FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 7962

FusionGeneSummary for COL4A2_NUBPL

check button Fusion gene summary
Fusion gene informationFusion gene name: COL4A2_NUBPL
Fusion gene ID: 7962
HgeneTgene
Gene symbol

COL4A2

NUBPL

Gene ID

1284

80224

Gene namecollagen type IV alpha 2 chainnucleotide binding protein like
SynonymsICH|POREN2C14orf127|IND1|huInd1
Cytomap

13q34

14q12

Type of geneprotein-codingprotein-coding
Descriptioncollagen alpha-2(IV) chaincanstatiniron-sulfur protein NUBPLIND1 homologiron-sulfur protein required for NADH dehydrogenase
Modification date2018052320180523
UniProtAcc

P08572

Q8TB37

Ensembl transtripts involved in fusion geneENST00000360467, ENST00000462309, 
ENST00000281081, ENST00000536705, 
ENST00000418681, 
Fusion gene scores* DoF score8 X 5 X 7=2808 X 5 X 6=240
# samples 98
** MAII scorelog2(9/280*10)=-1.63742992061529
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/240*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: COL4A2 [Title/Abstract] AND NUBPL [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCOL4A2

GO:0016525

negative regulation of angiogenesis

10625665


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-FX-A48G-01ACOL4A2chr13

110960470

+NUBPLchr14

32068495

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000360467ENST00000281081COL4A2chr13

110960470

+NUBPLchr14

32068495

+
In-frameENST00000360467ENST00000536705COL4A2chr13

110960470

+NUBPLchr14

32068495

+
5CDS-intronENST00000360467ENST00000418681COL4A2chr13

110960470

+NUBPLchr14

32068495

+
intron-3CDSENST00000462309ENST00000281081COL4A2chr13

110960470

+NUBPLchr14

32068495

+
intron-3CDSENST00000462309ENST00000536705COL4A2chr13

110960470

+NUBPLchr14

32068495

+
intron-intronENST00000462309ENST00000418681COL4A2chr13

110960470

+NUBPLchr14

32068495

+

Top

FusionProtFeatures for COL4A2_NUBPL


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
COL4A2

P08572

NUBPL

Q8TB37

Type IV collagen is the major structural component ofglomerular basement membranes (GBM), forming a 'chicken-wire'meshwork together with laminins, proteoglycans andentactin/nidogen. Canstatin, a cleavage product corresponding to thecollagen alpha 2(IV) NC1 domain, possesses both anti-angiogenicand anti-tumor cell activity. It inhibits proliferation andmigration of endothelial cells, reduces mitochondrial membranepotential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity.Ligand for alphavbeta3 and alphavbeta5 integrins. Required for the assembly of the mitochondrial membranerespiratory chain NADH dehydrogenase (Complex I). May deliver ofone or more Fe-S clusters to complex I subunits.{ECO:0000269|PubMed:19752196}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCOL4A2chr13:110960470chr14:32068495ENST00000360467+3481489_1712331713DomainCollagen IV NC1
HgeneCOL4A2chr13:110960470chr14:32068495ENST00000360467+348184_1484331713RegionNote=Triple-helical region
TgeneNUBPLchr13:110960470chr14:32068495ENST00000281081+21175_8297320Nucleotide bindingATP


Top

FusionGeneSequence for COL4A2_NUBPL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_COL4A2_ENST00000360467_chr13_110960470_+_NUBPL_ENST00000281081_chr14_32068495_+_256aa
MGRDQRAVAGPALRRWLLLGTVTVGFLAQSVLASKAIGLLDVDVYGPSVPKMMNLKGNPELSQSNLMRPLLNYGIACMSMGFLVEESEPV
VWRGLMVMSAIEKLLRQVDWGQLDYLVVDMPPGTGDVQLSVSQNIPITGAVIVSTPQDIALMDAHKGAEMFRRVHVPVLGLVQNMSVFQC

>In-frame_COL4A2_ENST00000360467_chr13_110960470_+_NUBPL_ENST00000536705_chr14_32068495_+_256aa
MGRDQRAVAGPALRRWLLLGTVTVGFLAQSVLASKAIGLLDVDVYGPSVPKMMNLKGNPELSQSNLMRPLLNYGIACMSMGFLVEESEPV
VWRGLMVMSAIEKLLRQVDWGQLDYLVVDMPPGTGDVQLSVSQNIPITGAVIVSTPQDIALMDAHKGAEMFRRVHVPVLGLVQNMSVFQC


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_COL4A2_ENST00000360467_chr13_110960470_+_NUBPL_ENST00000281081_chr14_32068495_+_768nt
ATGGGGAGAGACCAGCGCGCGGTGGCCGGCCCTGCCCTACGGCGGTGGCTGCTGCTGGGGACAGTGACCGTGGGGTTCCTCGCCCAGAGC
GTCTTGGCGTCCAAGGCCATTGGTTTGCTAGATGTGGATGTGTATGGACCTTCAGTTCCAAAGATGATGAATCTGAAAGGAAATCCGGAA
TTATCACAGAGCAACCTAATGAGGCCTCTCTTGAATTATGGTATTGCTTGTATGTCTATGGGCTTTCTGGTTGAAGAAAGTGAACCAGTA
GTTTGGAGAGGCCTTATGGTAATGTCGGCCATTGAGAAATTGTTGAGGCAGGTAGATTGGGGTCAACTGGACTACTTAGTTGTAGACATG
CCACCAGGAACTGGAGATGTGCAGTTATCAGTCTCACAGAATATTCCTATAACAGGTGCTGTGATTGTCTCCACGCCCCAGGACATCGCA
TTGATGGATGCACACAAGGGTGCTGAGATGTTTCGCAGAGTCCACGTGCCCGTCCTTGGCCTTGTCCAAAACATGAGTGTTTTCCAGTGT
CCAAAATGTAAACACAAAACTCATATTTTTGGTGCTGATGGTGCAAGGAAACTAGCACAGACCCTTGGTCTTGAAGTTCTAGGAGACATT
CCCTTACACCTTAATATAAGGGAAGCTTCAGATACAGGCCAGCCAATTGTGTTTTCACAGCCTGAAAGTGATGAGGCCAAAGCTTACTTG

>In-frame_COL4A2_ENST00000360467_chr13_110960470_+_NUBPL_ENST00000536705_chr14_32068495_+_768nt
ATGGGGAGAGACCAGCGCGCGGTGGCCGGCCCTGCCCTACGGCGGTGGCTGCTGCTGGGGACAGTGACCGTGGGGTTCCTCGCCCAGAGC
GTCTTGGCGTCCAAGGCCATTGGTTTGCTAGATGTGGATGTGTATGGACCTTCAGTTCCAAAGATGATGAATCTGAAAGGAAATCCGGAA
TTATCACAGAGCAACCTAATGAGGCCTCTCTTGAATTATGGTATTGCTTGTATGTCTATGGGCTTTCTGGTTGAAGAAAGTGAACCAGTA
GTTTGGAGAGGCCTTATGGTAATGTCGGCCATTGAGAAATTGTTGAGGCAGGTAGATTGGGGTCAACTGGACTACTTAGTTGTAGACATG
CCACCAGGAACTGGAGATGTGCAGTTATCAGTCTCACAGAATATTCCTATAACAGGTGCTGTGATTGTCTCCACGCCCCAGGACATCGCA
TTGATGGATGCACACAAGGGTGCTGAGATGTTTCGCAGAGTCCACGTGCCCGTCCTTGGCCTTGTCCAAAACATGAGTGTTTTCCAGTGT
CCAAAATGTAAACACAAAACTCATATTTTTGGTGCTGATGGTGCAAGGAAACTAGCACAGACCCTTGGTCTTGAAGTTCTAGGAGACATT
CCCTTACACCTTAATATAAGGGAAGCTTCAGATACAGGCCAGCCAATTGTGTTTTCACAGCCTGAAAGTGATGAGGCCAAAGCTTACTTG


* Fusion transcript sequences (Full-length transcript).
>In-frame_COL4A2_ENST00000360467_chr13_110960470_+_NUBPL_ENST00000281081_chr14_32068495_+_3118nt
GGGAGCGCGCGGCCCGGGAGTGTGGCTGCAGTGCGCCGGGACACCAGGGCTCCGCGCTCCGCACTCAAGAGGCTCCCGCGTCCCAACCCC
TCGCGCCCGCGCGTTCGCGGATCCAGGCCGAGGACCGAAAGGGGCCGCCCGAGCCCCCGGGGCCGGCGCCCAGAGAGCCCAGCAAGGCCG
GCCGCCCTGCCGGTGTGCCGCCGGCGGGTGCTTCTGGAAGGGCCAATGCGTTCGGGCAGCAGCCCCTGAAGCCGAGCCCGAGGCTAAGTG
GGACTGACCGGGGCCCAGAGTGGACGAACCGCCAGCATGGGGAGAGACCAGCGCGCGGTGGCCGGCCCTGCCCTACGGCGGTGGCTGCTG
CTGGGGACAGTGACCGTGGGGTTCCTCGCCCAGAGCGTCTTGGCGTCCAAGGCCATTGGTTTGCTAGATGTGGATGTGTATGGACCTTCA
GTTCCAAAGATGATGAATCTGAAAGGAAATCCGGAATTATCACAGAGCAACCTAATGAGGCCTCTCTTGAATTATGGTATTGCTTGTATG
TCTATGGGCTTTCTGGTTGAAGAAAGTGAACCAGTAGTTTGGAGAGGCCTTATGGTAATGTCGGCCATTGAGAAATTGTTGAGGCAGGTA
GATTGGGGTCAACTGGACTACTTAGTTGTAGACATGCCACCAGGAACTGGAGATGTGCAGTTATCAGTCTCACAGAATATTCCTATAACA
GGTGCTGTGATTGTCTCCACGCCCCAGGACATCGCATTGATGGATGCACACAAGGGTGCTGAGATGTTTCGCAGAGTCCACGTGCCCGTC
CTTGGCCTTGTCCAAAACATGAGTGTTTTCCAGTGTCCAAAATGTAAACACAAAACTCATATTTTTGGTGCTGATGGTGCAAGGAAACTA
GCACAGACCCTTGGTCTTGAAGTTCTAGGAGACATTCCCTTACACCTTAATATAAGGGAAGCTTCAGATACAGGCCAGCCAATTGTGTTT
TCACAGCCTGAAAGTGATGAGGCCAAAGCTTACTTGAGGATTGCTGTGGAAGTGGTAAGAAGATTGCCATCACCTTCAGAATGATTCCCC
AAGTGTCCTGGAAATTTGCCTGGTACTGACATTAAGAGGACCTTTGGAAATCAGCAATGTGGTGATGGAACCTACAGAAATAATAGAAAT
CATAACTGTTTTATTTCTAAGGAAAGAATGTCTTCATATTTGACTTGCTAAGCTAAGGTTCACAAAACTTTGATGTATCAATGTTAACTG
CTATATTTAGGAATTTTTTGAAAGCTGGTGTGTACCACCTGCAAAGAACTGCATTTTATTTTATTGAATTACCCCTTTAGAAATCACGAG
TTTATGATGTTACAAGTCCATTTTGGGAGAGAACTGTACACTTTTTGCAGGACCACAGAATTAGTAATTTAAATGATATACTAAATTTGT
GTATGGGCATAAGTATTACGCCTTCCCACCAGGCAATTTGGACTGTCTTTGAATCCTGTCTTTGGTACTGTCTTGGACATGTTCTTAATA
TGAACCTCTGCTTCTTCATCTGGATCACACTATACCCCAGACTTAATGAATTTCAGTCTCCAGGAGTGGAGCCTGAACATATGTATTTTT
AGTAAGACCATGATGATGTTGATGATGATTCTGGTAATCATGGCAGTAAGAATAATAGCTAACATTTAACAAGTTAATTATAATTGTTCT
TCCATTTGTGTGAGTGGGTACTATTATCTCCATTTTACAGATAAGTAATTTGAGATATAATTTGAAGGCACTCAACCTTGAGTGTCTTGC
TGAGGGTTACTGTATCTAGCAGGTGATGGAGCTTGGATTTGAACTTGAGTAATTCGATATTAGATTCATCTTTTTGTACACCAATGTGCT
TTTGTTAATTAAAAAAAGTCGGTGGTGGCTAGGCGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGTTGAGGTGGGTGGATCAT
GAGGTCAGGAGTTCAAGACCAGCCTGACCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGTGTGGTGGCATATG
CCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCATTTCAACCCGGGAGGCTGAGGTTGCAGTGAGTGGAGATTGTACCACTG
CACTCCAGCCTGGTCAATGGAGTGCGACTCCATCTCAAAAAAAAAAAAAAAAAAAAAAAAAGTCGGGGGAGATGCAATATTTAGCATTTC
CTCAAACTTTTTTTGGCCATGAAATCCACCACCCCCCTCCTTTTTCAGAGCATTTCATGAAGTTCACATTTCAAATAATACATTTTGAAA
AACATTTATCTTGTCTAATTGAAGCTCAAAGAGATAGAGTCAATGACTTTTCAAAGTCAGGTAGCAGATAGTTTTAAAGCTGCAAGTACT
GATAAGTGTGAGCCATTAGTTAATTCGCATTTATAAAGAAGTGGTCTGTCACTTTTGGCAAATGTCTTGACATCTGTTGCTCTACAGTTG
TCAACTAGAAAATTAGGCATAGAGTTTCACATTATTATAAGCATGTTTTCACACAAAAACATGTACATTGATGTTTATTGCAATTTTATG
TGTAATAACCAAAAACAACCCAGATTTTCTTCATTGGGTAAATGATTAAACAAACCATAGTACATTCATACCGTGAGTGCTACTCAGCAA
TAAAAAAGAACAAACTATGGGTACAGGCAGCAACTTATAATTCCAGAGAATTATGCTGAATGAAAAAGGCCAATTTAAAAAGGTTTTGTA
CCAAAAGATTCCATTTATATAACGTTCTTGAAGTGACATAATTATAGAAATGGAGAACAGATTAGTGGTGGCTGTGTTAAGGAGGGGGTG
AGGATGGGAGAGAATTGGGCGTGGCTGTGAGAAACATGAGGGATCCTTGTGATGATGGAAATGTTCTATATCACAGCTATCGATGTCAGT
ATCCCAGTTGTGATATTGTGCTATAGTTTTGCAAGATGTTACCACTGGGGGAAATTGGGTGAAGGGCACATGGAATCTCTGTATTATTTC

>In-frame_COL4A2_ENST00000360467_chr13_110960470_+_NUBPL_ENST00000536705_chr14_32068495_+_3087nt
GGGAGCGCGCGGCCCGGGAGTGTGGCTGCAGTGCGCCGGGACACCAGGGCTCCGCGCTCCGCACTCAAGAGGCTCCCGCGTCCCAACCCC
TCGCGCCCGCGCGTTCGCGGATCCAGGCCGAGGACCGAAAGGGGCCGCCCGAGCCCCCGGGGCCGGCGCCCAGAGAGCCCAGCAAGGCCG
GCCGCCCTGCCGGTGTGCCGCCGGCGGGTGCTTCTGGAAGGGCCAATGCGTTCGGGCAGCAGCCCCTGAAGCCGAGCCCGAGGCTAAGTG
GGACTGACCGGGGCCCAGAGTGGACGAACCGCCAGCATGGGGAGAGACCAGCGCGCGGTGGCCGGCCCTGCCCTACGGCGGTGGCTGCTG
CTGGGGACAGTGACCGTGGGGTTCCTCGCCCAGAGCGTCTTGGCGTCCAAGGCCATTGGTTTGCTAGATGTGGATGTGTATGGACCTTCA
GTTCCAAAGATGATGAATCTGAAAGGAAATCCGGAATTATCACAGAGCAACCTAATGAGGCCTCTCTTGAATTATGGTATTGCTTGTATG
TCTATGGGCTTTCTGGTTGAAGAAAGTGAACCAGTAGTTTGGAGAGGCCTTATGGTAATGTCGGCCATTGAGAAATTGTTGAGGCAGGTA
GATTGGGGTCAACTGGACTACTTAGTTGTAGACATGCCACCAGGAACTGGAGATGTGCAGTTATCAGTCTCACAGAATATTCCTATAACA
GGTGCTGTGATTGTCTCCACGCCCCAGGACATCGCATTGATGGATGCACACAAGGGTGCTGAGATGTTTCGCAGAGTCCACGTGCCCGTC
CTTGGCCTTGTCCAAAACATGAGTGTTTTCCAGTGTCCAAAATGTAAACACAAAACTCATATTTTTGGTGCTGATGGTGCAAGGAAACTA
GCACAGACCCTTGGTCTTGAAGTTCTAGGAGACATTCCCTTACACCTTAATATAAGGGAAGCTTCAGATACAGGCCAGCCAATTGTGTTT
TCACAGCCTGAAAGTGATGAGGCCAAAGCTTACTTGAGGATTGCTGTGGAAGTGGTAAGAAGATTGCCATCACCTTCAGAATGATTCCCC
AAGTGTCCTGGAAATTTGCCTGGTACTGACATTAAGAGGACCTTTGGAAATCAGCAATGTGGTGATGGAACCTACAGAAATAATAGAAAT
CATAACTGTTTTATTTCTAAGGAAAGAATGTCTTCATATTTGACTTGCTAAGCTAAGGTTCACAAAACTTTGATGTATCAATGTTAACTG
CTATATTTAGGAATTTTTTGAAAGCTGGTGTGTACCACCTGCAAAGAACTGCATTTTATTTTATTGAATTACCCCTTTAGAAATCACGAG
TTTATGATGTTACAAGTCCATTTTGGGAGAGAACTGTACACTTTTTGCAGGACCACAGAATTAGTAATTTAAATGATATACTAAATTTGT
GTATGGGCATAAGTATTACGCCTTCCCACCAGGCAATTTGGACTGTCTTTGAATCCTGTCTTTGGTACTGTCTTGGACATGTTCTTAATA
TGAACCTCTGCTTCTTCATCTGGATCACACTATACCCCAGACTTAATGAATTTCAGTCTCCAGGAGTGGAGCCTGAACATATGTATTTTT
AGTAAGACCATGATGATGTTGATGATGATTCTGGTAATCATGGCAGTAAGAATAATAGCTAACATTTAACAAGTTAATTATAATTGTTCT
TCCATTTGTGTGAGTGGGTACTATTATCTCCATTTTACAGATAAGTAATTTGAGATATAATTTGAAGGCACTCAACCTTGAGTGTCTTGC
TGAGGGTTACTGTATCTAGCAGGTGATGGAGCTTGGATTTGAACTTGAGTAATTCGATATTAGATTCATCTTTTTGTACACCAATGTGCT
TTTGTTAATTAAAAAAAGTCGGTGGTGGCTAGGCGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGTTGAGGTGGGTGGATCAT
GAGGTCAGGAGTTCAAGACCAGCCTGACCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGTGTGGTGGCATATG
CCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCATTTCAACCCGGGAGGCTGAGGTTGCAGTGAGTGGAGATTGTACCACTG
CACTCCAGCCTGGTCAATGGAGTGCGACTCCATCTCAAAAAAAAAAAAAAAAAAAAAAAAAGTCGGGGGAGATGCAATATTTAGCATTTC
CTCAAACTTTTTTTGGCCATGAAATCCACCACCCCCCTCCTTTTTCAGAGCATTTCATGAAGTTCACATTTCAAATAATACATTTTGAAA
AACATTTATCTTGTCTAATTGAAGCTCAAAGAGATAGAGTCAATGACTTTTCAAAGTCAGGTAGCAGATAGTTTTAAAGCTGCAAGTACT
GATAAGTGTGAGCCATTAGTTAATTCGCATTTATAAAGAAGTGGTCTGTCACTTTTGGCAAATGTCTTGACATCTGTTGCTCTACAGTTG
TCAACTAGAAAATTAGGCATAGAGTTTCACATTATTATAAGCATGTTTTCACACAAAAACATGTACATTGATGTTTATTGCAATTTTATG
TGTAATAACCAAAAACAACCCAGATTTTCTTCATTGGGTAAATGATTAAACAAACCATAGTACATTCATACCGTGAGTGCTACTCAGCAA
TAAAAAAGAACAAACTATGGGTACAGGCAGCAACTTATAATTCCAGAGAATTATGCTGAATGAAAAAGGCCAATTTAAAAAGGTTTTGTA
CCAAAAGATTCCATTTATATAACGTTCTTGAAGTGACATAATTATAGAAATGGAGAACAGATTAGTGGTGGCTGTGTTAAGGAGGGGGTG
AGGATGGGAGAGAATTGGGCGTGGCTGTGAGAAACATGAGGGATCCTTGTGATGATGGAAATGTTCTATATCACAGCTATCGATGTCAGT
ATCCCAGTTGTGATATTGTGCTATAGTTTTGCAAGATGTTACCACTGGGGGAAATTGGGTGAAGGGCACATGGAATCTCTGTATTATTTC


Top

FusionGenePPI for COL4A2_NUBPL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
COL4A2COL4A2, COL4A1, CSNK2B, DAZAP2, TK1, SMN1, ANXA7, VHL, SKIL, FAM46A, FBXO6, C1QB, C1QTNF2, CELA2B, FGL1, ITLN2, COL9A1, C1QTNF9, STBD1, SERPINA6, TMEM25, SEMG1, PTPRK, COL8A2, CLPSL1, TNPO3, PLOD1, COLGALT2, MMP9, MMP2, FKBP9, LYG2, COL10A1, COLQ, CRP, MSR1, IFNA21NUBPLMTUS2, RNF2, DNAJB11, UFD1L


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for COL4A2_NUBPL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for COL4A2_NUBPL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCOL4A2C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneCOL4A2C0027726Nephrotic Syndrome1CTD_human
HgeneCOL4A2C0149925Small cell carcinoma of lung1CTD_human
HgeneCOL4A2C3280970PORENCEPHALY 21UNIPROT
TgeneNUBPLC0751651Mitochondrial Diseases1CTD_human
TgeneNUBPLC1838979MITOCHONDRIAL COMPLEX I DEFICIENCY1CTD_human;UNIPROT