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Fusion gene ID: 8065 |
FusionGeneSummary for COPA_STAC2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: COPA_STAC2 | Fusion gene ID: 8065 | Hgene | Tgene | Gene symbol | COPA | STAC2 | Gene ID | 1314 | 342667 |
| Gene name | coatomer protein complex subunit alpha | SH3 and cysteine rich domain 2 | |
| Synonyms | AILJK|HEP-COP | 24b2|24b2/STAC2 | |
| Cytomap | 1q23.2 | 17q12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | coatomer subunit alphaHEPCOPalpha coat proteinalpha-COPproxeninxenin | SH3 and cysteine-rich domain-containing protein 2SRC homology 3 and cysteine-rich domain-containing protein 2 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P53621 | Q6ZMT1 | |
| Ensembl transtripts involved in fusion gene | ENST00000368069, ENST00000241704, | ENST00000333461, | |
| Fusion gene scores | * DoF score | 5 X 6 X 4=120 | 8 X 5 X 6=240 |
| # samples | 6 | 8 | |
| ** MAII score | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/240*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: COPA [Title/Abstract] AND STAC2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | COPA | GO:0030157 | pancreatic juice secretion | 1429581 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PRAD | TCGA-CH-5745-01A | COPA | chr1 | 160312921 | - | STAC2 | chr17 | 37374426 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000368069 | ENST00000333461 | COPA | chr1 | 160312921 | - | STAC2 | chr17 | 37374426 | - |
| In-frame | ENST00000241704 | ENST00000333461 | COPA | chr1 | 160312921 | - | STAC2 | chr17 | 37374426 | - |
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FusionProtFeatures for COPA_STAC2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| COPA | STAC2 |
| The coatomer is a cytosolic protein complex that bindsto dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosyntheticprotein transport from the ER, via the Golgi up to the trans Golginetwork. Coatomer complex is required for budding from Golgimembranes, and is essential for the retrograde Golgi-to-ERtransport of dilysine-tagged proteins. In mammals, the coatomercan only be recruited by membranes associated to ADP-ribosylationfactors (ARFs), which are small GTP-binding proteins; the complexalso influences the Golgi structural integrity, as well as theprocessing, activity, and endocytic recycling of LDL receptors (Bysimilarity). {ECO:0000250}. Xenin stimulates exocrine pancreatic secretion. Itinhibits pentagastrin-stimulated secretion of acid, to induceexocrine pancreatic secretion and to affect small and largeintestinal motility. In the gut, xenin interacts with theneurotensin receptor. | Plays a redundant role in promoting the expression ofcalcium channel CACNA1S at the cell membrane, and therebycontributes to increased channel activity. Slows down theinactivation rate of the calcium channel CACNA1C.{ECO:0000250|UniProtKB:Q8R1B0}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >STAC2 | chr1:160312921 | chr17:37374426 | ENST00000333461 | - | 0 | 11 | 70_101 | 30 | 412 | Compositional bias | Note=Pro-rich |
| Tgene | >STAC2 | chr1:160312921 | chr17:37374426 | ENST00000333461 | - | 0 | 11 | 292_351 | 30 | 412 | Domain | SH3 1 |
| Tgene | >STAC2 | chr1:160312921 | chr17:37374426 | ENST00000333461 | - | 0 | 11 | 354_411 | 30 | 412 | Domain | SH3 2 |
| Tgene | >STAC2 | chr1:160312921 | chr17:37374426 | ENST00000333461 | - | 0 | 11 | 110_161 | 30 | 412 | Zinc finger | Phorbol-ester/DAG-type |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >COPA | chr1:160312921 | chr17:37374426 | ENST00000241704 | - | 1 | 33 | 126_164 | 13 | 1225 | Repeat | Note=WD 4 |
| Hgene | >COPA | chr1:160312921 | chr17:37374426 | ENST00000241704 | - | 1 | 33 | 195_234 | 13 | 1225 | Repeat | Note=WD 5 |
| Hgene | >COPA | chr1:160312921 | chr17:37374426 | ENST00000241704 | - | 1 | 33 | 241_278 | 13 | 1225 | Repeat | Note=WD 6 |
| Hgene | >COPA | chr1:160312921 | chr17:37374426 | ENST00000241704 | - | 1 | 33 | 282_319 | 13 | 1225 | Repeat | Note=WD 7 |
| Hgene | >COPA | chr1:160312921 | chr17:37374426 | ENST00000241704 | - | 1 | 33 | 3_38 | 13 | 1225 | Repeat | Note=WD 1 |
| Hgene | >COPA | chr1:160312921 | chr17:37374426 | ENST00000241704 | - | 1 | 33 | 42_80 | 13 | 1225 | Repeat | Note=WD 2 |
| Hgene | >COPA | chr1:160312921 | chr17:37374426 | ENST00000241704 | - | 1 | 33 | 84_122 | 13 | 1225 | Repeat | Note=WD 3 |
| Hgene | >COPA | chr1:160312921 | chr17:37374426 | ENST00000368069 | - | 1 | 33 | 126_164 | 13 | 1234 | Repeat | Note=WD 4 |
| Hgene | >COPA | chr1:160312921 | chr17:37374426 | ENST00000368069 | - | 1 | 33 | 195_234 | 13 | 1234 | Repeat | Note=WD 5 |
| Hgene | >COPA | chr1:160312921 | chr17:37374426 | ENST00000368069 | - | 1 | 33 | 241_278 | 13 | 1234 | Repeat | Note=WD 6 |
| Hgene | >COPA | chr1:160312921 | chr17:37374426 | ENST00000368069 | - | 1 | 33 | 282_319 | 13 | 1234 | Repeat | Note=WD 7 |
| Hgene | >COPA | chr1:160312921 | chr17:37374426 | ENST00000368069 | - | 1 | 33 | 3_38 | 13 | 1234 | Repeat | Note=WD 1 |
| Hgene | >COPA | chr1:160312921 | chr17:37374426 | ENST00000368069 | - | 1 | 33 | 42_80 | 13 | 1234 | Repeat | Note=WD 2 |
| Hgene | >COPA | chr1:160312921 | chr17:37374426 | ENST00000368069 | - | 1 | 33 | 84_122 | 13 | 1234 | Repeat | Note=WD 3 |
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FusionGeneSequence for COPA_STAC2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_COPA_ENST00000368069_chr1_160312921_-_STAC2_ENST00000333461_chr17_37374426_-_395aa MLTKFETKSARVKAPAIQALPLPQDHPPKXELGELLPSLGLXAQVPHRGAADAPNPTAPSLPTTHSLGQGPGYPIPLPMPSPTPPGSAQT SEAAQLPGTCLQASXPLXAVPPAHRRKLQTGLAMXDVQSQRPPLVLXGDLPPAMPRQDVHLLPPQLQFPSPGAXAATSLCHKQRVPTHWG QWEGGPCLRDPALWHLPGTDEPLQFQQHLXVPDKEPEXAGXADRGWGRQHPQLXGGAWXQCISSIHSPSREXRARTRGEESWTAAPQSHP AEGCGAHVLLRCTLQVSAPGEQXSGSAAWRSDHAGGXLXRGLVEGQDRRPGWLLPSXFCATGEARRECLALLPTLLREQGTGLHEPQGEP >In-frame_COPA_ENST00000241704_chr1_160312921_-_STAC2_ENST00000333461_chr17_37374426_-_395aa MLTKFETKSARVKAPAIQALPLPQDHPPKXELGELLPSLGLXAQVPHRGAADAPNPTAPSLPTTHSLGQGPGYPIPLPMPSPTPPGSAQT SEAAQLPGTCLQASXPLXAVPPAHRRKLQTGLAMXDVQSQRPPLVLXGDLPPAMPRQDVHLLPPQLQFPSPGAXAATSLCHKQRVPTHWG QWEGGPCLRDPALWHLPGTDEPLQFQQHLXVPDKEPEXAGXADRGWGRQHPQLXGGAWXQCISSIHSPSREXRARTRGEESWTAAPQSHP AEGCGAHVLLRCTLQVSAPGEQXSGSAAWRSDHAGGXLXRGLVEGQDRRPGWLLPSXFCATGEARRECLALLPTLLREQGTGLHEPQGEP |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_COPA_ENST00000368069_chr1_160312921_-_STAC2_ENST00000333461_chr17_37374426_-_1186nt ATGTTAACCAAATTCGAGACCAAGAGCGCGCGGGTCAAAGCTCCAGCGATTCAAGCGCTCCCTCTCCCTCAAGACCATCCTCCGAAGTAA GAGCTTGGAGAACTTCTTCCTTCGCTCGGGCTCTGAGCTCAAGTGCCCCACCGAGGTGCTGCTGACGCCCCCAACCCCACTGCCCCCTCC CTCCCCACCACCCACAGCCTCGGACAGGGGCCTGGCTACCCCATCCCCCTCCCCATGCCCAGTCCCACGCCCCCTGGCAGCGCTCAAACC AGTGAGGCTGCACAGCTTCCAGGAACATGTCTTCAAGCGAGCTAGCCCTTGTGAGCTGTGCCACCAGCTCATCGTAGGAAACTCCAAACA GGGCTTGCGATGTAAGATGTGCAAAGTCAGCGTCCACCTCTGGTGCTCTGAGGAGATCTCCCACCAGCAATGCCCAGGCAAGACGTCCAC CTCCTTCCGCCGCAACTTCAGTTCCCCTCTCCTGGTGCATGAGCCGCCACCAGTCTGTGCCACAAGCAAAGAGTCCCCACCCACTGGGGA CAGTGGGAAGGTGGACCCTGTCTACGAGACCCTGCGCTATGGCACCTCCCTGGCACTGATGAACCGCTCCAGTTTCAGCAGCACCTCTGA GTCCCCGACAAGGAGCCTGAGTGAGCGGGATGAGCTGACCGAGGATGGGGAAGGCAGCATCCGCAGCTCTGAGGAGGGGCCTGGTGACAG TGCATCTCCAGTATTCACAGCCCCAGCAGAGAGTGAAGGGCCAGGACCAGAGGAGAAGAGTCCTGGACAGCAGCTCCCCAAAGCCACCCT GCGGAAGGATGTGGGGCCCATGTACTCCTACGTTGCACTCTACAAGTTTCTGCCCCAGGAGAACAATGATCTGGCTCTGCAGCCTGGAGA TCGGATCATGCTGGTGGATGACTCTAACGAGGACTGGTGGAAGGGCAAGATCGGCGACCGGGTTGGCTTCTTCCCAGCTAATTTTGTGCA ACGGGTGAGGCCAGGCGAGAATGTTTGGCGCTGCTGCCAACCCTTCTCCGGGAACAAGGAACAGGGTTACATGAGCCTCAAGGAGAACCA GATCTGCGTGGGCGTGGGCAGAAGCAAGGATGCTGACGGCTTCATCCGCGTCAGCAGTGGCAAGAAGCGGGGCCTGGTGCCAGTCGACGC >In-frame_COPA_ENST00000241704_chr1_160312921_-_STAC2_ENST00000333461_chr17_37374426_-_1186nt ATGTTAACCAAATTCGAGACCAAGAGCGCGCGGGTCAAAGCTCCAGCGATTCAAGCGCTCCCTCTCCCTCAAGACCATCCTCCGAAGTAA GAGCTTGGAGAACTTCTTCCTTCGCTCGGGCTCTGAGCTCAAGTGCCCCACCGAGGTGCTGCTGACGCCCCCAACCCCACTGCCCCCTCC CTCCCCACCACCCACAGCCTCGGACAGGGGCCTGGCTACCCCATCCCCCTCCCCATGCCCAGTCCCACGCCCCCTGGCAGCGCTCAAACC AGTGAGGCTGCACAGCTTCCAGGAACATGTCTTCAAGCGAGCTAGCCCTTGTGAGCTGTGCCACCAGCTCATCGTAGGAAACTCCAAACA GGGCTTGCGATGTAAGATGTGCAAAGTCAGCGTCCACCTCTGGTGCTCTGAGGAGATCTCCCACCAGCAATGCCCAGGCAAGACGTCCAC CTCCTTCCGCCGCAACTTCAGTTCCCCTCTCCTGGTGCATGAGCCGCCACCAGTCTGTGCCACAAGCAAAGAGTCCCCACCCACTGGGGA CAGTGGGAAGGTGGACCCTGTCTACGAGACCCTGCGCTATGGCACCTCCCTGGCACTGATGAACCGCTCCAGTTTCAGCAGCACCTCTGA GTCCCCGACAAGGAGCCTGAGTGAGCGGGATGAGCTGACCGAGGATGGGGAAGGCAGCATCCGCAGCTCTGAGGAGGGGCCTGGTGACAG TGCATCTCCAGTATTCACAGCCCCAGCAGAGAGTGAAGGGCCAGGACCAGAGGAGAAGAGTCCTGGACAGCAGCTCCCCAAAGCCACCCT GCGGAAGGATGTGGGGCCCATGTACTCCTACGTTGCACTCTACAAGTTTCTGCCCCAGGAGAACAATGATCTGGCTCTGCAGCCTGGAGA TCGGATCATGCTGGTGGATGACTCTAACGAGGACTGGTGGAAGGGCAAGATCGGCGACCGGGTTGGCTTCTTCCCAGCTAATTTTGTGCA ACGGGTGAGGCCAGGCGAGAATGTTTGGCGCTGCTGCCAACCCTTCTCCGGGAACAAGGAACAGGGTTACATGAGCCTCAAGGAGAACCA GATCTGCGTGGGCGTGGGCAGAAGCAAGGATGCTGACGGCTTCATCCGCGTCAGCAGTGGCAAGAAGCGGGGCCTGGTGCCAGTCGACGC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_COPA_ENST00000368069_chr1_160312921_-_STAC2_ENST00000333461_chr17_37374426_-_3020nt CGCTGACGTGGAGGCGTCCGAAGGGCAGCAGGGTGTGTCGGGGCTCGGATTAAGACATCGGAGTCGGAGACCTGAGAGATGTTAACCAAA TTCGAGACCAAGAGCGCGCGGGTCAAAGCTCCAGCGATTCAAGCGCTCCCTCTCCCTCAAGACCATCCTCCGAAGTAAGAGCTTGGAGAA CTTCTTCCTTCGCTCGGGCTCTGAGCTCAAGTGCCCCACCGAGGTGCTGCTGACGCCCCCAACCCCACTGCCCCCTCCCTCCCCACCACC CACAGCCTCGGACAGGGGCCTGGCTACCCCATCCCCCTCCCCATGCCCAGTCCCACGCCCCCTGGCAGCGCTCAAACCAGTGAGGCTGCA CAGCTTCCAGGAACATGTCTTCAAGCGAGCTAGCCCTTGTGAGCTGTGCCACCAGCTCATCGTAGGAAACTCCAAACAGGGCTTGCGATG TAAGATGTGCAAAGTCAGCGTCCACCTCTGGTGCTCTGAGGAGATCTCCCACCAGCAATGCCCAGGCAAGACGTCCACCTCCTTCCGCCG CAACTTCAGTTCCCCTCTCCTGGTGCATGAGCCGCCACCAGTCTGTGCCACAAGCAAAGAGTCCCCACCCACTGGGGACAGTGGGAAGGT GGACCCTGTCTACGAGACCCTGCGCTATGGCACCTCCCTGGCACTGATGAACCGCTCCAGTTTCAGCAGCACCTCTGAGTCCCCGACAAG GAGCCTGAGTGAGCGGGATGAGCTGACCGAGGATGGGGAAGGCAGCATCCGCAGCTCTGAGGAGGGGCCTGGTGACAGTGCATCTCCAGT ATTCACAGCCCCAGCAGAGAGTGAAGGGCCAGGACCAGAGGAGAAGAGTCCTGGACAGCAGCTCCCCAAAGCCACCCTGCGGAAGGATGT GGGGCCCATGTACTCCTACGTTGCACTCTACAAGTTTCTGCCCCAGGAGAACAATGATCTGGCTCTGCAGCCTGGAGATCGGATCATGCT GGTGGATGACTCTAACGAGGACTGGTGGAAGGGCAAGATCGGCGACCGGGTTGGCTTCTTCCCAGCTAATTTTGTGCAACGGGTGAGGCC AGGCGAGAATGTTTGGCGCTGCTGCCAACCCTTCTCCGGGAACAAGGAACAGGGTTACATGAGCCTCAAGGAGAACCAGATCTGCGTGGG CGTGGGCAGAAGCAAGGATGCTGACGGCTTCATCCGCGTCAGCAGTGGCAAGAAGCGGGGCCTGGTGCCAGTCGACGCCCTGACTGAGAT CTGAGAGGAGCCAAGGGAACCCAGATGACACCCTTGCCCATGCCTGGACCTTGCTTCTGGCCAGGGAGGGGATCAGGCCCCCTTGTCCAC TCCATACCCTTCCTCCCTCTGTCCCTCTCCTAGGTGCCACTTACCGTGGCTTAGGAGCCTTTTGTACTGGGGAAGATTTTATTTCTTGGG TGGGGTGCCCTGAGTGGGTTGATCCTCTGGGACTTGGCGGGGATGGGGTGGGGTGGGAGGGAATGAGGAAGCTACAGGTAGGTCCACCCA ACGCCCAGGCACCCCAGTCTACTTGCTGGGCTGAGTCCAGCCCTGGGGAAGATTCCTGGGGAATTTATTTGCTGCTTCTCCCAGCCTTCC CCTGCCCACACCACCTGCGCATGCCTGGCACACCCCTCTCCCCACAGAGCCTCTGCTTGGGTCTATGTGTGTGTGACCGTGCATCTGCTC CTTTGCAAGTGGGGTCTTGGGAGCAGGCCTTTTTGTGTCCTCGGCCCTCCACCCTTGGTGGGGAGGGGACCCAGGACCATAGGAAGGTCC TGAGTCCACCTCCTGGTCTCCACCTCTGTCATTCCGTCAATTCTCAGGAAAGTTTTGCAGGAATCTCTCCCGTTACTTGAAACCTGGGCG GACAGATGAGGGGAAGGCTGAGGTCCCTGGAAGGTGTAACAAATCAGAGACTATCTGTTCAAGTAGAAAACCCAAGAGCTGGCCAGGTGT GGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGCAGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACAT GGTGAAACCCCGTCTCTACTAAAAGTACGAAACTTAGCCAGGCATGATGGGGGTCTGCCTGTAATGCCAGCTACTCCAGAGGCTGAGGCA AGAGAATCACTTGAACCCGGGAGGCGGAGGTTTCAGTGAGCCGAGATTGCACCATTGCACCCCAGCCTGGGCAACAGAGCGAGACTCCGT CTCAAAAAAAAAAAAAGAAAGAAAGAAAAGGAAACCCAAGAGCTGCCTGGACACACGGAAACCCAACTGAGAACAAAATCCTGGCCCGTG CTTGGTCAAAGCAAACCCATTTCACTGTCAGGACCCCCGGTCACACAGGAACCACCCGCCAGGGGAGCCTGTGACTGTCAGTTCCTGTCC CAGGCTTTGCCCGGCCGCCCCAGGAACCCAACCCTCTGGGCTGACCTTTCTCCTGCTTCTCTCCAGGCTCTGCAGGGGACAGGGCAGGTG CTGCAGGAGCCCCTTTGCTGGCTTTATCTGCTCCCTTGTTCTGGACACAGAGCCCTGGGAAAAAGAGGGGGTGGAAGACAGACAAGGAAG GTGGAATGTTCTGTTTTGGCCACCAGGAAATGGGGTGGGGTGGGCATACACAGAGAGGACCCCTCTCTTAATACAGCTGCTTTTCTCGGT GCCAACCTCCCTCCCCCAAGCTCAGATCCTCCTCTTATGCCCTTGATTGTGCCAGCCCATGCCACCCCCATCCTGGGCACAGTTACACCC TCCCATGCAGTGGGAGAAACACAGACCCTCGTACCCAAAGGCCCCTGCCCCACTTCTCCCCCACAAAGCGGGGTCTCAAGCCACACTGCC CTGTTTGCTGCCATGAGGCCCCCCCCCCCAGCAATATCCCAGGGGCGGGCCCAATGCCCACTGTACATGAGGCTGCATGATGGGTCTGGG >In-frame_COPA_ENST00000241704_chr1_160312921_-_STAC2_ENST00000333461_chr17_37374426_-_3172nt CCATCTTGCCTCTCTGCTGAGCGGAAGCCCCCGTTCGGCTCCTGTCTGTTAGCGGCCTCTCTAGGCTACCACTGACACCGTCTCTGTGGC CCGGAGCCTAAGAGACCGGAAGTTCGTGTTTCCAGGCGCTTCCGGAAACCGCGGGAGAGGGTCGCTGACGTGGAGGCGTCCGAAGGGCAG CAGGGTGTGTCGGGGCTCGGATTAAGACATCGGAGTCGGAGACCTGAGAGATGTTAACCAAATTCGAGACCAAGAGCGCGCGGGTCAAAG CTCCAGCGATTCAAGCGCTCCCTCTCCCTCAAGACCATCCTCCGAAGTAAGAGCTTGGAGAACTTCTTCCTTCGCTCGGGCTCTGAGCTC AAGTGCCCCACCGAGGTGCTGCTGACGCCCCCAACCCCACTGCCCCCTCCCTCCCCACCACCCACAGCCTCGGACAGGGGCCTGGCTACC CCATCCCCCTCCCCATGCCCAGTCCCACGCCCCCTGGCAGCGCTCAAACCAGTGAGGCTGCACAGCTTCCAGGAACATGTCTTCAAGCGA GCTAGCCCTTGTGAGCTGTGCCACCAGCTCATCGTAGGAAACTCCAAACAGGGCTTGCGATGTAAGATGTGCAAAGTCAGCGTCCACCTC TGGTGCTCTGAGGAGATCTCCCACCAGCAATGCCCAGGCAAGACGTCCACCTCCTTCCGCCGCAACTTCAGTTCCCCTCTCCTGGTGCAT GAGCCGCCACCAGTCTGTGCCACAAGCAAAGAGTCCCCACCCACTGGGGACAGTGGGAAGGTGGACCCTGTCTACGAGACCCTGCGCTAT GGCACCTCCCTGGCACTGATGAACCGCTCCAGTTTCAGCAGCACCTCTGAGTCCCCGACAAGGAGCCTGAGTGAGCGGGATGAGCTGACC GAGGATGGGGAAGGCAGCATCCGCAGCTCTGAGGAGGGGCCTGGTGACAGTGCATCTCCAGTATTCACAGCCCCAGCAGAGAGTGAAGGG CCAGGACCAGAGGAGAAGAGTCCTGGACAGCAGCTCCCCAAAGCCACCCTGCGGAAGGATGTGGGGCCCATGTACTCCTACGTTGCACTC TACAAGTTTCTGCCCCAGGAGAACAATGATCTGGCTCTGCAGCCTGGAGATCGGATCATGCTGGTGGATGACTCTAACGAGGACTGGTGG AAGGGCAAGATCGGCGACCGGGTTGGCTTCTTCCCAGCTAATTTTGTGCAACGGGTGAGGCCAGGCGAGAATGTTTGGCGCTGCTGCCAA CCCTTCTCCGGGAACAAGGAACAGGGTTACATGAGCCTCAAGGAGAACCAGATCTGCGTGGGCGTGGGCAGAAGCAAGGATGCTGACGGC TTCATCCGCGTCAGCAGTGGCAAGAAGCGGGGCCTGGTGCCAGTCGACGCCCTGACTGAGATCTGAGAGGAGCCAAGGGAACCCAGATGA CACCCTTGCCCATGCCTGGACCTTGCTTCTGGCCAGGGAGGGGATCAGGCCCCCTTGTCCACTCCATACCCTTCCTCCCTCTGTCCCTCT CCTAGGTGCCACTTACCGTGGCTTAGGAGCCTTTTGTACTGGGGAAGATTTTATTTCTTGGGTGGGGTGCCCTGAGTGGGTTGATCCTCT GGGACTTGGCGGGGATGGGGTGGGGTGGGAGGGAATGAGGAAGCTACAGGTAGGTCCACCCAACGCCCAGGCACCCCAGTCTACTTGCTG GGCTGAGTCCAGCCCTGGGGAAGATTCCTGGGGAATTTATTTGCTGCTTCTCCCAGCCTTCCCCTGCCCACACCACCTGCGCATGCCTGG CACACCCCTCTCCCCACAGAGCCTCTGCTTGGGTCTATGTGTGTGTGACCGTGCATCTGCTCCTTTGCAAGTGGGGTCTTGGGAGCAGGC CTTTTTGTGTCCTCGGCCCTCCACCCTTGGTGGGGAGGGGACCCAGGACCATAGGAAGGTCCTGAGTCCACCTCCTGGTCTCCACCTCTG TCATTCCGTCAATTCTCAGGAAAGTTTTGCAGGAATCTCTCCCGTTACTTGAAACCTGGGCGGACAGATGAGGGGAAGGCTGAGGTCCCT GGAAGGTGTAACAAATCAGAGACTATCTGTTCAAGTAGAAAACCCAAGAGCTGGCCAGGTGTGGTGGCTCATGCCTGTAATCCCAGCACT TTGGGAGGCTGAGGTGGGCAGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAGTAC GAAACTTAGCCAGGCATGATGGGGGTCTGCCTGTAATGCCAGCTACTCCAGAGGCTGAGGCAAGAGAATCACTTGAACCCGGGAGGCGGA GGTTTCAGTGAGCCGAGATTGCACCATTGCACCCCAGCCTGGGCAACAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAGAAAGAAAGAAA AGGAAACCCAAGAGCTGCCTGGACACACGGAAACCCAACTGAGAACAAAATCCTGGCCCGTGCTTGGTCAAAGCAAACCCATTTCACTGT CAGGACCCCCGGTCACACAGGAACCACCCGCCAGGGGAGCCTGTGACTGTCAGTTCCTGTCCCAGGCTTTGCCCGGCCGCCCCAGGAACC CAACCCTCTGGGCTGACCTTTCTCCTGCTTCTCTCCAGGCTCTGCAGGGGACAGGGCAGGTGCTGCAGGAGCCCCTTTGCTGGCTTTATC TGCTCCCTTGTTCTGGACACAGAGCCCTGGGAAAAAGAGGGGGTGGAAGACAGACAAGGAAGGTGGAATGTTCTGTTTTGGCCACCAGGA AATGGGGTGGGGTGGGCATACACAGAGAGGACCCCTCTCTTAATACAGCTGCTTTTCTCGGTGCCAACCTCCCTCCCCCAAGCTCAGATC CTCCTCTTATGCCCTTGATTGTGCCAGCCCATGCCACCCCCATCCTGGGCACAGTTACACCCTCCCATGCAGTGGGAGAAACACAGACCC TCGTACCCAAAGGCCCCTGCCCCACTTCTCCCCCACAAAGCGGGGTCTCAAGCCACACTGCCCTGTTTGCTGCCATGAGGCCCCCCCCCC CAGCAATATCCCAGGGGCGGGCCCAATGCCCACTGTACATGAGGCTGCATGATGGGTCTGGGGCCTTGCTGATTCCCCAGACCCCTAATT |
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FusionGenePPI for COPA_STAC2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| COPA | SLC25A11, COPE, COPB2, COPB1, ARFGAP1, PDGFRB, BET1L, USP49, ATG101, DDA1, SPG20, SIRT7, FBXO25, CDK2, SACM1L, SMN1, GEMIN2, DDX20, TMED10, COPG1, COPA, ARCN1, COPZ1, COPG2, FBXO6, UBXN6, LMAN1, SEC24C, SEC23A, SEPT9, VCAM1, ITGA4, CCT3, SEPT2, DHX38, TCP1, RPA3, RPA2, RPA1, NUDCD1, STAU1, SHMT2, MOV10, NXF1, CUL7, OBSL1, CCDC8, SUZ12, RNF2, EGFR, UNK, CCDC97, GCN1L1, KHDRBS1, SF3B1, SRSF3, TRIP10, SF3B3, NTRK1, HERC2, OFD1, MKS1, CEP128, NPHP1, TMEM237, TMEM17, XPO1, SORT1, XRCC3, MATR3, DSN1, FOXB1, WBP1, CD8A, CRY2, FOXL1, FOXQ1, FOXR1, SNW1, CDC5L, RNF126, POU5F1, FAM210A, ZNF746, PPM1G, WBP2, MTNR1B, DLD, PDHA1, SDHA, SOD1, EDEM3, BRCA1, YAP1, TES, MTF1 | STAC2 | ATXN1, ATXN1L, LNX1, BRCA1, LMNA |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for COPA_STAC2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for COPA_STAC2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | COPA | C0003864 | Arthritis | 1 | CTD_human |
| Hgene | COPA | C0004364 | Autoimmune Diseases | 1 | CTD_human |
| Hgene | COPA | C0206062 | Lung Diseases, Interstitial | 1 | CTD_human |
| Hgene | COPA | C4225334 | AUTOIMMUNE INTERSTITIAL LUNG, JOINT, AND KIDNEY DISEASE | 1 | ORPHANET;UNIPROT |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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