|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 8084 |
FusionGeneSummary for COPRS_FAM102A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: COPRS_FAM102A | Fusion gene ID: 8084 | Hgene | Tgene | Gene symbol | COPRS | FAM102A | Gene ID | 55352 | 399665 |
| Gene name | coordinator of PRMT5 and differentiation stimulator | family with sequence similarity 102 member A | |
| Synonyms | C17orf79|COPR5|HSA272196|TTP1 | C9orf132|EEIG1|SYM-3A|bA203J24.7 | |
| Cytomap | 17q11.2 | 9q34.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | coordinator of PRMT5 and differentiation stimulatorcooperator of PRMT5coordinator of PRMT5, differentiation stimulator | protein FAM102AC230093N12Rikearly estrogen-induced gene 1 proteinsym-3 homolog A | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9NQ92 | Q5T9C2 | |
| Ensembl transtripts involved in fusion gene | ENST00000302362, ENST00000378634, | ENST00000373095, ENST00000373084, ENST00000300434, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 1 X 1 X 1=1 |
| # samples | 1 | 1 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: COPRS [Title/Abstract] AND FAM102A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | COPRS | GO:0043985 | histone H4-R3 methylation | 18404153 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BQ180870 | COPRS | chr17 | 30180022 | + | FAM102A | chr9 | 130703309 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000302362 | ENST00000373095 | COPRS | chr17 | 30180022 | + | FAM102A | chr9 | 130703309 | + |
| intron-3UTR | ENST00000302362 | ENST00000373084 | COPRS | chr17 | 30180022 | + | FAM102A | chr9 | 130703309 | + |
| intron-5UTR | ENST00000302362 | ENST00000300434 | COPRS | chr17 | 30180022 | + | FAM102A | chr9 | 130703309 | + |
| intron-3UTR | ENST00000378634 | ENST00000373095 | COPRS | chr17 | 30180022 | + | FAM102A | chr9 | 130703309 | + |
| intron-3UTR | ENST00000378634 | ENST00000373084 | COPRS | chr17 | 30180022 | + | FAM102A | chr9 | 130703309 | + |
| intron-5UTR | ENST00000378634 | ENST00000300434 | COPRS | chr17 | 30180022 | + | FAM102A | chr9 | 130703309 | + |
Top |
FusionProtFeatures for COPRS_FAM102A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| COPRS | FAM102A |
| Histone-binding protein required for histone H4methyltransferase activity of PRMT5. Specifically required forhistone H4 'Arg-3' methylation mediated by PRMT5, but not histoneH3 'Arg-8' methylation, suggesting that it modulates the substratespecificity of PRMT5. Specifically interacts with the N-terminusof histone H4 but not with histone H3, suggesting that it acts bypromoting the association between histone H4 and PRMT5. Involvedin CCNE1 promoter repression. Plays a role in muscle celldifferentiation by modulating the recruitment of PRMT5 to thepromoter of genes involved in the coordination between cell cycleexit and muscle differentiation (By similarity). {ECO:0000250,ECO:0000269|PubMed:18404153}. | May play a role in estrogen action.{ECO:0000269|PubMed:14605097}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for COPRS_FAM102A |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for COPRS_FAM102A |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for COPRS_FAM102A |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for COPRS_FAM102A |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|