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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 7924

FusionGeneSummary for COL2A1_ZNF609

check button Fusion gene summary
Fusion gene informationFusion gene name: COL2A1_ZNF609
Fusion gene ID: 7924
HgeneTgene
Gene symbol

COL2A1

ZNF609

Gene ID

1280

23060

Gene namecollagen type II alpha 1 chainzinc finger protein 609
SynonymsANFH|AOM|COL11A3|SEDC|STL1-
Cytomap

12q13.11

15q22.31

Type of geneprotein-codingprotein-coding
Descriptioncollagen alpha-1(II) chainalpha-1 type II collagenarthroophthalmopathy, progressive (Stickler syndrome)cartilage collagenchondrocalcincollagen II, alpha-1 polypeptidecollagen, type II, alpha 1zinc finger protein 609
Modification date2018052320180519
UniProtAcc

P02458

O15014

Ensembl transtripts involved in fusion geneENST00000380518, ENST00000493991, 
ENST00000337299, 
ENST00000326648, 
ENST00000416172, ENST00000559364, 
Fusion gene scores* DoF score4 X 5 X 2=407 X 9 X 3=189
# samples 510
** MAII scorelog2(5/40*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(10/189*10)=-0.918386234446348
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: COL2A1 [Title/Abstract] AND ZNF609 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneZNF609

GO:2000291

regulation of myoblast proliferation

28344082


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-EJ-5503-01ACOL2A1chr12

48398020

-ZNF609chr15

64915026

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000380518ENST00000326648COL2A1chr12

48398020

-ZNF609chr15

64915026

+
5CDS-intronENST00000380518ENST00000416172COL2A1chr12

48398020

-ZNF609chr15

64915026

+
5CDS-intronENST00000380518ENST00000559364COL2A1chr12

48398020

-ZNF609chr15

64915026

+
intron-3CDSENST00000493991ENST00000326648COL2A1chr12

48398020

-ZNF609chr15

64915026

+
intron-intronENST00000493991ENST00000416172COL2A1chr12

48398020

-ZNF609chr15

64915026

+
intron-intronENST00000493991ENST00000559364COL2A1chr12

48398020

-ZNF609chr15

64915026

+
In-frameENST00000337299ENST00000326648COL2A1chr12

48398020

-ZNF609chr15

64915026

+
5CDS-intronENST00000337299ENST00000416172COL2A1chr12

48398020

-ZNF609chr15

64915026

+
5CDS-intronENST00000337299ENST00000559364COL2A1chr12

48398020

-ZNF609chr15

64915026

+

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FusionProtFeatures for COL2A1_ZNF609


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
COL2A1

P02458

ZNF609

O15014

Transcription factor, which activates RAG1, and possiblyRAG2, transcription. Through the regulation of RAG1/2 expression,may regulate thymocyte maturation. Along with NIPBL and themultiprotein complex Integrator, promotes cortical neuronmigration during brain development by regulating the transcriptionof crucial genes in this process. Preferentially binds promoterscontaining paused RNA polymerase II. Up-regulates the expressionof SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others.{ECO:0000250|UniProtKB:Q8BZ47}. Isoform 2: Involved in the regulation of myoblastproliferation during myogenesis. {ECO:0000269|PubMed:28344082}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneZNF609chr12:48398020chr15:64915026ENST00000326648+091333_13362492578Compositional biasNote=Poly-Gly
TgeneZNF609chr12:48398020chr15:64915026ENST00000326648+091366_13712492578Compositional biasNote=Poly-His
TgeneZNF609chr12:48398020chr15:64915026ENST00000326648+09725_7352492578Compositional biasNote=Poly-Lys
TgeneZNF609chr12:48398020chr15:64915026ENST00000326648+09952_9552492578Compositional biasNote=Poly-Ser
TgeneZNF609chr12:48398020chr15:64915026ENST00000326648+09495_5202492578Zinc fingerC2H2-type

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCOL2A1chr12:48398020chr15:64915026ENST00000337299-1531253_1487281419DomainFibrillar collagen NC1
HgeneCOL2A1chr12:48398020chr15:64915026ENST00000337299-15332_90281419DomainVWFC
HgeneCOL2A1chr12:48398020chr15:64915026ENST00000380518-1541253_1487281488DomainFibrillar collagen NC1
HgeneCOL2A1chr12:48398020chr15:64915026ENST00000380518-15432_90281488DomainVWFC
HgeneCOL2A1chr12:48398020chr15:64915026ENST00000337299-1531215_1241281419RegionNote=Nonhelical region (C-terminal)
HgeneCOL2A1chr12:48398020chr15:64915026ENST00000337299-153201_1214281419RegionNote=Triple-helical region
HgeneCOL2A1chr12:48398020chr15:64915026ENST00000380518-1541215_1241281488RegionNote=Nonhelical region (C-terminal)
HgeneCOL2A1chr12:48398020chr15:64915026ENST00000380518-154201_1214281488RegionNote=Triple-helical region


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FusionGeneSequence for COL2A1_ZNF609


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_COL2A1_ENST00000380518_chr12_48398020_-_ZNF609_ENST00000326648_chr15_64915026_+_1191aa
MIRLGAPQTLVLLTLLVAAVLRCQGQDVHGVPCFHTSSAANTPFGASGQQXHLISLXADHGSYPISWGQHMXCGSGHRAXVLGPLXTWNX
RQPXRHRVAGNRRWDVGGKCNVEEQDICRYTPXLHTTXLGTPKVLXLPDQXPGNAQWPGXRQTHASQQXYTCQXDSHSLXQQRDQXQQQN
PGRSQXQRPSGQPEFFRAPPTCQQHFXGCQGQPFLSXXAEKQTPFRHGAEFXLRGLQREQACPYXFHGLSHWPPSWDKGRTHCSGQKLPL
PRPNXLSPPKLQQEVQAHQWTXVPPSSCPYRXXQQAGSGWGQXVRRGTYSPCRSWELQRCICLTKRFLVPCPLSYPQSSTCRAPXPFSFK
QIQHKRPLXEKVEWGRGHRPWGLIQXWLXXWTLSDGXNKQXCLXFFRKEVYGKRKMXKTLXFKTXKDSFQEPKVSPSHCPCHPPTANLHL
PDSHLHSSEPRLFLRLDRHSGTSHAQQSPTQAHSAQAHCYGRTFHSQPCLDSSQGQEKERQKKEGIFKGTXKSSDPWEGVSSRGRQKPIQ
GIFRRWDENGGAPKWLIRPPPKPTGXHQGXSRQDLQFHGQCPQPFHWRQXPPXKHYPYSAPDSLTCGDPEWSXSQLSQNQQPCILXHLXC
WGGWGGQGRQCQIKGRRTVGXRRGXENSFSPSASEQRLTILPRLXELLFSKLCTVQPWGSEPQQPGRSGEPGPEDKKGXGTXEHRRESEE
RYLXRKEARAEQFQSAALGHPAASQYVHAVPVLQPVCLCTPLWLQRPELPHPPSEHXHGLPAAVRRTAETPELRAAAAGSGQEGRDGPEG
AGGSTQGRVEAKAVNSTNSHQGPQPDRPGEIRTWQGQGARGXPSQISHHSQVRXLFKTPGPGPXRPXSEAEXCQPPKQGGLXGQDRCXVW
STGRDGSNTLVPTGGRAPDVDICLSCQVLRHQVRGXAVEGGAGPQIEGGKESEXGLCPQGRWEGKHKXXLQAAHVRGVSPWEQGAPAKCP
CACVLPTYPAPVLHPLHARLFLQSVLRPQPPQLPEHACCDDAELPRFLPAFQLLFFPIWQQGLRWXRCXQGTSQPQCDLXIQLRVQSPGH
LAAACQSLQEQVSHDKXXNFSGERSRRLWGGWGWWQLXQRRGSKWGXTECXPAPHLSFPAPDVHTPPPPPLGVLIAPSTVQLTLCSRAFF

>In-frame_COL2A1_ENST00000337299_chr12_48398020_-_ZNF609_ENST00000326648_chr15_64915026_+_1191aa
MIRLGAPQTLVLLTLLVAAVLRCQGQDVHGVPCFHTSSAANTPFGASGQQXHLISLXADHGSYPISWGQHMXCGSGHRAXVLGPLXTWNX
RQPXRHRVAGNRRWDVGGKCNVEEQDICRYTPXLHTTXLGTPKVLXLPDQXPGNAQWPGXRQTHASQQXYTCQXDSHSLXQQRDQXQQQN
PGRSQXQRPSGQPEFFRAPPTCQQHFXGCQGQPFLSXXAEKQTPFRHGAEFXLRGLQREQACPYXFHGLSHWPPSWDKGRTHCSGQKLPL
PRPNXLSPPKLQQEVQAHQWTXVPPSSCPYRXXQQAGSGWGQXVRRGTYSPCRSWELQRCICLTKRFLVPCPLSYPQSSTCRAPXPFSFK
QIQHKRPLXEKVEWGRGHRPWGLIQXWLXXWTLSDGXNKQXCLXFFRKEVYGKRKMXKTLXFKTXKDSFQEPKVSPSHCPCHPPTANLHL
PDSHLHSSEPRLFLRLDRHSGTSHAQQSPTQAHSAQAHCYGRTFHSQPCLDSSQGQEKERQKKEGIFKGTXKSSDPWEGVSSRGRQKPIQ
GIFRRWDENGGAPKWLIRPPPKPTGXHQGXSRQDLQFHGQCPQPFHWRQXPPXKHYPYSAPDSLTCGDPEWSXSQLSQNQQPCILXHLXC
WGGWGGQGRQCQIKGRRTVGXRRGXENSFSPSASEQRLTILPRLXELLFSKLCTVQPWGSEPQQPGRSGEPGPEDKKGXGTXEHRRESEE
RYLXRKEARAEQFQSAALGHPAASQYVHAVPVLQPVCLCTPLWLQRPELPHPPSEHXHGLPAAVRRTAETPELRAAAAGSGQEGRDGPEG
AGGSTQGRVEAKAVNSTNSHQGPQPDRPGEIRTWQGQGARGXPSQISHHSQVRXLFKTPGPGPXRPXSEAEXCQPPKQGGLXGQDRCXVW
STGRDGSNTLVPTGGRAPDVDICLSCQVLRHQVRGXAVEGGAGPQIEGGKESEXGLCPQGRWEGKHKXXLQAAHVRGVSPWEQGAPAKCP
CACVLPTYPAPVLHPLHARLFLQSVLRPQPPQLPEHACCDDAELPRFLPAFQLLFFPIWQQGLRWXRCXQGTSQPQCDLXIQLRVQSPGH
LAAACQSLQEQVSHDKXXNFSGERSRRLWGGWGWWQLXQRRGSKWGXTECXPAPHLSFPAPDVHTPPPPPLGVLIAPSTVQLTLCSRAFF


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_COL2A1_ENST00000380518_chr12_48398020_-_ZNF609_ENST00000326648_chr15_64915026_+_3574nt
ATGATTCGCCTCGGGGCTCCCCAGACGCTGGTGCTGCTGACGCTGCTCGTCGCCGCTGTCCTTCGGTGTCAGGGCCAGGATGTCCATGGA
GTCCCCTGTTTCCACACCAGCAGTGCTGCCAATACACCTTTTGGTGCCAGTGGTCAACAATGACATCTCATCTCCCTGTGAGCAGATCAT
GGTTCGTACCCGATCAGTTGGGGTCAACACATGTGATGTGGCTCTGGCCACAGAGCCTGAGTGCTTGGGCCCCTGTGAACCTGGAACTAG
CGTCAACCTTGAAGGCATCGTGTGGCAGGAAACAGAAGATGGGATGTTGGTGGTAAATGTAACGTGGAGGAACAAGACATATGTAGGTAC
ACTCCTTGACTGCACACGACATGATTGGGCACCCCCAAGGTTCTGTGACTCCCCGACCAGTGACCTGGAAATGCGCAATGGCCGGGGTAG
AGGCAAACGCATGCGTCCCAACAGTAATACACCTGTCAATGAGACAGCCACAGCCTCTGACAGCAAAGGGACCAGTAACAGCAGCAAAAC
CCGGGCAGGAGCCAATAGCAAAGGCCGTCGGGGCAGCCAGAATTCTTCAGAGCACCGCCCACCTGCCAGCAGCACTTCTGAGGATGTCAA
GGCCAGCCCTTCCTCAGCTAATAAGCGGAAAAACAAACCCCTTTCAGACATGGAGCTGAATTCTAGCTCAGAGGACTCCAAAGGGAGCAA
GCGTGTCCGTACTAATTCCATGGGCTCAGCCACTGGCCCCCTTCCTGGGACAAAGGTAGAACCCACTGTTCTGGACAGAAACTGCCCCTC
CCCCGTCCTAATTGACTGTCCCCACCCAAACTGCAACAAGAAGTACAAGCACATCAATGGACTTAAGTACCACCAAGCTCATGCCCATAC
AGATGATGACAGCAAGCCGGAAGCGGATGGGGACAGTGAGTACGGAGAGGAACCTATTCTCCATGCAGATCTTGGGAGCTGCAACGGTGC
ATCTGTCTCACAAAAAGGTTCCTTGTCCCCTGCCCGCTCAGCTACCCCCAAAGTTCGACTTGTAGAGCCCCATAGCCCTTCTCCTTCAAG
CAAATTCAGCACAAAAGGCCTCTGTAAGAAAAAGTTGAGTGGGGAAGGGGACACAGACCTTGGGGCCTTATCCAATGATGGCTCTGATGA
TGGACCCTCAGTGATGGATGAAACAAGCAATGATGCCTTTGATTCTTTAGAAAGGAAGTGTATGGAAAAAGAAAAATGTAAAAAACCCTC
TAGTTTAAAACCTGAAAAGATTCCTTCCAAGAGCCTAAAGTCAGCCCGTCCCATTGCCCCTGCCATCCCCCCACAGCAAATCTACACCTT
CCAGACAGCCACCTTCACAGCAGCGAGCCCAGGCTCTTCCTCAGGCTTGACCGCCACAGTGGCACAAGCCATGCCCAACAGTCCCCAACT
CAAGCCCATTCAGCCCAAGCCCACTGTTATGGGAGAACCTTTCACAGTCAACCCTGCCTTGACTCCAGCCAAGGACAAGAAAAAGAAAGA
CAAAAAAAAGAAGGAATCTTCAAAGGAACTTGAAAGTCCTCTGACCCCTGGGAAGGTGTGTCGAGCAGAGGAAGGCAAAAGCCCATTCAG
GGAATCTTCAGGAGATGGGATGAAAATGGAGGGGCTCCTAAATGGCTCATCAGACCCCCACCAAAGCCGACTGGCTAGCATCAAGGCTGA
AGCCGACAAGATCTACAGTTTCACGGACAATGCCCCCAGCCCTTCCATTGGAGGCAGTAGCCGCCTTGAAAACACTACCCCTACTCAGCC
CCTGACTCCCTTACATGTGGTGACCCAGAATGGAGCTGAAGCCAGCTCAGTCAAAACCAACAGCCCTGCATACTCTGACATCTCTGATGC
TGGGGAGGATGGGGAGGGCAAGGTAGACAGTGTCAAATCAAAGGACGCCGAACAGTTGGTTAAAGAAGGGGCTAAGAAAACTCTTTTTCC
CCCTCAGCCTCAGAGCAAAGACTCACCATATTACCAAGGCTTTGAGAGTTACTATTCTCCAAGTTATGCACAGTCCAGCCCTGGGGCTCT
GAACCCCAGCAGCCAGGCAGGAGTGGAGAGCCAGGCCCTGAAGACAAAAAGGGATGAGGAACCTGAGAGCATAGAAGGGAAAGTGAAGAA
CGATATCTGTGAAGAAAAGAAGCCCGAGCTGAGCAGTTCCAGTCAGCAGCCCTCGGTCATCCAGCAGCGTCCCAATATGTACATGCAGTC
CCTGTACTACAACCAGTATGCCTATGTACCCCCCTATGGCTACAGCGACCAGAGTTACCACACCCACCTTCTGAGCACTAACACGGCTTA
CCGGCAGCAGTACGAAGAACAGCAGAAACGCCAGAGCTTAGAGCAGCAGCAGCGGGGAGTGGACAAGAAGGCAGAGATGGGCCTGAAGGA
GCGGGAGGCAGCACTCAAGGAAGAGTGGAAGCAAAAGCCGTCAATTCCACCAACTCTCACCAAGGCCCCCAGCCTGACAGACCTGGTGAA
ATCAGGACCTGGCAAGGCCAAGGAGCCAGGGGCTGACCCAGCCAAATCAGTCATCATTCCCAAGTTAGATGACTCTTCAAAACTCCCGGG
CCAGGCCCCTGAAGGCCTTAAAGTGAAGCTGAGTGATGCCAGCCACCTAAGCAAGGAGGCCTCTGAGGCCAAGACAGGTGCTGAGTGTGG
TCGACAGGCAGAGATGGATCCAATACTCTGGTACCGACAGGAGGCAGAGCCCCGGATGTGGACATATGTTTATCCTGCCAAGTACTCAGA
CATCAAGTCAGAGGATGAGCGGTGGAAGGAGGAGCGGGACCGCAAATTGAAGGAGGAAAGGAGTCGGAGTAAGGACTCTGTCCCCAAGGA
AGATGGGAAGGAAAGCACAAGTAGTGACTGCAAGCTGCCCACGTCAGAGGAGTCTCGCCTTGGGAGCAAGGAGCCCCGGCCAAGTGTCCA
TGTGCCTGTGTCCTCCCCACTTACCCAGCACCAGTCCTACATCCCCTACATGCACGGCTATTCCTACAGTCAGTCCTACGACCCCAACCA
CCCCAGCTACCGGAGCATGCCTGCTGTGATGATGCAGAACTACCCAGGTTCCTACCTGCCTTCCAGCTACTCTTTTTCCCCATATGGCAG
CAAGGTCTCAGGTGGTGAAGATGCTGACAAGGCACGAGCCAGCCCCAGTGTGACTTGTAAATCCAGCTCAGAGTCCAAAGCCCTGGACAT
CTTGCAGCAGCATGCCAGTCACTACAAGAGCAAGTCTCCCACGATAAGTGATAAAACTTCTCAGGAGAGAGATCGAGGAGGCTGTGGGGT
GGTTGGGGGTGGTGGCAGCTGTAGCAGCGTCGGGGGAGCAAGTGGGGGTGAACGGAGTGTTGACCGGCCCCGCACCTCTCCTTCCCAGCG
CCTGATGTCCACACACCACCACCACCACCACTTGGGGTACTCATTGCTCCCAGCACAGTACAACTTACCCTATGCAGCAGGGCTTTCTTC

>In-frame_COL2A1_ENST00000337299_chr12_48398020_-_ZNF609_ENST00000326648_chr15_64915026_+_3574nt
ATGATTCGCCTCGGGGCTCCCCAGACGCTGGTGCTGCTGACGCTGCTCGTCGCCGCTGTCCTTCGGTGTCAGGGCCAGGATGTCCATGGA
GTCCCCTGTTTCCACACCAGCAGTGCTGCCAATACACCTTTTGGTGCCAGTGGTCAACAATGACATCTCATCTCCCTGTGAGCAGATCAT
GGTTCGTACCCGATCAGTTGGGGTCAACACATGTGATGTGGCTCTGGCCACAGAGCCTGAGTGCTTGGGCCCCTGTGAACCTGGAACTAG
CGTCAACCTTGAAGGCATCGTGTGGCAGGAAACAGAAGATGGGATGTTGGTGGTAAATGTAACGTGGAGGAACAAGACATATGTAGGTAC
ACTCCTTGACTGCACACGACATGATTGGGCACCCCCAAGGTTCTGTGACTCCCCGACCAGTGACCTGGAAATGCGCAATGGCCGGGGTAG
AGGCAAACGCATGCGTCCCAACAGTAATACACCTGTCAATGAGACAGCCACAGCCTCTGACAGCAAAGGGACCAGTAACAGCAGCAAAAC
CCGGGCAGGAGCCAATAGCAAAGGCCGTCGGGGCAGCCAGAATTCTTCAGAGCACCGCCCACCTGCCAGCAGCACTTCTGAGGATGTCAA
GGCCAGCCCTTCCTCAGCTAATAAGCGGAAAAACAAACCCCTTTCAGACATGGAGCTGAATTCTAGCTCAGAGGACTCCAAAGGGAGCAA
GCGTGTCCGTACTAATTCCATGGGCTCAGCCACTGGCCCCCTTCCTGGGACAAAGGTAGAACCCACTGTTCTGGACAGAAACTGCCCCTC
CCCCGTCCTAATTGACTGTCCCCACCCAAACTGCAACAAGAAGTACAAGCACATCAATGGACTTAAGTACCACCAAGCTCATGCCCATAC
AGATGATGACAGCAAGCCGGAAGCGGATGGGGACAGTGAGTACGGAGAGGAACCTATTCTCCATGCAGATCTTGGGAGCTGCAACGGTGC
ATCTGTCTCACAAAAAGGTTCCTTGTCCCCTGCCCGCTCAGCTACCCCCAAAGTTCGACTTGTAGAGCCCCATAGCCCTTCTCCTTCAAG
CAAATTCAGCACAAAAGGCCTCTGTAAGAAAAAGTTGAGTGGGGAAGGGGACACAGACCTTGGGGCCTTATCCAATGATGGCTCTGATGA
TGGACCCTCAGTGATGGATGAAACAAGCAATGATGCCTTTGATTCTTTAGAAAGGAAGTGTATGGAAAAAGAAAAATGTAAAAAACCCTC
TAGTTTAAAACCTGAAAAGATTCCTTCCAAGAGCCTAAAGTCAGCCCGTCCCATTGCCCCTGCCATCCCCCCACAGCAAATCTACACCTT
CCAGACAGCCACCTTCACAGCAGCGAGCCCAGGCTCTTCCTCAGGCTTGACCGCCACAGTGGCACAAGCCATGCCCAACAGTCCCCAACT
CAAGCCCATTCAGCCCAAGCCCACTGTTATGGGAGAACCTTTCACAGTCAACCCTGCCTTGACTCCAGCCAAGGACAAGAAAAAGAAAGA
CAAAAAAAAGAAGGAATCTTCAAAGGAACTTGAAAGTCCTCTGACCCCTGGGAAGGTGTGTCGAGCAGAGGAAGGCAAAAGCCCATTCAG
GGAATCTTCAGGAGATGGGATGAAAATGGAGGGGCTCCTAAATGGCTCATCAGACCCCCACCAAAGCCGACTGGCTAGCATCAAGGCTGA
AGCCGACAAGATCTACAGTTTCACGGACAATGCCCCCAGCCCTTCCATTGGAGGCAGTAGCCGCCTTGAAAACACTACCCCTACTCAGCC
CCTGACTCCCTTACATGTGGTGACCCAGAATGGAGCTGAAGCCAGCTCAGTCAAAACCAACAGCCCTGCATACTCTGACATCTCTGATGC
TGGGGAGGATGGGGAGGGCAAGGTAGACAGTGTCAAATCAAAGGACGCCGAACAGTTGGTTAAAGAAGGGGCTAAGAAAACTCTTTTTCC
CCCTCAGCCTCAGAGCAAAGACTCACCATATTACCAAGGCTTTGAGAGTTACTATTCTCCAAGTTATGCACAGTCCAGCCCTGGGGCTCT
GAACCCCAGCAGCCAGGCAGGAGTGGAGAGCCAGGCCCTGAAGACAAAAAGGGATGAGGAACCTGAGAGCATAGAAGGGAAAGTGAAGAA
CGATATCTGTGAAGAAAAGAAGCCCGAGCTGAGCAGTTCCAGTCAGCAGCCCTCGGTCATCCAGCAGCGTCCCAATATGTACATGCAGTC
CCTGTACTACAACCAGTATGCCTATGTACCCCCCTATGGCTACAGCGACCAGAGTTACCACACCCACCTTCTGAGCACTAACACGGCTTA
CCGGCAGCAGTACGAAGAACAGCAGAAACGCCAGAGCTTAGAGCAGCAGCAGCGGGGAGTGGACAAGAAGGCAGAGATGGGCCTGAAGGA
GCGGGAGGCAGCACTCAAGGAAGAGTGGAAGCAAAAGCCGTCAATTCCACCAACTCTCACCAAGGCCCCCAGCCTGACAGACCTGGTGAA
ATCAGGACCTGGCAAGGCCAAGGAGCCAGGGGCTGACCCAGCCAAATCAGTCATCATTCCCAAGTTAGATGACTCTTCAAAACTCCCGGG
CCAGGCCCCTGAAGGCCTTAAAGTGAAGCTGAGTGATGCCAGCCACCTAAGCAAGGAGGCCTCTGAGGCCAAGACAGGTGCTGAGTGTGG
TCGACAGGCAGAGATGGATCCAATACTCTGGTACCGACAGGAGGCAGAGCCCCGGATGTGGACATATGTTTATCCTGCCAAGTACTCAGA
CATCAAGTCAGAGGATGAGCGGTGGAAGGAGGAGCGGGACCGCAAATTGAAGGAGGAAAGGAGTCGGAGTAAGGACTCTGTCCCCAAGGA
AGATGGGAAGGAAAGCACAAGTAGTGACTGCAAGCTGCCCACGTCAGAGGAGTCTCGCCTTGGGAGCAAGGAGCCCCGGCCAAGTGTCCA
TGTGCCTGTGTCCTCCCCACTTACCCAGCACCAGTCCTACATCCCCTACATGCACGGCTATTCCTACAGTCAGTCCTACGACCCCAACCA
CCCCAGCTACCGGAGCATGCCTGCTGTGATGATGCAGAACTACCCAGGTTCCTACCTGCCTTCCAGCTACTCTTTTTCCCCATATGGCAG
CAAGGTCTCAGGTGGTGAAGATGCTGACAAGGCACGAGCCAGCCCCAGTGTGACTTGTAAATCCAGCTCAGAGTCCAAAGCCCTGGACAT
CTTGCAGCAGCATGCCAGTCACTACAAGAGCAAGTCTCCCACGATAAGTGATAAAACTTCTCAGGAGAGAGATCGAGGAGGCTGTGGGGT
GGTTGGGGGTGGTGGCAGCTGTAGCAGCGTCGGGGGAGCAAGTGGGGGTGAACGGAGTGTTGACCGGCCCCGCACCTCTCCTTCCCAGCG
CCTGATGTCCACACACCACCACCACCACCACTTGGGGTACTCATTGCTCCCAGCACAGTACAACTTACCCTATGCAGCAGGGCTTTCTTC


* Fusion transcript sequences (Full-length transcript).
>In-frame_COL2A1_ENST00000380518_chr12_48398020_-_ZNF609_ENST00000326648_chr15_64915026_+_8118nt
GGGAGAAGACGCAGAGCGCTGCTGGGCTGCCGGGTCTCCCGCTTCCCCCTCCTGCTCCAAGGGCCTCCTGCATGAGGGCGCGGTAGAGAC
CCGGACCCGCGCCGTGCTCCTGCCGTTTCGCTGCGCTCCGCCCGGGCCCGGCTCAGCCAGGCCCCGCGGTGAGCCATGATTCGCCTCGGG
GCTCCCCAGACGCTGGTGCTGCTGACGCTGCTCGTCGCCGCTGTCCTTCGGTGTCAGGGCCAGGATGTCCATGGAGTCCCCTGTTTCCAC
ACCAGCAGTGCTGCCAATACACCTTTTGGTGCCAGTGGTCAACAATGACATCTCATCTCCCTGTGAGCAGATCATGGTTCGTACCCGATC
AGTTGGGGTCAACACATGTGATGTGGCTCTGGCCACAGAGCCTGAGTGCTTGGGCCCCTGTGAACCTGGAACTAGCGTCAACCTTGAAGG
CATCGTGTGGCAGGAAACAGAAGATGGGATGTTGGTGGTAAATGTAACGTGGAGGAACAAGACATATGTAGGTACACTCCTTGACTGCAC
ACGACATGATTGGGCACCCCCAAGGTTCTGTGACTCCCCGACCAGTGACCTGGAAATGCGCAATGGCCGGGGTAGAGGCAAACGCATGCG
TCCCAACAGTAATACACCTGTCAATGAGACAGCCACAGCCTCTGACAGCAAAGGGACCAGTAACAGCAGCAAAACCCGGGCAGGAGCCAA
TAGCAAAGGCCGTCGGGGCAGCCAGAATTCTTCAGAGCACCGCCCACCTGCCAGCAGCACTTCTGAGGATGTCAAGGCCAGCCCTTCCTC
AGCTAATAAGCGGAAAAACAAACCCCTTTCAGACATGGAGCTGAATTCTAGCTCAGAGGACTCCAAAGGGAGCAAGCGTGTCCGTACTAA
TTCCATGGGCTCAGCCACTGGCCCCCTTCCTGGGACAAAGGTAGAACCCACTGTTCTGGACAGAAACTGCCCCTCCCCCGTCCTAATTGA
CTGTCCCCACCCAAACTGCAACAAGAAGTACAAGCACATCAATGGACTTAAGTACCACCAAGCTCATGCCCATACAGATGATGACAGCAA
GCCGGAAGCGGATGGGGACAGTGAGTACGGAGAGGAACCTATTCTCCATGCAGATCTTGGGAGCTGCAACGGTGCATCTGTCTCACAAAA
AGGTTCCTTGTCCCCTGCCCGCTCAGCTACCCCCAAAGTTCGACTTGTAGAGCCCCATAGCCCTTCTCCTTCAAGCAAATTCAGCACAAA
AGGCCTCTGTAAGAAAAAGTTGAGTGGGGAAGGGGACACAGACCTTGGGGCCTTATCCAATGATGGCTCTGATGATGGACCCTCAGTGAT
GGATGAAACAAGCAATGATGCCTTTGATTCTTTAGAAAGGAAGTGTATGGAAAAAGAAAAATGTAAAAAACCCTCTAGTTTAAAACCTGA
AAAGATTCCTTCCAAGAGCCTAAAGTCAGCCCGTCCCATTGCCCCTGCCATCCCCCCACAGCAAATCTACACCTTCCAGACAGCCACCTT
CACAGCAGCGAGCCCAGGCTCTTCCTCAGGCTTGACCGCCACAGTGGCACAAGCCATGCCCAACAGTCCCCAACTCAAGCCCATTCAGCC
CAAGCCCACTGTTATGGGAGAACCTTTCACAGTCAACCCTGCCTTGACTCCAGCCAAGGACAAGAAAAAGAAAGACAAAAAAAAGAAGGA
ATCTTCAAAGGAACTTGAAAGTCCTCTGACCCCTGGGAAGGTGTGTCGAGCAGAGGAAGGCAAAAGCCCATTCAGGGAATCTTCAGGAGA
TGGGATGAAAATGGAGGGGCTCCTAAATGGCTCATCAGACCCCCACCAAAGCCGACTGGCTAGCATCAAGGCTGAAGCCGACAAGATCTA
CAGTTTCACGGACAATGCCCCCAGCCCTTCCATTGGAGGCAGTAGCCGCCTTGAAAACACTACCCCTACTCAGCCCCTGACTCCCTTACA
TGTGGTGACCCAGAATGGAGCTGAAGCCAGCTCAGTCAAAACCAACAGCCCTGCATACTCTGACATCTCTGATGCTGGGGAGGATGGGGA
GGGCAAGGTAGACAGTGTCAAATCAAAGGACGCCGAACAGTTGGTTAAAGAAGGGGCTAAGAAAACTCTTTTTCCCCCTCAGCCTCAGAG
CAAAGACTCACCATATTACCAAGGCTTTGAGAGTTACTATTCTCCAAGTTATGCACAGTCCAGCCCTGGGGCTCTGAACCCCAGCAGCCA
GGCAGGAGTGGAGAGCCAGGCCCTGAAGACAAAAAGGGATGAGGAACCTGAGAGCATAGAAGGGAAAGTGAAGAACGATATCTGTGAAGA
AAAGAAGCCCGAGCTGAGCAGTTCCAGTCAGCAGCCCTCGGTCATCCAGCAGCGTCCCAATATGTACATGCAGTCCCTGTACTACAACCA
GTATGCCTATGTACCCCCCTATGGCTACAGCGACCAGAGTTACCACACCCACCTTCTGAGCACTAACACGGCTTACCGGCAGCAGTACGA
AGAACAGCAGAAACGCCAGAGCTTAGAGCAGCAGCAGCGGGGAGTGGACAAGAAGGCAGAGATGGGCCTGAAGGAGCGGGAGGCAGCACT
CAAGGAAGAGTGGAAGCAAAAGCCGTCAATTCCACCAACTCTCACCAAGGCCCCCAGCCTGACAGACCTGGTGAAATCAGGACCTGGCAA
GGCCAAGGAGCCAGGGGCTGACCCAGCCAAATCAGTCATCATTCCCAAGTTAGATGACTCTTCAAAACTCCCGGGCCAGGCCCCTGAAGG
CCTTAAAGTGAAGCTGAGTGATGCCAGCCACCTAAGCAAGGAGGCCTCTGAGGCCAAGACAGGTGCTGAGTGTGGTCGACAGGCAGAGAT
GGATCCAATACTCTGGTACCGACAGGAGGCAGAGCCCCGGATGTGGACATATGTTTATCCTGCCAAGTACTCAGACATCAAGTCAGAGGA
TGAGCGGTGGAAGGAGGAGCGGGACCGCAAATTGAAGGAGGAAAGGAGTCGGAGTAAGGACTCTGTCCCCAAGGAAGATGGGAAGGAAAG
CACAAGTAGTGACTGCAAGCTGCCCACGTCAGAGGAGTCTCGCCTTGGGAGCAAGGAGCCCCGGCCAAGTGTCCATGTGCCTGTGTCCTC
CCCACTTACCCAGCACCAGTCCTACATCCCCTACATGCACGGCTATTCCTACAGTCAGTCCTACGACCCCAACCACCCCAGCTACCGGAG
CATGCCTGCTGTGATGATGCAGAACTACCCAGGTTCCTACCTGCCTTCCAGCTACTCTTTTTCCCCATATGGCAGCAAGGTCTCAGGTGG
TGAAGATGCTGACAAGGCACGAGCCAGCCCCAGTGTGACTTGTAAATCCAGCTCAGAGTCCAAAGCCCTGGACATCTTGCAGCAGCATGC
CAGTCACTACAAGAGCAAGTCTCCCACGATAAGTGATAAAACTTCTCAGGAGAGAGATCGAGGAGGCTGTGGGGTGGTTGGGGGTGGTGG
CAGCTGTAGCAGCGTCGGGGGAGCAAGTGGGGGTGAACGGAGTGTTGACCGGCCCCGCACCTCTCCTTCCCAGCGCCTGATGTCCACACA
CCACCACCACCACCACTTGGGGTACTCATTGCTCCCAGCACAGTACAACTTACCCTATGCAGCAGGGCTTTCTTCTACAGCCATTGTTGC
CAGCCAACAAGGCTCAACTCCCTCACTCTACCCACCCCCCAGGAGGTGAGAATGACACCAAGTGCCCGGATAAAGTCAGCTTCACGGGCC
CGGACTGGCTTACCCAAGGAGGTGCTGAAGGTGCCGTTTAGACATCAGTTAAATGGTGTTGATCATCCTGTTTGCCGTTTCCACCATGAC
TGAAGGCAGACCCTTGGCTATCTCACCTCCACCAGACCTCCGGACTACCTGACCCTACCTCTTCCTCAGGAGCTGGAGAGCTGGTACTTA
GCAAAAATATTTATTCTCTCAGCCACAGTTATGACTATTGTGGCCTCTGTGGAGATGAAGGCACGGGAAGCAACCAGGGGAACATGGCCT
CAGCCCAGAGAAGCCACTGCTCTGTTCCCCAAGCCCTTGGTCTGCTGCTGGAGCAGTACCAGCCCCCCCGCCCACCAGGGAGGGACCCCC
ACCCCCAAGCACTGGGTAAGGTCTGAAGACAGCACAGCAGCCATACCCCTCACCATCATTACCACCATCACCAGATTCTGCATCTCCCTA
GTGCTTTGCACCCTGGGAATTGGCAGCATGTGGAGGAACTAGAATCTCAGGAAAGAAATTGGGGGTTGTTTTCTACATAATTGTGAAAAC
AAGGTCTTCAAATGTGGAGACTTCTCCCCATTTACATGAGCACATATAAACGCTCACAACCTAGCCTGGAAAGGAAGACCAAGGCATCTG
CCCCAACATGGCCTTGAGCTGCCTGTGAGGCAGGGGGCAGGGGTTCCAACACCAGCACAGGGCTCCCCAGGGACACTGGGAGCAAGCTGG
TGCTGGAGCATGAATGACGTCTGTGAAGTAGAACCTGCGTCCCCACTAAGTCCTGCTGCTTCTTATTCCCCAACTCCTTGCCCTTTTCCC
TTCCCTCCTAACCCCTTGGTGCCTTTCCCAGGGGGATCCCCACACTGGTCTTGCCTCTTCTTTTCCACTGCTTGGCTCTTAAGCCTCAGG
CAGATAAACTAGTATTCCCCCCAGCTTGGGGAACCTTGGAGTCTGCCAGGTCACCTTAGGGCAAGGCCCAGAAGGCAGCCCCTGGGAGCA
CCCAGCAGTTCTTGGAGATGTCCTGTCATCTAGCCATCTGATATCTTCCTCATTTGAGGCCACAGATATATACAGCCCAATTCCTCTGTC
TACAAGTACATGATTTTATATAGCTCAGTCTATAACCTCCATGTGGGCCAATATAAGCTGTGTTTCTTGGTAACACATATTTTGTTTGAG
GGGCCACTGGCCATGGGAGGTTATTTGTTCCTTAGACCCTGGAATAACACATCCAAGCCATTACTTATTAGAGTCTCAGAATGTACTCAG
TGGAGCTGTGCTTTGAGGCAGCCAACATTTCTCTGCTCTCCTTAGAAATGCAGTCTCCCAATGGAAGCTTTATACTCTTTGTACTGGGAA
AGTGAGGATGATTTGGTAGCTTTATTGGGGTCATGTCTTCCCCAAGGTGTGGGGAGCTTAGCTTACTTGGCTTTTGAGGTATCATCCCTC
TGTTCTCCCCTCCTATCTTTCCATGACCCTCTGGATTGAGAGAGAGAGATAAAGACTGACAGACACCAGTGTAGGCTGGAAAAGGGAGTG
TGTGACCAGAGTGCCAAAAGTGACTAGGAGCAGGAACTTGGCTCCGACTCAGTTTGGAAAATGGGAAATAGGGGACAGTAAGCACAATGC
CCAGTAGTAGTTGATTTCCAAGGACCCTGGAACCCTACACTTGAGAGGCTTAGGGTCACCATCTGCTCAAGAGGATCCCCTCTGATCTAC
AGGCCTTTTCCCTAGGTTTCTGCCTCCTCGTTTTTGTTCAAGTTGGGTTCTGAGTCCTCCCCAAAAACCATTGTTTTAGACCTCTTGGCA
GGGCCCCAAAACAGCCTCCCTCATACCCATCATTCCCTCTGCCTTCTGCTGCCCTCATGGGCAGTGCTCTGAGCAGTGACCTCCCTTTCC
TCCGTGGAAGTAGCTAGTGCAGACACCGTCATCCCACCCCACCTGAGTCACCCCAACCAAGAGGGTGACTGAATTTCAGCCTGATTATGC
CCTCCTGGGGCTCCTGTGAGGTGGAGCCAAGGTTCCCTCTCTGTTCCTGTTTGTTTTTAAATATTGTTGTGTGTTTTGTATCTGTGGCAC
TGGCCTGCAGCATACTCTGTATATATTGTAAAGAAACCGTTAGGAGTAATTTTCTTTTGCATTGGGCAGGCATGGCCCTGCATTCCTGCC
CTTTCCACTCATTCTGTAACACAGAGGACGAACTTCTGTATTAGCTGGGCAGCCTTGGGTTCTCCAGAAGAGAACAGGTTTTTCTTTTCC
TTTTTAATTTTTCTTCTTAAACATTTGGCTCTTTGATCCTCATATCCAAGTCTCCCCTGAAGAGTAGGAGCTGCTCAGAAGAGCAGGTGA
AAGCCACCATGGCAGATCCTGATGCCTGCCGGGCCTAGTCTTCCCTCTGAAATAACATGAAGCAGCAGCTGTGGAGATTCTTGACAAGTG
CTGAGTGAAAGATTTGCTGCCCACCTCTACATGGGGAGGAGAAACACAGGTGGGAGCTACCTGTGGCATCCATGACCTAGTCAGAGGGAT
GAGATGCTCAGCAGGGGTCCCCATCCTATCCCACCCCACAAACAAAGGCTGGAAAAATTTGCTACCAAGGGCCAAGACCACCAGACCAAG
CCTGTTTATGAGCCACCCCTGCCCAGGCCCTCACAGACATTGCTCACGGGGCTTCCCATAGAGGAGAAGCTAAAGAGGGAGGGGGCCTCA
TCCCCAGATAGATCAGGCAAGGCTTGGAGAGCTGCTCTTTAGGATCCACATCAACTACTTCCTCATTTTAAGGTATGGCAGTTCCCTTCA
TCCCCTTTTCCTGCCTTGTACATGTACATGTATGAAATTTCCTTCTCTTACCGAACTCTCTCCACACATCACAAGGTCAAAGAACCACAC
GCTTAGAAGGGTAAGAGGGCACCCTATGAAATGAAATGGTGATTTCTTGAGTCTCTTTTTTCCACGTTTAAGGGGCCATGGCAGGACTTA
GAGTTGCGAGTTAAGACTGCAGAGGGCTAGAGAATTATTTCATACAGGCTTTGAGGCCACCCATGTCACTTATCCCGTATACCCTCTCAC
CATCCCCTTGTCTACTCTGATGCCCCCAAGATGCAACTGGGCAGCTAGTTGGCCCCATAATTCTGGGCCTTTGTTGTTTGTTTTAATTAC
TTGGGCATCCCAGGAAGCTTTCCAGTGATCTCCTACCATGGGCCCCCCTCCTGGGATCAAGCCCCTCCCAGGCCCTGTCCCCAGCCCCTC
CTGCCCCAGCCCACCCGCTTGCCTTGGTGCTCAGCCCTCCCATTGGGAGCAGGTTGGGGCGAGCTGGAGGCCCGGGCTGGAGGGGCAGTG
TTGCTGTTCATAGATTTTGTTCCATTGGCGTTGCTCTGTTGAATTTAATTTCAGTCTTCCTGATTCTTCCCTTCTGTAAAGTGTACATTA
CCAAGTTCCTTGTTTTTTTATATATATATATAAATATATATATATACAAACTGTACTCTTTTTGCCTTTGTACATTCAGGCAAGAAGAGA
AAATAAATCTTTTTAAGAGACAATCACAAATCTGTGAGGGCTGCTGGTTATTTCTCCTGGAGTTTGCTGCTGAGCTGCCTCTTCCTTCCT
CCCAATTTTCCTGTTCTCCCTCAGCTCTCCTGATCTTCCTGGCCCTGCTCCATATGCATCCTCAGCTTCACTTTCCCTGGCTGATGGCAA
GCTGTTGAATCCAGTGTCCAGACTACCTGCCTTGTAACCCTTTTCTGCCCAGCATTGTTTTCTGGCTTGGCCACTGGCTTAGCCCAGGAG
CTTTACTCTGTGCCCTGGCCTCCCCTCTCTTCACCTTTAGATTTCCATTCACCGAAGTGGCTTTGGACCCCTGGGTACTCTGGGACCTGT
TTCCTGGAGGCCCTGGCTTGGGACACTCACCTGTGAAACTATGCAGCTGGGAGCTCTCTGCCTAAGAGTTTGCACTATTTAAACCTGCCT
GGGAGTTAGGACGGATGGTTTTAGGAATGACCGGAAAACTACCCCTAAAACTCCCCCGACATTCCAGCCTCTAGAATGCTCTGATCCAGA
GCTCAGTGGATGATTCCCAGCTGGTGGACTCCTGTGGCTACCCCATCAGAACAAGGGCTAAGGGTTTATGGGTCAAGAGTATTTGATCAG
AATTTTAAAGGGTGGTATACTCTGAAACACAGCCCAACCAAACCATTGTTTGGCCGCTTTCTCTTTTCCTCTACCTTCCTCATCCCCACT
TTTTTCCCTTTCTCTCTACTTCCTCTTCTTAATTGGCTTTGGAATTGAAATATATTTTTAAATTATTTGTTGTATTTATTGAATAAAGTT

>In-frame_COL2A1_ENST00000337299_chr12_48398020_-_ZNF609_ENST00000326648_chr15_64915026_+_7953nt
ATGATTCGCCTCGGGGCTCCCCAGACGCTGGTGCTGCTGACGCTGCTCGTCGCCGCTGTCCTTCGGTGTCAGGGCCAGGATGTCCATGGA
GTCCCCTGTTTCCACACCAGCAGTGCTGCCAATACACCTTTTGGTGCCAGTGGTCAACAATGACATCTCATCTCCCTGTGAGCAGATCAT
GGTTCGTACCCGATCAGTTGGGGTCAACACATGTGATGTGGCTCTGGCCACAGAGCCTGAGTGCTTGGGCCCCTGTGAACCTGGAACTAG
CGTCAACCTTGAAGGCATCGTGTGGCAGGAAACAGAAGATGGGATGTTGGTGGTAAATGTAACGTGGAGGAACAAGACATATGTAGGTAC
ACTCCTTGACTGCACACGACATGATTGGGCACCCCCAAGGTTCTGTGACTCCCCGACCAGTGACCTGGAAATGCGCAATGGCCGGGGTAG
AGGCAAACGCATGCGTCCCAACAGTAATACACCTGTCAATGAGACAGCCACAGCCTCTGACAGCAAAGGGACCAGTAACAGCAGCAAAAC
CCGGGCAGGAGCCAATAGCAAAGGCCGTCGGGGCAGCCAGAATTCTTCAGAGCACCGCCCACCTGCCAGCAGCACTTCTGAGGATGTCAA
GGCCAGCCCTTCCTCAGCTAATAAGCGGAAAAACAAACCCCTTTCAGACATGGAGCTGAATTCTAGCTCAGAGGACTCCAAAGGGAGCAA
GCGTGTCCGTACTAATTCCATGGGCTCAGCCACTGGCCCCCTTCCTGGGACAAAGGTAGAACCCACTGTTCTGGACAGAAACTGCCCCTC
CCCCGTCCTAATTGACTGTCCCCACCCAAACTGCAACAAGAAGTACAAGCACATCAATGGACTTAAGTACCACCAAGCTCATGCCCATAC
AGATGATGACAGCAAGCCGGAAGCGGATGGGGACAGTGAGTACGGAGAGGAACCTATTCTCCATGCAGATCTTGGGAGCTGCAACGGTGC
ATCTGTCTCACAAAAAGGTTCCTTGTCCCCTGCCCGCTCAGCTACCCCCAAAGTTCGACTTGTAGAGCCCCATAGCCCTTCTCCTTCAAG
CAAATTCAGCACAAAAGGCCTCTGTAAGAAAAAGTTGAGTGGGGAAGGGGACACAGACCTTGGGGCCTTATCCAATGATGGCTCTGATGA
TGGACCCTCAGTGATGGATGAAACAAGCAATGATGCCTTTGATTCTTTAGAAAGGAAGTGTATGGAAAAAGAAAAATGTAAAAAACCCTC
TAGTTTAAAACCTGAAAAGATTCCTTCCAAGAGCCTAAAGTCAGCCCGTCCCATTGCCCCTGCCATCCCCCCACAGCAAATCTACACCTT
CCAGACAGCCACCTTCACAGCAGCGAGCCCAGGCTCTTCCTCAGGCTTGACCGCCACAGTGGCACAAGCCATGCCCAACAGTCCCCAACT
CAAGCCCATTCAGCCCAAGCCCACTGTTATGGGAGAACCTTTCACAGTCAACCCTGCCTTGACTCCAGCCAAGGACAAGAAAAAGAAAGA
CAAAAAAAAGAAGGAATCTTCAAAGGAACTTGAAAGTCCTCTGACCCCTGGGAAGGTGTGTCGAGCAGAGGAAGGCAAAAGCCCATTCAG
GGAATCTTCAGGAGATGGGATGAAAATGGAGGGGCTCCTAAATGGCTCATCAGACCCCCACCAAAGCCGACTGGCTAGCATCAAGGCTGA
AGCCGACAAGATCTACAGTTTCACGGACAATGCCCCCAGCCCTTCCATTGGAGGCAGTAGCCGCCTTGAAAACACTACCCCTACTCAGCC
CCTGACTCCCTTACATGTGGTGACCCAGAATGGAGCTGAAGCCAGCTCAGTCAAAACCAACAGCCCTGCATACTCTGACATCTCTGATGC
TGGGGAGGATGGGGAGGGCAAGGTAGACAGTGTCAAATCAAAGGACGCCGAACAGTTGGTTAAAGAAGGGGCTAAGAAAACTCTTTTTCC
CCCTCAGCCTCAGAGCAAAGACTCACCATATTACCAAGGCTTTGAGAGTTACTATTCTCCAAGTTATGCACAGTCCAGCCCTGGGGCTCT
GAACCCCAGCAGCCAGGCAGGAGTGGAGAGCCAGGCCCTGAAGACAAAAAGGGATGAGGAACCTGAGAGCATAGAAGGGAAAGTGAAGAA
CGATATCTGTGAAGAAAAGAAGCCCGAGCTGAGCAGTTCCAGTCAGCAGCCCTCGGTCATCCAGCAGCGTCCCAATATGTACATGCAGTC
CCTGTACTACAACCAGTATGCCTATGTACCCCCCTATGGCTACAGCGACCAGAGTTACCACACCCACCTTCTGAGCACTAACACGGCTTA
CCGGCAGCAGTACGAAGAACAGCAGAAACGCCAGAGCTTAGAGCAGCAGCAGCGGGGAGTGGACAAGAAGGCAGAGATGGGCCTGAAGGA
GCGGGAGGCAGCACTCAAGGAAGAGTGGAAGCAAAAGCCGTCAATTCCACCAACTCTCACCAAGGCCCCCAGCCTGACAGACCTGGTGAA
ATCAGGACCTGGCAAGGCCAAGGAGCCAGGGGCTGACCCAGCCAAATCAGTCATCATTCCCAAGTTAGATGACTCTTCAAAACTCCCGGG
CCAGGCCCCTGAAGGCCTTAAAGTGAAGCTGAGTGATGCCAGCCACCTAAGCAAGGAGGCCTCTGAGGCCAAGACAGGTGCTGAGTGTGG
TCGACAGGCAGAGATGGATCCAATACTCTGGTACCGACAGGAGGCAGAGCCCCGGATGTGGACATATGTTTATCCTGCCAAGTACTCAGA
CATCAAGTCAGAGGATGAGCGGTGGAAGGAGGAGCGGGACCGCAAATTGAAGGAGGAAAGGAGTCGGAGTAAGGACTCTGTCCCCAAGGA
AGATGGGAAGGAAAGCACAAGTAGTGACTGCAAGCTGCCCACGTCAGAGGAGTCTCGCCTTGGGAGCAAGGAGCCCCGGCCAAGTGTCCA
TGTGCCTGTGTCCTCCCCACTTACCCAGCACCAGTCCTACATCCCCTACATGCACGGCTATTCCTACAGTCAGTCCTACGACCCCAACCA
CCCCAGCTACCGGAGCATGCCTGCTGTGATGATGCAGAACTACCCAGGTTCCTACCTGCCTTCCAGCTACTCTTTTTCCCCATATGGCAG
CAAGGTCTCAGGTGGTGAAGATGCTGACAAGGCACGAGCCAGCCCCAGTGTGACTTGTAAATCCAGCTCAGAGTCCAAAGCCCTGGACAT
CTTGCAGCAGCATGCCAGTCACTACAAGAGCAAGTCTCCCACGATAAGTGATAAAACTTCTCAGGAGAGAGATCGAGGAGGCTGTGGGGT
GGTTGGGGGTGGTGGCAGCTGTAGCAGCGTCGGGGGAGCAAGTGGGGGTGAACGGAGTGTTGACCGGCCCCGCACCTCTCCTTCCCAGCG
CCTGATGTCCACACACCACCACCACCACCACTTGGGGTACTCATTGCTCCCAGCACAGTACAACTTACCCTATGCAGCAGGGCTTTCTTC
TACAGCCATTGTTGCCAGCCAACAAGGCTCAACTCCCTCACTCTACCCACCCCCCAGGAGGTGAGAATGACACCAAGTGCCCGGATAAAG
TCAGCTTCACGGGCCCGGACTGGCTTACCCAAGGAGGTGCTGAAGGTGCCGTTTAGACATCAGTTAAATGGTGTTGATCATCCTGTTTGC
CGTTTCCACCATGACTGAAGGCAGACCCTTGGCTATCTCACCTCCACCAGACCTCCGGACTACCTGACCCTACCTCTTCCTCAGGAGCTG
GAGAGCTGGTACTTAGCAAAAATATTTATTCTCTCAGCCACAGTTATGACTATTGTGGCCTCTGTGGAGATGAAGGCACGGGAAGCAACC
AGGGGAACATGGCCTCAGCCCAGAGAAGCCACTGCTCTGTTCCCCAAGCCCTTGGTCTGCTGCTGGAGCAGTACCAGCCCCCCCGCCCAC
CAGGGAGGGACCCCCACCCCCAAGCACTGGGTAAGGTCTGAAGACAGCACAGCAGCCATACCCCTCACCATCATTACCACCATCACCAGA
TTCTGCATCTCCCTAGTGCTTTGCACCCTGGGAATTGGCAGCATGTGGAGGAACTAGAATCTCAGGAAAGAAATTGGGGGTTGTTTTCTA
CATAATTGTGAAAACAAGGTCTTCAAATGTGGAGACTTCTCCCCATTTACATGAGCACATATAAACGCTCACAACCTAGCCTGGAAAGGA
AGACCAAGGCATCTGCCCCAACATGGCCTTGAGCTGCCTGTGAGGCAGGGGGCAGGGGTTCCAACACCAGCACAGGGCTCCCCAGGGACA
CTGGGAGCAAGCTGGTGCTGGAGCATGAATGACGTCTGTGAAGTAGAACCTGCGTCCCCACTAAGTCCTGCTGCTTCTTATTCCCCAACT
CCTTGCCCTTTTCCCTTCCCTCCTAACCCCTTGGTGCCTTTCCCAGGGGGATCCCCACACTGGTCTTGCCTCTTCTTTTCCACTGCTTGG
CTCTTAAGCCTCAGGCAGATAAACTAGTATTCCCCCCAGCTTGGGGAACCTTGGAGTCTGCCAGGTCACCTTAGGGCAAGGCCCAGAAGG
CAGCCCCTGGGAGCACCCAGCAGTTCTTGGAGATGTCCTGTCATCTAGCCATCTGATATCTTCCTCATTTGAGGCCACAGATATATACAG
CCCAATTCCTCTGTCTACAAGTACATGATTTTATATAGCTCAGTCTATAACCTCCATGTGGGCCAATATAAGCTGTGTTTCTTGGTAACA
CATATTTTGTTTGAGGGGCCACTGGCCATGGGAGGTTATTTGTTCCTTAGACCCTGGAATAACACATCCAAGCCATTACTTATTAGAGTC
TCAGAATGTACTCAGTGGAGCTGTGCTTTGAGGCAGCCAACATTTCTCTGCTCTCCTTAGAAATGCAGTCTCCCAATGGAAGCTTTATAC
TCTTTGTACTGGGAAAGTGAGGATGATTTGGTAGCTTTATTGGGGTCATGTCTTCCCCAAGGTGTGGGGAGCTTAGCTTACTTGGCTTTT
GAGGTATCATCCCTCTGTTCTCCCCTCCTATCTTTCCATGACCCTCTGGATTGAGAGAGAGAGATAAAGACTGACAGACACCAGTGTAGG
CTGGAAAAGGGAGTGTGTGACCAGAGTGCCAAAAGTGACTAGGAGCAGGAACTTGGCTCCGACTCAGTTTGGAAAATGGGAAATAGGGGA
CAGTAAGCACAATGCCCAGTAGTAGTTGATTTCCAAGGACCCTGGAACCCTACACTTGAGAGGCTTAGGGTCACCATCTGCTCAAGAGGA
TCCCCTCTGATCTACAGGCCTTTTCCCTAGGTTTCTGCCTCCTCGTTTTTGTTCAAGTTGGGTTCTGAGTCCTCCCCAAAAACCATTGTT
TTAGACCTCTTGGCAGGGCCCCAAAACAGCCTCCCTCATACCCATCATTCCCTCTGCCTTCTGCTGCCCTCATGGGCAGTGCTCTGAGCA
GTGACCTCCCTTTCCTCCGTGGAAGTAGCTAGTGCAGACACCGTCATCCCACCCCACCTGAGTCACCCCAACCAAGAGGGTGACTGAATT
TCAGCCTGATTATGCCCTCCTGGGGCTCCTGTGAGGTGGAGCCAAGGTTCCCTCTCTGTTCCTGTTTGTTTTTAAATATTGTTGTGTGTT
TTGTATCTGTGGCACTGGCCTGCAGCATACTCTGTATATATTGTAAAGAAACCGTTAGGAGTAATTTTCTTTTGCATTGGGCAGGCATGG
CCCTGCATTCCTGCCCTTTCCACTCATTCTGTAACACAGAGGACGAACTTCTGTATTAGCTGGGCAGCCTTGGGTTCTCCAGAAGAGAAC
AGGTTTTTCTTTTCCTTTTTAATTTTTCTTCTTAAACATTTGGCTCTTTGATCCTCATATCCAAGTCTCCCCTGAAGAGTAGGAGCTGCT
CAGAAGAGCAGGTGAAAGCCACCATGGCAGATCCTGATGCCTGCCGGGCCTAGTCTTCCCTCTGAAATAACATGAAGCAGCAGCTGTGGA
GATTCTTGACAAGTGCTGAGTGAAAGATTTGCTGCCCACCTCTACATGGGGAGGAGAAACACAGGTGGGAGCTACCTGTGGCATCCATGA
CCTAGTCAGAGGGATGAGATGCTCAGCAGGGGTCCCCATCCTATCCCACCCCACAAACAAAGGCTGGAAAAATTTGCTACCAAGGGCCAA
GACCACCAGACCAAGCCTGTTTATGAGCCACCCCTGCCCAGGCCCTCACAGACATTGCTCACGGGGCTTCCCATAGAGGAGAAGCTAAAG
AGGGAGGGGGCCTCATCCCCAGATAGATCAGGCAAGGCTTGGAGAGCTGCTCTTTAGGATCCACATCAACTACTTCCTCATTTTAAGGTA
TGGCAGTTCCCTTCATCCCCTTTTCCTGCCTTGTACATGTACATGTATGAAATTTCCTTCTCTTACCGAACTCTCTCCACACATCACAAG
GTCAAAGAACCACACGCTTAGAAGGGTAAGAGGGCACCCTATGAAATGAAATGGTGATTTCTTGAGTCTCTTTTTTCCACGTTTAAGGGG
CCATGGCAGGACTTAGAGTTGCGAGTTAAGACTGCAGAGGGCTAGAGAATTATTTCATACAGGCTTTGAGGCCACCCATGTCACTTATCC
CGTATACCCTCTCACCATCCCCTTGTCTACTCTGATGCCCCCAAGATGCAACTGGGCAGCTAGTTGGCCCCATAATTCTGGGCCTTTGTT
GTTTGTTTTAATTACTTGGGCATCCCAGGAAGCTTTCCAGTGATCTCCTACCATGGGCCCCCCTCCTGGGATCAAGCCCCTCCCAGGCCC
TGTCCCCAGCCCCTCCTGCCCCAGCCCACCCGCTTGCCTTGGTGCTCAGCCCTCCCATTGGGAGCAGGTTGGGGCGAGCTGGAGGCCCGG
GCTGGAGGGGCAGTGTTGCTGTTCATAGATTTTGTTCCATTGGCGTTGCTCTGTTGAATTTAATTTCAGTCTTCCTGATTCTTCCCTTCT
GTAAAGTGTACATTACCAAGTTCCTTGTTTTTTTATATATATATATAAATATATATATATACAAACTGTACTCTTTTTGCCTTTGTACAT
TCAGGCAAGAAGAGAAAATAAATCTTTTTAAGAGACAATCACAAATCTGTGAGGGCTGCTGGTTATTTCTCCTGGAGTTTGCTGCTGAGC
TGCCTCTTCCTTCCTCCCAATTTTCCTGTTCTCCCTCAGCTCTCCTGATCTTCCTGGCCCTGCTCCATATGCATCCTCAGCTTCACTTTC
CCTGGCTGATGGCAAGCTGTTGAATCCAGTGTCCAGACTACCTGCCTTGTAACCCTTTTCTGCCCAGCATTGTTTTCTGGCTTGGCCACT
GGCTTAGCCCAGGAGCTTTACTCTGTGCCCTGGCCTCCCCTCTCTTCACCTTTAGATTTCCATTCACCGAAGTGGCTTTGGACCCCTGGG
TACTCTGGGACCTGTTTCCTGGAGGCCCTGGCTTGGGACACTCACCTGTGAAACTATGCAGCTGGGAGCTCTCTGCCTAAGAGTTTGCAC
TATTTAAACCTGCCTGGGAGTTAGGACGGATGGTTTTAGGAATGACCGGAAAACTACCCCTAAAACTCCCCCGACATTCCAGCCTCTAGA
ATGCTCTGATCCAGAGCTCAGTGGATGATTCCCAGCTGGTGGACTCCTGTGGCTACCCCATCAGAACAAGGGCTAAGGGTTTATGGGTCA
AGAGTATTTGATCAGAATTTTAAAGGGTGGTATACTCTGAAACACAGCCCAACCAAACCATTGTTTGGCCGCTTTCTCTTTTCCTCTACC
TTCCTCATCCCCACTTTTTTCCCTTTCTCTCTACTTCCTCTTCTTAATTGGCTTTGGAATTGAAATATATTTTTAAATTATTTGTTGTAT


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FusionGenePPI for COL2A1_ZNF609


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
COL2A1BMP2, TGFB1, PRELP, ITGA2B, COL9A1, THBS1, MAG, ANXA5, PKD1, PDIA2, PDGFA, PDGFB, HYAL1, RELA, C1QTNF2, C1QTNF9, COL8A2, PLOD1, MMP9, COLGALT2, MMP2, FKBP9, CNPY2ZNF609ATXN1, SOX2, HDAC1, AUTS2, NTRK1, PRKCI, USP7, DYNLL1, ATL3, VWA9, NANOG, EYA2, FLCN, SBSPON, THSD4, PIGT, RCCD1, EXOC5, CYLD, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for COL2A1_ZNF609


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneCOL2A1P02458DB00048Collagenase clostridium histolyticumCollagen alpha-1(II) chain {ECO:0000305}biotechapproved|investigational

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RelatedDiseases for COL2A1_ZNF609


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCOL2A1C0220685Achondrogenesis type 29CTD_human;ORPHANET;UNIPROT
HgeneCOL2A1C0993582Arthritis, Experimental7CTD_human
HgeneCOL2A1C2745959Spondyloepiphyseal dysplasia, congenita7CTD_human;ORPHANET;UNIPROT
HgeneCOL2A1C1858079Osteoarthritis with Mild Chondrodysplasia5CTD_human;ORPHANET;UNIPROT
HgeneCOL2A1C1836080Stickler Syndrome, Type I, Nonsyndromic Ocular4CTD_human;ORPHANET;UNIPROT
HgeneCOL2A1C1836683Czech dysplasia, metatarsal type4ORPHANET;UNIPROT
HgeneCOL2A1C0410480Avascular Necrosis of Femur Head3ORPHANET;UNIPROT
HgeneCOL2A1C1835437Platyspondylic Lethal Skeletal Dysplasia, Torrance Type3CTD_human;ORPHANET;UNIPROT
HgeneCOL2A1C0003864Arthritis2CTD_human
HgeneCOL2A1C0029408Degenerative polyarthritis2CTD_human;HPO
HgeneCOL2A1C0265279Kniest dysplasia2CTD_human;ORPHANET;UNIPROT
HgeneCOL2A1C0376634Craniofacial Abnormalities2CTD_human
HgeneCOL2A1C0700635Strudwick syndrome2CTD_human;HPO;ORPHANET;UNIPROT
HgeneCOL2A1C1851536Epiphyseal Dysplasia, Multiple, with Myopia and Conductive Deafness2CTD_human;ORPHANET;UNIPROT
HgeneCOL2A1C2020284Stickler syndrome, type 12CTD_human;ORPHANET;UNIPROT
HgeneCOL2A1C0008479Chondrosarcoma1CTD_human
HgeneCOL2A1C0008925Cleft Palate1CTD_human;HPO
HgeneCOL2A1C0013604Edema1CTD_human;HPO
HgeneCOL2A1C0018784Sensorineural Hearing Loss (disorder)1CTD_human;HPO
HgeneCOL2A1C0020507Hyperplasia1CTD_human
HgeneCOL2A1C0021368Inflammation1CTD_human
HgeneCOL2A1C0025202melanoma1CTD_human
HgeneCOL2A1C0027092Myopia1CTD_human;HPO
HgeneCOL2A1C0029422Osteochondrodysplasias1CTD_human;HPO
HgeneCOL2A1C0035305Retinal Detachment1CTD_human;HPO
HgeneCOL2A1C0039103Synovitis1CTD_human
HgeneCOL2A1C0041834Erythema1CTD_human
HgeneCOL2A1C0086543Cataract1CTD_human;HPO
HgeneCOL2A1C1262477Weight decreased1CTD_human
HgeneCOL2A1C1840452Hyaloideoretinal degeneration of Wagner1CTD_human
HgeneCOL2A1C1855310Megaepiphyseal dwarfism1CTD_human
HgeneCOL2A1C4225273SPONDYLOEPIPHYSEAL DYSPLASIA, STANESCU TYPE1ORPHANET;UNIPROT