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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 8074

FusionGeneSummary for COPE_TMED1

check button Fusion gene summary
Fusion gene informationFusion gene name: COPE_TMED1
Fusion gene ID: 8074
HgeneTgene
Gene symbol

COPE

TMED1

Gene ID

11316

11018

Gene namecoatomer protein complex subunit epsilontransmembrane p24 trafficking protein 1
Synonymsepsilon-COPIL1RL1LG|Il1rl1l|Tp24|p24g1
Cytomap

19p13.11

19p13.2

Type of geneprotein-codingprotein-coding
Descriptioncoatomer subunit epsiloncoatomer epsilon subunitepsilon coat proteintransmembrane emp24 domain-containing protein 1IL1RL1-binding proteininterleukin 1 receptor-like 1 ligandp24 family protein gamma-1putative T1/ST2 receptor-binding proteintransmembrane emp24 protein transport domain containing 1
Modification date2018052320180523
UniProtAcc

O14579

Q13445

Ensembl transtripts involved in fusion geneENST00000262812, ENST00000349893, 
ENST00000600932, ENST00000598969, 
ENST00000351079, 
ENST00000214869, 
ENST00000591695, ENST00000588289, 
Fusion gene scores* DoF score5 X 5 X 3=752 X 2 X 2=8
# samples 52
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: COPE [Title/Abstract] AND TMED1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-DX-A8BL-01ACOPEchr19

19023793

-TMED1chr19

10946029

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000262812ENST00000214869COPEchr19

19023793

-TMED1chr19

10946029

-
In-frameENST00000262812ENST00000591695COPEchr19

19023793

-TMED1chr19

10946029

-
5CDS-5UTRENST00000262812ENST00000588289COPEchr19

19023793

-TMED1chr19

10946029

-
In-frameENST00000349893ENST00000214869COPEchr19

19023793

-TMED1chr19

10946029

-
In-frameENST00000349893ENST00000591695COPEchr19

19023793

-TMED1chr19

10946029

-
5CDS-5UTRENST00000349893ENST00000588289COPEchr19

19023793

-TMED1chr19

10946029

-
In-frameENST00000600932ENST00000214869COPEchr19

19023793

-TMED1chr19

10946029

-
In-frameENST00000600932ENST00000591695COPEchr19

19023793

-TMED1chr19

10946029

-
5CDS-5UTRENST00000600932ENST00000588289COPEchr19

19023793

-TMED1chr19

10946029

-
5UTR-3CDSENST00000598969ENST00000214869COPEchr19

19023793

-TMED1chr19

10946029

-
5UTR-3CDSENST00000598969ENST00000591695COPEchr19

19023793

-TMED1chr19

10946029

-
5UTR-5UTRENST00000598969ENST00000588289COPEchr19

19023793

-TMED1chr19

10946029

-
In-frameENST00000351079ENST00000214869COPEchr19

19023793

-TMED1chr19

10946029

-
In-frameENST00000351079ENST00000591695COPEchr19

19023793

-TMED1chr19

10946029

-
5CDS-5UTRENST00000351079ENST00000588289COPEchr19

19023793

-TMED1chr19

10946029

-

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FusionProtFeatures for COPE_TMED1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
COPE

O14579

TMED1

Q13445

The coatomer is a cytosolic protein complex that bindsto dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosyntheticprotein transport from the ER, via the Golgi up to the trans Golginetwork. The coatomer complex is required for budding from Golgimembranes, and is essential for the retrograde Golgi-to-ERtransport of dilysine-tagged proteins. In mammals, the coatomercan only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins;the complex also influences the Golgi structural integrity, aswell as the processing, activity, and endocytic recycling of LDLreceptors (By similarity). {ECO:0000250}. Potential role in vesicular protein trafficking, mainlyin the early secretory pathway. May act as a cargo receptor at thelumenal side for incorporation of secretory cargo molecules intotransport vesicles and may be involved in vesicle coat formationat the cytoplasmic side.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTMED1chr19:19023793chr19:10946029ENST00000214869-04145_17061228Coiled coilOntology_term=ECO:0000255
TgeneTMED1chr19:19023793chr19:10946029ENST00000214869-04218_21961228MotifCOPII vesicle coat-binding
TgeneTMED1chr19:19023793chr19:10946029ENST00000214869-04218_22761228MotifCOPI vesicle coat-binding
TgeneTMED1chr19:19023793chr19:10946029ENST00000214869-04216_22761228Topological domainCytoplasmic
TgeneTMED1chr19:19023793chr19:10946029ENST00000214869-04195_21561228TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTMED1chr19:19023793chr19:10946029ENST00000214869-0443_12561228DomainGOLD
TgeneTMED1chr19:19023793chr19:10946029ENST00000214869-0424_19461228Topological domainExtracellular


Top

FusionGeneSequence for COPE_TMED1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_COPE_ENST00000262812_chr19_19023793_-_TMED1_ENST00000214869_chr19_10946029_-_230aa
MAPPAPGPASGGSGEVDELFDVKNAFYIGSYQQCINEAQRVKLSSPERDVERDVFLYRAYLAQVIGGAGLDVDFTLESPQGVLLVSESRK
ADGVHTVEPTEAGDYKLCFDNSFSTISEKLVFFELIFDSLQDDEEVEGWAEAVEPEEMLDVKMEDIKESIETMRTRLERSIQMLTLLRAF

>In-frame_COPE_ENST00000262812_chr19_19023793_-_TMED1_ENST00000591695_chr19_10946029_-_188aa
MAPPAPGPASGGSGEVDELFDVKNAFYIGSYQQCINEAQRVKLSSPERDVERDVFLYRAYLAQVIGGAGLDVDFTLESPQGVLLVSESRK
ADGVHTSPLRPCGPGWSAASRCSRYCGPSRHVTATCKRATWSGSTSGQLSTWRCCCWWLCCRSARSSASSRTSARCPRSPCHGRKNGTKE

>In-frame_COPE_ENST00000349893_chr19_19023793_-_TMED1_ENST00000214869_chr19_10946029_-_230aa
MAPPAPGPASGGSGEVDELFDVKNAFYIGSYQQCINEAQRVKLSSPERDVERDVFLYRAYLAQVIGGAGLDVDFTLESPQGVLLVSESRK
ADGVHTVEPTEAGDYKLCFDNSFSTISEKLVFFELIFDSLQDDEEVEGWAEAVEPEEMLDVKMEDIKESIETMRTRLERSIQMLTLLRAF

>In-frame_COPE_ENST00000349893_chr19_19023793_-_TMED1_ENST00000591695_chr19_10946029_-_188aa
MAPPAPGPASGGSGEVDELFDVKNAFYIGSYQQCINEAQRVKLSSPERDVERDVFLYRAYLAQVIGGAGLDVDFTLESPQGVLLVSESRK
ADGVHTSPLRPCGPGWSAASRCSRYCGPSRHVTATCKRATWSGSTSGQLSTWRCCCWWLCCRSARSSASSRTSARCPRSPCHGRKNGTKE

>In-frame_COPE_ENST00000600932_chr19_19023793_-_TMED1_ENST00000214869_chr19_10946029_-_230aa
MAPPAPGPASGGSGEVDELFDVKNAFYIGSYQQCINEAQRVKLSSPERDVERDVFLYRAYLAQVIGGAGLDVDFTLESPQGVLLVSESRK
ADGVHTVEPTEAGDYKLCFDNSFSTISEKLVFFELIFDSLQDDEEVEGWAEAVEPEEMLDVKMEDIKESIETMRTRLERSIQMLTLLRAF

>In-frame_COPE_ENST00000600932_chr19_19023793_-_TMED1_ENST00000591695_chr19_10946029_-_188aa
MAPPAPGPASGGSGEVDELFDVKNAFYIGSYQQCINEAQRVKLSSPERDVERDVFLYRAYLAQVIGGAGLDVDFTLESPQGVLLVSESRK
ADGVHTSPLRPCGPGWSAASRCSRYCGPSRHVTATCKRATWSGSTSGQLSTWRCCCWWLCCRSARSSASSRTSARCPRSPCHGRKNGTKE

>In-frame_COPE_ENST00000351079_chr19_19023793_-_TMED1_ENST00000214869_chr19_10946029_-_230aa
MAPPAPGPASGGSGEVDELFDVKNAFYIGSYQQCINEAQRVKLSSPERDVERDVFLYRAYLAQVIGGAGLDVDFTLESPQGVLLVSESRK
ADGVHTVEPTEAGDYKLCFDNSFSTISEKLVFFELIFDSLQDDEEVEGWAEAVEPEEMLDVKMEDIKESIETMRTRLERSIQMLTLLRAF

>In-frame_COPE_ENST00000351079_chr19_19023793_-_TMED1_ENST00000591695_chr19_10946029_-_188aa
MAPPAPGPASGGSGEVDELFDVKNAFYIGSYQQCINEAQRVKLSSPERDVERDVFLYRAYLAQVIGGAGLDVDFTLESPQGVLLVSESRK
ADGVHTSPLRPCGPGWSAASRCSRYCGPSRHVTATCKRATWSGSTSGQLSTWRCCCWWLCCRSARSSASSRTSARCPRSPCHGRKNGTKE


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_COPE_ENST00000262812_chr19_19023793_-_TMED1_ENST00000214869_chr19_10946029_-_690nt
ATGGCGCCTCCGGCCCCCGGCCCGGCCTCCGGCGGCTCCGGGGAGGTAGACGAGCTGTTCGACGTAAAGAACGCCTTCTACATCGGCAGC
TACCAGCAGTGCATAAACGAGGCGCAGCGGGTGAAGCTATCAAGCCCAGAGAGAGACGTGGAGAGGGACGTCTTCCTGTATAGAGCGTAC
CTGGCGCAGGTGATCGGAGGTGCTGGACTGGACGTGGACTTCACGCTGGAGAGCCCTCAGGGCGTGCTGTTGGTCAGCGAGTCCCGCAAG
GCTGATGGGGTACACACGGTGGAGCCAACGGAGGCCGGGGACTACAAGCTGTGCTTTGACAACTCCTTCAGCACCATCTCCGAGAAGCTG
GTGTTCTTTGAACTGATCTTTGACAGCCTCCAGGATGACGAGGAGGTCGAAGGATGGGCAGAGGCTGTGGAGCCCGAGGAGATGCTGGAT
GTTAAAATGGAGGACATCAAGGAGTCCATTGAGACCATGCGGACCCGGCTGGAGCGCAGCATCCAGATGCTCACGCTACTGCGGGCCTTC
GAGGCACGTGACCGCAACCTGCAAGAGGGCAACTTGGAGCGGGTCAACTTCTGGTCAGCTGTCAACGTGGCGGTGCTGCTGCTGGTGGCT

>In-frame_COPE_ENST00000262812_chr19_19023793_-_TMED1_ENST00000591695_chr19_10946029_-_564nt
ATGGCGCCTCCGGCCCCCGGCCCGGCCTCCGGCGGCTCCGGGGAGGTAGACGAGCTGTTCGACGTAAAGAACGCCTTCTACATCGGCAGC
TACCAGCAGTGCATAAACGAGGCGCAGCGGGTGAAGCTATCAAGCCCAGAGAGAGACGTGGAGAGGGACGTCTTCCTGTATAGAGCGTAC
CTGGCGCAGGTGATCGGAGGTGCTGGACTGGACGTGGACTTCACGCTGGAGAGCCCTCAGGGCGTGCTGTTGGTCAGCGAGTCCCGCAAG
GCTGATGGGGTACACACGAGTCCATTGAGACCATGCGGACCCGGCTGGAGCGCAGCATCCAGATGCTCACGCTACTGCGGGCCTTCGAGG
CACGTGACCGCAACCTGCAAGAGGGCAACTTGGAGCGGGTCAACTTCTGGTCAGCTGTCAACGTGGCGGTGCTGCTGCTGGTGGCTGTGC
TGCAGGTCTGCACGCTCAAGCGCTTCTTCCAGGACAAGCGCCCGGTGCCCACGTAGCCCCTGCCATGGAAGGAAGAACGGGACAAAGGAG

>In-frame_COPE_ENST00000349893_chr19_19023793_-_TMED1_ENST00000214869_chr19_10946029_-_690nt
ATGGCGCCTCCGGCCCCCGGCCCGGCCTCCGGCGGCTCCGGGGAGGTAGACGAGCTGTTCGACGTAAAGAACGCCTTCTACATCGGCAGC
TACCAGCAGTGCATAAACGAGGCGCAGCGGGTGAAGCTATCAAGCCCAGAGAGAGACGTGGAGAGGGACGTCTTCCTGTATAGAGCGTAC
CTGGCGCAGGTGATCGGAGGTGCTGGACTGGACGTGGACTTCACGCTGGAGAGCCCTCAGGGCGTGCTGTTGGTCAGCGAGTCCCGCAAG
GCTGATGGGGTACACACGGTGGAGCCAACGGAGGCCGGGGACTACAAGCTGTGCTTTGACAACTCCTTCAGCACCATCTCCGAGAAGCTG
GTGTTCTTTGAACTGATCTTTGACAGCCTCCAGGATGACGAGGAGGTCGAAGGATGGGCAGAGGCTGTGGAGCCCGAGGAGATGCTGGAT
GTTAAAATGGAGGACATCAAGGAGTCCATTGAGACCATGCGGACCCGGCTGGAGCGCAGCATCCAGATGCTCACGCTACTGCGGGCCTTC
GAGGCACGTGACCGCAACCTGCAAGAGGGCAACTTGGAGCGGGTCAACTTCTGGTCAGCTGTCAACGTGGCGGTGCTGCTGCTGGTGGCT

>In-frame_COPE_ENST00000349893_chr19_19023793_-_TMED1_ENST00000591695_chr19_10946029_-_564nt
ATGGCGCCTCCGGCCCCCGGCCCGGCCTCCGGCGGCTCCGGGGAGGTAGACGAGCTGTTCGACGTAAAGAACGCCTTCTACATCGGCAGC
TACCAGCAGTGCATAAACGAGGCGCAGCGGGTGAAGCTATCAAGCCCAGAGAGAGACGTGGAGAGGGACGTCTTCCTGTATAGAGCGTAC
CTGGCGCAGGTGATCGGAGGTGCTGGACTGGACGTGGACTTCACGCTGGAGAGCCCTCAGGGCGTGCTGTTGGTCAGCGAGTCCCGCAAG
GCTGATGGGGTACACACGAGTCCATTGAGACCATGCGGACCCGGCTGGAGCGCAGCATCCAGATGCTCACGCTACTGCGGGCCTTCGAGG
CACGTGACCGCAACCTGCAAGAGGGCAACTTGGAGCGGGTCAACTTCTGGTCAGCTGTCAACGTGGCGGTGCTGCTGCTGGTGGCTGTGC
TGCAGGTCTGCACGCTCAAGCGCTTCTTCCAGGACAAGCGCCCGGTGCCCACGTAGCCCCTGCCATGGAAGGAAGAACGGGACAAAGGAG

>In-frame_COPE_ENST00000600932_chr19_19023793_-_TMED1_ENST00000214869_chr19_10946029_-_690nt
ATGGCGCCTCCGGCCCCCGGCCCGGCCTCCGGCGGCTCCGGGGAGGTAGACGAGCTGTTCGACGTAAAGAACGCCTTCTACATCGGCAGC
TACCAGCAGTGCATAAACGAGGCGCAGCGGGTGAAGCTATCAAGCCCAGAGAGAGACGTGGAGAGGGACGTCTTCCTGTATAGAGCGTAC
CTGGCGCAGGTGATCGGAGGTGCTGGACTGGACGTGGACTTCACGCTGGAGAGCCCTCAGGGCGTGCTGTTGGTCAGCGAGTCCCGCAAG
GCTGATGGGGTACACACGGTGGAGCCAACGGAGGCCGGGGACTACAAGCTGTGCTTTGACAACTCCTTCAGCACCATCTCCGAGAAGCTG
GTGTTCTTTGAACTGATCTTTGACAGCCTCCAGGATGACGAGGAGGTCGAAGGATGGGCAGAGGCTGTGGAGCCCGAGGAGATGCTGGAT
GTTAAAATGGAGGACATCAAGGAGTCCATTGAGACCATGCGGACCCGGCTGGAGCGCAGCATCCAGATGCTCACGCTACTGCGGGCCTTC
GAGGCACGTGACCGCAACCTGCAAGAGGGCAACTTGGAGCGGGTCAACTTCTGGTCAGCTGTCAACGTGGCGGTGCTGCTGCTGGTGGCT

>In-frame_COPE_ENST00000600932_chr19_19023793_-_TMED1_ENST00000591695_chr19_10946029_-_564nt
ATGGCGCCTCCGGCCCCCGGCCCGGCCTCCGGCGGCTCCGGGGAGGTAGACGAGCTGTTCGACGTAAAGAACGCCTTCTACATCGGCAGC
TACCAGCAGTGCATAAACGAGGCGCAGCGGGTGAAGCTATCAAGCCCAGAGAGAGACGTGGAGAGGGACGTCTTCCTGTATAGAGCGTAC
CTGGCGCAGGTGATCGGAGGTGCTGGACTGGACGTGGACTTCACGCTGGAGAGCCCTCAGGGCGTGCTGTTGGTCAGCGAGTCCCGCAAG
GCTGATGGGGTACACACGAGTCCATTGAGACCATGCGGACCCGGCTGGAGCGCAGCATCCAGATGCTCACGCTACTGCGGGCCTTCGAGG
CACGTGACCGCAACCTGCAAGAGGGCAACTTGGAGCGGGTCAACTTCTGGTCAGCTGTCAACGTGGCGGTGCTGCTGCTGGTGGCTGTGC
TGCAGGTCTGCACGCTCAAGCGCTTCTTCCAGGACAAGCGCCCGGTGCCCACGTAGCCCCTGCCATGGAAGGAAGAACGGGACAAAGGAG

>In-frame_COPE_ENST00000351079_chr19_19023793_-_TMED1_ENST00000214869_chr19_10946029_-_690nt
ATGGCGCCTCCGGCCCCCGGCCCGGCCTCCGGCGGCTCCGGGGAGGTAGACGAGCTGTTCGACGTAAAGAACGCCTTCTACATCGGCAGC
TACCAGCAGTGCATAAACGAGGCGCAGCGGGTGAAGCTATCAAGCCCAGAGAGAGACGTGGAGAGGGACGTCTTCCTGTATAGAGCGTAC
CTGGCGCAGGTGATCGGAGGTGCTGGACTGGACGTGGACTTCACGCTGGAGAGCCCTCAGGGCGTGCTGTTGGTCAGCGAGTCCCGCAAG
GCTGATGGGGTACACACGGTGGAGCCAACGGAGGCCGGGGACTACAAGCTGTGCTTTGACAACTCCTTCAGCACCATCTCCGAGAAGCTG
GTGTTCTTTGAACTGATCTTTGACAGCCTCCAGGATGACGAGGAGGTCGAAGGATGGGCAGAGGCTGTGGAGCCCGAGGAGATGCTGGAT
GTTAAAATGGAGGACATCAAGGAGTCCATTGAGACCATGCGGACCCGGCTGGAGCGCAGCATCCAGATGCTCACGCTACTGCGGGCCTTC
GAGGCACGTGACCGCAACCTGCAAGAGGGCAACTTGGAGCGGGTCAACTTCTGGTCAGCTGTCAACGTGGCGGTGCTGCTGCTGGTGGCT

>In-frame_COPE_ENST00000351079_chr19_19023793_-_TMED1_ENST00000591695_chr19_10946029_-_564nt
ATGGCGCCTCCGGCCCCCGGCCCGGCCTCCGGCGGCTCCGGGGAGGTAGACGAGCTGTTCGACGTAAAGAACGCCTTCTACATCGGCAGC
TACCAGCAGTGCATAAACGAGGCGCAGCGGGTGAAGCTATCAAGCCCAGAGAGAGACGTGGAGAGGGACGTCTTCCTGTATAGAGCGTAC
CTGGCGCAGGTGATCGGAGGTGCTGGACTGGACGTGGACTTCACGCTGGAGAGCCCTCAGGGCGTGCTGTTGGTCAGCGAGTCCCGCAAG
GCTGATGGGGTACACACGAGTCCATTGAGACCATGCGGACCCGGCTGGAGCGCAGCATCCAGATGCTCACGCTACTGCGGGCCTTCGAGG
CACGTGACCGCAACCTGCAAGAGGGCAACTTGGAGCGGGTCAACTTCTGGTCAGCTGTCAACGTGGCGGTGCTGCTGCTGGTGGCTGTGC
TGCAGGTCTGCACGCTCAAGCGCTTCTTCCAGGACAAGCGCCCGGTGCCCACGTAGCCCCTGCCATGGAAGGAAGAACGGGACAAAGGAG


* Fusion transcript sequences (Full-length transcript).
>In-frame_COPE_ENST00000262812_chr19_19023793_-_TMED1_ENST00000214869_chr19_10946029_-_1296nt
TCCGGCTGACGTGTCTTTCAGGAAGAGGAGCTGGTGAGAAGACAGCGAAATGGCGCCTCCGGCCCCCGGCCCGGCCTCCGGCGGCTCCGG
GGAGGTAGACGAGCTGTTCGACGTAAAGAACGCCTTCTACATCGGCAGCTACCAGCAGTGCATAAACGAGGCGCAGCGGGTGAAGCTATC
AAGCCCAGAGAGAGACGTGGAGAGGGACGTCTTCCTGTATAGAGCGTACCTGGCGCAGGTGATCGGAGGTGCTGGACTGGACGTGGACTT
CACGCTGGAGAGCCCTCAGGGCGTGCTGTTGGTCAGCGAGTCCCGCAAGGCTGATGGGGTACACACGGTGGAGCCAACGGAGGCCGGGGA
CTACAAGCTGTGCTTTGACAACTCCTTCAGCACCATCTCCGAGAAGCTGGTGTTCTTTGAACTGATCTTTGACAGCCTCCAGGATGACGA
GGAGGTCGAAGGATGGGCAGAGGCTGTGGAGCCCGAGGAGATGCTGGATGTTAAAATGGAGGACATCAAGGAGTCCATTGAGACCATGCG
GACCCGGCTGGAGCGCAGCATCCAGATGCTCACGCTACTGCGGGCCTTCGAGGCACGTGACCGCAACCTGCAAGAGGGCAACTTGGAGCG
GGTCAACTTCTGGTCAGCTGTCAACGTGGCGGTGCTGCTGCTGGTGGCTGTGCTGCAGGTCTGCACGCTCAAGCGCTTCTTCCAGGACAA
GCGCCCGGTGCCCACGTAGCCCCTGCCATGGAAGGAAGAACGGGACAAAGGAGGGGCAGCAGGGTGTGTGCATATGAGACTTGGGGGTCC
CTCCCCAATTTTAGTTTCCTGCCAAAACGGGAGTGTGCAGTCAGGGCCTGCGGTCTGGCCCCATGAGTCTCCTTCCGTCCTCAGCGGGCA
GGGAACACCTCTGGCTTGTAGAAGGGACGGCTCAGTGGCTGCACCGACGGTCCTGGAAATCTCACATGGTGGGCACTGCAGCGTTGGAAC
GTGAGCCTCGGATTTCCTGGCCCCTCTACTGTAAATGTGCCTTAGCCTAAGCCTCCCATCCTGTGTTAGCGTTGCCTGGTGCGGGGCAGG
GCCTAACAAGGAAACCTGGGCCCTCCAAGCCAGGTTGAGGTCTGGTAACAGAATGCCAGGAAGGGGGCCTGGAAGACCACCTGCCCCGGC
CCCTCTCCTGCAGGGGCCCCACACAGGCATGAGGGATGGCCCGGCCAAAGTCTAGGCAGAAGCCTCCTATAACAAAGGGTGGTGTGGCCT

>In-frame_COPE_ENST00000262812_chr19_19023793_-_TMED1_ENST00000591695_chr19_10946029_-_737nt
TCCGGCTGACGTGTCTTTCAGGAAGAGGAGCTGGTGAGAAGACAGCGAAATGGCGCCTCCGGCCCCCGGCCCGGCCTCCGGCGGCTCCGG
GGAGGTAGACGAGCTGTTCGACGTAAAGAACGCCTTCTACATCGGCAGCTACCAGCAGTGCATAAACGAGGCGCAGCGGGTGAAGCTATC
AAGCCCAGAGAGAGACGTGGAGAGGGACGTCTTCCTGTATAGAGCGTACCTGGCGCAGGTGATCGGAGGTGCTGGACTGGACGTGGACTT
CACGCTGGAGAGCCCTCAGGGCGTGCTGTTGGTCAGCGAGTCCCGCAAGGCTGATGGGGTACACACGAGTCCATTGAGACCATGCGGACC
CGGCTGGAGCGCAGCATCCAGATGCTCACGCTACTGCGGGCCTTCGAGGCACGTGACCGCAACCTGCAAGAGGGCAACTTGGAGCGGGTC
AACTTCTGGTCAGCTGTCAACGTGGCGGTGCTGCTGCTGGTGGCTGTGCTGCAGGTCTGCACGCTCAAGCGCTTCTTCCAGGACAAGCGC
CCGGTGCCCACGTAGCCCCTGCCATGGAAGGAAGAACGGGACAAAGGAGGGGCAGCAGGGTGTGTGCATATGAGACTTGGGGGTCCCTCC
CCAATTTTAGTTTCCTGCCAAAACGGGAGTGTGCAGTCAGGGCCTGCGGTCTGGCCCCATGAGTCTCCTTCCGTCCTCAGCGGGCAGGGA

>In-frame_COPE_ENST00000349893_chr19_19023793_-_TMED1_ENST00000214869_chr19_10946029_-_1262nt
TGAGAAGACAGCGAAATGGCGCCTCCGGCCCCCGGCCCGGCCTCCGGCGGCTCCGGGGAGGTAGACGAGCTGTTCGACGTAAAGAACGCC
TTCTACATCGGCAGCTACCAGCAGTGCATAAACGAGGCGCAGCGGGTGAAGCTATCAAGCCCAGAGAGAGACGTGGAGAGGGACGTCTTC
CTGTATAGAGCGTACCTGGCGCAGGTGATCGGAGGTGCTGGACTGGACGTGGACTTCACGCTGGAGAGCCCTCAGGGCGTGCTGTTGGTC
AGCGAGTCCCGCAAGGCTGATGGGGTACACACGGTGGAGCCAACGGAGGCCGGGGACTACAAGCTGTGCTTTGACAACTCCTTCAGCACC
ATCTCCGAGAAGCTGGTGTTCTTTGAACTGATCTTTGACAGCCTCCAGGATGACGAGGAGGTCGAAGGATGGGCAGAGGCTGTGGAGCCC
GAGGAGATGCTGGATGTTAAAATGGAGGACATCAAGGAGTCCATTGAGACCATGCGGACCCGGCTGGAGCGCAGCATCCAGATGCTCACG
CTACTGCGGGCCTTCGAGGCACGTGACCGCAACCTGCAAGAGGGCAACTTGGAGCGGGTCAACTTCTGGTCAGCTGTCAACGTGGCGGTG
CTGCTGCTGGTGGCTGTGCTGCAGGTCTGCACGCTCAAGCGCTTCTTCCAGGACAAGCGCCCGGTGCCCACGTAGCCCCTGCCATGGAAG
GAAGAACGGGACAAAGGAGGGGCAGCAGGGTGTGTGCATATGAGACTTGGGGGTCCCTCCCCAATTTTAGTTTCCTGCCAAAACGGGAGT
GTGCAGTCAGGGCCTGCGGTCTGGCCCCATGAGTCTCCTTCCGTCCTCAGCGGGCAGGGAACACCTCTGGCTTGTAGAAGGGACGGCTCA
GTGGCTGCACCGACGGTCCTGGAAATCTCACATGGTGGGCACTGCAGCGTTGGAACGTGAGCCTCGGATTTCCTGGCCCCTCTACTGTAA
ATGTGCCTTAGCCTAAGCCTCCCATCCTGTGTTAGCGTTGCCTGGTGCGGGGCAGGGCCTAACAAGGAAACCTGGGCCCTCCAAGCCAGG
TTGAGGTCTGGTAACAGAATGCCAGGAAGGGGGCCTGGAAGACCACCTGCCCCGGCCCCTCTCCTGCAGGGGCCCCACACAGGCATGAGG
GATGGCCCGGCCAAAGTCTAGGCAGAAGCCTCCTATAACAAAGGGTGGTGTGGCCTGGGCATTGGAGTCAATAAATTATGGTCAGAAAAT

>In-frame_COPE_ENST00000349893_chr19_19023793_-_TMED1_ENST00000591695_chr19_10946029_-_703nt
TGAGAAGACAGCGAAATGGCGCCTCCGGCCCCCGGCCCGGCCTCCGGCGGCTCCGGGGAGGTAGACGAGCTGTTCGACGTAAAGAACGCC
TTCTACATCGGCAGCTACCAGCAGTGCATAAACGAGGCGCAGCGGGTGAAGCTATCAAGCCCAGAGAGAGACGTGGAGAGGGACGTCTTC
CTGTATAGAGCGTACCTGGCGCAGGTGATCGGAGGTGCTGGACTGGACGTGGACTTCACGCTGGAGAGCCCTCAGGGCGTGCTGTTGGTC
AGCGAGTCCCGCAAGGCTGATGGGGTACACACGAGTCCATTGAGACCATGCGGACCCGGCTGGAGCGCAGCATCCAGATGCTCACGCTAC
TGCGGGCCTTCGAGGCACGTGACCGCAACCTGCAAGAGGGCAACTTGGAGCGGGTCAACTTCTGGTCAGCTGTCAACGTGGCGGTGCTGC
TGCTGGTGGCTGTGCTGCAGGTCTGCACGCTCAAGCGCTTCTTCCAGGACAAGCGCCCGGTGCCCACGTAGCCCCTGCCATGGAAGGAAG
AACGGGACAAAGGAGGGGCAGCAGGGTGTGTGCATATGAGACTTGGGGGTCCCTCCCCAATTTTAGTTTCCTGCCAAAACGGGAGTGTGC

>In-frame_COPE_ENST00000600932_chr19_19023793_-_TMED1_ENST00000214869_chr19_10946029_-_1279nt
TCAGGAAGAGGAGCTGGTGAGAAGACAGCGAAATGGCGCCTCCGGCCCCCGGCCCGGCCTCCGGCGGCTCCGGGGAGGTAGACGAGCTGT
TCGACGTAAAGAACGCCTTCTACATCGGCAGCTACCAGCAGTGCATAAACGAGGCGCAGCGGGTGAAGCTATCAAGCCCAGAGAGAGACG
TGGAGAGGGACGTCTTCCTGTATAGAGCGTACCTGGCGCAGGTGATCGGAGGTGCTGGACTGGACGTGGACTTCACGCTGGAGAGCCCTC
AGGGCGTGCTGTTGGTCAGCGAGTCCCGCAAGGCTGATGGGGTACACACGGTGGAGCCAACGGAGGCCGGGGACTACAAGCTGTGCTTTG
ACAACTCCTTCAGCACCATCTCCGAGAAGCTGGTGTTCTTTGAACTGATCTTTGACAGCCTCCAGGATGACGAGGAGGTCGAAGGATGGG
CAGAGGCTGTGGAGCCCGAGGAGATGCTGGATGTTAAAATGGAGGACATCAAGGAGTCCATTGAGACCATGCGGACCCGGCTGGAGCGCA
GCATCCAGATGCTCACGCTACTGCGGGCCTTCGAGGCACGTGACCGCAACCTGCAAGAGGGCAACTTGGAGCGGGTCAACTTCTGGTCAG
CTGTCAACGTGGCGGTGCTGCTGCTGGTGGCTGTGCTGCAGGTCTGCACGCTCAAGCGCTTCTTCCAGGACAAGCGCCCGGTGCCCACGT
AGCCCCTGCCATGGAAGGAAGAACGGGACAAAGGAGGGGCAGCAGGGTGTGTGCATATGAGACTTGGGGGTCCCTCCCCAATTTTAGTTT
CCTGCCAAAACGGGAGTGTGCAGTCAGGGCCTGCGGTCTGGCCCCATGAGTCTCCTTCCGTCCTCAGCGGGCAGGGAACACCTCTGGCTT
GTAGAAGGGACGGCTCAGTGGCTGCACCGACGGTCCTGGAAATCTCACATGGTGGGCACTGCAGCGTTGGAACGTGAGCCTCGGATTTCC
TGGCCCCTCTACTGTAAATGTGCCTTAGCCTAAGCCTCCCATCCTGTGTTAGCGTTGCCTGGTGCGGGGCAGGGCCTAACAAGGAAACCT
GGGCCCTCCAAGCCAGGTTGAGGTCTGGTAACAGAATGCCAGGAAGGGGGCCTGGAAGACCACCTGCCCCGGCCCCTCTCCTGCAGGGGC
CCCACACAGGCATGAGGGATGGCCCGGCCAAAGTCTAGGCAGAAGCCTCCTATAACAAAGGGTGGTGTGGCCTGGGCATTGGAGTCAATA

>In-frame_COPE_ENST00000600932_chr19_19023793_-_TMED1_ENST00000591695_chr19_10946029_-_720nt
TCAGGAAGAGGAGCTGGTGAGAAGACAGCGAAATGGCGCCTCCGGCCCCCGGCCCGGCCTCCGGCGGCTCCGGGGAGGTAGACGAGCTGT
TCGACGTAAAGAACGCCTTCTACATCGGCAGCTACCAGCAGTGCATAAACGAGGCGCAGCGGGTGAAGCTATCAAGCCCAGAGAGAGACG
TGGAGAGGGACGTCTTCCTGTATAGAGCGTACCTGGCGCAGGTGATCGGAGGTGCTGGACTGGACGTGGACTTCACGCTGGAGAGCCCTC
AGGGCGTGCTGTTGGTCAGCGAGTCCCGCAAGGCTGATGGGGTACACACGAGTCCATTGAGACCATGCGGACCCGGCTGGAGCGCAGCAT
CCAGATGCTCACGCTACTGCGGGCCTTCGAGGCACGTGACCGCAACCTGCAAGAGGGCAACTTGGAGCGGGTCAACTTCTGGTCAGCTGT
CAACGTGGCGGTGCTGCTGCTGGTGGCTGTGCTGCAGGTCTGCACGCTCAAGCGCTTCTTCCAGGACAAGCGCCCGGTGCCCACGTAGCC
CCTGCCATGGAAGGAAGAACGGGACAAAGGAGGGGCAGCAGGGTGTGTGCATATGAGACTTGGGGGTCCCTCCCCAATTTTAGTTTCCTG
CCAAAACGGGAGTGTGCAGTCAGGGCCTGCGGTCTGGCCCCATGAGTCTCCTTCCGTCCTCAGCGGGCAGGGAACACCTCTGGCTTGTAG

>In-frame_COPE_ENST00000351079_chr19_19023793_-_TMED1_ENST00000214869_chr19_10946029_-_1274nt
AAGAGGAGCTGGTGAGAAGACAGCGAAATGGCGCCTCCGGCCCCCGGCCCGGCCTCCGGCGGCTCCGGGGAGGTAGACGAGCTGTTCGAC
GTAAAGAACGCCTTCTACATCGGCAGCTACCAGCAGTGCATAAACGAGGCGCAGCGGGTGAAGCTATCAAGCCCAGAGAGAGACGTGGAG
AGGGACGTCTTCCTGTATAGAGCGTACCTGGCGCAGGTGATCGGAGGTGCTGGACTGGACGTGGACTTCACGCTGGAGAGCCCTCAGGGC
GTGCTGTTGGTCAGCGAGTCCCGCAAGGCTGATGGGGTACACACGGTGGAGCCAACGGAGGCCGGGGACTACAAGCTGTGCTTTGACAAC
TCCTTCAGCACCATCTCCGAGAAGCTGGTGTTCTTTGAACTGATCTTTGACAGCCTCCAGGATGACGAGGAGGTCGAAGGATGGGCAGAG
GCTGTGGAGCCCGAGGAGATGCTGGATGTTAAAATGGAGGACATCAAGGAGTCCATTGAGACCATGCGGACCCGGCTGGAGCGCAGCATC
CAGATGCTCACGCTACTGCGGGCCTTCGAGGCACGTGACCGCAACCTGCAAGAGGGCAACTTGGAGCGGGTCAACTTCTGGTCAGCTGTC
AACGTGGCGGTGCTGCTGCTGGTGGCTGTGCTGCAGGTCTGCACGCTCAAGCGCTTCTTCCAGGACAAGCGCCCGGTGCCCACGTAGCCC
CTGCCATGGAAGGAAGAACGGGACAAAGGAGGGGCAGCAGGGTGTGTGCATATGAGACTTGGGGGTCCCTCCCCAATTTTAGTTTCCTGC
CAAAACGGGAGTGTGCAGTCAGGGCCTGCGGTCTGGCCCCATGAGTCTCCTTCCGTCCTCAGCGGGCAGGGAACACCTCTGGCTTGTAGA
AGGGACGGCTCAGTGGCTGCACCGACGGTCCTGGAAATCTCACATGGTGGGCACTGCAGCGTTGGAACGTGAGCCTCGGATTTCCTGGCC
CCTCTACTGTAAATGTGCCTTAGCCTAAGCCTCCCATCCTGTGTTAGCGTTGCCTGGTGCGGGGCAGGGCCTAACAAGGAAACCTGGGCC
CTCCAAGCCAGGTTGAGGTCTGGTAACAGAATGCCAGGAAGGGGGCCTGGAAGACCACCTGCCCCGGCCCCTCTCCTGCAGGGGCCCCAC
ACAGGCATGAGGGATGGCCCGGCCAAAGTCTAGGCAGAAGCCTCCTATAACAAAGGGTGGTGTGGCCTGGGCATTGGAGTCAATAAATTA

>In-frame_COPE_ENST00000351079_chr19_19023793_-_TMED1_ENST00000591695_chr19_10946029_-_715nt
AAGAGGAGCTGGTGAGAAGACAGCGAAATGGCGCCTCCGGCCCCCGGCCCGGCCTCCGGCGGCTCCGGGGAGGTAGACGAGCTGTTCGAC
GTAAAGAACGCCTTCTACATCGGCAGCTACCAGCAGTGCATAAACGAGGCGCAGCGGGTGAAGCTATCAAGCCCAGAGAGAGACGTGGAG
AGGGACGTCTTCCTGTATAGAGCGTACCTGGCGCAGGTGATCGGAGGTGCTGGACTGGACGTGGACTTCACGCTGGAGAGCCCTCAGGGC
GTGCTGTTGGTCAGCGAGTCCCGCAAGGCTGATGGGGTACACACGAGTCCATTGAGACCATGCGGACCCGGCTGGAGCGCAGCATCCAGA
TGCTCACGCTACTGCGGGCCTTCGAGGCACGTGACCGCAACCTGCAAGAGGGCAACTTGGAGCGGGTCAACTTCTGGTCAGCTGTCAACG
TGGCGGTGCTGCTGCTGGTGGCTGTGCTGCAGGTCTGCACGCTCAAGCGCTTCTTCCAGGACAAGCGCCCGGTGCCCACGTAGCCCCTGC
CATGGAAGGAAGAACGGGACAAAGGAGGGGCAGCAGGGTGTGTGCATATGAGACTTGGGGGTCCCTCCCCAATTTTAGTTTCCTGCCAAA


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FusionGenePPI for COPE_TMED1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
COPECOPA, COPB2, COPG1, ARF1, COPB1, RCHY1, UBC, SACM1L, TMED10, COPE, LMAN1, ARCN1, COPG2, BRCA1, ECT2, MDC1, PAXIP1, VCP, FN1, NPM1, BAG3, SEPT2, KIF5B, RABGAP1, GPRASP2, NUDCD1, EFHC2, SHMT2, NTRK1, MCM5, SF3B2, SRSF2, SRSF3, STAG2, SULT1C4, TRIP10, DTNBP1, MCFD2, OSBPL9, PSMD12, SF3B3, SF3B4, SF3B5, HERC2, TCTN3, TMEM17, XPO1, MYH6, XRCC3, FAM210A, PPM1G, WBP2, DLD, HSD17B10, VDAC1, TRIM25, CCND2TMED1IL1RL1, SMAD3, TMED9, SEC23B, UBL4A, TMED10, CHST8, VAPA, JUN, SPPL2B, TMED2, FGF3, CDK5RAP3, JPH4, TPTE, IQCB1, EXOC1, EXOC3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for COPE_TMED1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for COPE_TMED1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource