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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 7852

FusionGeneSummary for COL16A1_SPOCD1

check button Fusion gene summary
Fusion gene informationFusion gene name: COL16A1_SPOCD1
Fusion gene ID: 7852
HgeneTgene
Gene symbol

COL16A1

SPOCD1

Gene ID

1307

90853

Gene namecollagen type XVI alpha 1 chainSPOC domain containing 1
Synonyms447AA|FP1572PPP1R146
Cytomap

1p35.2

1p35.2

Type of geneprotein-codingprotein-coding
Descriptioncollagen alpha-1(XVI) chainalpha 1 type XVI collagencollagen XVI, alpha-1 polypeptidecollagen, type XVI, alpha 1SPOC domain-containing protein 1protein phosphatase 1, regulatory subunit 146
Modification date2018052320180519
UniProtAcc

Q07092

Q6ZMY3

Ensembl transtripts involved in fusion geneENST00000271069, ENST00000373672, 
ENST00000461217, ENST00000373668, 
ENST00000257100, ENST00000373648, 
ENST00000360482, ENST00000533231, 
Fusion gene scores* DoF score5 X 5 X 5=1254 X 3 X 3=36
# samples 64
** MAII scorelog2(6/125*10)=-1.05889368905357
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: COL16A1 [Title/Abstract] AND SPOCD1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCOL16A1

GO:0007155

cell adhesion

16754661

HgeneCOL16A1

GO:0033622

integrin activation

16754661

HgeneCOL16A1

GO:0033627

cell adhesion mediated by integrin

16754661

HgeneCOL16A1

GO:0051894

positive regulation of focal adhesion assembly

24466237

TgeneSPOCD1

GO:0010923

negative regulation of phosphatase activity

19389623


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDCESCTCGA-EA-A1QS-01ACOL16A1chr1

32155342

-SPOCD1chr1

32267306

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000271069ENST00000257100COL16A1chr1

32155342

-SPOCD1chr1

32267306

-
5CDS-5UTRENST00000271069ENST00000373648COL16A1chr1

32155342

-SPOCD1chr1

32267306

-
5CDS-5UTRENST00000271069ENST00000360482COL16A1chr1

32155342

-SPOCD1chr1

32267306

-
5CDS-5UTRENST00000271069ENST00000533231COL16A1chr1

32155342

-SPOCD1chr1

32267306

-
5CDS-5UTRENST00000373672ENST00000257100COL16A1chr1

32155342

-SPOCD1chr1

32267306

-
5CDS-5UTRENST00000373672ENST00000373648COL16A1chr1

32155342

-SPOCD1chr1

32267306

-
5CDS-5UTRENST00000373672ENST00000360482COL16A1chr1

32155342

-SPOCD1chr1

32267306

-
5CDS-5UTRENST00000373672ENST00000533231COL16A1chr1

32155342

-SPOCD1chr1

32267306

-
intron-5UTRENST00000461217ENST00000257100COL16A1chr1

32155342

-SPOCD1chr1

32267306

-
intron-5UTRENST00000461217ENST00000373648COL16A1chr1

32155342

-SPOCD1chr1

32267306

-
intron-5UTRENST00000461217ENST00000360482COL16A1chr1

32155342

-SPOCD1chr1

32267306

-
intron-5UTRENST00000461217ENST00000533231COL16A1chr1

32155342

-SPOCD1chr1

32267306

-
5CDS-5UTRENST00000373668ENST00000257100COL16A1chr1

32155342

-SPOCD1chr1

32267306

-
5CDS-5UTRENST00000373668ENST00000373648COL16A1chr1

32155342

-SPOCD1chr1

32267306

-
5CDS-5UTRENST00000373668ENST00000360482COL16A1chr1

32155342

-SPOCD1chr1

32267306

-
5CDS-5UTRENST00000373668ENST00000533231COL16A1chr1

32155342

-SPOCD1chr1

32267306

-

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FusionProtFeatures for COL16A1_SPOCD1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
COL16A1

Q07092

SPOCD1

Q6ZMY3

Involved in mediating cell attachment and inducingintegrin-mediated cellular reactions, such as cell spreading andalterations in cell morphology. {ECO:0000269|PubMed:16754661}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for COL16A1_SPOCD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for COL16A1_SPOCD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
COL16A1SPOCD1PPP1CC


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for COL16A1_SPOCD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for COL16A1_SPOCD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource