|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 8022 |
FusionGeneSummary for COLGALT1_COPE |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: COLGALT1_COPE | Fusion gene ID: 8022 | Hgene | Tgene | Gene symbol | COLGALT1 | COPE | Gene ID | 79709 | 11316 |
| Gene name | collagen beta(1-O)galactosyltransferase 1 | coatomer protein complex subunit epsilon | |
| Synonyms | ColGalT 1|GLT25D1 | epsilon-COP | |
| Cytomap | 19p13.11 | 19p13.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | procollagen galactosyltransferase 1glycosyltransferase 25 domain containing 1glycosyltransferase 25 family member 1hydroxylysine galactosyltransferase 1 | coatomer subunit epsiloncoatomer epsilon subunitepsilon coat protein | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q8NBJ5 | O14579 | |
| Ensembl transtripts involved in fusion gene | ENST00000252599, ENST00000601354, | ENST00000262812, ENST00000349893, ENST00000600932, ENST00000598969, ENST00000351079, | |
| Fusion gene scores | * DoF score | 7 X 6 X 4=168 | 4 X 4 X 3=48 |
| # samples | 6 | 4 | |
| ** MAII score | log2(6/168*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: COLGALT1 [Title/Abstract] AND COPE [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LGG | TCGA-TM-A7CF-01A | COLGALT1 | chr19 | 17671274 | + | COPE | chr19 | 19021880 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000252599 | ENST00000262812 | COLGALT1 | chr19 | 17671274 | + | COPE | chr19 | 19021880 | - |
| In-frame | ENST00000252599 | ENST00000349893 | COLGALT1 | chr19 | 17671274 | + | COPE | chr19 | 19021880 | - |
| In-frame | ENST00000252599 | ENST00000600932 | COLGALT1 | chr19 | 17671274 | + | COPE | chr19 | 19021880 | - |
| 5CDS-5UTR | ENST00000252599 | ENST00000598969 | COLGALT1 | chr19 | 17671274 | + | COPE | chr19 | 19021880 | - |
| 5CDS-5UTR | ENST00000252599 | ENST00000351079 | COLGALT1 | chr19 | 17671274 | + | COPE | chr19 | 19021880 | - |
| intron-3CDS | ENST00000601354 | ENST00000262812 | COLGALT1 | chr19 | 17671274 | + | COPE | chr19 | 19021880 | - |
| intron-3CDS | ENST00000601354 | ENST00000349893 | COLGALT1 | chr19 | 17671274 | + | COPE | chr19 | 19021880 | - |
| intron-3CDS | ENST00000601354 | ENST00000600932 | COLGALT1 | chr19 | 17671274 | + | COPE | chr19 | 19021880 | - |
| intron-5UTR | ENST00000601354 | ENST00000598969 | COLGALT1 | chr19 | 17671274 | + | COPE | chr19 | 19021880 | - |
| intron-5UTR | ENST00000601354 | ENST00000351079 | COLGALT1 | chr19 | 17671274 | + | COPE | chr19 | 19021880 | - |
Top |
FusionProtFeatures for COLGALT1_COPE |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| COLGALT1 | COPE |
| Beta-galactosyltransferase that transfers beta-galactoseto hydroxylysine residues of type I collagen (PubMed:19075007,PubMed:22216269, PubMed:27402836). By acting on collagenglycosylation, facilitates the formation of collagen triple helix(PubMed:27402836). {ECO:0000269|PubMed:19075007,ECO:0000269|PubMed:22216269, ECO:0000269|PubMed:27402836}. | The coatomer is a cytosolic protein complex that bindsto dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosyntheticprotein transport from the ER, via the Golgi up to the trans Golginetwork. The coatomer complex is required for budding from Golgimembranes, and is essential for the retrograde Golgi-to-ERtransport of dilysine-tagged proteins. In mammals, the coatomercan only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins;the complex also influences the Golgi structural integrity, aswell as the processing, activity, and endocytic recycling of LDLreceptors (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >COLGALT1 | chr19:17671274 | chr19:19021880 | ENST00000252599 | + | 3 | 12 | 619_622 | 163 | 623 | Motif | Note=Endoplasmic reticulum retention motif |
Top |
FusionGeneSequence for COLGALT1_COPE |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_COLGALT1_ENST00000252599_chr19_17671274_+_COPE_ENST00000262812_chr19_19021880_-_409aa MAAAPRAGRRRGQPLLALLLLLLAPLPPGAPPGADAYFPEERWSPESPLQAPRVLIALLARNAAHALPTTLGALERLRHPRERTALWVAT DHNMDNTSTVLREWLVAVKSLYHSVEWRPAEEPRSYPDEEGPKHWSDSRYEHVMKLRQAALKSARDMWADYILRKFGVVLDEIKPSSAPE LQAVRMFADYLAHESRRDSIVAELDREMSRSVDVTNTTFLLMAASIYLHDQNPDAALRALHQGDSLECTAMTVQILLKLDRLDLARKELK RMQDLDEDATLTQLATAWVSLATGGEKLQDAYYIFQEMADKCSPTLLLLNGQAACHMAQGRWEAAEGLLQEALDKDSGYPETLVNLIVLS >In-frame_COLGALT1_ENST00000252599_chr19_17671274_+_COPE_ENST00000349893_chr19_19021880_-_357aa MAAAPRAGRRRGQPLLALLLLLLAPLPPGAPPGADAYFPEERWSPESPLQAPRVLIALLARNAAHALPTTLGALERLRHPRERTALWVAT DHNMDNTSTVLREWLVAVKSLYHSVEWRPAEEPRSYPDEEGPKHWSDSRYEHVMKLRQAALKSARDMWADYILRKFGVVLDEIKPSSAPE LQAVRMFADYLAHESRRDSIVAELDREMSRSVDVTNTTFLLMAASIYLHDQNPDAALRALHQGDSLECTAMTVQILLKLDRLDLARKELK >In-frame_COLGALT1_ENST00000252599_chr19_17671274_+_COPE_ENST00000600932_chr19_19021880_-_432aa MAAAPRAGRRRGQPLLALLLLLLAPLPPGAPPGADAYFPEERWSPESPLQAPRVLIALLARNAAHALPTTLGALERLRHPRERTALWVAT DHNMDNTSTVLREWLVAVKSLYHSVEWRPAEEPRSYPDEEGPKHWSDSRYEHVMKLRQAALKSARDMWADYILRKFGVVLDEIKPSSAPE LQAVRMFADYLAHESRRDSIVAELDREMSRSVDVTNTTFLLMAASIYLHDQNPDAALRALHQGDSLEWVSSPGRALHLEAQPMEAASPDG RTAMTVQILLKLDRLDLARKELKRMQDLDEDATLTQLATAWVSLATGGEKLQDAYYIFQEMADKCSPTLLLLNGQAACHMAQGRWEAAEG |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_COLGALT1_ENST00000252599_chr19_17671274_+_COPE_ENST00000262812_chr19_19021880_-_1227nt ATGGCGGCGGCCCCACGCGCGGGCCGGCGGCGCGGGCAGCCGCTCCTGGCGCTGCTGCTTCTGCTGCTGGCGCCACTGCCGCCGGGGGCC CCGCCGGGCGCCGACGCCTACTTCCCCGAGGAGCGCTGGAGCCCGGAGTCGCCCCTGCAGGCGCCGCGCGTGCTCATCGCGCTGTTGGCG CGAAACGCGGCCCACGCGTTGCCCACCACGCTGGGCGCACTCGAGCGGCTGCGGCACCCGCGGGAGCGCACGGCGCTATGGGTGGCTACG GACCACAACATGGATAACACGTCAACTGTGCTGCGGGAGTGGCTGGTGGCCGTGAAGAGTTTGTACCATTCCGTGGAGTGGCGGCCAGCA GAGGAGCCCAGGTCCTACCCGGACGAGGAAGGCCCGAAACACTGGTCTGACTCACGCTACGAGCATGTCATGAAGTTGCGCCAGGCAGCC CTGAAATCAGCTCGAGACATGTGGGCTGATTACATCCTGAGGAAGTTCGGTGTGGTCCTGGATGAGATCAAGCCCTCCTCGGCCCCTGAG CTCCAGGCCGTGCGCATGTTTGCTGACTACCTCGCCCACGAGAGTCGGAGGGACAGCATCGTGGCCGAGCTGGACCGAGAGATGAGCAGG AGCGTGGACGTGACCAACACCACCTTCCTGCTCATGGCCGCCTCCATCTATCTCCACGACCAGAACCCGGATGCCGCCCTGCGTGCGCTG CACCAGGGGGACAGCCTGGAGTGCACAGCCATGACAGTGCAGATCCTGCTGAAGCTGGACCGCCTGGACCTCGCCCGGAAGGAGCTGAAG AGAATGCAGGACCTGGACGAGGATGCCACCCTCACCCAGCTCGCCACTGCCTGGGTCAGCCTGGCCACGGGTGGTGAGAAGCTGCAGGAT GCCTACTACATCTTCCAGGAGATGGCTGACAAGTGCTCGCCCACCCTGCTGCTGCTCAATGGGCAGGCGGCCTGCCACATGGCCCAGGGC CGCTGGGAGGCCGCTGAGGGCCTGCTGCAGGAGGCGCTAGACAAGGATAGTGGCTACCCAGAGACGCTGGTCAACCTCATCGTCCTGTCC CAGCACCTGGGCAAGCCCCCTGAGGTGACAAACCGATACCTGTCCCAGCTGAAGGATGCCCACAGGTCCCATCCCTTCATCAAGGAGTAC >In-frame_COLGALT1_ENST00000252599_chr19_17671274_+_COPE_ENST00000349893_chr19_19021880_-_1071nt ATGGCGGCGGCCCCACGCGCGGGCCGGCGGCGCGGGCAGCCGCTCCTGGCGCTGCTGCTTCTGCTGCTGGCGCCACTGCCGCCGGGGGCC CCGCCGGGCGCCGACGCCTACTTCCCCGAGGAGCGCTGGAGCCCGGAGTCGCCCCTGCAGGCGCCGCGCGTGCTCATCGCGCTGTTGGCG CGAAACGCGGCCCACGCGTTGCCCACCACGCTGGGCGCACTCGAGCGGCTGCGGCACCCGCGGGAGCGCACGGCGCTATGGGTGGCTACG GACCACAACATGGATAACACGTCAACTGTGCTGCGGGAGTGGCTGGTGGCCGTGAAGAGTTTGTACCATTCCGTGGAGTGGCGGCCAGCA GAGGAGCCCAGGTCCTACCCGGACGAGGAAGGCCCGAAACACTGGTCTGACTCACGCTACGAGCATGTCATGAAGTTGCGCCAGGCAGCC CTGAAATCAGCTCGAGACATGTGGGCTGATTACATCCTGAGGAAGTTCGGTGTGGTCCTGGATGAGATCAAGCCCTCCTCGGCCCCTGAG CTCCAGGCCGTGCGCATGTTTGCTGACTACCTCGCCCACGAGAGTCGGAGGGACAGCATCGTGGCCGAGCTGGACCGAGAGATGAGCAGG AGCGTGGACGTGACCAACACCACCTTCCTGCTCATGGCCGCCTCCATCTATCTCCACGACCAGAACCCGGATGCCGCCCTGCGTGCGCTG CACCAGGGGGACAGCCTGGAGTGCACAGCCATGACAGTGCAGATCCTGCTGAAGCTGGACCGCCTGGACCTCGCCCGGAAGGAGCTGAAG AGAATGCAGGACCTGGACGAGGATGCCACCCTCACCCAGCTCGCCACTGCCTGGGTCAGCCTGGCCACGGATAGTGGCTACCCAGAGACG CTGGTCAACCTCATCGTCCTGTCCCAGCACCTGGGCAAGCCCCCTGAGGTGACAAACCGATACCTGTCCCAGCTGAAGGATGCCCACAGG >In-frame_COLGALT1_ENST00000252599_chr19_17671274_+_COPE_ENST00000600932_chr19_19021880_-_1296nt ATGGCGGCGGCCCCACGCGCGGGCCGGCGGCGCGGGCAGCCGCTCCTGGCGCTGCTGCTTCTGCTGCTGGCGCCACTGCCGCCGGGGGCC CCGCCGGGCGCCGACGCCTACTTCCCCGAGGAGCGCTGGAGCCCGGAGTCGCCCCTGCAGGCGCCGCGCGTGCTCATCGCGCTGTTGGCG CGAAACGCGGCCCACGCGTTGCCCACCACGCTGGGCGCACTCGAGCGGCTGCGGCACCCGCGGGAGCGCACGGCGCTATGGGTGGCTACG GACCACAACATGGATAACACGTCAACTGTGCTGCGGGAGTGGCTGGTGGCCGTGAAGAGTTTGTACCATTCCGTGGAGTGGCGGCCAGCA GAGGAGCCCAGGTCCTACCCGGACGAGGAAGGCCCGAAACACTGGTCTGACTCACGCTACGAGCATGTCATGAAGTTGCGCCAGGCAGCC CTGAAATCAGCTCGAGACATGTGGGCTGATTACATCCTGAGGAAGTTCGGTGTGGTCCTGGATGAGATCAAGCCCTCCTCGGCCCCTGAG CTCCAGGCCGTGCGCATGTTTGCTGACTACCTCGCCCACGAGAGTCGGAGGGACAGCATCGTGGCCGAGCTGGACCGAGAGATGAGCAGG AGCGTGGACGTGACCAACACCACCTTCCTGCTCATGGCCGCCTCCATCTATCTCCACGACCAGAACCCGGATGCCGCCCTGCGTGCGCTG CACCAGGGGGACAGCCTGGAGTGGGTGTCGAGTCCGGGCAGGGCCCTCCATCTGGAAGCACAGCCCATGGAGGCTGCTTCTCCAGATGGG CGCACAGCCATGACAGTGCAGATCCTGCTGAAGCTGGACCGCCTGGACCTCGCCCGGAAGGAGCTGAAGAGAATGCAGGACCTGGACGAG GATGCCACCCTCACCCAGCTCGCCACTGCCTGGGTCAGCCTGGCCACGGGTGGTGAGAAGCTGCAGGATGCCTACTACATCTTCCAGGAG ATGGCTGACAAGTGCTCGCCCACCCTGCTGCTGCTCAATGGGCAGGCGGCCTGCCACATGGCCCAGGGCCGCTGGGAGGCCGCTGAGGGC CTGCTGCAGGAGGCGCTAGACAAGGATAGTGGCTACCCAGAGACGCTGGTCAACCTCATCGTCCTGTCCCAGCACCTGGGCAAGCCCCCT GAGGTGACAAACCGATACCTGTCCCAGCTGAAGGATGCCCACAGGTCCCATCCCTTCATCAAGGAGTACCAGGCCAAGGAGAACGACTTT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_COLGALT1_ENST00000252599_chr19_17671274_+_COPE_ENST00000262812_chr19_19021880_-_1512nt TTCACGCCCGGCGCGCTCCTCCCCTTTAAGGCGCGCGGCCGGGCGGGGCCCCTATGACCCCTTTAAGGCGCGGCCAGAGTCCTCCCGCAG AAAAACGACTTAAAGGAGACGCGTGGCGCGATGGCGGCGGCCCCACGCGCGGGCCGGCGGCGCGGGCAGCCGCTCCTGGCGCTGCTGCTT CTGCTGCTGGCGCCACTGCCGCCGGGGGCCCCGCCGGGCGCCGACGCCTACTTCCCCGAGGAGCGCTGGAGCCCGGAGTCGCCCCTGCAG GCGCCGCGCGTGCTCATCGCGCTGTTGGCGCGAAACGCGGCCCACGCGTTGCCCACCACGCTGGGCGCACTCGAGCGGCTGCGGCACCCG CGGGAGCGCACGGCGCTATGGGTGGCTACGGACCACAACATGGATAACACGTCAACTGTGCTGCGGGAGTGGCTGGTGGCCGTGAAGAGT TTGTACCATTCCGTGGAGTGGCGGCCAGCAGAGGAGCCCAGGTCCTACCCGGACGAGGAAGGCCCGAAACACTGGTCTGACTCACGCTAC GAGCATGTCATGAAGTTGCGCCAGGCAGCCCTGAAATCAGCTCGAGACATGTGGGCTGATTACATCCTGAGGAAGTTCGGTGTGGTCCTG GATGAGATCAAGCCCTCCTCGGCCCCTGAGCTCCAGGCCGTGCGCATGTTTGCTGACTACCTCGCCCACGAGAGTCGGAGGGACAGCATC GTGGCCGAGCTGGACCGAGAGATGAGCAGGAGCGTGGACGTGACCAACACCACCTTCCTGCTCATGGCCGCCTCCATCTATCTCCACGAC CAGAACCCGGATGCCGCCCTGCGTGCGCTGCACCAGGGGGACAGCCTGGAGTGCACAGCCATGACAGTGCAGATCCTGCTGAAGCTGGAC CGCCTGGACCTCGCCCGGAAGGAGCTGAAGAGAATGCAGGACCTGGACGAGGATGCCACCCTCACCCAGCTCGCCACTGCCTGGGTCAGC CTGGCCACGGGTGGTGAGAAGCTGCAGGATGCCTACTACATCTTCCAGGAGATGGCTGACAAGTGCTCGCCCACCCTGCTGCTGCTCAAT GGGCAGGCGGCCTGCCACATGGCCCAGGGCCGCTGGGAGGCCGCTGAGGGCCTGCTGCAGGAGGCGCTAGACAAGGATAGTGGCTACCCA GAGACGCTGGTCAACCTCATCGTCCTGTCCCAGCACCTGGGCAAGCCCCCTGAGGTGACAAACCGATACCTGTCCCAGCTGAAGGATGCC CACAGGTCCCATCCCTTCATCAAGGAGTACCAGGCCAAGGAGAACGACTTTGACAGGCTGGTGCTACAGTACGCTCCCAGCGCCTGAGGC TGGCCCAGAGCTGTCAGGACCATGAAGCCAGGACAGAGGCCAGGAGCCAGCCCTGCAGCCCTCCCCACCCGGCATCCACCTGCATCCCCT >In-frame_COLGALT1_ENST00000252599_chr19_17671274_+_COPE_ENST00000349893_chr19_19021880_-_1353nt TTCACGCCCGGCGCGCTCCTCCCCTTTAAGGCGCGCGGCCGGGCGGGGCCCCTATGACCCCTTTAAGGCGCGGCCAGAGTCCTCCCGCAG AAAAACGACTTAAAGGAGACGCGTGGCGCGATGGCGGCGGCCCCACGCGCGGGCCGGCGGCGCGGGCAGCCGCTCCTGGCGCTGCTGCTT CTGCTGCTGGCGCCACTGCCGCCGGGGGCCCCGCCGGGCGCCGACGCCTACTTCCCCGAGGAGCGCTGGAGCCCGGAGTCGCCCCTGCAG GCGCCGCGCGTGCTCATCGCGCTGTTGGCGCGAAACGCGGCCCACGCGTTGCCCACCACGCTGGGCGCACTCGAGCGGCTGCGGCACCCG CGGGAGCGCACGGCGCTATGGGTGGCTACGGACCACAACATGGATAACACGTCAACTGTGCTGCGGGAGTGGCTGGTGGCCGTGAAGAGT TTGTACCATTCCGTGGAGTGGCGGCCAGCAGAGGAGCCCAGGTCCTACCCGGACGAGGAAGGCCCGAAACACTGGTCTGACTCACGCTAC GAGCATGTCATGAAGTTGCGCCAGGCAGCCCTGAAATCAGCTCGAGACATGTGGGCTGATTACATCCTGAGGAAGTTCGGTGTGGTCCTG GATGAGATCAAGCCCTCCTCGGCCCCTGAGCTCCAGGCCGTGCGCATGTTTGCTGACTACCTCGCCCACGAGAGTCGGAGGGACAGCATC GTGGCCGAGCTGGACCGAGAGATGAGCAGGAGCGTGGACGTGACCAACACCACCTTCCTGCTCATGGCCGCCTCCATCTATCTCCACGAC CAGAACCCGGATGCCGCCCTGCGTGCGCTGCACCAGGGGGACAGCCTGGAGTGCACAGCCATGACAGTGCAGATCCTGCTGAAGCTGGAC CGCCTGGACCTCGCCCGGAAGGAGCTGAAGAGAATGCAGGACCTGGACGAGGATGCCACCCTCACCCAGCTCGCCACTGCCTGGGTCAGC CTGGCCACGGATAGTGGCTACCCAGAGACGCTGGTCAACCTCATCGTCCTGTCCCAGCACCTGGGCAAGCCCCCTGAGGTGACAAACCGA TACCTGTCCCAGCTGAAGGATGCCCACAGGTCCCATCCCTTCATCAAGGAGTACCAGGCCAAGGAGAACGACTTTGACAGGCTGGTGCTA CAGTACGCTCCCAGCGCCTGAGGCTGGCCCAGAGCTGTCAGGACCATGAAGCCAGGACAGAGGCCAGGAGCCAGCCCTGCAGCCCTCCCC ACCCGGCATCCACCTGCATCCCCTCTGGGGGCAGGAGCCCACCCCCAGCACCCCCATCTGTTAATAAATATCTCAACTCCAGGGTGTTCC >In-frame_COLGALT1_ENST00000252599_chr19_17671274_+_COPE_ENST00000600932_chr19_19021880_-_1532nt TTCACGCCCGGCGCGCTCCTCCCCTTTAAGGCGCGCGGCCGGGCGGGGCCCCTATGACCCCTTTAAGGCGCGGCCAGAGTCCTCCCGCAG AAAAACGACTTAAAGGAGACGCGTGGCGCGATGGCGGCGGCCCCACGCGCGGGCCGGCGGCGCGGGCAGCCGCTCCTGGCGCTGCTGCTT CTGCTGCTGGCGCCACTGCCGCCGGGGGCCCCGCCGGGCGCCGACGCCTACTTCCCCGAGGAGCGCTGGAGCCCGGAGTCGCCCCTGCAG GCGCCGCGCGTGCTCATCGCGCTGTTGGCGCGAAACGCGGCCCACGCGTTGCCCACCACGCTGGGCGCACTCGAGCGGCTGCGGCACCCG CGGGAGCGCACGGCGCTATGGGTGGCTACGGACCACAACATGGATAACACGTCAACTGTGCTGCGGGAGTGGCTGGTGGCCGTGAAGAGT TTGTACCATTCCGTGGAGTGGCGGCCAGCAGAGGAGCCCAGGTCCTACCCGGACGAGGAAGGCCCGAAACACTGGTCTGACTCACGCTAC GAGCATGTCATGAAGTTGCGCCAGGCAGCCCTGAAATCAGCTCGAGACATGTGGGCTGATTACATCCTGAGGAAGTTCGGTGTGGTCCTG GATGAGATCAAGCCCTCCTCGGCCCCTGAGCTCCAGGCCGTGCGCATGTTTGCTGACTACCTCGCCCACGAGAGTCGGAGGGACAGCATC GTGGCCGAGCTGGACCGAGAGATGAGCAGGAGCGTGGACGTGACCAACACCACCTTCCTGCTCATGGCCGCCTCCATCTATCTCCACGAC CAGAACCCGGATGCCGCCCTGCGTGCGCTGCACCAGGGGGACAGCCTGGAGTGGGTGTCGAGTCCGGGCAGGGCCCTCCATCTGGAAGCA CAGCCCATGGAGGCTGCTTCTCCAGATGGGCGCACAGCCATGACAGTGCAGATCCTGCTGAAGCTGGACCGCCTGGACCTCGCCCGGAAG GAGCTGAAGAGAATGCAGGACCTGGACGAGGATGCCACCCTCACCCAGCTCGCCACTGCCTGGGTCAGCCTGGCCACGGGTGGTGAGAAG CTGCAGGATGCCTACTACATCTTCCAGGAGATGGCTGACAAGTGCTCGCCCACCCTGCTGCTGCTCAATGGGCAGGCGGCCTGCCACATG GCCCAGGGCCGCTGGGAGGCCGCTGAGGGCCTGCTGCAGGAGGCGCTAGACAAGGATAGTGGCTACCCAGAGACGCTGGTCAACCTCATC GTCCTGTCCCAGCACCTGGGCAAGCCCCCTGAGGTGACAAACCGATACCTGTCCCAGCTGAAGGATGCCCACAGGTCCCATCCCTTCATC AAGGAGTACCAGGCCAAGGAGAACGACTTTGACAGGCTGGTGCTACAGTACGCTCCCAGCGCCTGAGGCTGGCCCAGAGCTGTCAGGACC ATGAAGCCAGGACAGAGGCCAGGAGCCAGCCCTGCAGCCCTCCCCACCCGGCATCCACCTGCATCCCCTCTGGGGGCAGGAGCCCACCCC |
Top |
FusionGenePPI for COLGALT1_COPE |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| COLGALT1 | VHL, ELAVL1, FBXO6, STRIP1, HSPD1, OS9, ATF2, RNF2, PLOD1, PLOD2, PLOD3, PRPF40A, PYGL, NTRK1, TCTN1, PML, TGM2, NANOG, POU5F1, UBLCP1, PTPRN, COLGALT2, PDHA1, TRIM25 | COPE | COPA, COPB2, COPG1, ARF1, COPB1, RCHY1, UBC, SACM1L, TMED10, COPE, LMAN1, ARCN1, COPG2, BRCA1, ECT2, MDC1, PAXIP1, VCP, FN1, NPM1, BAG3, SEPT2, KIF5B, RABGAP1, GPRASP2, NUDCD1, EFHC2, SHMT2, NTRK1, MCM5, SF3B2, SRSF2, SRSF3, STAG2, SULT1C4, TRIP10, DTNBP1, MCFD2, OSBPL9, PSMD12, SF3B3, SF3B4, SF3B5, HERC2, TCTN3, TMEM17, XPO1, MYH6, XRCC3, FAM210A, PPM1G, WBP2, DLD, HSD17B10, VDAC1, TRIM25, CCND2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for COLGALT1_COPE |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for COLGALT1_COPE |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|