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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 807

FusionGeneSummary for ADCY1_ADCY1

check button Fusion gene summary
Fusion gene informationFusion gene name: ADCY1_ADCY1
Fusion gene ID: 807
HgeneTgene
Gene symbol

ADCY1

ADCY1

Gene ID

107

107

Gene nameadenylate cyclase 1adenylate cyclase 1
SynonymsAC1|DFNB44AC1|DFNB44
Cytomap

7p12.3

7p12.3

Type of geneprotein-codingprotein-coding
Descriptionadenylate cyclase type 13',5'-cyclic AMP synthetaseATP pyrophosphate-lyase 1Ca(2+)/calmodulin-activated adenylyl cyclaseadenyl cyclaseadenylate cyclase 1 (brain)adenylate cyclase type Iadenylyl cyclase 1adenylate cyclase type 13',5'-cyclic AMP synthetaseATP pyrophosphate-lyase 1Ca(2+)/calmodulin-activated adenylyl cyclaseadenyl cyclaseadenylate cyclase 1 (brain)adenylate cyclase type Iadenylyl cyclase 1
Modification date2018052320180523
UniProtAcc

Q08828

Q08828

Ensembl transtripts involved in fusion geneENST00000297323, ENST00000432715, 
ENST00000297323, ENST00000432715, 
Fusion gene scores* DoF score5 X 5 X 3=753 X 3 X 2=18
# samples 53
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ADCY1 [Title/Abstract] AND ADCY1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AU252813ADCY1chr7

45758918

+ADCY1chr7

45757167

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000297323ENST00000297323ADCY1chr7

45758918

+ADCY1chr7

45757167

+
3UTR-intronENST00000297323ENST00000432715ADCY1chr7

45758918

+ADCY1chr7

45757167

+
intron-3UTRENST00000432715ENST00000297323ADCY1chr7

45758918

+ADCY1chr7

45757167

+
intron-intronENST00000432715ENST00000432715ADCY1chr7

45758918

+ADCY1chr7

45757167

+

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FusionProtFeatures for ADCY1_ADCY1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ADCY1

Q08828

ADCY1

Q08828

Catalyzes the formation of the signaling molecule cAMPin response to G-protein signaling. Mediates responses toincreased cellular Ca(2+)/calmodulin levels (By similarity). Maybe involved in regulatory processes in the central nervous system.May play a role in memory and learning. Plays a role in theregulation of the circadian rhythm of daytime contrast sensitivityprobably by modulating the rhythmic synthesis of cyclic AMP in theretina (By similarity). {ECO:0000250|UniProtKB:O88444,ECO:0000250|UniProtKB:P19754}. Catalyzes the formation of the signaling molecule cAMPin response to G-protein signaling. Mediates responses toincreased cellular Ca(2+)/calmodulin levels (By similarity). Maybe involved in regulatory processes in the central nervous system.May play a role in memory and learning. Plays a role in theregulation of the circadian rhythm of daytime contrast sensitivityprobably by modulating the rhythmic synthesis of cyclic AMP in theretina (By similarity). {ECO:0000250|UniProtKB:O88444,ECO:0000250|UniProtKB:P19754}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ADCY1_ADCY1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ADCY1_ADCY1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ADCY1_ADCY1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneADCY1Q08828DB09121AurothioglucoseAdenylate cyclase type 1small moleculeapproved|withdrawn
TgeneADCY1Q08828DB09121AurothioglucoseAdenylate cyclase type 1small moleculeapproved|withdrawn

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RelatedDiseases for ADCY1_ADCY1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneADCY1C0038587Substance Withdrawal Syndrome1CTD_human
HgeneADCY1C0149925Small cell carcinoma of lung1CTD_human
HgeneADCY1C0424295Hyperactive behavior1CTD_human
TgeneADCY1C0038587Substance Withdrawal Syndrome1CTD_human
TgeneADCY1C0149925Small cell carcinoma of lung1CTD_human
TgeneADCY1C0424295Hyperactive behavior1CTD_human