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Fusion gene ID: 8043 |
FusionGeneSummary for COMMD7_MMP24 |
Fusion gene summary |
Fusion gene information | Fusion gene name: COMMD7_MMP24 | Fusion gene ID: 8043 | Hgene | Tgene | Gene symbol | COMMD7 | MMP24 | Gene ID | 149951 | 10893 |
Gene name | COMM domain containing 7 | matrix metallopeptidase 24 | |
Synonyms | C20orf92|dJ1085F17.3 | MMP-24|MMP25|MT-MMP 5|MT-MMP5|MT5-MMP|MT5MMP|MTMMP5 | |
Cytomap | 20q11.21 | 20q11.22 | |
Type of gene | protein-coding | protein-coding | |
Description | COMM domain-containing protein 7 | matrix metalloproteinase-24matrix metallopeptidase 24 (membrane-inserted)matrix metalloproteinase 24 (membrane-inserted)membrane-type 5 matrix metalloproteinasemembrane-type matrix metalloproteinase 5 | |
Modification date | 20180519 | 20180522 | |
UniProtAcc | Q86VX2 | Q9Y5R2 | |
Ensembl transtripts involved in fusion gene | ENST00000278980, ENST00000446419, | ENST00000246186, | |
Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 5 X 3 X 4=60 |
# samples | 3 | 4 | |
** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/60*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: COMMD7 [Title/Abstract] AND MMP24 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | COMMD7 | GO:0032088 | negative regulation of NF-kappaB transcription factor activity | 15799966 |
Hgene | COMMD7 | GO:0033209 | tumor necrosis factor-mediated signaling pathway | 15799966 |
Hgene | COMMD7 | GO:0045892 | negative regulation of transcription, DNA-templated | 15799966 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | STAD | TCGA-BR-7723-01A | COMMD7 | chr20 | 31315700 | - | MMP24 | chr20 | 33851594 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000278980 | ENST00000246186 | COMMD7 | chr20 | 31315700 | - | MMP24 | chr20 | 33851594 | + |
In-frame | ENST00000446419 | ENST00000246186 | COMMD7 | chr20 | 31315700 | - | MMP24 | chr20 | 33851594 | + |
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FusionProtFeatures for COMMD7_MMP24 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
COMMD7 | MMP24 |
May modulate activity of cullin-RING E3 ubiquitin ligase(CRL) complexes (PubMed:21778237). Associates with the NF-kappa-Bcomplex and suppresses its transcriptional activity(PubMed:15799966). {ECO:0000269|PubMed:15799966,ECO:0000305|PubMed:21778237}. | Metalloprotease that mediates cleavage of N-cadherin(CDH2) and acts as a regulator of neuro-immune interactions andneural stem cell quiescence. Involved in cell-cell interactionsbetween nociceptive neurites and mast cells, possibly by mediatingcleavage of CDH2, thereby acting as a mediator of peripheralthermal nociception and inflammatory hyperalgesia. Key regulatorof neural stem cells quiescence by mediating cleavage of CDH2,affecting CDH2-mediated anchorage of neural stem cells toependymocytes in the adult subependymal zone, leading to modulatetheir quiescence. May play a role in axonal growth. Able toactivate progelatinase A. May also be a proteoglycanase involvedin degradation of proteoglycans, such as dermatan sulfate andchondroitin sulfate proteoglycans. Cleaves partially fibronectin,but not collagen type I, nor laminin (By similarity).{ECO:0000250}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | >MMP24 | chr20:31315700 | chr20:33851594 | ENST00000246186 | + | 3 | 9 | 643_645 | 272 | 646 | Motif | Note=PDZ-binding |
Tgene | >MMP24 | chr20:31315700 | chr20:33851594 | ENST00000246186 | + | 3 | 9 | 377_425 | 272 | 646 | Repeat | Note=Hemopexin 1 |
Tgene | >MMP24 | chr20:31315700 | chr20:33851594 | ENST00000246186 | + | 3 | 9 | 426_471 | 272 | 646 | Repeat | Note=Hemopexin 2 |
Tgene | >MMP24 | chr20:31315700 | chr20:33851594 | ENST00000246186 | + | 3 | 9 | 473_521 | 272 | 646 | Repeat | Note=Hemopexin 3 |
Tgene | >MMP24 | chr20:31315700 | chr20:33851594 | ENST00000246186 | + | 3 | 9 | 522_569 | 272 | 646 | Repeat | Note=Hemopexin 4 |
Tgene | >MMP24 | chr20:31315700 | chr20:33851594 | ENST00000246186 | + | 3 | 9 | 624_645 | 272 | 646 | Topological domain | Cytoplasmic |
Tgene | >MMP24 | chr20:31315700 | chr20:33851594 | ENST00000246186 | + | 3 | 9 | 603_623 | 272 | 646 | Transmembrane | Helical |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >COMMD7 | chr20:31315700 | chr20:33851594 | ENST00000278980 | - | 3 | 9 | 133_200 | 80 | 201 | Domain | COMM |
Hgene | >COMMD7 | chr20:31315700 | chr20:33851594 | ENST00000446419 | - | 3 | 9 | 133_200 | 79 | 200 | Domain | COMM |
Tgene | MMP24 | chr20:31315700 | chr20:33851594 | ENST00000246186 | + | 3 | 9 | 149_152 | 272 | 646 | Compositional bias | Note=Poly-Arg |
Tgene | MMP24 | chr20:31315700 | chr20:33851594 | ENST00000246186 | + | 3 | 9 | 137_144 | 272 | 646 | Motif | Cysteine switch |
Tgene | MMP24 | chr20:31315700 | chr20:33851594 | ENST00000246186 | + | 3 | 9 | 53_602 | 272 | 646 | Topological domain | Extracellular |
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FusionGeneSequence for COMMD7_MMP24 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_COMMD7_ENST00000278980_chr20_31315700_-_MMP24_ENST00000246186_chr20_33851594_+_454aa MGRLHCTEDPVPEAVGGDMQQLNQLGAQQFSALTEVLFHFLTEPKEVERFLAQLSEFATTNQISLGSLRSIVKSLLLVPNGNDLFLVAVH ELGHALGLEHSSDPSAIMAPFYQYMETHNFKLPQDDLQGIQKIYGPPAEPLEPTRPLPTLPVRRIHSPSERKHERQPRPPRPPLGDRPST PGTKPNICDGNFNTVALFRGEMFVFKDRWFWRLRNNRVQEGYPMQIEQFWKGLPARIDAAYERADGRFVFFKGDKYWVFKEVTVEPGYPH SLGELGSCLPREGIDTALRWEPVGKTYFFKGERYWRYSEERRATDPGYPKPITVWKGIPQAPQGAFISKEGYYTYFYKGRDYWKFDNQKL SVEPGYPRNILRDWMGCNQKEVERRKERRLPQDDVDIMVTINDVPGSVNAVAVVIPCILSLCILVLVYTIFQFKNKTGPQPVTYYKRPVQ >In-frame_COMMD7_ENST00000446419_chr20_31315700_-_MMP24_ENST00000246186_chr20_33851594_+_453aa MGRLHCTEDPVPEAVGGDMQQLNQLGAQFSALTEVLFHFLTEPKEVERFLAQLSEFATTNQISLGSLRSIVKSLLLVPNGNDLFLVAVHE LGHALGLEHSSDPSAIMAPFYQYMETHNFKLPQDDLQGIQKIYGPPAEPLEPTRPLPTLPVRRIHSPSERKHERQPRPPRPPLGDRPSTP GTKPNICDGNFNTVALFRGEMFVFKDRWFWRLRNNRVQEGYPMQIEQFWKGLPARIDAAYERADGRFVFFKGDKYWVFKEVTVEPGYPHS LGELGSCLPREGIDTALRWEPVGKTYFFKGERYWRYSEERRATDPGYPKPITVWKGIPQAPQGAFISKEGYYTYFYKGRDYWKFDNQKLS VEPGYPRNILRDWMGCNQKEVERRKERRLPQDDVDIMVTINDVPGSVNAVAVVIPCILSLCILVLVYTIFQFKNKTGPQPVTYYKRPVQE |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_COMMD7_ENST00000278980_chr20_31315700_-_MMP24_ENST00000246186_chr20_33851594_+_1362nt ATGGGCCGCCTGCACTGCACTGAGGACCCGGTGCCGGAGGCCGTGGGCGGCGACATGCAGCAGCTGAACCAGCTGGGCGCGCAGCAGTTC TCAGCCCTGACAGAGGTGCTTTTCCACTTCCTAACTGAGCCAAAAGAGGTGGAAAGATTTCTGGCTCAGCTCTCTGAATTTGCCACCACC AATCAGATCAGTCTTGGCTCCCTCAGAAGCATCGTGAAAAGCCTCCTTCTGGTTCCAAATGGGAACGACCTCTTCCTGGTGGCTGTGCAT GAGCTGGGCCACGCGCTGGGACTGGAGCACTCCAGCGACCCCAGCGCCATCATGGCGCCCTTCTACCAGTACATGGAGACGCACAACTTC AAGCTGCCCCAGGACGATCTCCAGGGCATCCAGAAGATCTATGGACCCCCAGCCGAGCCTCTGGAGCCCACAAGGCCACTCCCTACACTC CCCGTCCGCAGGATCCACTCACCATCGGAGAGGAAACACGAGCGCCAGCCCAGGCCCCCTCGGCCGCCCCTCGGGGACCGGCCATCCACA CCAGGCACCAAACCCAACATCTGTGACGGCAACTTCAACACAGTGGCCCTCTTCCGGGGCGAGATGTTTGTCTTTAAGGATCGCTGGTTC TGGCGTCTGCGCAATAACCGAGTGCAGGAGGGCTACCCCATGCAGATCGAGCAGTTCTGGAAGGGCCTGCCTGCCCGCATCGACGCAGCC TATGAAAGGGCCGATGGGAGATTTGTCTTCTTCAAAGGTGACAAGTATTGGGTGTTTAAGGAGGTGACGGTGGAGCCTGGGTACCCCCAC AGCCTGGGGGAGCTGGGCAGCTGTTTGCCCCGTGAAGGCATTGACACAGCTCTGCGCTGGGAACCTGTGGGCAAGACCTACTTTTTCAAA GGCGAGCGGTACTGGCGCTACAGCGAGGAGCGGCGGGCCACGGACCCTGGCTACCCTAAGCCCATCACCGTGTGGAAGGGCATCCCACAG GCTCCCCAAGGAGCCTTCATCAGCAAGGAAGGATATTACACCTATTTCTACAAGGGCCGGGACTACTGGAAGTTTGACAACCAGAAACTG AGCGTGGAGCCAGGCTACCCGCGCAACATCCTGCGTGACTGGATGGGCTGCAACCAGAAGGAGGTGGAGCGGCGGAAGGAGCGGCGGCTG CCCCAGGACGACGTGGACATCATGGTGACCATCAACGATGTGCCGGGCTCCGTGAACGCCGTGGCCGTGGTCATCCCCTGCATCCTGTCC CTCTGCATCCTGGTGCTGGTCTACACCATCTTCCAGTTCAAGAACAAGACAGGCCCTCAGCCTGTCACCTACTATAAGCGGCCAGTCCAG >In-frame_COMMD7_ENST00000446419_chr20_31315700_-_MMP24_ENST00000246186_chr20_33851594_+_1359nt ATGGGCCGCCTGCACTGCACTGAGGACCCGGTGCCGGAGGCCGTGGGCGGCGACATGCAGCAGCTGAACCAGCTGGGCGCGCAGTTCTCA GCCCTGACAGAGGTGCTTTTCCACTTCCTAACTGAGCCAAAAGAGGTGGAAAGATTTCTGGCTCAGCTCTCTGAATTTGCCACCACCAAT CAGATCAGTCTTGGCTCCCTCAGAAGCATCGTGAAAAGCCTCCTTCTGGTTCCAAATGGGAACGACCTCTTCCTGGTGGCTGTGCATGAG CTGGGCCACGCGCTGGGACTGGAGCACTCCAGCGACCCCAGCGCCATCATGGCGCCCTTCTACCAGTACATGGAGACGCACAACTTCAAG CTGCCCCAGGACGATCTCCAGGGCATCCAGAAGATCTATGGACCCCCAGCCGAGCCTCTGGAGCCCACAAGGCCACTCCCTACACTCCCC GTCCGCAGGATCCACTCACCATCGGAGAGGAAACACGAGCGCCAGCCCAGGCCCCCTCGGCCGCCCCTCGGGGACCGGCCATCCACACCA GGCACCAAACCCAACATCTGTGACGGCAACTTCAACACAGTGGCCCTCTTCCGGGGCGAGATGTTTGTCTTTAAGGATCGCTGGTTCTGG CGTCTGCGCAATAACCGAGTGCAGGAGGGCTACCCCATGCAGATCGAGCAGTTCTGGAAGGGCCTGCCTGCCCGCATCGACGCAGCCTAT GAAAGGGCCGATGGGAGATTTGTCTTCTTCAAAGGTGACAAGTATTGGGTGTTTAAGGAGGTGACGGTGGAGCCTGGGTACCCCCACAGC CTGGGGGAGCTGGGCAGCTGTTTGCCCCGTGAAGGCATTGACACAGCTCTGCGCTGGGAACCTGTGGGCAAGACCTACTTTTTCAAAGGC GAGCGGTACTGGCGCTACAGCGAGGAGCGGCGGGCCACGGACCCTGGCTACCCTAAGCCCATCACCGTGTGGAAGGGCATCCCACAGGCT CCCCAAGGAGCCTTCATCAGCAAGGAAGGATATTACACCTATTTCTACAAGGGCCGGGACTACTGGAAGTTTGACAACCAGAAACTGAGC GTGGAGCCAGGCTACCCGCGCAACATCCTGCGTGACTGGATGGGCTGCAACCAGAAGGAGGTGGAGCGGCGGAAGGAGCGGCGGCTGCCC CAGGACGACGTGGACATCATGGTGACCATCAACGATGTGCCGGGCTCCGTGAACGCCGTGGCCGTGGTCATCCCCTGCATCCTGTCCCTC TGCATCCTGGTGCTGGTCTACACCATCTTCCAGTTCAAGAACAAGACAGGCCCTCAGCCTGTCACCTACTATAAGCGGCCAGTCCAGGAA |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_COMMD7_ENST00000278980_chr20_31315700_-_MMP24_ENST00000246186_chr20_33851594_+_4357nt GTGATGCTGGGGTGATGCTGATGCCCTTCCAAGGTTGAGACCTAGTCTCTACTCTGATGTCAGCTCTCCGAGAGACACTCTGGCCTGCTT TGTTCCCTTCCCTGTCCCCAGTGTCTGGCATCGAGTAGGCTGCCATAAATATCTCTGGAGTGCATAGTAACAGTGATGATGATAATAGCA GCTAGCCATTGATTGAAGACCTCTTGTGTGCCGGTCTCTGCGTTAAACATTTCTGGAGGCTTAACTCATTTAAGGAGCTACCCCAGCCAT CATTTTCTCAGATGGTGAAACTGAGGTTCAGAGAGGCCAAGCGCCGTACCCAAAGGTCACTCAGCGGGAGAGCTGGCAGGAAACCTCGCG TCTGCCGGTGCCGGCGCCGCCCCTGCCCCTCCCCGGAGCCCGGCGGCCGCGCGTGTCCGCGGCCCTGCGAGGGCTCCCCGGCTCCGGACA GCCCAGGGCGGCCGGGGGAGGAGTGCGCTGCGACGGCCGTGGCGAAAGTGCGGTTGTGGATGCGCGGAGAGGCCGGCAGCGGTGGCAGCG GCAGCGGAGGAGGAAGCTGAGCAGGGCGGCGGCGGCGGTGGAACCTGCGGGGCTGGGGCGCGCGCCATGGGCCGCCTGCACTGCACTGAG GACCCGGTGCCGGAGGCCGTGGGCGGCGACATGCAGCAGCTGAACCAGCTGGGCGCGCAGCAGTTCTCAGCCCTGACAGAGGTGCTTTTC CACTTCCTAACTGAGCCAAAAGAGGTGGAAAGATTTCTGGCTCAGCTCTCTGAATTTGCCACCACCAATCAGATCAGTCTTGGCTCCCTC AGAAGCATCGTGAAAAGCCTCCTTCTGGTTCCAAATGGGAACGACCTCTTCCTGGTGGCTGTGCATGAGCTGGGCCACGCGCTGGGACTG GAGCACTCCAGCGACCCCAGCGCCATCATGGCGCCCTTCTACCAGTACATGGAGACGCACAACTTCAAGCTGCCCCAGGACGATCTCCAG GGCATCCAGAAGATCTATGGACCCCCAGCCGAGCCTCTGGAGCCCACAAGGCCACTCCCTACACTCCCCGTCCGCAGGATCCACTCACCA TCGGAGAGGAAACACGAGCGCCAGCCCAGGCCCCCTCGGCCGCCCCTCGGGGACCGGCCATCCACACCAGGCACCAAACCCAACATCTGT GACGGCAACTTCAACACAGTGGCCCTCTTCCGGGGCGAGATGTTTGTCTTTAAGGATCGCTGGTTCTGGCGTCTGCGCAATAACCGAGTG CAGGAGGGCTACCCCATGCAGATCGAGCAGTTCTGGAAGGGCCTGCCTGCCCGCATCGACGCAGCCTATGAAAGGGCCGATGGGAGATTT GTCTTCTTCAAAGGTGACAAGTATTGGGTGTTTAAGGAGGTGACGGTGGAGCCTGGGTACCCCCACAGCCTGGGGGAGCTGGGCAGCTGT TTGCCCCGTGAAGGCATTGACACAGCTCTGCGCTGGGAACCTGTGGGCAAGACCTACTTTTTCAAAGGCGAGCGGTACTGGCGCTACAGC GAGGAGCGGCGGGCCACGGACCCTGGCTACCCTAAGCCCATCACCGTGTGGAAGGGCATCCCACAGGCTCCCCAAGGAGCCTTCATCAGC AAGGAAGGATATTACACCTATTTCTACAAGGGCCGGGACTACTGGAAGTTTGACAACCAGAAACTGAGCGTGGAGCCAGGCTACCCGCGC AACATCCTGCGTGACTGGATGGGCTGCAACCAGAAGGAGGTGGAGCGGCGGAAGGAGCGGCGGCTGCCCCAGGACGACGTGGACATCATG GTGACCATCAACGATGTGCCGGGCTCCGTGAACGCCGTGGCCGTGGTCATCCCCTGCATCCTGTCCCTCTGCATCCTGGTGCTGGTCTAC ACCATCTTCCAGTTCAAGAACAAGACAGGCCCTCAGCCTGTCACCTACTATAAGCGGCCAGTCCAGGAATGGGTGTGAGCAGCCCAGAGC CCTCTCTATCCACTTGGTCTGGCCAGCCAGGCCCTTCCTCACCAGGGTCTGAGGGGCAGCTCTGGCCAGTGCTCACCAGGGCCAGCAGGG CCCTAGGCTGGGGTCGTACAGCTGAAGTGGTGGGTGCATTGGCCTAGGCTGAGCGTGGGGCAGGGAATTATGGGGGCTGTGCCCCAGGGT GGGTGTCTGGCACCCAGCTGCCAGCCTTCTGTCCTGGGCAAACTACTCCCTACTTAAGGGAATAGGCCAGGCTCCATCCGGAGGCAGGGA CCATGCCAGGAGGAGCCCCTGTGGTCACGGCATCCTGTGGTGTCCATGAGGTACCACAGCTCCACTCCTGGCTGGAACCCAGCACCCTCT GTGGGAAGCCAGCACTAGCTCTCATCCCCCATCCGGGAGATACCACCAGTCCTGGTCCCCTTTTGCCAACACCTGCTGGTCAGATGTCCC CCTACCCCCACCCCACTGTCCTCCAAGGCTACAGGACCCCTGCTTCTGACACAGTGAGCAACAAGCCTGGGTTTCCCTGCTGGCAGACGG CAGATCCCTCAGGAAACCTGCTCCACTTGTCAGGGTCTCTTCGGAGACCCAGGATTTAGGGTCACATGCTGCAGGCAGGGCTGTGGCCCA GCTGGGTCTGACAAGGACCCAGCTGTCACATCGTGAATATTTAAATGTCCTGTCACTACTGTCCCATTTTGCAAAGGCTGCTTGAGGCTT TAGGTGAACTAGAGGTGACTGTCTTGGTGATGAGGCCAGCATAGCGGCCCTCCCCCAGGCGACAAGGACCAAGGTGCTGCTAAGGCCACT CTAGCGCCCAGACACCCCAGTAGCTGAGCTCTGCTCCTATGGCTACAGAGCTGGGGCAGAAGCTGACCCCATTTCTGGAGGAAGATCCGA GTTTGTGACCGTCCTCCACTCCCCTCTATTGTCACTGTCCCCAGCTTTGCTCCAGTCTGTCACTTGCAGCCTGGAGCTCAGCCTCACCAG TTAGGTGAGGCAGAGATGGCTGCAGGGCCAACACTGGCAGAGCCTGGGAGTCCTTCGGAAGGGGACCAGGGCGTCTGAAGTGCTCAGTGC CCCCACTACTCTGAGGCCGACTCCAGCTACTCTGAGGCCGACTCAATCTCTCGGCTGGAAGCAGTGTTTTCCCAGAGCTTGGCCCTTGCT GACCTCGCTCACTGGGCCCATCTTCCCACACTGCTCTTAGAAGGACACCCCTACCGGTAGCAGCCCCAAGCTGAGGGGGCTCCCTTTTTG ACCTTCACTGGCCCGCCCTTCACTGTCTCCAGCAGGAGTTCCTAGGGCTTGGCCTGCCTTGCTCCACAGTACGGCGGAGGCAGCCCTGCT TGTCACTGAGGAGCCCTAGACAAGGCCAATGGGTTCATCAATGCCCACTGGCTCTCTGCCAAAGCCAAAAAGGTGTCAGGCAGTCTCCAG CGTGCTGGCCGGGTCTCGGATGCCACCCCTGCTCACTGAGCCTGCATGGGCCTTGCCCCCGACCCTGTGGTCTCTGGGATTGGGGTCGGC TTACCCTGTAGCACAGACAGGGACTCCTGCTGCCCTGGGAGCTGTCTCAAGCAAAATCTCTTGTCCCAGAGGTGCCCATGTGGGTCCGCT GTGTCCCCTGTCATCATCCTTGTTTTTTCTCATTTTGGCCAAGGGCAGGCTCCCTGGGACAGGCAGGGAACAACTGCGGAGATATTAGTG ATTCATAGGTTTGTACAGTGTTTTATACTTTGCAAAGCACTTTATTAGCTCACACCTGTCCACTCACATGAAACTCGTGTTAGGCCCTGG GAGGCCGACGGTAACTCTCACCGTGCCCTCAGATGAAGCACAGAGAGGTTGTTACTTGCCCGGGCCATCCAGTGGGCTGGCTGGGTCTTG TGTCCCCATCTGTGGACCCCTCTAGGGTCTGAGATGAGATGAGAAGTGTCTCCTGTATCCACCTCTTCCTGGCCTCCCTTCCCCCACTTC CTGGTCCCTGTCCACTCCTCAGGTTGGTGCTCTCACTTCTTGAAAGCTCTAGGCACCCCCGCCTCCCGCCAGGCTCCCCATTGGCTCCTG GCAGGCCAGCTGAGAATGAACAGGAGATGGAGGCAGGCAGCCCAGGCTGCAGAGGTGAGGGATGTGGGGCCAGGCCCAGAGGGCTCAGCC TAGAGGCTTCCAATCTCAGATTCTCCTGCCTGTGGTCATCTGTTTGTCCATCACCCCAGGACAGGGCAGACAGAGGGGCAAAGCACTGGG GGCCCCAGAGCCTAGCTTCCCCTCAGCCTGGGGGACATCACAGCATTTCAGTGTCAGTCACATTTTAAACTGATCAGCCTTTGTATAATG >In-frame_COMMD7_ENST00000446419_chr20_31315700_-_MMP24_ENST00000246186_chr20_33851594_+_3812nt AGCGGAGGAGGAAGCTGAGCAGGGCGGCGGCGGCGGTGGAACCTGCGGGGCTGGGGCGCGCGCCATGGGCCGCCTGCACTGCACTGAGGA CCCGGTGCCGGAGGCCGTGGGCGGCGACATGCAGCAGCTGAACCAGCTGGGCGCGCAGTTCTCAGCCCTGACAGAGGTGCTTTTCCACTT CCTAACTGAGCCAAAAGAGGTGGAAAGATTTCTGGCTCAGCTCTCTGAATTTGCCACCACCAATCAGATCAGTCTTGGCTCCCTCAGAAG CATCGTGAAAAGCCTCCTTCTGGTTCCAAATGGGAACGACCTCTTCCTGGTGGCTGTGCATGAGCTGGGCCACGCGCTGGGACTGGAGCA CTCCAGCGACCCCAGCGCCATCATGGCGCCCTTCTACCAGTACATGGAGACGCACAACTTCAAGCTGCCCCAGGACGATCTCCAGGGCAT CCAGAAGATCTATGGACCCCCAGCCGAGCCTCTGGAGCCCACAAGGCCACTCCCTACACTCCCCGTCCGCAGGATCCACTCACCATCGGA GAGGAAACACGAGCGCCAGCCCAGGCCCCCTCGGCCGCCCCTCGGGGACCGGCCATCCACACCAGGCACCAAACCCAACATCTGTGACGG CAACTTCAACACAGTGGCCCTCTTCCGGGGCGAGATGTTTGTCTTTAAGGATCGCTGGTTCTGGCGTCTGCGCAATAACCGAGTGCAGGA GGGCTACCCCATGCAGATCGAGCAGTTCTGGAAGGGCCTGCCTGCCCGCATCGACGCAGCCTATGAAAGGGCCGATGGGAGATTTGTCTT CTTCAAAGGTGACAAGTATTGGGTGTTTAAGGAGGTGACGGTGGAGCCTGGGTACCCCCACAGCCTGGGGGAGCTGGGCAGCTGTTTGCC CCGTGAAGGCATTGACACAGCTCTGCGCTGGGAACCTGTGGGCAAGACCTACTTTTTCAAAGGCGAGCGGTACTGGCGCTACAGCGAGGA GCGGCGGGCCACGGACCCTGGCTACCCTAAGCCCATCACCGTGTGGAAGGGCATCCCACAGGCTCCCCAAGGAGCCTTCATCAGCAAGGA AGGATATTACACCTATTTCTACAAGGGCCGGGACTACTGGAAGTTTGACAACCAGAAACTGAGCGTGGAGCCAGGCTACCCGCGCAACAT CCTGCGTGACTGGATGGGCTGCAACCAGAAGGAGGTGGAGCGGCGGAAGGAGCGGCGGCTGCCCCAGGACGACGTGGACATCATGGTGAC CATCAACGATGTGCCGGGCTCCGTGAACGCCGTGGCCGTGGTCATCCCCTGCATCCTGTCCCTCTGCATCCTGGTGCTGGTCTACACCAT CTTCCAGTTCAAGAACAAGACAGGCCCTCAGCCTGTCACCTACTATAAGCGGCCAGTCCAGGAATGGGTGTGAGCAGCCCAGAGCCCTCT CTATCCACTTGGTCTGGCCAGCCAGGCCCTTCCTCACCAGGGTCTGAGGGGCAGCTCTGGCCAGTGCTCACCAGGGCCAGCAGGGCCCTA GGCTGGGGTCGTACAGCTGAAGTGGTGGGTGCATTGGCCTAGGCTGAGCGTGGGGCAGGGAATTATGGGGGCTGTGCCCCAGGGTGGGTG TCTGGCACCCAGCTGCCAGCCTTCTGTCCTGGGCAAACTACTCCCTACTTAAGGGAATAGGCCAGGCTCCATCCGGAGGCAGGGACCATG CCAGGAGGAGCCCCTGTGGTCACGGCATCCTGTGGTGTCCATGAGGTACCACAGCTCCACTCCTGGCTGGAACCCAGCACCCTCTGTGGG AAGCCAGCACTAGCTCTCATCCCCCATCCGGGAGATACCACCAGTCCTGGTCCCCTTTTGCCAACACCTGCTGGTCAGATGTCCCCCTAC CCCCACCCCACTGTCCTCCAAGGCTACAGGACCCCTGCTTCTGACACAGTGAGCAACAAGCCTGGGTTTCCCTGCTGGCAGACGGCAGAT CCCTCAGGAAACCTGCTCCACTTGTCAGGGTCTCTTCGGAGACCCAGGATTTAGGGTCACATGCTGCAGGCAGGGCTGTGGCCCAGCTGG GTCTGACAAGGACCCAGCTGTCACATCGTGAATATTTAAATGTCCTGTCACTACTGTCCCATTTTGCAAAGGCTGCTTGAGGCTTTAGGT GAACTAGAGGTGACTGTCTTGGTGATGAGGCCAGCATAGCGGCCCTCCCCCAGGCGACAAGGACCAAGGTGCTGCTAAGGCCACTCTAGC GCCCAGACACCCCAGTAGCTGAGCTCTGCTCCTATGGCTACAGAGCTGGGGCAGAAGCTGACCCCATTTCTGGAGGAAGATCCGAGTTTG TGACCGTCCTCCACTCCCCTCTATTGTCACTGTCCCCAGCTTTGCTCCAGTCTGTCACTTGCAGCCTGGAGCTCAGCCTCACCAGTTAGG TGAGGCAGAGATGGCTGCAGGGCCAACACTGGCAGAGCCTGGGAGTCCTTCGGAAGGGGACCAGGGCGTCTGAAGTGCTCAGTGCCCCCA CTACTCTGAGGCCGACTCCAGCTACTCTGAGGCCGACTCAATCTCTCGGCTGGAAGCAGTGTTTTCCCAGAGCTTGGCCCTTGCTGACCT CGCTCACTGGGCCCATCTTCCCACACTGCTCTTAGAAGGACACCCCTACCGGTAGCAGCCCCAAGCTGAGGGGGCTCCCTTTTTGACCTT CACTGGCCCGCCCTTCACTGTCTCCAGCAGGAGTTCCTAGGGCTTGGCCTGCCTTGCTCCACAGTACGGCGGAGGCAGCCCTGCTTGTCA CTGAGGAGCCCTAGACAAGGCCAATGGGTTCATCAATGCCCACTGGCTCTCTGCCAAAGCCAAAAAGGTGTCAGGCAGTCTCCAGCGTGC TGGCCGGGTCTCGGATGCCACCCCTGCTCACTGAGCCTGCATGGGCCTTGCCCCCGACCCTGTGGTCTCTGGGATTGGGGTCGGCTTACC CTGTAGCACAGACAGGGACTCCTGCTGCCCTGGGAGCTGTCTCAAGCAAAATCTCTTGTCCCAGAGGTGCCCATGTGGGTCCGCTGTGTC CCCTGTCATCATCCTTGTTTTTTCTCATTTTGGCCAAGGGCAGGCTCCCTGGGACAGGCAGGGAACAACTGCGGAGATATTAGTGATTCA TAGGTTTGTACAGTGTTTTATACTTTGCAAAGCACTTTATTAGCTCACACCTGTCCACTCACATGAAACTCGTGTTAGGCCCTGGGAGGC CGACGGTAACTCTCACCGTGCCCTCAGATGAAGCACAGAGAGGTTGTTACTTGCCCGGGCCATCCAGTGGGCTGGCTGGGTCTTGTGTCC CCATCTGTGGACCCCTCTAGGGTCTGAGATGAGATGAGAAGTGTCTCCTGTATCCACCTCTTCCTGGCCTCCCTTCCCCCACTTCCTGGT CCCTGTCCACTCCTCAGGTTGGTGCTCTCACTTCTTGAAAGCTCTAGGCACCCCCGCCTCCCGCCAGGCTCCCCATTGGCTCCTGGCAGG CCAGCTGAGAATGAACAGGAGATGGAGGCAGGCAGCCCAGGCTGCAGAGGTGAGGGATGTGGGGCCAGGCCCAGAGGGCTCAGCCTAGAG GCTTCCAATCTCAGATTCTCCTGCCTGTGGTCATCTGTTTGTCCATCACCCCAGGACAGGGCAGACAGAGGGGCAAAGCACTGGGGGCCC CAGAGCCTAGCTTCCCCTCAGCCTGGGGGACATCACAGCATTTCAGTGTCAGTCACATTTTAAACTGATCAGCCTTTGTATAATGTTTTT |
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FusionGenePPI for COMMD7_MMP24 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
COMMD7 | COMMD1, RELA, COMMD8, COMMD10, COMMD9, COMMD3, COMMD4, CCDC22, CCDC93, IKBKG, COMMD6, CHUK, IKBKB, COMMD2, FAM45A, VPS29 | MMP24 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for COMMD7_MMP24 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for COMMD7_MMP24 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | MMP24 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |