|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 8107 |
FusionGeneSummary for COPZ1_C19orf18 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: COPZ1_C19orf18 | Fusion gene ID: 8107 | Hgene | Tgene | Gene symbol | COPZ1 | C19orf18 | Gene ID | 22818 | 147685 |
| Gene name | coatomer protein complex subunit zeta 1 | chromosome 19 open reading frame 18 | |
| Synonyms | CGI-120|COPZ|HSPC181|zeta-COP|zeta1-COP | - | |
| Cytomap | 12q13.13 | 19q13.43 | |
| Type of gene | protein-coding | protein-coding | |
| Description | coatomer subunit zeta-1coatomer protein complex, subunit zetazeta-1 COPzeta-1-coat protein | uncharacterized protein C19orf18 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P61923 | Q8NEA5 | |
| Ensembl transtripts involved in fusion gene | ENST00000262061, ENST00000549043, ENST00000552218, ENST00000553231, ENST00000552362, ENST00000455864, ENST00000416254, ENST00000549116, ENST00000551779, ENST00000548281, ENST00000548753, | ENST00000314391, | |
| Fusion gene scores | * DoF score | 8 X 3 X 7=168 | 3 X 3 X 3=27 |
| # samples | 8 | 3 | |
| ** MAII score | log2(8/168*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: COPZ1 [Title/Abstract] AND C19orf18 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | COPZ1 | GO:0006891 | intra-Golgi vesicle-mediated transport | 11056392 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | THCA | TCGA-FE-A235-01A | COPZ1 | chr12 | 54741628 | + | C19orf18 | chr19 | 58472919 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000262061 | ENST00000314391 | COPZ1 | chr12 | 54741628 | + | C19orf18 | chr19 | 58472919 | - |
| In-frame | ENST00000549043 | ENST00000314391 | COPZ1 | chr12 | 54741628 | + | C19orf18 | chr19 | 58472919 | - |
| In-frame | ENST00000552218 | ENST00000314391 | COPZ1 | chr12 | 54741628 | + | C19orf18 | chr19 | 58472919 | - |
| In-frame | ENST00000553231 | ENST00000314391 | COPZ1 | chr12 | 54741628 | + | C19orf18 | chr19 | 58472919 | - |
| In-frame | ENST00000552362 | ENST00000314391 | COPZ1 | chr12 | 54741628 | + | C19orf18 | chr19 | 58472919 | - |
| In-frame | ENST00000455864 | ENST00000314391 | COPZ1 | chr12 | 54741628 | + | C19orf18 | chr19 | 58472919 | - |
| In-frame | ENST00000416254 | ENST00000314391 | COPZ1 | chr12 | 54741628 | + | C19orf18 | chr19 | 58472919 | - |
| In-frame | ENST00000549116 | ENST00000314391 | COPZ1 | chr12 | 54741628 | + | C19orf18 | chr19 | 58472919 | - |
| In-frame | ENST00000551779 | ENST00000314391 | COPZ1 | chr12 | 54741628 | + | C19orf18 | chr19 | 58472919 | - |
| 3UTR-3CDS | ENST00000548281 | ENST00000314391 | COPZ1 | chr12 | 54741628 | + | C19orf18 | chr19 | 58472919 | - |
| In-frame | ENST00000548753 | ENST00000314391 | COPZ1 | chr12 | 54741628 | + | C19orf18 | chr19 | 58472919 | - |
Top |
FusionProtFeatures for COPZ1_C19orf18 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| COPZ1 | C19orf18 |
| The coatomer is a cytosolic protein complex that bindsto dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosyntheticprotein transport from the ER, via the Golgi up to the trans Golginetwork. Coatomer complex is required for budding from Golgimembranes, and is essential for the retrograde Golgi-to-ERtransport of dilysine-tagged proteins. In mammals, the coatomercan only be recruited by membranes associated to ADP-ribosylationfactors (ARFs), which are small GTP-binding proteins; the complexalso influences the Golgi structural integrity, as well as theprocessing, activity, and endocytic recycling of LDL receptors (Bysimilarity). {ECO:0000250}. The zeta subunit may be involved in regulating the coatassembly and, hence, the rate of biosynthetic protein transportdue to its association-dissociation properties with the coatomercomplex. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >C19orf18 | chr12:54741628 | chr19:58472919 | ENST00000314391 | - | 3 | 6 | 122_215 | 123 | 216 | Topological domain | Cytoplasmic |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | C19orf18 | chr12:54741628 | chr19:58472919 | ENST00000314391 | - | 3 | 6 | 30_100 | 123 | 216 | Topological domain | Extracellular |
| Tgene | C19orf18 | chr12:54741628 | chr19:58472919 | ENST00000314391 | - | 3 | 6 | 101_121 | 123 | 216 | Transmembrane | Helical |
Top |
FusionGeneSequence for COPZ1_C19orf18 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_COPZ1_ENST00000262061_chr12_54741628_+_C19orf18_ENST00000314391_chr19_58472919_-_224aa MEALILEPSLYTVKAILILDNDGDRLFAKYYDDTYPSVKEQKAFEKNIFNKTHRTDSEIALLEGLTVVYKSSIDLYFYVIGSSYENELML MAVLNCLFDSLSQMLRKNVEKRALLENMEGLFLAVDEIVDGGRLAQAEERQQLESLYKNLRIPLLGDEEEGSEDEGESTHLLPENENELE >In-frame_COPZ1_ENST00000549043_chr12_54741628_+_C19orf18_ENST00000314391_chr19_58472919_-_232aa MGGFRTEGMFVSLQEPSLYTVKAILILDNDGDRLFAKYYDDTYPSVKEQKAFEKNIFNKTHRTDSEIALLEGLTVVYKSSIDLYFYVIGS SYENELMLMAVLNCLFDSLSQMLRKNVEKRALLENMEGLFLAVDEIVDGGRLAQAEERQQLESLYKNLRIPLLGDEEEGSEDEGESTHLL >In-frame_COPZ1_ENST00000552218_chr12_54741628_+_C19orf18_ENST00000314391_chr19_58472919_-_245aa MEALILEPSLYTVKAILILDNDGDRLFAKYYDDTYPSVKEQKAFEKNIFNKTHRTDSEIALLEGLTVVYKSSIDLYFYVIGSSYENELML MAVLNCLFDSLSQMLRTGSTQAGGLHESSSRQAWATQKNVEKRALLENMEGLFLAVDEIVDGGRLAQAEERQQLESLYKNLRIPLLGDEE >In-frame_COPZ1_ENST00000553231_chr12_54741628_+_C19orf18_ENST00000314391_chr19_58472919_-_201aa MEALILYYDDTYPSVKEQKAFEKNIFNKTHRTDSEIALLEGLTVVYKSSIDLYFYVIGSSYENELMLMAVLNCLFDSLSQMLRKNVEKRA LLENMEGLFLAVDEIVDGGRLAQAEERQQLESLYKNLRIPLLGDEEEGSEDEGESTHLLPENENELEKFIHSVIISKRSKNIKKKLKEEQ >In-frame_COPZ1_ENST00000552362_chr12_54741628_+_C19orf18_ENST00000314391_chr19_58472919_-_224aa MEALILEPSLYTVKAILILDNDGDRLFAKYYDDTYPSVKEQKAFEKNIFNKTHRTDSEIALLEGLTVVYKSSIDLYFYVIGSSYENELML MAVLNCLFDSLSQMLRKNVEKRALLENMEGLFLAVDEIVDGGRLAQAEERQQLESLYKNLRIPLLGDEEEGSEDEGESTHLLPENENELE >In-frame_COPZ1_ENST00000455864_chr12_54741628_+_C19orf18_ENST00000314391_chr19_58472919_-_201aa MEALILYYDDTYPSVKEQKAFEKNIFNKTHRTDSEIALLEGLTVVYKSSIDLYFYVIGSSYENELMLMAVLNCLFDSLSQMLRKNVEKRA LLENMEGLFLAVDEIVDGGRLAQAEERQQLESLYKNLRIPLLGDEEEGSEDEGESTHLLPENENELEKFIHSVIISKRSKNIKKKLKEEQ >In-frame_COPZ1_ENST00000416254_chr12_54741628_+_C19orf18_ENST00000314391_chr19_58472919_-_173aa MMEIDFLPSTMTTPTPVSRSKRPLRRTFSTRPIGLTLMLMAVLNCLFDSLSQMLRKNVEKRALLENMEGLFLAVDEIVDGGRLAQAEERQ >In-frame_COPZ1_ENST00000549116_chr12_54741628_+_C19orf18_ENST00000314391_chr19_58472919_-_166aa MEALILEPSLYTVKAILILDNDGDRLFAKLMLMAVLNCLFDSLSQMLRKNVEKRALLENMEGLFLAVDEIVDGGRLAQAEERQQLESLYK >In-frame_COPZ1_ENST00000551779_chr12_54741628_+_C19orf18_ENST00000314391_chr19_58472919_-_224aa MEALILEPSLYTVKAILILDNDGDRLFAKYYDDTYPSVKEQKAFEKNIFNKTHRTDSEIALLEGLTVVYKSSIDLYFYVIGSSYENELML MAVLNCLFDSLSQMLRKNVEKRALLENMEGLFLAVDEIVDGGRLAQAEERQQLESLYKNLRIPLLGDEEEGSEDEGESTHLLPENENELE >In-frame_COPZ1_ENST00000548753_chr12_54741628_+_C19orf18_ENST00000314391_chr19_58472919_-_136aa MLMAVLNCLFDSLSQMLRKNVEKRALLENMEGLFLAVDEIVDGGRLAQAEERQQLESLYKNLRIPLLGDEEEGSEDEGESTHLLPENENE |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_COPZ1_ENST00000262061_chr12_54741628_+_C19orf18_ENST00000314391_chr19_58472919_-_672nt ATGGAGGCGCTGATTTTGGAACCTTCCCTGTATACTGTCAAAGCCATCCTGATTCTGGACAATGATGGAGATCGACTTTTTGCCAAGTAC TATGACGACACCTACCCCAGTGTCAAGGAGCAAAAGGCCTTTGAGAAGAACATTTTCAACAAGACCCATCGGACTGACAGTGAAATTGCC CTCTTGGAAGGCCTGACAGTGGTATACAAAAGCAGTATAGATCTCTATTTCTATGTGATTGGCAGCTCCTATGAAAATGAGCTGATGCTT ATGGCTGTTCTGAACTGTCTCTTCGACTCATTGAGCCAGATGCTGAGGAAAAATGTAGAAAAGCGAGCACTGCTGGAGAACATGGAGGGG CTGTTCTTGGCTGTGGATGAAATTGTAGATGGAGGTCGACTGGCACAGGCTGAGGAAAGACAACAGCTCGAGTCACTTTATAAGAACCTC AGGATACCGTTATTAGGAGATGAAGAAGAGGGCTCAGAGGACGAGGGTGAGTCCACGCACCTACTTCCAGAGAACGAAAATGAGCTGGAA AAGTTCATCCACTCAGTTATTATATCAAAAAGAAGCAAAAATATTAAGAAGAAACTGAAGGAAGAGCAAAACTCAGTAACAGAAAACAAA >In-frame_COPZ1_ENST00000549043_chr12_54741628_+_C19orf18_ENST00000314391_chr19_58472919_-_696nt ATGGGAGGCTTCAGGACTGAAGGTATGTTCGTATCTCTTCAGGAACCTTCCCTGTATACTGTCAAAGCCATCCTGATTCTGGACAATGAT GGAGATCGACTTTTTGCCAAGTACTATGACGACACCTACCCCAGTGTCAAGGAGCAAAAGGCCTTTGAGAAGAACATTTTCAACAAGACC CATCGGACTGACAGTGAAATTGCCCTCTTGGAAGGCCTGACAGTGGTATACAAAAGCAGTATAGATCTCTATTTCTATGTGATTGGCAGC TCCTATGAAAATGAGCTGATGCTTATGGCTGTTCTGAACTGTCTCTTCGACTCATTGAGCCAGATGCTGAGGAAAAATGTAGAAAAGCGA GCACTGCTGGAGAACATGGAGGGGCTGTTCTTGGCTGTGGATGAAATTGTAGATGGAGGTCGACTGGCACAGGCTGAGGAAAGACAACAG CTCGAGTCACTTTATAAGAACCTCAGGATACCGTTATTAGGAGATGAAGAAGAGGGCTCAGAGGACGAGGGTGAGTCCACGCACCTACTT CCAGAGAACGAAAATGAGCTGGAAAAGTTCATCCACTCAGTTATTATATCAAAAAGAAGCAAAAATATTAAGAAGAAACTGAAGGAAGAG >In-frame_COPZ1_ENST00000552218_chr12_54741628_+_C19orf18_ENST00000314391_chr19_58472919_-_735nt ATGGAGGCGCTGATTTTGGAACCTTCCCTGTATACTGTCAAAGCCATCCTGATTCTGGACAATGATGGAGATCGACTTTTTGCCAAGTAC TATGACGACACCTACCCCAGTGTCAAGGAGCAAAAGGCCTTTGAGAAGAACATTTTCAACAAGACCCATCGGACTGACAGTGAAATTGCC CTCTTGGAAGGCCTGACAGTGGTATACAAAAGCAGTATAGATCTCTATTTCTATGTGATTGGCAGCTCCTATGAAAATGAGCTGATGCTT ATGGCTGTTCTGAACTGTCTCTTCGACTCATTGAGCCAGATGCTGAGAACAGGAAGCACCCAGGCAGGAGGACTGCATGAGTCGAGTTCA AGACAAGCTTGGGCAACACAGAAAAATGTAGAAAAGCGAGCACTGCTGGAGAACATGGAGGGGCTGTTCTTGGCTGTGGATGAAATTGTA GATGGAGGTCGACTGGCACAGGCTGAGGAAAGACAACAGCTCGAGTCACTTTATAAGAACCTCAGGATACCGTTATTAGGAGATGAAGAA GAGGGCTCAGAGGACGAGGGTGAGTCCACGCACCTACTTCCAGAGAACGAAAATGAGCTGGAAAAGTTCATCCACTCAGTTATTATATCA AAAAGAAGCAAAAATATTAAGAAGAAACTGAAGGAAGAGCAAAACTCAGTAACAGAAAACAAAACAAAGAATGCGTCACATAATGGAAAA >In-frame_COPZ1_ENST00000553231_chr12_54741628_+_C19orf18_ENST00000314391_chr19_58472919_-_603nt ATGGAGGCGCTGATTTTGTACTATGACGACACCTACCCCAGTGTCAAGGAGCAAAAGGCCTTTGAGAAGAACATTTTCAACAAGACCCAT CGGACTGACAGTGAAATTGCCCTCTTGGAAGGCCTGACAGTGGTATACAAAAGCAGTATAGATCTCTATTTCTATGTGATTGGCAGCTCC TATGAAAATGAGCTGATGCTTATGGCTGTTCTGAACTGTCTCTTCGACTCATTGAGCCAGATGCTGAGGAAAAATGTAGAAAAGCGAGCA CTGCTGGAGAACATGGAGGGGCTGTTCTTGGCTGTGGATGAAATTGTAGATGGAGGTCGACTGGCACAGGCTGAGGAAAGACAACAGCTC GAGTCACTTTATAAGAACCTCAGGATACCGTTATTAGGAGATGAAGAAGAGGGCTCAGAGGACGAGGGTGAGTCCACGCACCTACTTCCA GAGAACGAAAATGAGCTGGAAAAGTTCATCCACTCAGTTATTATATCAAAAAGAAGCAAAAATATTAAGAAGAAACTGAAGGAAGAGCAA >In-frame_COPZ1_ENST00000552362_chr12_54741628_+_C19orf18_ENST00000314391_chr19_58472919_-_672nt ATGGAGGCGCTGATTTTGGAACCTTCCCTGTATACTGTCAAAGCCATCCTGATTCTGGACAATGATGGAGATCGACTTTTTGCCAAGTAC TATGACGACACCTACCCCAGTGTCAAGGAGCAAAAGGCCTTTGAGAAGAACATTTTCAACAAGACCCATCGGACTGACAGTGAAATTGCC CTCTTGGAAGGCCTGACAGTGGTATACAAAAGCAGTATAGATCTCTATTTCTATGTGATTGGCAGCTCCTATGAAAATGAGCTGATGCTT ATGGCTGTTCTGAACTGTCTCTTCGACTCATTGAGCCAGATGCTGAGGAAAAATGTAGAAAAGCGAGCACTGCTGGAGAACATGGAGGGG CTGTTCTTGGCTGTGGATGAAATTGTAGATGGAGGTCGACTGGCACAGGCTGAGGAAAGACAACAGCTCGAGTCACTTTATAAGAACCTC AGGATACCGTTATTAGGAGATGAAGAAGAGGGCTCAGAGGACGAGGGTGAGTCCACGCACCTACTTCCAGAGAACGAAAATGAGCTGGAA AAGTTCATCCACTCAGTTATTATATCAAAAAGAAGCAAAAATATTAAGAAGAAACTGAAGGAAGAGCAAAACTCAGTAACAGAAAACAAA >In-frame_COPZ1_ENST00000455864_chr12_54741628_+_C19orf18_ENST00000314391_chr19_58472919_-_603nt ATGGAGGCGCTGATTTTGTACTATGACGACACCTACCCCAGTGTCAAGGAGCAAAAGGCCTTTGAGAAGAACATTTTCAACAAGACCCAT CGGACTGACAGTGAAATTGCCCTCTTGGAAGGCCTGACAGTGGTATACAAAAGCAGTATAGATCTCTATTTCTATGTGATTGGCAGCTCC TATGAAAATGAGCTGATGCTTATGGCTGTTCTGAACTGTCTCTTCGACTCATTGAGCCAGATGCTGAGGAAAAATGTAGAAAAGCGAGCA CTGCTGGAGAACATGGAGGGGCTGTTCTTGGCTGTGGATGAAATTGTAGATGGAGGTCGACTGGCACAGGCTGAGGAAAGACAACAGCTC GAGTCACTTTATAAGAACCTCAGGATACCGTTATTAGGAGATGAAGAAGAGGGCTCAGAGGACGAGGGTGAGTCCACGCACCTACTTCCA GAGAACGAAAATGAGCTGGAAAAGTTCATCCACTCAGTTATTATATCAAAAAGAAGCAAAAATATTAAGAAGAAACTGAAGGAAGAGCAA >In-frame_COPZ1_ENST00000416254_chr12_54741628_+_C19orf18_ENST00000314391_chr19_58472919_-_519nt ATGATGGAGATCGACTTTTTGCCAAGTACTATGACGACACCTACCCCAGTGTCAAGGAGCAAAAGGCCTTTGAGAAGAACATTTTCAACA AGACCCATCGGACTGACACTGATGCTTATGGCTGTTCTGAACTGTCTCTTCGACTCATTGAGCCAGATGCTGAGGAAAAATGTAGAAAAG CGAGCACTGCTGGAGAACATGGAGGGGCTGTTCTTGGCTGTGGATGAAATTGTAGATGGAGGTCGACTGGCACAGGCTGAGGAAAGACAA CAGCTCGAGTCACTTTATAAGAACCTCAGGATACCGTTATTAGGAGATGAAGAAGAGGGCTCAGAGGACGAGGGTGAGTCCACGCACCTA CTTCCAGAGAACGAAAATGAGCTGGAAAAGTTCATCCACTCAGTTATTATATCAAAAAGAAGCAAAAATATTAAGAAGAAACTGAAGGAA >In-frame_COPZ1_ENST00000549116_chr12_54741628_+_C19orf18_ENST00000314391_chr19_58472919_-_498nt ATGGAGGCGCTGATTTTGGAACCTTCCCTGTATACTGTCAAAGCCATCCTGATTCTGGACAATGATGGAGATCGACTTTTTGCCAAGCTG ATGCTTATGGCTGTTCTGAACTGTCTCTTCGACTCATTGAGCCAGATGCTGAGGAAAAATGTAGAAAAGCGAGCACTGCTGGAGAACATG GAGGGGCTGTTCTTGGCTGTGGATGAAATTGTAGATGGAGGTCGACTGGCACAGGCTGAGGAAAGACAACAGCTCGAGTCACTTTATAAG AACCTCAGGATACCGTTATTAGGAGATGAAGAAGAGGGCTCAGAGGACGAGGGTGAGTCCACGCACCTACTTCCAGAGAACGAAAATGAG CTGGAAAAGTTCATCCACTCAGTTATTATATCAAAAAGAAGCAAAAATATTAAGAAGAAACTGAAGGAAGAGCAAAACTCAGTAACAGAA >In-frame_COPZ1_ENST00000551779_chr12_54741628_+_C19orf18_ENST00000314391_chr19_58472919_-_672nt ATGGAGGCGCTGATTTTGGAACCTTCCCTGTATACTGTCAAAGCCATCCTGATTCTGGACAATGATGGAGATCGACTTTTTGCCAAGTAC TATGACGACACCTACCCCAGTGTCAAGGAGCAAAAGGCCTTTGAGAAGAACATTTTCAACAAGACCCATCGGACTGACAGTGAAATTGCC CTCTTGGAAGGCCTGACAGTGGTATACAAAAGCAGTATAGATCTCTATTTCTATGTGATTGGCAGCTCCTATGAAAATGAGCTGATGCTT ATGGCTGTTCTGAACTGTCTCTTCGACTCATTGAGCCAGATGCTGAGGAAAAATGTAGAAAAGCGAGCACTGCTGGAGAACATGGAGGGG CTGTTCTTGGCTGTGGATGAAATTGTAGATGGAGGTCGACTGGCACAGGCTGAGGAAAGACAACAGCTCGAGTCACTTTATAAGAACCTC AGGATACCGTTATTAGGAGATGAAGAAGAGGGCTCAGAGGACGAGGGTGAGTCCACGCACCTACTTCCAGAGAACGAAAATGAGCTGGAA AAGTTCATCCACTCAGTTATTATATCAAAAAGAAGCAAAAATATTAAGAAGAAACTGAAGGAAGAGCAAAACTCAGTAACAGAAAACAAA >In-frame_COPZ1_ENST00000548753_chr12_54741628_+_C19orf18_ENST00000314391_chr19_58472919_-_408nt ATGCTTATGGCTGTTCTGAACTGTCTCTTCGACTCATTGAGCCAGATGCTGAGGAAAAATGTAGAAAAGCGAGCACTGCTGGAGAACATG GAGGGGCTGTTCTTGGCTGTGGATGAAATTGTAGATGGAGGTCGACTGGCACAGGCTGAGGAAAGACAACAGCTCGAGTCACTTTATAAG AACCTCAGGATACCGTTATTAGGAGATGAAGAAGAGGGCTCAGAGGACGAGGGTGAGTCCACGCACCTACTTCCAGAGAACGAAAATGAG CTGGAAAAGTTCATCCACTCAGTTATTATATCAAAAAGAAGCAAAAATATTAAGAAGAAACTGAAGGAAGAGCAAAACTCAGTAACAGAA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_COPZ1_ENST00000262061_chr12_54741628_+_C19orf18_ENST00000314391_chr19_58472919_-_874nt TTTTGCGGCTCCACGTCGGCACCAGCTGCGGGGCAAGATGGAGGCGCTGATTTTGGAACCTTCCCTGTATACTGTCAAAGCCATCCTGAT TCTGGACAATGATGGAGATCGACTTTTTGCCAAGTACTATGACGACACCTACCCCAGTGTCAAGGAGCAAAAGGCCTTTGAGAAGAACAT TTTCAACAAGACCCATCGGACTGACAGTGAAATTGCCCTCTTGGAAGGCCTGACAGTGGTATACAAAAGCAGTATAGATCTCTATTTCTA TGTGATTGGCAGCTCCTATGAAAATGAGCTGATGCTTATGGCTGTTCTGAACTGTCTCTTCGACTCATTGAGCCAGATGCTGAGGAAAAA TGTAGAAAAGCGAGCACTGCTGGAGAACATGGAGGGGCTGTTCTTGGCTGTGGATGAAATTGTAGATGGAGGTCGACTGGCACAGGCTGA GGAAAGACAACAGCTCGAGTCACTTTATAAGAACCTCAGGATACCGTTATTAGGAGATGAAGAAGAGGGCTCAGAGGACGAGGGTGAGTC CACGCACCTACTTCCAGAGAACGAAAATGAGCTGGAAAAGTTCATCCACTCAGTTATTATATCAAAAAGAAGCAAAAATATTAAGAAGAA ACTGAAGGAAGAGCAAAACTCAGTAACAGAAAACAAAACAAAGAATGCGTCACATAATGGAAAAATGGAAGACTTGTGAACGCAGACGAC AGAGGTGCCGGCTGAGGCAGAGGAGAAACTATGGGGGTGCTGGGAGACTGAGCCTGTGGGCGTGGCTTGCTCCCAGAGAACCTTATGGAA >In-frame_COPZ1_ENST00000549043_chr12_54741628_+_C19orf18_ENST00000314391_chr19_58472919_-_956nt TTGCGGCTCCACGTCGGCACCAGCTGCGGGGCAAGATGGAGGCGCTGATTTTGCCCCAGTGGGACTAGGGGAAGGTATCTGGTTTACCAG TGGTGATGGGAGGCTTCAGGACTGAAGGTATGTTCGTATCTCTTCAGGAACCTTCCCTGTATACTGTCAAAGCCATCCTGATTCTGGACA ATGATGGAGATCGACTTTTTGCCAAGTACTATGACGACACCTACCCCAGTGTCAAGGAGCAAAAGGCCTTTGAGAAGAACATTTTCAACA AGACCCATCGGACTGACAGTGAAATTGCCCTCTTGGAAGGCCTGACAGTGGTATACAAAAGCAGTATAGATCTCTATTTCTATGTGATTG GCAGCTCCTATGAAAATGAGCTGATGCTTATGGCTGTTCTGAACTGTCTCTTCGACTCATTGAGCCAGATGCTGAGGAAAAATGTAGAAA AGCGAGCACTGCTGGAGAACATGGAGGGGCTGTTCTTGGCTGTGGATGAAATTGTAGATGGAGGTCGACTGGCACAGGCTGAGGAAAGAC AACAGCTCGAGTCACTTTATAAGAACCTCAGGATACCGTTATTAGGAGATGAAGAAGAGGGCTCAGAGGACGAGGGTGAGTCCACGCACC TACTTCCAGAGAACGAAAATGAGCTGGAAAAGTTCATCCACTCAGTTATTATATCAAAAAGAAGCAAAAATATTAAGAAGAAACTGAAGG AAGAGCAAAACTCAGTAACAGAAAACAAAACAAAGAATGCGTCACATAATGGAAAAATGGAAGACTTGTGAACGCAGACGACAGAGGTGC CGGCTGAGGCAGAGGAGAAACTATGGGGGTGCTGGGAGACTGAGCCTGTGGGCGTGGCTTGCTCCCAGAGAACCTTATGGAAGAGGACAT >In-frame_COPZ1_ENST00000552218_chr12_54741628_+_C19orf18_ENST00000314391_chr19_58472919_-_933nt GCGGCTCCACGTCGGCACCAGCTGCGGGGCAAGATGGAGGCGCTGATTTTGGAACCTTCCCTGTATACTGTCAAAGCCATCCTGATTCTG GACAATGATGGAGATCGACTTTTTGCCAAGTACTATGACGACACCTACCCCAGTGTCAAGGAGCAAAAGGCCTTTGAGAAGAACATTTTC AACAAGACCCATCGGACTGACAGTGAAATTGCCCTCTTGGAAGGCCTGACAGTGGTATACAAAAGCAGTATAGATCTCTATTTCTATGTG ATTGGCAGCTCCTATGAAAATGAGCTGATGCTTATGGCTGTTCTGAACTGTCTCTTCGACTCATTGAGCCAGATGCTGAGAACAGGAAGC ACCCAGGCAGGAGGACTGCATGAGTCGAGTTCAAGACAAGCTTGGGCAACACAGAAAAATGTAGAAAAGCGAGCACTGCTGGAGAACATG GAGGGGCTGTTCTTGGCTGTGGATGAAATTGTAGATGGAGGTCGACTGGCACAGGCTGAGGAAAGACAACAGCTCGAGTCACTTTATAAG AACCTCAGGATACCGTTATTAGGAGATGAAGAAGAGGGCTCAGAGGACGAGGGTGAGTCCACGCACCTACTTCCAGAGAACGAAAATGAG CTGGAAAAGTTCATCCACTCAGTTATTATATCAAAAAGAAGCAAAAATATTAAGAAGAAACTGAAGGAAGAGCAAAACTCAGTAACAGAA AACAAAACAAAGAATGCGTCACATAATGGAAAAATGGAAGACTTGTGAACGCAGACGACAGAGGTGCCGGCTGAGGCAGAGGAGAAACTA TGGGGGTGCTGGGAGACTGAGCCTGTGGGCGTGGCTTGCTCCCAGAGAACCTTATGGAAGAGGACATCAAAGAAAGAAATGCCAGACCTG >In-frame_COPZ1_ENST00000553231_chr12_54741628_+_C19orf18_ENST00000314391_chr19_58472919_-_793nt ACGTCGGCACCAGCTGCGGGGCAAGATGGAGGCGCTGATTTTGTACTATGACGACACCTACCCCAGTGTCAAGGAGCAAAAGGCCTTTGA GAAGAACATTTTCAACAAGACCCATCGGACTGACAGTGAAATTGCCCTCTTGGAAGGCCTGACAGTGGTATACAAAAGCAGTATAGATCT CTATTTCTATGTGATTGGCAGCTCCTATGAAAATGAGCTGATGCTTATGGCTGTTCTGAACTGTCTCTTCGACTCATTGAGCCAGATGCT GAGGAAAAATGTAGAAAAGCGAGCACTGCTGGAGAACATGGAGGGGCTGTTCTTGGCTGTGGATGAAATTGTAGATGGAGGTCGACTGGC ACAGGCTGAGGAAAGACAACAGCTCGAGTCACTTTATAAGAACCTCAGGATACCGTTATTAGGAGATGAAGAAGAGGGCTCAGAGGACGA GGGTGAGTCCACGCACCTACTTCCAGAGAACGAAAATGAGCTGGAAAAGTTCATCCACTCAGTTATTATATCAAAAAGAAGCAAAAATAT TAAGAAGAAACTGAAGGAAGAGCAAAACTCAGTAACAGAAAACAAAACAAAGAATGCGTCACATAATGGAAAAATGGAAGACTTGTGAAC GCAGACGACAGAGGTGCCGGCTGAGGCAGAGGAGAAACTATGGGGGTGCTGGGAGACTGAGCCTGTGGGCGTGGCTTGCTCCCAGAGAAC >In-frame_COPZ1_ENST00000552362_chr12_54741628_+_C19orf18_ENST00000314391_chr19_58472919_-_862nt ACGTCGGCACCAGCTGCGGGGCAAGATGGAGGCGCTGATTTTGGAACCTTCCCTGTATACTGTCAAAGCCATCCTGATTCTGGACAATGA TGGAGATCGACTTTTTGCCAAGTACTATGACGACACCTACCCCAGTGTCAAGGAGCAAAAGGCCTTTGAGAAGAACATTTTCAACAAGAC CCATCGGACTGACAGTGAAATTGCCCTCTTGGAAGGCCTGACAGTGGTATACAAAAGCAGTATAGATCTCTATTTCTATGTGATTGGCAG CTCCTATGAAAATGAGCTGATGCTTATGGCTGTTCTGAACTGTCTCTTCGACTCATTGAGCCAGATGCTGAGGAAAAATGTAGAAAAGCG AGCACTGCTGGAGAACATGGAGGGGCTGTTCTTGGCTGTGGATGAAATTGTAGATGGAGGTCGACTGGCACAGGCTGAGGAAAGACAACA GCTCGAGTCACTTTATAAGAACCTCAGGATACCGTTATTAGGAGATGAAGAAGAGGGCTCAGAGGACGAGGGTGAGTCCACGCACCTACT TCCAGAGAACGAAAATGAGCTGGAAAAGTTCATCCACTCAGTTATTATATCAAAAAGAAGCAAAAATATTAAGAAGAAACTGAAGGAAGA GCAAAACTCAGTAACAGAAAACAAAACAAAGAATGCGTCACATAATGGAAAAATGGAAGACTTGTGAACGCAGACGACAGAGGTGCCGGC TGAGGCAGAGGAGAAACTATGGGGGTGCTGGGAGACTGAGCCTGTGGGCGTGGCTTGCTCCCAGAGAACCTTATGGAAGAGGACATCAAA >In-frame_COPZ1_ENST00000455864_chr12_54741628_+_C19orf18_ENST00000314391_chr19_58472919_-_793nt ACGTCGGCACCAGCTGCGGGGCAAGATGGAGGCGCTGATTTTGTACTATGACGACACCTACCCCAGTGTCAAGGAGCAAAAGGCCTTTGA GAAGAACATTTTCAACAAGACCCATCGGACTGACAGTGAAATTGCCCTCTTGGAAGGCCTGACAGTGGTATACAAAAGCAGTATAGATCT CTATTTCTATGTGATTGGCAGCTCCTATGAAAATGAGCTGATGCTTATGGCTGTTCTGAACTGTCTCTTCGACTCATTGAGCCAGATGCT GAGGAAAAATGTAGAAAAGCGAGCACTGCTGGAGAACATGGAGGGGCTGTTCTTGGCTGTGGATGAAATTGTAGATGGAGGTCGACTGGC ACAGGCTGAGGAAAGACAACAGCTCGAGTCACTTTATAAGAACCTCAGGATACCGTTATTAGGAGATGAAGAAGAGGGCTCAGAGGACGA GGGTGAGTCCACGCACCTACTTCCAGAGAACGAAAATGAGCTGGAAAAGTTCATCCACTCAGTTATTATATCAAAAAGAAGCAAAAATAT TAAGAAGAAACTGAAGGAAGAGCAAAACTCAGTAACAGAAAACAAAACAAAGAATGCGTCACATAATGGAAAAATGGAAGACTTGTGAAC GCAGACGACAGAGGTGCCGGCTGAGGCAGAGGAGAAACTATGGGGGTGCTGGGAGACTGAGCCTGTGGGCGTGGCTTGCTCCCAGAGAAC >In-frame_COPZ1_ENST00000416254_chr12_54741628_+_C19orf18_ENST00000314391_chr19_58472919_-_770nt ACGTCGGCACCAGCTGCGGGGCAAGATGGAGGCGCTGATTTTGGAACCTTCCCTGTATACTGTCAAAGCCATCCTGATTCTGGACAATGA TGGAGATCGACTTTTTGCCAAGTACTATGACGACACCTACCCCAGTGTCAAGGAGCAAAAGGCCTTTGAGAAGAACATTTTCAACAAGAC CCATCGGACTGACACTGATGCTTATGGCTGTTCTGAACTGTCTCTTCGACTCATTGAGCCAGATGCTGAGGAAAAATGTAGAAAAGCGAG CACTGCTGGAGAACATGGAGGGGCTGTTCTTGGCTGTGGATGAAATTGTAGATGGAGGTCGACTGGCACAGGCTGAGGAAAGACAACAGC TCGAGTCACTTTATAAGAACCTCAGGATACCGTTATTAGGAGATGAAGAAGAGGGCTCAGAGGACGAGGGTGAGTCCACGCACCTACTTC CAGAGAACGAAAATGAGCTGGAAAAGTTCATCCACTCAGTTATTATATCAAAAAGAAGCAAAAATATTAAGAAGAAACTGAAGGAAGAGC AAAACTCAGTAACAGAAAACAAAACAAAGAATGCGTCACATAATGGAAAAATGGAAGACTTGTGAACGCAGACGACAGAGGTGCCGGCTG AGGCAGAGGAGAAACTATGGGGGTGCTGGGAGACTGAGCCTGTGGGCGTGGCTTGCTCCCAGAGAACCTTATGGAAGAGGACATCAAAGA >In-frame_COPZ1_ENST00000549116_chr12_54741628_+_C19orf18_ENST00000314391_chr19_58472919_-_683nt GGCACCAGCTGCGGGGCAAGATGGAGGCGCTGATTTTGGAACCTTCCCTGTATACTGTCAAAGCCATCCTGATTCTGGACAATGATGGAG ATCGACTTTTTGCCAAGCTGATGCTTATGGCTGTTCTGAACTGTCTCTTCGACTCATTGAGCCAGATGCTGAGGAAAAATGTAGAAAAGC GAGCACTGCTGGAGAACATGGAGGGGCTGTTCTTGGCTGTGGATGAAATTGTAGATGGAGGTCGACTGGCACAGGCTGAGGAAAGACAAC AGCTCGAGTCACTTTATAAGAACCTCAGGATACCGTTATTAGGAGATGAAGAAGAGGGCTCAGAGGACGAGGGTGAGTCCACGCACCTAC TTCCAGAGAACGAAAATGAGCTGGAAAAGTTCATCCACTCAGTTATTATATCAAAAAGAAGCAAAAATATTAAGAAGAAACTGAAGGAAG AGCAAAACTCAGTAACAGAAAACAAAACAAAGAATGCGTCACATAATGGAAAAATGGAAGACTTGTGAACGCAGACGACAGAGGTGCCGG CTGAGGCAGAGGAGAAACTATGGGGGTGCTGGGAGACTGAGCCTGTGGGCGTGGCTTGCTCCCAGAGAACCTTATGGAAGAGGACATCAA >In-frame_COPZ1_ENST00000551779_chr12_54741628_+_C19orf18_ENST00000314391_chr19_58472919_-_850nt GCTGCGGGGCAAGATGGAGGCGCTGATTTTGGAACCTTCCCTGTATACTGTCAAAGCCATCCTGATTCTGGACAATGATGGAGATCGACT TTTTGCCAAGTACTATGACGACACCTACCCCAGTGTCAAGGAGCAAAAGGCCTTTGAGAAGAACATTTTCAACAAGACCCATCGGACTGA CAGTGAAATTGCCCTCTTGGAAGGCCTGACAGTGGTATACAAAAGCAGTATAGATCTCTATTTCTATGTGATTGGCAGCTCCTATGAAAA TGAGCTGATGCTTATGGCTGTTCTGAACTGTCTCTTCGACTCATTGAGCCAGATGCTGAGGAAAAATGTAGAAAAGCGAGCACTGCTGGA GAACATGGAGGGGCTGTTCTTGGCTGTGGATGAAATTGTAGATGGAGGTCGACTGGCACAGGCTGAGGAAAGACAACAGCTCGAGTCACT TTATAAGAACCTCAGGATACCGTTATTAGGAGATGAAGAAGAGGGCTCAGAGGACGAGGGTGAGTCCACGCACCTACTTCCAGAGAACGA AAATGAGCTGGAAAAGTTCATCCACTCAGTTATTATATCAAAAAGAAGCAAAAATATTAAGAAGAAACTGAAGGAAGAGCAAAACTCAGT AACAGAAAACAAAACAAAGAATGCGTCACATAATGGAAAAATGGAAGACTTGTGAACGCAGACGACAGAGGTGCCGGCTGAGGCAGAGGA GAAACTATGGGGGTGCTGGGAGACTGAGCCTGTGGGCGTGGCTTGCTCCCAGAGAACCTTATGGAAGAGGACATCAAAGAAAGAAATGCC >In-frame_COPZ1_ENST00000548753_chr12_54741628_+_C19orf18_ENST00000314391_chr19_58472919_-_918nt TGATGGTTTCCCAAGTTTGACTCTCCATTGCCGATTCCCTGCCACATTCCTTCAGGAAACTGTTTTGTCTTCGGTTTCCTGTTAATCCCT ATTATATAGGAACCTTCCCTGTATACTGTCAAAGCCATCCTGATTCTGGACAATGATGGAGATCGACTTTTTGCCAAGTACTATGACGAC ACCTACCCCAGTGTCAAGGAGCAAAAGGCCTTTGAGAAGAACATTTTCAACAAGACCCATCGGACTGACAGTGAAATTGCCCTCTTGGAA GGCCTGACAGTGGTATACAAAAGCAGTATAGATCTCTATTTCTATGTGATTGGCAGCTCCTATGAAAATGAGCTGATGCTTATGGCTGTT CTGAACTGTCTCTTCGACTCATTGAGCCAGATGCTGAGGAAAAATGTAGAAAAGCGAGCACTGCTGGAGAACATGGAGGGGCTGTTCTTG GCTGTGGATGAAATTGTAGATGGAGGTCGACTGGCACAGGCTGAGGAAAGACAACAGCTCGAGTCACTTTATAAGAACCTCAGGATACCG TTATTAGGAGATGAAGAAGAGGGCTCAGAGGACGAGGGTGAGTCCACGCACCTACTTCCAGAGAACGAAAATGAGCTGGAAAAGTTCATC CACTCAGTTATTATATCAAAAAGAAGCAAAAATATTAAGAAGAAACTGAAGGAAGAGCAAAACTCAGTAACAGAAAACAAAACAAAGAAT GCGTCACATAATGGAAAAATGGAAGACTTGTGAACGCAGACGACAGAGGTGCCGGCTGAGGCAGAGGAGAAACTATGGGGGTGCTGGGAG ACTGAGCCTGTGGGCGTGGCTTGCTCCCAGAGAACCTTATGGAAGAGGACATCAAAGAAAGAAATGCCAGACCTGTATCCCAGAAAATAA |
Top |
FusionGenePPI for COPZ1_C19orf18 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| COPZ1 | COPG1, TMED10, COPA, COPB1, COPZ1, APP, ARCN1, COPB2, COPG2, GOPC, TMED9, UGT1A1, BAG3, TLE3, DIAPH1, KLC1, RUFY1, TTI1, NUDCD1, STAU1, DTNBP1, SF3B1, REV3L, HERC2, MKS1, XPO1, DUSP1, DUSP28, DUSP8, SARNP, SUB1, CHORDC1, DRG1, DIS3, SEPT7, PRCC, CDK5, SH3GLB1, SCYL2, ZC3HAV1, DLD, DLST, TRIM25 | C19orf18 | APP |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for COPZ1_C19orf18 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for COPZ1_C19orf18 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | C19orf18 | C0236969 | Substance-Related Disorders | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|