1chr12

54677596

+
intron-intronENST00000548281ENST00000551803COPZ1chr12

54737100

+HNRNPA1chr12

54677596

+
5UTR-3CDSENST00000548753ENST00000546500COPZ1chr12

54737100

+HNRNPA1chr12

54677596

+
5UTR-3CDSENST00000548753ENST00000340913COPZ1chr12

54737100

+HNRNPA1chr12

54677596

+
5UTR-3CDSENST00000548753ENST00000330752COPZ1chr12

54737100

+HNRNPA1chr12

54677596

+
5UTR-intronENST00000548753ENST00000547276COPZ1chr12

54737100

+HNRNPA1chr12

54677596

+
5UTR-intronENST00000548753ENST00000551803COPZ1chr12

54737100

+HNRNPA1chr12

54677596

+

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FusionProtFeatures for COPZ1_HNRNPA1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
COPZ1

P61923

HNRNPA1

P09651

The coatomer is a cytosolic protein complex that bindsto dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosyntheticprotein transport from the ER, via the Golgi up to the trans Golginetwork. Coatomer complex is required for budding from Golgimembranes, and is essential for the retrograde Golgi-to-ERtransport of dilysine-tagged proteins. In mammals, the coatomercan only be recruited by membranes associated to ADP-ribosylationfactors (ARFs), which are small GTP-binding proteins; the complexalso influences the Golgi structural integrity, as well as theprocessing, activity, and endocytic recycling of LDL receptors (Bysimilarity). {ECO:0000250}. The zeta subunit may be involved in regulating the coatassembly and, hence, the rate of biosynthetic protein transportdue to its association-dissociation properties with the coatomercomplex. Involved in the packaging of pre-mRNA into hnRNPparticles, transport of poly(A) mRNA from the nucleus to thecytoplasm and may modulate splice site selection(PubMed:17371836). May bind to specific miRNA hairpins(PubMed:28431233). {ECO:0000269|PubMed:17371836,ECO:0000269|PubMed:28431233}. (Microbial infection) May play a role in HCV RNAreplication. {ECO:0000269|PubMed:17229681}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for COPZ1_HNRNPA1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for COPZ1_HNRNPA1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
COPZ1COPG1, TMED10, COPA, COPB1, COPZ1, APP, ARCN1, COPB2, COPG2, GOPC, TMED9, UGT1A1, BAG3, TLE3, DIAPH1, KLC1, RUFY1, TTI1, NUDCD1, STAU1, DTNBP1, SF3B1, REV3L, HERC2, MKS1, XPO1, DUSP1, DUSP28, DUSP8, SARNP, SUB1, CHORDC1, DRG1, DIS3, SEPT7, PRCC, CDK5, SH3GLB1, SCYL2, ZC3HAV1, DLD, DLST, TRIM25HNRNPA1PRRC2A, FEN1, PRMT1, KHSRP, HNRNPA1, NFKBIA, SAFB, RRP1B, MEPCE, CDK9, DDX17, DDX5, HSP90AB1, IGF2BP1, IGF2BP3, UBR2, HNRNPA2B1, HNRNPH1, HNRNPK, HNRNPR, ILF2, ILF3, SYNCRIP, KHDRBS2, RPAP1, HNRNPUL2, IGF2BP2, LARP7, HNRNPM, RBMX, HNRNPC, HSPA9, SRP72, MRPS27, PABPC1, CCNT1, ZFR, YTHDF2, RBM39, HSPA2, GTF2E2, KIAA0368, ARHGAP23, SYTL2, ARID2, HNRNPAB, PABPC4, PRMT8, HNRNPCL2, TARDBP, UBR1, GTF2A1, PLOD3, PURA, MOV10, HNRNPA1P70, HNRNPDL, PLOD2, ROCK1, CENPC, CAPN2, HNRNPL, MRPL37, FRMD4A, NNT, SAP25, SRRM2, TOPORS, H2AFX, SMN1, CD4, HDAC5, NOP56, NR3C1, TOP1, PSMA3, VHL, SREK1, ELAVL1, SF3A2, ARRB1, ARRB2, XRN2, PTBP1, FIP1L1, NONO, CPSF2, NUDT21, SFPQ, CPSF6, CSTF3, CSTF1, SNRNP200, PUF60, PRPF8, SUGP2, SRSF4, PRPF4, SRSF1, CDC5L, PNN, SRSF6, PRPF19, SNRPD1, SNRPD2, SNRPD3, AQR, XAB2, HNRNPD, HNRNPH2, HNRNPF, HNRNPH3, DDX1, DHX15, DDX21, DDX28, DDX23, DHX30, DHX9, EWSR1, RBM26, ADAR, RBM12, RBM7, RBM14, AKAP8, LMNB1, NUP205, NCBP1, ALYREF, MLLT4, WDR82, NFATC1, NFATC2, NKRF, MEF2A, RAD50, G3BP1, BRINP1, WDR33, PTCD1, PTCD3, GADD45GIP1, ZNF326, ACIN1, CARF, XRCC6, PPIA, LRPPRC, XRCC5, SRRT, PRKDC, CUL3, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, DCUN1D1, CAND1, NEDD8, RN7SK, BRCA1, RNF14, XIAP, HIPK3, SRSF7, APP, HNRNPU, SF3B6, PHF5A, RPS8, RPS3A, RPS6, RPSA, CPSF7, RPLP2, RPS5, RPS21, RPS3, HSP90AA1, CLIC4, RBM3, PPP5C, ESR1, LIG4, SMURF1, CTNNB1, VCP, FN1, VCAM1, PPIL1, TRA2B, IFIT2, IFIT3, NOS2, ITGA4, PRMT2, PRMT3, CARM1, PAN2, CD81, IGSF8, ICAM1, HMGA1, LMNA, CSF2, NR0B2, TFEC, XRN1, SRPK1, YWHAQ, FBXO6, PARK2, AIMP2, HIST1H2AB, CCAR2, QARS, RPL27A, RPL38, IQGAP1, ZC3HC1, RPA1, RPA2, RPA3, ERG, ASB2, HSPA5, PSMD9, CHUK, TNF, PSMB4, IVNS1ABP, STAU1, AURKA, AURKB, NEDD1, TP53, TUBGCP3, HIST3H3, CUL7, OBSL1, CCDC8, EED, RNF2, FBXW11, MRPL16, MRPL28, MRPS18A, MRPL4, RPL26, RPS27A, MTERF3, FAM120A, STRBP, NGRN, UPF1, PDCD11, YARS2, RPS7, MRPS23, HNRNPA1L2, TRUB2, MRPL9, MRPL32, MRPL3, ZCCHC3, MRPS10, DAP3, MRPL1, LARP1, LARP1B, FASTKD2, MRPS5, MRPS7, MRPS22, MRPL10, RPS15, MRPL44, MRPS9, PAIP2, PAIP2B, PRKRIR, MRPL27, MALSU1, DHX36, MRPL47, DUSP11, MRPS24, YTHDC1, RALY, RBMS1, MRPL15, MRPL21, MRPL13, MCAT, FARS2, ICT1, DNTTIP2, MRPS18C, RPUSD3, MRPL57, SUPV3L1, MRPL52, RPS6KB2, PDCD4, BCL2L1, YWHAE, YWHAZ, A2ML1, ACTB, ADA, AKR1B10, ALB, ALDOA, ANGEL2, ANXA1, ANXA2, ARF3, ARG1, ASPRV1, ATP5A1, ATP5B, STRAP, C14orf166, C1orf68, RTCB, C3, CALML3, CALML5, CANX, CAPRIN1, CDKN2AIP, CFL1, CKMT1A, CLTC, YBX3, CTSD, DCD, DDX3X, DDX6, DIMT1, DNAJC10, DSG1, DSP, EEF1A1, EEF1G, EEF2, EIF2B1, EIF2B3, EIF3H, EIF4A2, EIF4A3, ENO1, EPPK1, FAM120C, FAM35A, FAM98B, FLG, FLG2, FLNA, FUS, G3BP2, GADD45A, GAPDH, GDE1, GM2A, GNB2L1, GSN, GSTP1, GTF2I, H1FX, H3F3A, HAL, HIST1H1E, HNRNPA0, HNRNPA3, HNRNPUL1, HRNR, HSPA1A, HSPA8, HSPB1, HSPD1, IL36G, IVL, JUP, KPRP, KRT1, KRT10, KRT14, KRT15, KRT16, KRT17, KRT2, KRT33A, KRT34, KRT5, KRT6A, KRT6B, KRT6C, KRT78, KRT79, KRT80, KRT83, KRT9, LAMP1, SSB, LCN2, LDHA, LGALS7, LTV1, MARK2, MATR3, MRPL11, MRPL18, MRPL19, MRPL22, MRPL24, MRPL38, MRPL39, MRPL43, MRPL45, MRPL46, MRPL48, MRPS15, MRPS18B, MRPS2, MRPS28, MRPS30, MRPS31, MRPS35, MX1, MYH9, MYL12A, NAMPT, NCCRP1, NCL, NSUN5, NXF1, P4HB, PCBP2, PFN1, PGK1, PHB2, PICALM, PKM, PKP1, PLOD1, PNO1, PNP, POF1B, POLDIP3, PPL, PPP2R1A, PRDX1, PRPF31, PRSS3, MAEL, AASDHPPT, ACAA2, ANXA5, CARS, CDC42, CYB5B, EIF4EBP1, FDPS, HMBS, ATP5F1, CRIP1, DUT, GART, GLO1, KAT8, MSN, PAPOLA, PHGDH, PROSC, PRRC1, RAB1A, UBE2I, UBE2K, ITPA, MSI2, SEC31A, NTRK1, SCARNA22, SRPK2, CLK1, XPO1, AHSA1, ADARB1, CIRBP, GTF2F1, SEC16A, ZWINT, EXOSC4, PARD6B, TAF15, TNK1, FUBP3, APOBEC3B, SAFB2, RBM6, KHDRBS1, ZNF638, YLPM1, NCOA5, NBEAL1, SCAI, RBM12B, GAN, UBQLN2, MCM2, MCM5, SNW1, U2AF2, MRPL35, RPS15A, C17orf89, CYLD, COX15, PDHA1, SDHA, TRIM25, HEY1, MTF1, HIST1H3A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for COPZ1_HNRNPA1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for COPZ1_HNRNPA1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneHNRNPA1C3715156AMYOTROPHIC LATERAL SCLEROSIS 202UNIPROT
TgeneHNRNPA1C3809469INCLUSION BODY MYOPATHY WITH EARLY-ONSET PAGET DISEASE WITH OR WITHOUT FRONTOTEMPORAL DEMENTIA 32UNIPROT
TgeneHNRNPA1C0024667Animal Mammary Neoplasms1CTD_human
TgeneHNRNPA1C0024668Mammary Neoplasms, Experimental1CTD_human