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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8066

FusionGeneSummary for COPB1_COPB1

check button Fusion gene summary
Fusion gene informationFusion gene name: COPB1_COPB1
Fusion gene ID: 8066
HgeneTgene
Gene symbol

COPB1

COPB1

Gene ID

1315

1315

Gene namecoatomer protein complex subunit beta 1coatomer protein complex subunit beta 1
SynonymsCOPBCOPB
Cytomap

11p15.2

11p15.2

Type of geneprotein-codingprotein-coding
Descriptioncoatomer subunit betabeta coat proteinbeta-copcoatomer subunit betabeta coat proteinbeta-cop
Modification date2018052320180523
UniProtAcc

P53618

P53618

Ensembl transtripts involved in fusion geneENST00000249923, ENST00000439561, 
ENST00000526191, 
ENST00000249923, 
ENST00000439561, ENST00000526191, 
Fusion gene scores* DoF score3 X 4 X 3=363 X 4 X 2=24
# samples 44
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: COPB1 [Title/Abstract] AND COPB1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BX484531COPB1chr11

14482721

-COPB1chr11

14498654

-
ChiTaRS3.1BG393843COPB1chr11

14479328

+COPB1chr11

14479250

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000249923ENST00000249923COPB1chr11

14482721

-COPB1chr11

14498654

-
intron-intronENST00000249923ENST00000439561COPB1chr11

14482721

-COPB1chr11

14498654

-
intron-intronENST00000249923ENST00000526191COPB1chr11

14482721

-COPB1chr11

14498654

-
intron-intronENST00000439561ENST00000249923COPB1chr11

14482721

-COPB1chr11

14498654

-
intron-intronENST00000439561ENST00000439561COPB1chr11

14482721

-COPB1chr11

14498654

-
intron-intronENST00000439561ENST00000526191COPB1chr11

14482721

-COPB1chr11

14498654

-
intron-intronENST00000526191ENST00000249923COPB1chr11

14482721

-COPB1chr11

14498654

-
intron-intronENST00000526191ENST00000439561COPB1chr11

14482721

-COPB1chr11

14498654

-
intron-intronENST00000526191ENST00000526191COPB1chr11

14482721

-COPB1chr11

14498654

-
intron-3UTRENST00000249923ENST00000249923COPB1chr11

14479328

+COPB1chr11

14479250

-
intron-3UTRENST00000249923ENST00000439561COPB1chr11

14479328

+COPB1chr11

14479250

-
intron-intronENST00000249923ENST00000526191COPB1chr11

14479328

+COPB1chr11

14479250

-
intron-3UTRENST00000439561ENST00000249923COPB1chr11

14479328

+COPB1chr11

14479250

-
intron-3UTRENST00000439561ENST00000439561COPB1chr11

14479328

+COPB1chr11

14479250

-
intron-intronENST00000439561ENST00000526191COPB1chr11

14479328

+COPB1chr11

14479250

-
intron-3UTRENST00000526191ENST00000249923COPB1chr11

14479328

+COPB1chr11

14479250

-
intron-3UTRENST00000526191ENST00000439561COPB1chr11

14479328

+COPB1chr11

14479250

-
intron-intronENST00000526191ENST00000526191COPB1chr11

14479328

+COPB1chr11

14479250

-

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FusionProtFeatures for COPB1_COPB1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
COPB1

P53618

COPB1

P53618

The coatomer is a cytosolic protein complex that bindsto dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosyntheticprotein transport from the ER, via the Golgi up to the trans Golginetwork. Coatomer complex is required for budding from Golgimembranes, and is essential for the retrograde Golgi-to-ERtransport of dilysine-tagged proteins. In mammals, the coatomercan only be recruited by membranes associated to ADP-ribosylationfactors (ARFs), which are small GTP-binding proteins; the complexalso influences the Golgi structural integrity, as well as theprocessing, activity, and endocytic recycling of LDL receptors.Plays a functional role in facilitating the transport of kappa-type opioid receptor mRNAs into axons and enhances translation ofthese proteins. Required for limiting lipid storage in lipiddroplets. Involved in lipid homeostasis by regulating the presenceof perilipin family members PLIN2 and PLIN3 at the lipid dropletsurface and promoting the association of adipocyte surfacetriglyceride lipase (PNPLA2) with the lipid droplet to mediatelipolysis (By similarity). Involved in the Golgi disassembly andreassembly processes during cell cycle. Involved in autophagy byplaying a role in early endosome function. Plays a role inorganellar compartmentalization of secretory compartmentsincluding endoplasmic reticulum (ER)-Golgi intermediatecompartment (ERGIC), Golgi, trans-Golgi network (TGN) andrecycling endosomes, and in biosynthetic transport of CAV1.Promotes degradation of Nef cellular targets CD4 and MHC class Iantigens by facilitating their trafficking to degradativecompartments. {ECO:0000250, ECO:0000269|PubMed:18385291,ECO:0000269|PubMed:18725938, ECO:0000269|PubMed:19364919,ECO:0000269|PubMed:20056612}. The coatomer is a cytosolic protein complex that bindsto dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosyntheticprotein transport from the ER, via the Golgi up to the trans Golginetwork. Coatomer complex is required for budding from Golgimembranes, and is essential for the retrograde Golgi-to-ERtransport of dilysine-tagged proteins. In mammals, the coatomercan only be recruited by membranes associated to ADP-ribosylationfactors (ARFs), which are small GTP-binding proteins; the complexalso influences the Golgi structural integrity, as well as theprocessing, activity, and endocytic recycling of LDL receptors.Plays a functional role in facilitating the transport of kappa-type opioid receptor mRNAs into axons and enhances translation ofthese proteins. Required for limiting lipid storage in lipiddroplets. Involved in lipid homeostasis by regulating the presenceof perilipin family members PLIN2 and PLIN3 at the lipid dropletsurface and promoting the association of adipocyte surfacetriglyceride lipase (PNPLA2) with the lipid droplet to mediatelipolysis (By similarity). Involved in the Golgi disassembly andreassembly processes during cell cycle. Involved in autophagy byplaying a role in early endosome function. Plays a role inorganellar compartmentalization of secretory compartmentsincluding endoplasmic reticulum (ER)-Golgi intermediatecompartment (ERGIC), Golgi, trans-Golgi network (TGN) andrecycling endosomes, and in biosynthetic transport of CAV1.Promotes degradation of Nef cellular targets CD4 and MHC class Iantigens by facilitating their trafficking to degradativecompartments. {ECO:0000250, ECO:0000269|PubMed:18385291,ECO:0000269|PubMed:18725938, ECO:0000269|PubMed:19364919,ECO:0000269|PubMed:20056612}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for COPB1_COPB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for COPB1_COPB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for COPB1_COPB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for COPB1_COPB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource