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Fusion gene ID: 7835 |
FusionGeneSummary for COG6_STXBP4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: COG6_STXBP4 | Fusion gene ID: 7835 | Hgene | Tgene | Gene symbol | COG6 | STXBP4 | Gene ID | 57511 | 252983 |
| Gene name | component of oligomeric golgi complex 6 | syntaxin binding protein 4 | |
| Synonyms | CDG2L|COD2|SHNS | Synip | |
| Cytomap | 13q14.11 | 17q22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | conserved oligomeric Golgi complex subunit 6COG complex subunit 6complexed with Dor1p 2conserved oligomeric Golgi complex protein 6testicular tissue protein Li 41 | syntaxin-binding protein 4STX4-interacting proteinsyntaxin 4 interacting protein | |
| Modification date | 20180523 | 20180520 | |
| UniProtAcc | Q9Y2V7 | Q6ZWJ1 | |
| Ensembl transtripts involved in fusion gene | ENST00000416691, ENST00000455146, ENST00000465775, | ENST00000299341, ENST00000376352, ENST00000405898, ENST00000434978, ENST00000398391, | |
| Fusion gene scores | * DoF score | 6 X 5 X 5=150 | 8 X 5 X 5=200 |
| # samples | 6 | 7 | |
| ** MAII score | log2(6/150*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/200*10)=-1.51457317282976 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: COG6 [Title/Abstract] AND STXBP4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | STXBP4 | GO:0006974 | cellular response to DNA damage stimulus | 19451233 |
| Tgene | STXBP4 | GO:0061178 | regulation of insulin secretion involved in cellular response to glucose stimulus | 12855681 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | READ | TCGA-AG-3731-01A | COG6 | chr13 | 40235018 | + | STXBP4 | chr17 | 53108529 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000416691 | ENST00000299341 | COG6 | chr13 | 40235018 | + | STXBP4 | chr17 | 53108529 | + |
| In-frame | ENST00000416691 | ENST00000376352 | COG6 | chr13 | 40235018 | + | STXBP4 | chr17 | 53108529 | + |
| In-frame | ENST00000416691 | ENST00000405898 | COG6 | chr13 | 40235018 | + | STXBP4 | chr17 | 53108529 | + |
| In-frame | ENST00000416691 | ENST00000434978 | COG6 | chr13 | 40235018 | + | STXBP4 | chr17 | 53108529 | + |
| In-frame | ENST00000416691 | ENST00000398391 | COG6 | chr13 | 40235018 | + | STXBP4 | chr17 | 53108529 | + |
| In-frame | ENST00000455146 | ENST00000299341 | COG6 | chr13 | 40235018 | + | STXBP4 | chr17 | 53108529 | + |
| In-frame | ENST00000455146 | ENST00000376352 | COG6 | chr13 | 40235018 | + | STXBP4 | chr17 | 53108529 | + |
| In-frame | ENST00000455146 | ENST00000405898 | COG6 | chr13 | 40235018 | + | STXBP4 | chr17 | 53108529 | + |
| In-frame | ENST00000455146 | ENST00000434978 | COG6 | chr13 | 40235018 | + | STXBP4 | chr17 | 53108529 | + |
| In-frame | ENST00000455146 | ENST00000398391 | COG6 | chr13 | 40235018 | + | STXBP4 | chr17 | 53108529 | + |
| intron-3CDS | ENST00000465775 | ENST00000299341 | COG6 | chr13 | 40235018 | + | STXBP4 | chr17 | 53108529 | + |
| intron-3CDS | ENST00000465775 | ENST00000376352 | COG6 | chr13 | 40235018 | + | STXBP4 | chr17 | 53108529 | + |
| intron-3CDS | ENST00000465775 | ENST00000405898 | COG6 | chr13 | 40235018 | + | STXBP4 | chr17 | 53108529 | + |
| intron-3CDS | ENST00000465775 | ENST00000434978 | COG6 | chr13 | 40235018 | + | STXBP4 | chr17 | 53108529 | + |
| intron-3CDS | ENST00000465775 | ENST00000398391 | COG6 | chr13 | 40235018 | + | STXBP4 | chr17 | 53108529 | + |
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FusionProtFeatures for COG6_STXBP4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| COG6 | STXBP4 |
| Required for normal Golgi function. {ECO:0000250}. | Plays a role in the translocation of transport vesiclesfrom the cytoplasm to the plasma membrane. Inhibits thetranslocation of SLC2A4 from intracellular vesicles to the plasmamembrane by STX4A binding and preventing the interaction betweenSTX4A and VAMP2. Stimulation with insulin disrupts the interactionwith STX4A, leading to increased levels of SLC2A4 at the plasmamembrane. May also play a role in the regulation of insulinrelease by pancreatic beta cells after stimulation by glucose (Bysimilarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >STXBP4 | chr13:40235018 | chr17:53108529 | ENST00000299341 | + | 7 | 12 | 291_417 | 147 | 246 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >STXBP4 | chr13:40235018 | chr17:53108529 | ENST00000376352 | + | 7 | 18 | 291_417 | 222 | 554 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >STXBP4 | chr13:40235018 | chr17:53108529 | ENST00000398391 | + | 6 | 11 | 291_417 | 147 | 246 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >STXBP4 | chr13:40235018 | chr17:53108529 | ENST00000299341 | + | 7 | 12 | 496_529 | 147 | 246 | Domain | WW |
| Tgene | >STXBP4 | chr13:40235018 | chr17:53108529 | ENST00000376352 | + | 7 | 18 | 496_529 | 222 | 554 | Domain | WW |
| Tgene | >STXBP4 | chr13:40235018 | chr17:53108529 | ENST00000398391 | + | 6 | 11 | 496_529 | 147 | 246 | Domain | WW |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | STXBP4 | chr13:40235018 | chr17:53108529 | ENST00000299341 | + | 7 | 12 | 19_105 | 147 | 246 | Domain | PDZ |
| Tgene | STXBP4 | chr13:40235018 | chr17:53108529 | ENST00000376352 | + | 7 | 18 | 19_105 | 222 | 554 | Domain | PDZ |
| Tgene | STXBP4 | chr13:40235018 | chr17:53108529 | ENST00000398391 | + | 6 | 11 | 19_105 | 147 | 246 | Domain | PDZ |
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FusionGeneSequence for COG6_STXBP4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_COG6_ENST00000416691_chr13_40235018_+_STXBP4_ENST00000299341_chr17_53108529_+_222aa MAEGSGEVVAVSATGAANGLNNGAGGTSATTCNPLSRKLHKILETRLDNDKEMLEALKALSTFFVENSLRTRRNLRGDIERKSLAINEEF VSIFKEVKEELESISEDVQAMSNCCQDMTSRLQALNYLGIQPTKEQHQALRQQVQADSKGTVSFGDFVQVARNLFCLQLDEVNVGAHEIS >In-frame_COG6_ENST00000416691_chr13_40235018_+_STXBP4_ENST00000376352_chr17_53108529_+_455aa MAEGSGEVVAVSATGAANGLNNGAGGTSATTCNPLSRKLHKILETRLDNDKEMLEALKALSTFFVENSLRTRRNLRGDIERKSLAINEEF VSIFKEVKEELESISEDVQAMSNCCQDMTSRLQALNYLGIQPTKEQHQALRQQVQADSKGTVSFGDFVQVARNLFCLQLDEVNVGAHEIS NILDSQLLPCDSSEADEMERLKCERDDALKEVNTLKEKLLESDKQRKQLTEELQNVKQEAKAVVEETRALRSRIHLAEAAQRQAHGMEMD YEEVIRLLEAKITELKAQLADYSDQNKESVQDLKKRIMVLDCQLRKSEMARKTFEASTEKLLHFVEAIQEVFSDNSTPLSNLSERRAVLA SQTSLTPLGRNGRSIPATLALESKELVKSVRALLDMDCLPYGWEEAYTADGIKYFINHVTQTTSWIHPVMSVLNLSRSEENEEDCSRELP >In-frame_COG6_ENST00000416691_chr13_40235018_+_STXBP4_ENST00000405898_chr17_53108529_+_222aa MAEGSGEVVAVSATGAANGLNNGAGGTSATTCNPLSRKLHKILETRLDNDKEMLEALKALSTFFVENSLRTRRNLRGDIERKSLAINEEF VSIFKEVKEELESISEDVQAMSNCCQDMTSRLQALNYLGIQPTKEQHQALRQQVQADSKGTVSFGDFVQVARNLFCLQLDEVNVGAHEIS >In-frame_COG6_ENST00000416691_chr13_40235018_+_STXBP4_ENST00000434978_chr17_53108529_+_433aa MAEGSGEVVAVSATGAANGLNNGAGGTSATTCNPLSRKLHKILETRLDNDKEMLEALKALSTFFVENSLRTRRNLRGDIERKSLAINEEF VSIFKEVKEELESISEDVQAMSNCCQDMTSRLQALNYLGIQPTKEQHQALRQQVQADSKGTVSFGDFVQVARNLFCLQLDEVNVGAHEIS NILDSQLLPCDSSEADEMERLKCERDDALKEVNTLKEAKAVVEETRALRSRIHLAEAAQRQAHGMEMDYEEVIRLLEAKITELKAQLADY SDQNKESVQDLKKRIMVLDCQLRKSEMARKTFEASTEKLLHFVEAIQEVFSDNSTPLSNLSERRAVLASQTSLTPLGRNGRSIPATLALE >In-frame_COG6_ENST00000416691_chr13_40235018_+_STXBP4_ENST00000398391_chr17_53108529_+_222aa MAEGSGEVVAVSATGAANGLNNGAGGTSATTCNPLSRKLHKILETRLDNDKEMLEALKALSTFFVENSLRTRRNLRGDIERKSLAINEEF VSIFKEVKEELESISEDVQAMSNCCQDMTSRLQALNYLGIQPTKEQHQALRQQVQADSKGTVSFGDFVQVARNLFCLQLDEVNVGAHEIS >In-frame_COG6_ENST00000455146_chr13_40235018_+_STXBP4_ENST00000299341_chr17_53108529_+_222aa MAEGSGEVVAVSATGAANGLNNGAGGTSATTCNPLSRKLHKILETRLDNDKEMLEALKALSTFFVENSLRTRRNLRGDIERKSLAINEEF VSIFKEVKEELESISEDVQAMSNCCQDMTSRLQALNYLGIQPTKEQHQALRQQVQADSKGTVSFGDFVQVARNLFCLQLDEVNVGAHEIS >In-frame_COG6_ENST00000455146_chr13_40235018_+_STXBP4_ENST00000376352_chr17_53108529_+_455aa MAEGSGEVVAVSATGAANGLNNGAGGTSATTCNPLSRKLHKILETRLDNDKEMLEALKALSTFFVENSLRTRRNLRGDIERKSLAINEEF VSIFKEVKEELESISEDVQAMSNCCQDMTSRLQALNYLGIQPTKEQHQALRQQVQADSKGTVSFGDFVQVARNLFCLQLDEVNVGAHEIS NILDSQLLPCDSSEADEMERLKCERDDALKEVNTLKEKLLESDKQRKQLTEELQNVKQEAKAVVEETRALRSRIHLAEAAQRQAHGMEMD YEEVIRLLEAKITELKAQLADYSDQNKESVQDLKKRIMVLDCQLRKSEMARKTFEASTEKLLHFVEAIQEVFSDNSTPLSNLSERRAVLA SQTSLTPLGRNGRSIPATLALESKELVKSVRALLDMDCLPYGWEEAYTADGIKYFINHVTQTTSWIHPVMSVLNLSRSEENEEDCSRELP >In-frame_COG6_ENST00000455146_chr13_40235018_+_STXBP4_ENST00000405898_chr17_53108529_+_222aa MAEGSGEVVAVSATGAANGLNNGAGGTSATTCNPLSRKLHKILETRLDNDKEMLEALKALSTFFVENSLRTRRNLRGDIERKSLAINEEF VSIFKEVKEELESISEDVQAMSNCCQDMTSRLQALNYLGIQPTKEQHQALRQQVQADSKGTVSFGDFVQVARNLFCLQLDEVNVGAHEIS >In-frame_COG6_ENST00000455146_chr13_40235018_+_STXBP4_ENST00000434978_chr17_53108529_+_433aa MAEGSGEVVAVSATGAANGLNNGAGGTSATTCNPLSRKLHKILETRLDNDKEMLEALKALSTFFVENSLRTRRNLRGDIERKSLAINEEF VSIFKEVKEELESISEDVQAMSNCCQDMTSRLQALNYLGIQPTKEQHQALRQQVQADSKGTVSFGDFVQVARNLFCLQLDEVNVGAHEIS NILDSQLLPCDSSEADEMERLKCERDDALKEVNTLKEAKAVVEETRALRSRIHLAEAAQRQAHGMEMDYEEVIRLLEAKITELKAQLADY SDQNKESVQDLKKRIMVLDCQLRKSEMARKTFEASTEKLLHFVEAIQEVFSDNSTPLSNLSERRAVLASQTSLTPLGRNGRSIPATLALE >In-frame_COG6_ENST00000455146_chr13_40235018_+_STXBP4_ENST00000398391_chr17_53108529_+_222aa MAEGSGEVVAVSATGAANGLNNGAGGTSATTCNPLSRKLHKILETRLDNDKEMLEALKALSTFFVENSLRTRRNLRGDIERKSLAINEEF VSIFKEVKEELESISEDVQAMSNCCQDMTSRLQALNYLGIQPTKEQHQALRQQVQADSKGTVSFGDFVQVARNLFCLQLDEVNVGAHEIS |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_COG6_ENST00000416691_chr13_40235018_+_STXBP4_ENST00000299341_chr17_53108529_+_666nt ATGGCAGAGGGCAGCGGGGAAGTGGTCGCAGTGTCTGCGACCGGGGCTGCCAACGGCCTCAACAATGGGGCAGGCGGGACCTCGGCGACG ACCTGCAACCCGCTGTCGCGCAAGCTGCATAAGATCCTGGAGACGCGGCTGGACAACGACAAGGAGATGTTAGAAGCTCTCAAGGCACTT TCAACCTTTTTTGTTGAAAATAGTCTGCGGACTCGAAGAAATTTACGTGGAGATATTGAACGTAAAAGTTTAGCCATCAATGAAGAATTT GTAAGCATTTTCAAGGAAGTGAAGGAGGAACTTGAAAGCATAAGCGAAGATGTTCAAGCAATGAGCAACTGTTGTCAAGATATGACAAGT CGCCTACAGGCTCTAAATTATCTTGGTATTCAGCCCACAAAGGAACAACACCAAGCCCTGAGACAGCAAGTACAAGCAGACTCAAAAGGG ACAGTGTCTTTTGGAGATTTTGTCCAGGTTGCCAGAAACTTGTTTTGCTTGCAGTTGGATGAAGTAAATGTTGGTGCACATGAAATTTCC AATATATTAGATTCACAGCTTCTTCCTTGTGATTCTTCAGAAGCAGATGAAATGGAAAGGCTCAAGTGTGAAAGAGATGATGCCTTGAAA >In-frame_COG6_ENST00000416691_chr13_40235018_+_STXBP4_ENST00000376352_chr17_53108529_+_1365nt ATGGCAGAGGGCAGCGGGGAAGTGGTCGCAGTGTCTGCGACCGGGGCTGCCAACGGCCTCAACAATGGGGCAGGCGGGACCTCGGCGACG ACCTGCAACCCGCTGTCGCGCAAGCTGCATAAGATCCTGGAGACGCGGCTGGACAACGACAAGGAGATGTTAGAAGCTCTCAAGGCACTT TCAACCTTTTTTGTTGAAAATAGTCTGCGGACTCGAAGAAATTTACGTGGAGATATTGAACGTAAAAGTTTAGCCATCAATGAAGAATTT GTAAGCATTTTCAAGGAAGTGAAGGAGGAACTTGAAAGCATAAGCGAAGATGTTCAAGCAATGAGCAACTGTTGTCAAGATATGACAAGT CGCCTACAGGCTCTAAATTATCTTGGTATTCAGCCCACAAAGGAACAACACCAAGCCCTGAGACAGCAAGTACAAGCAGACTCAAAAGGG ACAGTGTCTTTTGGAGATTTTGTCCAGGTTGCCAGAAACTTGTTTTGCTTGCAGTTGGATGAAGTAAATGTTGGTGCACATGAAATTTCC AATATATTAGATTCACAGCTTCTTCCTTGTGATTCTTCAGAAGCAGATGAAATGGAAAGGCTCAAGTGTGAAAGAGATGATGCCTTGAAA GAAGTAAATACACTTAAGGAAAAATTATTGGAATCAGATAAGCAAAGGAAACAATTGACAGAAGAGCTCCAGAATGTGAAACAAGAAGCC AAAGCTGTAGTTGAAGAAACAAGAGCCCTGCGTAGTCGGATTCATCTTGCTGAAGCTGCTCAGAGACAGGCACATGGAATGGAAATGGAC TATGAAGAAGTGATCCGTCTGTTAGAGGCCAAGATTACAGAGCTAAAGGCTCAGCTTGCTGATTATTCTGACCAAAATAAAGAAAGTGTT CAGGATTTAAAAAAGAGAATCATGGTACTCGACTGCCAATTACGAAAATCAGAAATGGCTCGAAAAACTTTTGAGGCATCCACTGAAAAG CTTCTTCATTTTGTAGAGGCTATTCAAGAAGTATTTTCTGATAATTCTACTCCTTTATCAAATTTAAGTGAAAGAAGAGCTGTGTTAGCT TCTCAGACTTCCCTCACACCACTGGGAAGGAATGGACGTAGCATCCCAGCAACGCTGGCGCTTGAATCTAAGGAACTTGTTAAATCTGTT CGTGCCTTACTTGATATGGATTGTTTACCTTATGGGTGGGAGGAAGCTTACACAGCAGATGGAATCAAGTACTTCATCAATCATGTAACA CAGACTACATCCTGGATCCATCCCGTGATGAGTGTCCTGAATCTATCTCGCTCAGAGGAGAATGAAGAGGATTGCTCTAGAGAACTCCCC >In-frame_COG6_ENST00000416691_chr13_40235018_+_STXBP4_ENST00000405898_chr17_53108529_+_666nt ATGGCAGAGGGCAGCGGGGAAGTGGTCGCAGTGTCTGCGACCGGGGCTGCCAACGGCCTCAACAATGGGGCAGGCGGGACCTCGGCGACG ACCTGCAACCCGCTGTCGCGCAAGCTGCATAAGATCCTGGAGACGCGGCTGGACAACGACAAGGAGATGTTAGAAGCTCTCAAGGCACTT TCAACCTTTTTTGTTGAAAATAGTCTGCGGACTCGAAGAAATTTACGTGGAGATATTGAACGTAAAAGTTTAGCCATCAATGAAGAATTT GTAAGCATTTTCAAGGAAGTGAAGGAGGAACTTGAAAGCATAAGCGAAGATGTTCAAGCAATGAGCAACTGTTGTCAAGATATGACAAGT CGCCTACAGGCTCTAAATTATCTTGGTATTCAGCCCACAAAGGAACAACACCAAGCCCTGAGACAGCAAGTACAAGCAGACTCAAAAGGG ACAGTGTCTTTTGGAGATTTTGTCCAGGTTGCCAGAAACTTGTTTTGCTTGCAGTTGGATGAAGTAAATGTTGGTGCACATGAAATTTCC AATATATTAGATTCACAGCTTCTTCCTTGTGATTCTTCAGAAGCAGATGAAATGGAAAGGCTCAAGTGTGAAAGAGATGATGCCTTGAAA >In-frame_COG6_ENST00000416691_chr13_40235018_+_STXBP4_ENST00000434978_chr17_53108529_+_1299nt ATGGCAGAGGGCAGCGGGGAAGTGGTCGCAGTGTCTGCGACCGGGGCTGCCAACGGCCTCAACAATGGGGCAGGCGGGACCTCGGCGACG ACCTGCAACCCGCTGTCGCGCAAGCTGCATAAGATCCTGGAGACGCGGCTGGACAACGACAAGGAGATGTTAGAAGCTCTCAAGGCACTT TCAACCTTTTTTGTTGAAAATAGTCTGCGGACTCGAAGAAATTTACGTGGAGATATTGAACGTAAAAGTTTAGCCATCAATGAAGAATTT GTAAGCATTTTCAAGGAAGTGAAGGAGGAACTTGAAAGCATAAGCGAAGATGTTCAAGCAATGAGCAACTGTTGTCAAGATATGACAAGT CGCCTACAGGCTCTAAATTATCTTGGTATTCAGCCCACAAAGGAACAACACCAAGCCCTGAGACAGCAAGTACAAGCAGACTCAAAAGGG ACAGTGTCTTTTGGAGATTTTGTCCAGGTTGCCAGAAACTTGTTTTGCTTGCAGTTGGATGAAGTAAATGTTGGTGCACATGAAATTTCC AATATATTAGATTCACAGCTTCTTCCTTGTGATTCTTCAGAAGCAGATGAAATGGAAAGGCTCAAGTGTGAAAGAGATGATGCCTTGAAA GAAGTAAATACACTTAAGGAAGCCAAAGCTGTAGTTGAAGAAACAAGAGCCCTGCGTAGTCGGATTCATCTTGCTGAAGCTGCTCAGAGA CAGGCACATGGAATGGAAATGGACTATGAAGAAGTGATCCGTCTGTTAGAGGCCAAGATTACAGAGCTAAAGGCTCAGCTTGCTGATTAT TCTGACCAAAATAAAGAAAGTGTTCAGGATTTAAAAAAGAGAATCATGGTACTCGACTGCCAATTACGAAAATCAGAAATGGCTCGAAAA ACTTTTGAGGCATCCACTGAAAAGCTTCTTCATTTTGTAGAGGCTATTCAAGAAGTATTTTCTGATAATTCTACTCCTTTATCAAATTTA AGTGAAAGAAGAGCTGTGTTAGCTTCTCAGACTTCCCTCACACCACTGGGAAGGAATGGACGTAGCATCCCAGCAACGCTGGCGCTTGAA TCTAAGGAACTTGTTAAATCTGTTCGTGCCTTACTTGATATGGATTGTTTACCTTATGGGTGGGAGGAAGCTTACACAGCAGATGGAATC AAGTACTTCATCAATCATGTAACACAGACTACATCCTGGATCCATCCCGTGATGAGTGTCCTGAATCTATCTCGCTCAGAGGAGAATGAA >In-frame_COG6_ENST00000416691_chr13_40235018_+_STXBP4_ENST00000398391_chr17_53108529_+_666nt ATGGCAGAGGGCAGCGGGGAAGTGGTCGCAGTGTCTGCGACCGGGGCTGCCAACGGCCTCAACAATGGGGCAGGCGGGACCTCGGCGACG ACCTGCAACCCGCTGTCGCGCAAGCTGCATAAGATCCTGGAGACGCGGCTGGACAACGACAAGGAGATGTTAGAAGCTCTCAAGGCACTT TCAACCTTTTTTGTTGAAAATAGTCTGCGGACTCGAAGAAATTTACGTGGAGATATTGAACGTAAAAGTTTAGCCATCAATGAAGAATTT GTAAGCATTTTCAAGGAAGTGAAGGAGGAACTTGAAAGCATAAGCGAAGATGTTCAAGCAATGAGCAACTGTTGTCAAGATATGACAAGT CGCCTACAGGCTCTAAATTATCTTGGTATTCAGCCCACAAAGGAACAACACCAAGCCCTGAGACAGCAAGTACAAGCAGACTCAAAAGGG ACAGTGTCTTTTGGAGATTTTGTCCAGGTTGCCAGAAACTTGTTTTGCTTGCAGTTGGATGAAGTAAATGTTGGTGCACATGAAATTTCC AATATATTAGATTCACAGCTTCTTCCTTGTGATTCTTCAGAAGCAGATGAAATGGAAAGGCTCAAGTGTGAAAGAGATGATGCCTTGAAA >In-frame_COG6_ENST00000455146_chr13_40235018_+_STXBP4_ENST00000299341_chr17_53108529_+_666nt ATGGCAGAGGGCAGCGGGGAAGTGGTCGCAGTGTCTGCGACCGGGGCTGCCAACGGCCTCAACAATGGGGCAGGCGGGACCTCGGCGACG ACCTGCAACCCGCTGTCGCGCAAGCTGCATAAGATCCTGGAGACGCGGCTGGACAACGACAAGGAGATGTTAGAAGCTCTCAAGGCACTT TCAACCTTTTTTGTTGAAAATAGTCTGCGGACTCGAAGAAATTTACGTGGAGATATTGAACGTAAAAGTTTAGCCATCAATGAAGAATTT GTAAGCATTTTCAAGGAAGTGAAGGAGGAACTTGAAAGCATAAGCGAAGATGTTCAAGCAATGAGCAACTGTTGTCAAGATATGACAAGT CGCCTACAGGCTCTAAATTATCTTGGTATTCAGCCCACAAAGGAACAACACCAAGCCCTGAGACAGCAAGTACAAGCAGACTCAAAAGGG ACAGTGTCTTTTGGAGATTTTGTCCAGGTTGCCAGAAACTTGTTTTGCTTGCAGTTGGATGAAGTAAATGTTGGTGCACATGAAATTTCC AATATATTAGATTCACAGCTTCTTCCTTGTGATTCTTCAGAAGCAGATGAAATGGAAAGGCTCAAGTGTGAAAGAGATGATGCCTTGAAA >In-frame_COG6_ENST00000455146_chr13_40235018_+_STXBP4_ENST00000376352_chr17_53108529_+_1365nt ATGGCAGAGGGCAGCGGGGAAGTGGTCGCAGTGTCTGCGACCGGGGCTGCCAACGGCCTCAACAATGGGGCAGGCGGGACCTCGGCGACG ACCTGCAACCCGCTGTCGCGCAAGCTGCATAAGATCCTGGAGACGCGGCTGGACAACGACAAGGAGATGTTAGAAGCTCTCAAGGCACTT TCAACCTTTTTTGTTGAAAATAGTCTGCGGACTCGAAGAAATTTACGTGGAGATATTGAACGTAAAAGTTTAGCCATCAATGAAGAATTT GTAAGCATTTTCAAGGAAGTGAAGGAGGAACTTGAAAGCATAAGCGAAGATGTTCAAGCAATGAGCAACTGTTGTCAAGATATGACAAGT CGCCTACAGGCTCTAAATTATCTTGGTATTCAGCCCACAAAGGAACAACACCAAGCCCTGAGACAGCAAGTACAAGCAGACTCAAAAGGG ACAGTGTCTTTTGGAGATTTTGTCCAGGTTGCCAGAAACTTGTTTTGCTTGCAGTTGGATGAAGTAAATGTTGGTGCACATGAAATTTCC AATATATTAGATTCACAGCTTCTTCCTTGTGATTCTTCAGAAGCAGATGAAATGGAAAGGCTCAAGTGTGAAAGAGATGATGCCTTGAAA GAAGTAAATACACTTAAGGAAAAATTATTGGAATCAGATAAGCAAAGGAAACAATTGACAGAAGAGCTCCAGAATGTGAAACAAGAAGCC AAAGCTGTAGTTGAAGAAACAAGAGCCCTGCGTAGTCGGATTCATCTTGCTGAAGCTGCTCAGAGACAGGCACATGGAATGGAAATGGAC TATGAAGAAGTGATCCGTCTGTTAGAGGCCAAGATTACAGAGCTAAAGGCTCAGCTTGCTGATTATTCTGACCAAAATAAAGAAAGTGTT CAGGATTTAAAAAAGAGAATCATGGTACTCGACTGCCAATTACGAAAATCAGAAATGGCTCGAAAAACTTTTGAGGCATCCACTGAAAAG CTTCTTCATTTTGTAGAGGCTATTCAAGAAGTATTTTCTGATAATTCTACTCCTTTATCAAATTTAAGTGAAAGAAGAGCTGTGTTAGCT TCTCAGACTTCCCTCACACCACTGGGAAGGAATGGACGTAGCATCCCAGCAACGCTGGCGCTTGAATCTAAGGAACTTGTTAAATCTGTT CGTGCCTTACTTGATATGGATTGTTTACCTTATGGGTGGGAGGAAGCTTACACAGCAGATGGAATCAAGTACTTCATCAATCATGTAACA CAGACTACATCCTGGATCCATCCCGTGATGAGTGTCCTGAATCTATCTCGCTCAGAGGAGAATGAAGAGGATTGCTCTAGAGAACTCCCC >In-frame_COG6_ENST00000455146_chr13_40235018_+_STXBP4_ENST00000405898_chr17_53108529_+_666nt ATGGCAGAGGGCAGCGGGGAAGTGGTCGCAGTGTCTGCGACCGGGGCTGCCAACGGCCTCAACAATGGGGCAGGCGGGACCTCGGCGACG ACCTGCAACCCGCTGTCGCGCAAGCTGCATAAGATCCTGGAGACGCGGCTGGACAACGACAAGGAGATGTTAGAAGCTCTCAAGGCACTT TCAACCTTTTTTGTTGAAAATAGTCTGCGGACTCGAAGAAATTTACGTGGAGATATTGAACGTAAAAGTTTAGCCATCAATGAAGAATTT GTAAGCATTTTCAAGGAAGTGAAGGAGGAACTTGAAAGCATAAGCGAAGATGTTCAAGCAATGAGCAACTGTTGTCAAGATATGACAAGT CGCCTACAGGCTCTAAATTATCTTGGTATTCAGCCCACAAAGGAACAACACCAAGCCCTGAGACAGCAAGTACAAGCAGACTCAAAAGGG ACAGTGTCTTTTGGAGATTTTGTCCAGGTTGCCAGAAACTTGTTTTGCTTGCAGTTGGATGAAGTAAATGTTGGTGCACATGAAATTTCC AATATATTAGATTCACAGCTTCTTCCTTGTGATTCTTCAGAAGCAGATGAAATGGAAAGGCTCAAGTGTGAAAGAGATGATGCCTTGAAA >In-frame_COG6_ENST00000455146_chr13_40235018_+_STXBP4_ENST00000434978_chr17_53108529_+_1299nt ATGGCAGAGGGCAGCGGGGAAGTGGTCGCAGTGTCTGCGACCGGGGCTGCCAACGGCCTCAACAATGGGGCAGGCGGGACCTCGGCGACG ACCTGCAACCCGCTGTCGCGCAAGCTGCATAAGATCCTGGAGACGCGGCTGGACAACGACAAGGAGATGTTAGAAGCTCTCAAGGCACTT TCAACCTTTTTTGTTGAAAATAGTCTGCGGACTCGAAGAAATTTACGTGGAGATATTGAACGTAAAAGTTTAGCCATCAATGAAGAATTT GTAAGCATTTTCAAGGAAGTGAAGGAGGAACTTGAAAGCATAAGCGAAGATGTTCAAGCAATGAGCAACTGTTGTCAAGATATGACAAGT CGCCTACAGGCTCTAAATTATCTTGGTATTCAGCCCACAAAGGAACAACACCAAGCCCTGAGACAGCAAGTACAAGCAGACTCAAAAGGG ACAGTGTCTTTTGGAGATTTTGTCCAGGTTGCCAGAAACTTGTTTTGCTTGCAGTTGGATGAAGTAAATGTTGGTGCACATGAAATTTCC AATATATTAGATTCACAGCTTCTTCCTTGTGATTCTTCAGAAGCAGATGAAATGGAAAGGCTCAAGTGTGAAAGAGATGATGCCTTGAAA GAAGTAAATACACTTAAGGAAGCCAAAGCTGTAGTTGAAGAAACAAGAGCCCTGCGTAGTCGGATTCATCTTGCTGAAGCTGCTCAGAGA CAGGCACATGGAATGGAAATGGACTATGAAGAAGTGATCCGTCTGTTAGAGGCCAAGATTACAGAGCTAAAGGCTCAGCTTGCTGATTAT TCTGACCAAAATAAAGAAAGTGTTCAGGATTTAAAAAAGAGAATCATGGTACTCGACTGCCAATTACGAAAATCAGAAATGGCTCGAAAA ACTTTTGAGGCATCCACTGAAAAGCTTCTTCATTTTGTAGAGGCTATTCAAGAAGTATTTTCTGATAATTCTACTCCTTTATCAAATTTA AGTGAAAGAAGAGCTGTGTTAGCTTCTCAGACTTCCCTCACACCACTGGGAAGGAATGGACGTAGCATCCCAGCAACGCTGGCGCTTGAA TCTAAGGAACTTGTTAAATCTGTTCGTGCCTTACTTGATATGGATTGTTTACCTTATGGGTGGGAGGAAGCTTACACAGCAGATGGAATC AAGTACTTCATCAATCATGTAACACAGACTACATCCTGGATCCATCCCGTGATGAGTGTCCTGAATCTATCTCGCTCAGAGGAGAATGAA >In-frame_COG6_ENST00000455146_chr13_40235018_+_STXBP4_ENST00000398391_chr17_53108529_+_666nt ATGGCAGAGGGCAGCGGGGAAGTGGTCGCAGTGTCTGCGACCGGGGCTGCCAACGGCCTCAACAATGGGGCAGGCGGGACCTCGGCGACG ACCTGCAACCCGCTGTCGCGCAAGCTGCATAAGATCCTGGAGACGCGGCTGGACAACGACAAGGAGATGTTAGAAGCTCTCAAGGCACTT TCAACCTTTTTTGTTGAAAATAGTCTGCGGACTCGAAGAAATTTACGTGGAGATATTGAACGTAAAAGTTTAGCCATCAATGAAGAATTT GTAAGCATTTTCAAGGAAGTGAAGGAGGAACTTGAAAGCATAAGCGAAGATGTTCAAGCAATGAGCAACTGTTGTCAAGATATGACAAGT CGCCTACAGGCTCTAAATTATCTTGGTATTCAGCCCACAAAGGAACAACACCAAGCCCTGAGACAGCAAGTACAAGCAGACTCAAAAGGG ACAGTGTCTTTTGGAGATTTTGTCCAGGTTGCCAGAAACTTGTTTTGCTTGCAGTTGGATGAAGTAAATGTTGGTGCACATGAAATTTCC AATATATTAGATTCACAGCTTCTTCCTTGTGATTCTTCAGAAGCAGATGAAATGGAAAGGCTCAAGTGTGAAAGAGATGATGCCTTGAAA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_COG6_ENST00000416691_chr13_40235018_+_STXBP4_ENST00000299341_chr17_53108529_+_766nt GATGCGCATGCGCGGCCGATTTGCACATGCGCAATACTCGCGCTGCCTCCGTGGTCCCTGCCTGGCTGAGGTGGCAGCAGGGGGCGGGAC GCGCAGCGCTATGGCAGAGGGCAGCGGGGAAGTGGTCGCAGTGTCTGCGACCGGGGCTGCCAACGGCCTCAACAATGGGGCAGGCGGGAC CTCGGCGACGACCTGCAACCCGCTGTCGCGCAAGCTGCATAAGATCCTGGAGACGCGGCTGGACAACGACAAGGAGATGTTAGAAGCTCT CAAGGCACTTTCAACCTTTTTTGTTGAAAATAGTCTGCGGACTCGAAGAAATTTACGTGGAGATATTGAACGTAAAAGTTTAGCCATCAA TGAAGAATTTGTAAGCATTTTCAAGGAAGTGAAGGAGGAACTTGAAAGCATAAGCGAAGATGTTCAAGCAATGAGCAACTGTTGTCAAGA TATGACAAGTCGCCTACAGGCTCTAAATTATCTTGGTATTCAGCCCACAAAGGAACAACACCAAGCCCTGAGACAGCAAGTACAAGCAGA CTCAAAAGGGACAGTGTCTTTTGGAGATTTTGTCCAGGTTGCCAGAAACTTGTTTTGCTTGCAGTTGGATGAAGTAAATGTTGGTGCACA TGAAATTTCCAATATATTAGATTCACAGCTTCTTCCTTGTGATTCTTCAGAAGCAGATGAAATGGAAAGGCTCAAGTGTGAAAGAGATGA >In-frame_COG6_ENST00000416691_chr13_40235018_+_STXBP4_ENST00000376352_chr17_53108529_+_5839nt GATGCGCATGCGCGGCCGATTTGCACATGCGCAATACTCGCGCTGCCTCCGTGGTCCCTGCCTGGCTGAGGTGGCAGCAGGGGGCGGGAC GCGCAGCGCTATGGCAGAGGGCAGCGGGGAAGTGGTCGCAGTGTCTGCGACCGGGGCTGCCAACGGCCTCAACAATGGGGCAGGCGGGAC CTCGGCGACGACCTGCAACCCGCTGTCGCGCAAGCTGCATAAGATCCTGGAGACGCGGCTGGACAACGACAAGGAGATGTTAGAAGCTCT CAAGGCACTTTCAACCTTTTTTGTTGAAAATAGTCTGCGGACTCGAAGAAATTTACGTGGAGATATTGAACGTAAAAGTTTAGCCATCAA TGAAGAATTTGTAAGCATTTTCAAGGAAGTGAAGGAGGAACTTGAAAGCATAAGCGAAGATGTTCAAGCAATGAGCAACTGTTGTCAAGA TATGACAAGTCGCCTACAGGCTCTAAATTATCTTGGTATTCAGCCCACAAAGGAACAACACCAAGCCCTGAGACAGCAAGTACAAGCAGA CTCAAAAGGGACAGTGTCTTTTGGAGATTTTGTCCAGGTTGCCAGAAACTTGTTTTGCTTGCAGTTGGATGAAGTAAATGTTGGTGCACA TGAAATTTCCAATATATTAGATTCACAGCTTCTTCCTTGTGATTCTTCAGAAGCAGATGAAATGGAAAGGCTCAAGTGTGAAAGAGATGA TGCCTTGAAAGAAGTAAATACACTTAAGGAAAAATTATTGGAATCAGATAAGCAAAGGAAACAATTGACAGAAGAGCTCCAGAATGTGAA ACAAGAAGCCAAAGCTGTAGTTGAAGAAACAAGAGCCCTGCGTAGTCGGATTCATCTTGCTGAAGCTGCTCAGAGACAGGCACATGGAAT GGAAATGGACTATGAAGAAGTGATCCGTCTGTTAGAGGCCAAGATTACAGAGCTAAAGGCTCAGCTTGCTGATTATTCTGACCAAAATAA AGAAAGTGTTCAGGATTTAAAAAAGAGAATCATGGTACTCGACTGCCAATTACGAAAATCAGAAATGGCTCGAAAAACTTTTGAGGCATC CACTGAAAAGCTTCTTCATTTTGTAGAGGCTATTCAAGAAGTATTTTCTGATAATTCTACTCCTTTATCAAATTTAAGTGAAAGAAGAGC TGTGTTAGCTTCTCAGACTTCCCTCACACCACTGGGAAGGAATGGACGTAGCATCCCAGCAACGCTGGCGCTTGAATCTAAGGAACTTGT TAAATCTGTTCGTGCCTTACTTGATATGGATTGTTTACCTTATGGGTGGGAGGAAGCTTACACAGCAGATGGAATCAAGTACTTCATCAA TCATGTAACACAGACTACATCCTGGATCCATCCCGTGATGAGTGTCCTGAATCTATCTCGCTCAGAGGAGAATGAAGAGGATTGCTCTAG AGAACTCCCCAACCAGAAAAGTTGATGGTTTTCCTTAGGAAGTGGAGCTACATGGATGATGTGAGCAGAGACGCATAACATCCAATTCTG AGATGAAACAGTCTAAAATAGGAGTAAAGCATGCACTACTTGTTGAAGTGTGAAATGGAGACTCTGGACTTTGGGTATTTTTGTAAAACT TTTGATATTTCTGTATACATTTAAAAAATCAATTGCCACTACAGTAGTTCCTTAAGAATAATCTAGTTATATTTTTTGAAATCACATATA ATTAGACTTTATAATATATATACTTTTTCATATATAATTAGATCTTTCTTTGTAATTTCATATGTAGTTCTTCATAGGGTCTCAGATACA ATGGTTTTTATAATTGACATATTGAAAAAGTATATGAACATAATGAAACACCTCATTTATTTGATAATTCACTAATGTTTTATATTCATA TATTAGGAAAGTGAACTTAGCAAGCTTTTTGGAATTTAAGGATCACATTTAGACATCTCATGGGCTGATGAATACAGCTGGTATCTTTGT GGAGCTTTCTAATTTACAAAATGCTTTGTAGACCCCATTGTCTTTAAACCATACAACATGCCCGTGAAGCTGATCTGGTGGGTATGTTTA TTCTTGGTTTTCAGTAGGGAAATAGCAGTTCAGAGAGAGGAAGCTCTCTGTCCCAGCACCGAGACTCACTCCTAAGTCTTCTGATTCCAT GAGCAGTCCCCCTTCCCCCATACCCTGCTGTCTCCACGGAGGGAGGTCACAGCCCATCACGCAGGACACTGTGATTGTGTTGATGCAGCT GGCTCCACAGCTGTGCATTCCACAGAGATTCAGAAGGCACCTCTTCGGTCAAACATGGCCCCTCTATAACCCCACTATTCTTCTCCTATA AACCCTTCCCCCTTCTCTGCACCCAAGCCTTCGCCAAGTAGGCGCACTCTTTGTGATATTGTTTCAGCAGACTTCTTTCAGCAGCTCGTG TTTTTCTAAAGTGAAAGGCATGGTTTGTCCTGCTTAGGTTGCCCTTCCCAGAGGGATGGTTTGAGGGGAGCTGATGAGAAGAGAGGTATC TGTTAAAACATTACTGCTCTACTCGAAACAAGATGGAAGCCTAAAGCCCAAGTCGAGCAGCTCCCAGCACTGCTGTGCAGACCTAGAGGT CCTTAGAACATAGTCTAAGAACCATTCATTGTAGCCATTTTATAGTTGAGTAAACTGAGATCTTAAGTCTCCTAGTCTACTGAATTTCAT ATGGTGTATAATACAGATTTATATGGTAAAGATATACATATACATTGTGCTCAACTATACATTCCTGAATCCATTTAGGATTTGTGATTT ATGTCTTGAGTAATAATATAAAGTCAACTCCAGACTGATAGGTAGTCATTAGCCATGAGAAATGTTTCAGGATGGCTAGGGAAGACTTGT GTTTTGCCTGACAGCCATTTGAATGTTAGGAAGCTTCGGGGAGACAAGTTTTGAGAGAAGCCCCAGAGGGAGCTATTTCCTTGCACCCCC CAGAGGTGAATGAGGTATTCTATAAGTTAGTGTCTATAATTGTGAAAGTACAAACTTCTTGTTTTTGTCAAATTAATGGTATGAAATTTC TCTCCCCCTGCTTGAAGAGTTTTCTAATTCGTTTCTAGTGAGCAAAACAAAGAAGGTGCTTGAGTCACTGAAATCAAAGTACTCAGGCAC ACAGCCCACTGACAAGAGACACCTCATCCATTAACTGCTGTTTTGTACCACTTGCCGCCCTGTTTCTGTCAAATACCTAGTGAAAAAGGC CTAAACAATTGTAATGATATTATTTATTGGGCATTTTGTGCCATACATGGTGATGAGCAGTTTGCATATATTTATTTATGATCTTCTTAA AACCATTCCATGAAATAGGAACTGTAATTATCCCCAATTCTAAAAGAAAAAACTTAGTTTTAGAGAGTTAGTAATCTTTGCCTAAGGGTC ACAAAGCACCTATGTGTAGAAGCTAGGGTTCAAGGCAGATCTGTGATTCCAGAAGCTGTTCTCTAAACCACTATGGAGAACTGCTTAGAT TCATTGTCTATGGGTACATTTTATAAAAAGGCAGATTCTAGTTCAGTGTCATAAGGAACTTTCTAGTAATTAGAGCTGATAAGAAAAGAA TTCCCCAGGAGAAAATGGAAACACTATCCCAGCAATCTGAATTCCTTACTTGGGGAATGTTGCTGAGGAGGTTCAGTGTGTGAATGGACT GAACCAGTTGGCCACTCTCTCAGATTCCCTCTTCATAAAGCTTCCGTGACTTCTAAACCATCAGGTCGGTGCCATAAGAGATGCTCAAAA AAGCATGGTCAGGGCTTAGCAAGAATCCTTTTCCAGTGCAAATACGACCCTCATATTATGTTTTGGCGAGTAGCCAGTCTTTCTTTAACA TCAATCAACCGTAGCAATGTGGTCATCACGAAGTCTTCATTGACTCACTGGCTTGGATTTTAGGGTTAGAAAATCTGAATGTTCTTATGT CCTTCCGTCTCACTTTACTAGAGTGCCCAAGTTGACTCATCCTTACTCACTCATTCCCTCAAAATATTTATTGAGCACCAACAATGTCAC AAGCACTGTGCTAAACACTGTGGTGAAGTAGAACAATTGCTAATCATTTCCTGGGTTCCACTTACTCTTGATTTAAAAAAAAAAAAACAA CAAAAGAGTTTGTGTGTGGCCAGGACTAAACAGCTGCTTCTTAATTTTTGAATTTTAAAACTAATCTATTTTATTTAAAAAAAATCAAGT ACTTTGGAAGTGAATAAAGTAAGAGATAGCCTGTCTCACTTTCCAGAGGTAGCAGTCACTAATACTGTGGTGAGTGATTTTACTCAAAGG AAATCACACTATTAAGCAGCTTGGTTTTGACATGTTATGTTGTGGTCATCTTTTCATGTCAATACATAGATTAATCTTTTATTTCAAATG TCTACATAAAATATCACTACCCACATAACCTATAATTTGTGTGGCCAGCAATTTATTGAACACTAAAATGTTTTAAGTTTTCTTATTGCT AACAATGTCACAGTGAACATTTATATATTCATTAAATCCTTTTCCTCATGTATCTTTGCACTCTTGTGCTAGTATGTCTATAGTGTGAAT ACATTCATAAATTTCTTGATCAAAGCTAGGTCAAAGTTACATTCATTTTAATTTTGGTACATATCCATAAATTCTCCATAAAAGTAGGAC CAACTTACATTACCACCAATAGTGTATGTGAGCCTTATTTTTATGTATGATAGGACTTTTTTTAGTCCAAATGTTCCTATAGATTTTCTG GGTTTTTTTTTTTTTTTTGTCCTTGGAAGAATAACCTTCCTTCCACCAAGTCCAAGAACCTGAGATTTTTAATCATTAGGTTTTAGATTT CCTTTAGCAGCAGAGACTGACTTGCTGTATAGAGGGAAGTCAAGTAGTGACTAACTCACTATATGTCAAACACATCATTACTCTTCTCTT TTCCTACTTTACATGTAATGGTTGCGAGGACCAACTTTCAAATGAGCTAACTTGGGTGAGACGTTCACTAAAGTACCAAGCACAATACAA ATGCATCTTCGAGTTCTTTGGGCCTCACTTTCCCTATCTGAATAATAAGGATAGTAATCCCTTGCCTTTTCTCAAACCAGTTCAACTCAG CAAACACTTCCTGAGCACCTGCTACATGCCAGGCAAAATGTGAAATTTGCATGCTATGAGGCTAAATGGTACTGATTCTCAAAACAAGGA GCTCATAGTCTAAAACCATTTTTCTTTCTTTTTTTTCCCCCTAAACAACCTCTTAAAGGGGTAAGAAGTTAGGGGGTTGTTTATTAAGAA CCCCTGAAGAGCAACCCTTTACCACTCTCTTAAATTTGAAAAATTCCAAAATAATATTAACACCTCTTGACTAGAAAAGGAAAAAAAAGG AACATGCCGTATGAAGAGCCTCTCCAATAATAAATGCAAAGCAGCTGTCAAAATATAGAGTCAAGTGATACTTTCATAAAGTGTTTGCAC AATTAGAAAATGTTATCCTTTTTCTCGGGAGAAATGGGACATTTTTATTTTCTCTGCTAAGTGAAATGCAACTTTTTGAAGAATCAACAC GCTTGACATTTTTACAATGTACATAAAGAACTGAACTATTATTAAAACAACTTACACACTCCATTGCTTATAACTTTTGAGAGAATGAAA AGAACCTTAAACAGAATGTGCCTGTGGAGCTTCGCTTTAGAAATGAAATACCCAAGGTGTTTTAACTACAACTGTCTACATGTAATAGTG >In-frame_COG6_ENST00000416691_chr13_40235018_+_STXBP4_ENST00000405898_chr17_53108529_+_1913nt GATGCGCATGCGCGGCCGATTTGCACATGCGCAATACTCGCGCTGCCTCCGTGGTCCCTGCCTGGCTGAGGTGGCAGCAGGGGGCGGGAC GCGCAGCGCTATGGCAGAGGGCAGCGGGGAAGTGGTCGCAGTGTCTGCGACCGGGGCTGCCAACGGCCTCAACAATGGGGCAGGCGGGAC CTCGGCGACGACCTGCAACCCGCTGTCGCGCAAGCTGCATAAGATCCTGGAGACGCGGCTGGACAACGACAAGGAGATGTTAGAAGCTCT CAAGGCACTTTCAACCTTTTTTGTTGAAAATAGTCTGCGGACTCGAAGAAATTTACGTGGAGATATTGAACGTAAAAGTTTAGCCATCAA TGAAGAATTTGTAAGCATTTTCAAGGAAGTGAAGGAGGAACTTGAAAGCATAAGCGAAGATGTTCAAGCAATGAGCAACTGTTGTCAAGA TATGACAAGTCGCCTACAGGCTCTAAATTATCTTGGTATTCAGCCCACAAAGGAACAACACCAAGCCCTGAGACAGCAAGTACAAGCAGA CTCAAAAGGGACAGTGTCTTTTGGAGATTTTGTCCAGGTTGCCAGAAACTTGTTTTGCTTGCAGTTGGATGAAGTAAATGTTGGTGCACA TGAAATTTCCAATATATTAGATTCACAGCTTCTTCCTTGTGATTCTTCAGAAGCAGATGAAATGGAAAGGCTCAAGTGTGAAAGAGATGA TGCCTTGAAAGAAGTAAATACACTTAAGTGGCCAGGGCAGAATTAGATGAAGAGCCAATAAAGCAAGTCGTGGCAATTTTGGATCCTGTG AGTTCTTTGGGAAATACATTTTTTTTCATGTGCAGGGCTATTCTTAAGGGACATCATGTTTTGCTAACGTAATTTGGAATTAATATTATT TTAGAGAGGAAAAAAACACACATATCCCAAATATACTGTAACATTTTTCTTCTCTTTTTTTGTTTGTTTGGTTTTTTGATTCTTGTTTTT GTTTTGTGTTTTTGAGACAGGGTCGCACTCTGTCGCCCAGGCTGGAGTGCAATACTGCAATCACGTCTCACTGCAGCCTCAACCTCCTGG GTTCAAGTGATTCTCCCACCTCAACCTCCCAAGTAACTGGGACAACATGTCCATGCCACCATGCTCAACTAATTTTTTTTTAAATTTTTA TTTTGTAGAGATGGTGTCTCACTATTTTGTTCAGACTGGTCTCAAACACCTGGGCTCAAATGACCCACCTACCTCAGCCTCTCAAAGTGC TGGGATTACAGGTGTGAGCCACCATGTCTGGCCTTGATTCTCTTTATGTGGTTTCATTCTGTTTTTAGAAGAATATTACATTTAAATTAT ATCCTAATTTTTATAGAAAGCTATATTTTCCAAATCTTTAGGAAAAGCAACATAACTACTTGATTTACCACTAATTCGTCATAGGCACAT ATTTTTAAAATTATTTTATTAAATAAGGTATAGTATATTGATAATTATTTAATTTTTATTAAATAGAAAATATTTACACCAAAAGGAAAG AAAATTTGTTTTGCTACCTTAGTTTTTATAATCTCAACCTCTAGAGGAAGCCATTGTTGCAAATATATTATTTATCTTTTCATAGATTTT TCTCTACACAGAAAATTATATTTTTTAAAAATAGGCAGGGCATGATGGCTGACACCTTTAATCGCAGTACTTTGGGAGGCTGAGGCAAGA GGATTACTTGAGCTCAGGAGTTTAACATCAGCCTGGGCAACATAGCAGGACCCCATCTCTACTATTTAAAACATAAAAACAAAAATAAAT AAATATATGTATATGTGGGGACAGGGAGTATGTGAGAAATTTCTGTACTTTCCCTTCAATTTTGCTATGAATCCAAAACTGCTTCAAAAA >In-frame_COG6_ENST00000416691_chr13_40235018_+_STXBP4_ENST00000434978_chr17_53108529_+_2414nt GATGCGCATGCGCGGCCGATTTGCACATGCGCAATACTCGCGCTGCCTCCGTGGTCCCTGCCTGGCTGAGGTGGCAGCAGGGGGCGGGAC GCGCAGCGCTATGGCAGAGGGCAGCGGGGAAGTGGTCGCAGTGTCTGCGACCGGGGCTGCCAACGGCCTCAACAATGGGGCAGGCGGGAC CTCGGCGACGACCTGCAACCCGCTGTCGCGCAAGCTGCATAAGATCCTGGAGACGCGGCTGGACAACGACAAGGAGATGTTAGAAGCTCT CAAGGCACTTTCAACCTTTTTTGTTGAAAATAGTCTGCGGACTCGAAGAAATTTACGTGGAGATATTGAACGTAAAAGTTTAGCCATCAA TGAAGAATTTGTAAGCATTTTCAAGGAAGTGAAGGAGGAACTTGAAAGCATAAGCGAAGATGTTCAAGCAATGAGCAACTGTTGTCAAGA TATGACAAGTCGCCTACAGGCTCTAAATTATCTTGGTATTCAGCCCACAAAGGAACAACACCAAGCCCTGAGACAGCAAGTACAAGCAGA CTCAAAAGGGACAGTGTCTTTTGGAGATTTTGTCCAGGTTGCCAGAAACTTGTTTTGCTTGCAGTTGGATGAAGTAAATGTTGGTGCACA TGAAATTTCCAATATATTAGATTCACAGCTTCTTCCTTGTGATTCTTCAGAAGCAGATGAAATGGAAAGGCTCAAGTGTGAAAGAGATGA TGCCTTGAAAGAAGTAAATACACTTAAGGAAGCCAAAGCTGTAGTTGAAGAAACAAGAGCCCTGCGTAGTCGGATTCATCTTGCTGAAGC TGCTCAGAGACAGGCACATGGAATGGAAATGGACTATGAAGAAGTGATCCGTCTGTTAGAGGCCAAGATTACAGAGCTAAAGGCTCAGCT TGCTGATTATTCTGACCAAAATAAAGAAAGTGTTCAGGATTTAAAAAAGAGAATCATGGTACTCGACTGCCAATTACGAAAATCAGAAAT GGCTCGAAAAACTTTTGAGGCATCCACTGAAAAGCTTCTTCATTTTGTAGAGGCTATTCAAGAAGTATTTTCTGATAATTCTACTCCTTT ATCAAATTTAAGTGAAAGAAGAGCTGTGTTAGCTTCTCAGACTTCCCTCACACCACTGGGAAGGAATGGACGTAGCATCCCAGCAACGCT GGCGCTTGAATCTAAGGAACTTGTTAAATCTGTTCGTGCCTTACTTGATATGGATTGTTTACCTTATGGGTGGGAGGAAGCTTACACAGC AGATGGAATCAAGTACTTCATCAATCATGTAACACAGACTACATCCTGGATCCATCCCGTGATGAGTGTCCTGAATCTATCTCGCTCAGA GGAGAATGAAGAGGATTGCTCTAGAGAACTCCCCAACCAGAAAAGTTGATGGTTTTCCTTAGGAAGTGGAGCTACATGGATGATGTGAGC AGAGACGCATAACATCCAATTCTGAGATGAAACAGTCTAAAATAGGAGTAAAGCATGCACTACTTGTTGAAGTGTGAAATGGAGACTCTG GACTTTGGGTATTTTTGTAAAACTTTTGATATTTCTGTATACATTTAAAAAATCAATTGCCACTACAGTAGTTCCTTAAGAATAATCTAG TTATATTTTTTGAAATCACATATAATTAGACTTTATAATATATATACTTTTTCATATATAATTAGATCTTTCTTTGTAATTTCATATGTA GTTCTTCATAGGGTCTCAGATACAATGGTTTTTATAATTGACATATTGAAAAAGTATATGAACATAATGAAACACCTCATTTATTTGATA ATTCACTAATGTTTTATATTCATATATTAGGAAAGTGAACTTAGCAAGCTTTTTGGAATTTAAGGATCACATTTAGACATCTCATGGGCT GATGAATACAGCTGGTATCTTTGTGGAGCTTTCTAATTTACAAAATGCTTTGTAGACCCCATTGTCTTTAAACCATACAACATGCCCGTG AAGCTGATCTGGTGGGTATGTTTATTCTTGGTTTTCAGTAGGGAAATAGCAGTTCAGAGAGAGGAAGCTCTCTGTCCCAGCACCGAGACT CACTCCTAAGTCTTCTGATTCCATGAGCAGTCCCCCTTCCCCCATACCCTGCTGTCTCCACGGAGGGAGGTCACAGCCCATCACGCAGGA CACTGTGATTGTGTTGATGCAGCTGGCTCCACAGCTGTGCATTCCACAGAGATTCAGAAGGCACCTCTTCGGTCAAACATGGCCCCTCTA TAACCCCACTATTCTTCTCCTATAAACCCTTCCCCCTTCTCTGCACCCAAGCCTTCGCCAAGTAGGCGCACTCTTTGTGATATTGTTTCA >In-frame_COG6_ENST00000416691_chr13_40235018_+_STXBP4_ENST00000398391_chr17_53108529_+_1913nt GATGCGCATGCGCGGCCGATTTGCACATGCGCAATACTCGCGCTGCCTCCGTGGTCCCTGCCTGGCTGAGGTGGCAGCAGGGGGCGGGAC GCGCAGCGCTATGGCAGAGGGCAGCGGGGAAGTGGTCGCAGTGTCTGCGACCGGGGCTGCCAACGGCCTCAACAATGGGGCAGGCGGGAC CTCGGCGACGACCTGCAACCCGCTGTCGCGCAAGCTGCATAAGATCCTGGAGACGCGGCTGGACAACGACAAGGAGATGTTAGAAGCTCT CAAGGCACTTTCAACCTTTTTTGTTGAAAATAGTCTGCGGACTCGAAGAAATTTACGTGGAGATATTGAACGTAAAAGTTTAGCCATCAA TGAAGAATTTGTAAGCATTTTCAAGGAAGTGAAGGAGGAACTTGAAAGCATAAGCGAAGATGTTCAAGCAATGAGCAACTGTTGTCAAGA TATGACAAGTCGCCTACAGGCTCTAAATTATCTTGGTATTCAGCCCACAAAGGAACAACACCAAGCCCTGAGACAGCAAGTACAAGCAGA CTCAAAAGGGACAGTGTCTTTTGGAGATTTTGTCCAGGTTGCCAGAAACTTGTTTTGCTTGCAGTTGGATGAAGTAAATGTTGGTGCACA TGAAATTTCCAATATATTAGATTCACAGCTTCTTCCTTGTGATTCTTCAGAAGCAGATGAAATGGAAAGGCTCAAGTGTGAAAGAGATGA TGCCTTGAAAGAAGTAAATACACTTAAGTGGCCAGGGCAGAATTAGATGAAGAGCCAATAAAGCAAGTCGTGGCAATTTTGGATCCTGTG AGTTCTTTGGGAAATACATTTTTTTTCATGTGCAGGGCTATTCTTAAGGGACATCATGTTTTGCTAACGTAATTTGGAATTAATATTATT TTAGAGAGGAAAAAAACACACATATCCCAAATATACTGTAACATTTTTCTTCTCTTTTTTTGTTTGTTTGGTTTTTTGATTCTTGTTTTT GTTTTGTGTTTTTGAGACAGGGTCGCACTCTGTCGCCCAGGCTGGAGTGCAATACTGCAATCACGTCTCACTGCAGCCTCAACCTCCTGG GTTCAAGTGATTCTCCCACCTCAACCTCCCAAGTAACTGGGACAACATGTCCATGCCACCATGCTCAACTAATTTTTTTTTAAATTTTTA TTTTGTAGAGATGGTGTCTCACTATTTTGTTCAGACTGGTCTCAAACACCTGGGCTCAAATGACCCACCTACCTCAGCCTCTCAAAGTGC TGGGATTACAGGTGTGAGCCACCATGTCTGGCCTTGATTCTCTTTATGTGGTTTCATTCTGTTTTTAGAAGAATATTACATTTAAATTAT ATCCTAATTTTTATAGAAAGCTATATTTTCCAAATCTTTAGGAAAAGCAACATAACTACTTGATTTACCACTAATTCGTCATAGGCACAT ATTTTTAAAATTATTTTATTAAATAAGGTATAGTATATTGATAATTATTTAATTTTTATTAAATAGAAAATATTTACACCAAAAGGAAAG AAAATTTGTTTTGCTACCTTAGTTTTTATAATCTCAACCTCTAGAGGAAGCCATTGTTGCAAATATATTATTTATCTTTTCATAGATTTT TCTCTACACAGAAAATTATATTTTTTAAAAATAGGCAGGGCATGATGGCTGACACCTTTAATCGCAGTACTTTGGGAGGCTGAGGCAAGA GGATTACTTGAGCTCAGGAGTTTAACATCAGCCTGGGCAACATAGCAGGACCCCATCTCTACTATTTAAAACATAAAAACAAAAATAAAT AAATATATGTATATGTGGGGACAGGGAGTATGTGAGAAATTTCTGTACTTTCCCTTCAATTTTGCTATGAATCCAAAACTGCTTCAAAAA >In-frame_COG6_ENST00000455146_chr13_40235018_+_STXBP4_ENST00000299341_chr17_53108529_+_716nt GTGGTCCCTGCCTGGCTGAGGTGGCAGCAGGGGGCGGGACGCGCAGCGCTATGGCAGAGGGCAGCGGGGAAGTGGTCGCAGTGTCTGCGA CCGGGGCTGCCAACGGCCTCAACAATGGGGCAGGCGGGACCTCGGCGACGACCTGCAACCCGCTGTCGCGCAAGCTGCATAAGATCCTGG AGACGCGGCTGGACAACGACAAGGAGATGTTAGAAGCTCTCAAGGCACTTTCAACCTTTTTTGTTGAAAATAGTCTGCGGACTCGAAGAA ATTTACGTGGAGATATTGAACGTAAAAGTTTAGCCATCAATGAAGAATTTGTAAGCATTTTCAAGGAAGTGAAGGAGGAACTTGAAAGCA TAAGCGAAGATGTTCAAGCAATGAGCAACTGTTGTCAAGATATGACAAGTCGCCTACAGGCTCTAAATTATCTTGGTATTCAGCCCACAA AGGAACAACACCAAGCCCTGAGACAGCAAGTACAAGCAGACTCAAAAGGGACAGTGTCTTTTGGAGATTTTGTCCAGGTTGCCAGAAACT TGTTTTGCTTGCAGTTGGATGAAGTAAATGTTGGTGCACATGAAATTTCCAATATATTAGATTCACAGCTTCTTCCTTGTGATTCTTCAG >In-frame_COG6_ENST00000455146_chr13_40235018_+_STXBP4_ENST00000376352_chr17_53108529_+_5789nt GTGGTCCCTGCCTGGCTGAGGTGGCAGCAGGGGGCGGGACGCGCAGCGCTATGGCAGAGGGCAGCGGGGAAGTGGTCGCAGTGTCTGCGA CCGGGGCTGCCAACGGCCTCAACAATGGGGCAGGCGGGACCTCGGCGACGACCTGCAACCCGCTGTCGCGCAAGCTGCATAAGATCCTGG AGACGCGGCTGGACAACGACAAGGAGATGTTAGAAGCTCTCAAGGCACTTTCAACCTTTTTTGTTGAAAATAGTCTGCGGACTCGAAGAA ATTTACGTGGAGATATTGAACGTAAAAGTTTAGCCATCAATGAAGAATTTGTAAGCATTTTCAAGGAAGTGAAGGAGGAACTTGAAAGCA TAAGCGAAGATGTTCAAGCAATGAGCAACTGTTGTCAAGATATGACAAGTCGCCTACAGGCTCTAAATTATCTTGGTATTCAGCCCACAA AGGAACAACACCAAGCCCTGAGACAGCAAGTACAAGCAGACTCAAAAGGGACAGTGTCTTTTGGAGATTTTGTCCAGGTTGCCAGAAACT TGTTTTGCTTGCAGTTGGATGAAGTAAATGTTGGTGCACATGAAATTTCCAATATATTAGATTCACAGCTTCTTCCTTGTGATTCTTCAG AAGCAGATGAAATGGAAAGGCTCAAGTGTGAAAGAGATGATGCCTTGAAAGAAGTAAATACACTTAAGGAAAAATTATTGGAATCAGATA AGCAAAGGAAACAATTGACAGAAGAGCTCCAGAATGTGAAACAAGAAGCCAAAGCTGTAGTTGAAGAAACAAGAGCCCTGCGTAGTCGGA TTCATCTTGCTGAAGCTGCTCAGAGACAGGCACATGGAATGGAAATGGACTATGAAGAAGTGATCCGTCTGTTAGAGGCCAAGATTACAG AGCTAAAGGCTCAGCTTGCTGATTATTCTGACCAAAATAAAGAAAGTGTTCAGGATTTAAAAAAGAGAATCATGGTACTCGACTGCCAAT TACGAAAATCAGAAATGGCTCGAAAAACTTTTGAGGCATCCACTGAAAAGCTTCTTCATTTTGTAGAGGCTATTCAAGAAGTATTTTCTG ATAATTCTACTCCTTTATCAAATTTAAGTGAAAGAAGAGCTGTGTTAGCTTCTCAGACTTCCCTCACACCACTGGGAAGGAATGGACGTA GCATCCCAGCAACGCTGGCGCTTGAATCTAAGGAACTTGTTAAATCTGTTCGTGCCTTACTTGATATGGATTGTTTACCTTATGGGTGGG AGGAAGCTTACACAGCAGATGGAATCAAGTACTTCATCAATCATGTAACACAGACTACATCCTGGATCCATCCCGTGATGAGTGTCCTGA ATCTATCTCGCTCAGAGGAGAATGAAGAGGATTGCTCTAGAGAACTCCCCAACCAGAAAAGTTGATGGTTTTCCTTAGGAAGTGGAGCTA CATGGATGATGTGAGCAGAGACGCATAACATCCAATTCTGAGATGAAACAGTCTAAAATAGGAGTAAAGCATGCACTACTTGTTGAAGTG TGAAATGGAGACTCTGGACTTTGGGTATTTTTGTAAAACTTTTGATATTTCTGTATACATTTAAAAAATCAATTGCCACTACAGTAGTTC CTTAAGAATAATCTAGTTATATTTTTTGAAATCACATATAATTAGACTTTATAATATATATACTTTTTCATATATAATTAGATCTTTCTT TGTAATTTCATATGTAGTTCTTCATAGGGTCTCAGATACAATGGTTTTTATAATTGACATATTGAAAAAGTATATGAACATAATGAAACA CCTCATTTATTTGATAATTCACTAATGTTTTATATTCATATATTAGGAAAGTGAACTTAGCAAGCTTTTTGGAATTTAAGGATCACATTT AGACATCTCATGGGCTGATGAATACAGCTGGTATCTTTGTGGAGCTTTCTAATTTACAAAATGCTTTGTAGACCCCATTGTCTTTAAACC ATACAACATGCCCGTGAAGCTGATCTGGTGGGTATGTTTATTCTTGGTTTTCAGTAGGGAAATAGCAGTTCAGAGAGAGGAAGCTCTCTG TCCCAGCACCGAGACTCACTCCTAAGTCTTCTGATTCCATGAGCAGTCCCCCTTCCCCCATACCCTGCTGTCTCCACGGAGGGAGGTCAC AGCCCATCACGCAGGACACTGTGATTGTGTTGATGCAGCTGGCTCCACAGCTGTGCATTCCACAGAGATTCAGAAGGCACCTCTTCGGTC AAACATGGCCCCTCTATAACCCCACTATTCTTCTCCTATAAACCCTTCCCCCTTCTCTGCACCCAAGCCTTCGCCAAGTAGGCGCACTCT TTGTGATATTGTTTCAGCAGACTTCTTTCAGCAGCTCGTGTTTTTCTAAAGTGAAAGGCATGGTTTGTCCTGCTTAGGTTGCCCTTCCCA GAGGGATGGTTTGAGGGGAGCTGATGAGAAGAGAGGTATCTGTTAAAACATTACTGCTCTACTCGAAACAAGATGGAAGCCTAAAGCCCA AGTCGAGCAGCTCCCAGCACTGCTGTGCAGACCTAGAGGTCCTTAGAACATAGTCTAAGAACCATTCATTGTAGCCATTTTATAGTTGAG TAAACTGAGATCTTAAGTCTCCTAGTCTACTGAATTTCATATGGTGTATAATACAGATTTATATGGTAAAGATATACATATACATTGTGC TCAACTATACATTCCTGAATCCATTTAGGATTTGTGATTTATGTCTTGAGTAATAATATAAAGTCAACTCCAGACTGATAGGTAGTCATT AGCCATGAGAAATGTTTCAGGATGGCTAGGGAAGACTTGTGTTTTGCCTGACAGCCATTTGAATGTTAGGAAGCTTCGGGGAGACAAGTT TTGAGAGAAGCCCCAGAGGGAGCTATTTCCTTGCACCCCCCAGAGGTGAATGAGGTATTCTATAAGTTAGTGTCTATAATTGTGAAAGTA CAAACTTCTTGTTTTTGTCAAATTAATGGTATGAAATTTCTCTCCCCCTGCTTGAAGAGTTTTCTAATTCGTTTCTAGTGAGCAAAACAA AGAAGGTGCTTGAGTCACTGAAATCAAAGTACTCAGGCACACAGCCCACTGACAAGAGACACCTCATCCATTAACTGCTGTTTTGTACCA CTTGCCGCCCTGTTTCTGTCAAATACCTAGTGAAAAAGGCCTAAACAATTGTAATGATATTATTTATTGGGCATTTTGTGCCATACATGG TGATGAGCAGTTTGCATATATTTATTTATGATCTTCTTAAAACCATTCCATGAAATAGGAACTGTAATTATCCCCAATTCTAAAAGAAAA AACTTAGTTTTAGAGAGTTAGTAATCTTTGCCTAAGGGTCACAAAGCACCTATGTGTAGAAGCTAGGGTTCAAGGCAGATCTGTGATTCC AGAAGCTGTTCTCTAAACCACTATGGAGAACTGCTTAGATTCATTGTCTATGGGTACATTTTATAAAAAGGCAGATTCTAGTTCAGTGTC ATAAGGAACTTTCTAGTAATTAGAGCTGATAAGAAAAGAATTCCCCAGGAGAAAATGGAAACACTATCCCAGCAATCTGAATTCCTTACT TGGGGAATGTTGCTGAGGAGGTTCAGTGTGTGAATGGACTGAACCAGTTGGCCACTCTCTCAGATTCCCTCTTCATAAAGCTTCCGTGAC TTCTAAACCATCAGGTCGGTGCCATAAGAGATGCTCAAAAAAGCATGGTCAGGGCTTAGCAAGAATCCTTTTCCAGTGCAAATACGACCC TCATATTATGTTTTGGCGAGTAGCCAGTCTTTCTTTAACATCAATCAACCGTAGCAATGTGGTCATCACGAAGTCTTCATTGACTCACTG GCTTGGATTTTAGGGTTAGAAAATCTGAATGTTCTTATGTCCTTCCGTCTCACTTTACTAGAGTGCCCAAGTTGACTCATCCTTACTCAC TCATTCCCTCAAAATATTTATTGAGCACCAACAATGTCACAAGCACTGTGCTAAACACTGTGGTGAAGTAGAACAATTGCTAATCATTTC CTGGGTTCCACTTACTCTTGATTTAAAAAAAAAAAAACAACAAAAGAGTTTGTGTGTGGCCAGGACTAAACAGCTGCTTCTTAATTTTTG AATTTTAAAACTAATCTATTTTATTTAAAAAAAATCAAGTACTTTGGAAGTGAATAAAGTAAGAGATAGCCTGTCTCACTTTCCAGAGGT AGCAGTCACTAATACTGTGGTGAGTGATTTTACTCAAAGGAAATCACACTATTAAGCAGCTTGGTTTTGACATGTTATGTTGTGGTCATC TTTTCATGTCAATACATAGATTAATCTTTTATTTCAAATGTCTACATAAAATATCACTACCCACATAACCTATAATTTGTGTGGCCAGCA ATTTATTGAACACTAAAATGTTTTAAGTTTTCTTATTGCTAACAATGTCACAGTGAACATTTATATATTCATTAAATCCTTTTCCTCATG TATCTTTGCACTCTTGTGCTAGTATGTCTATAGTGTGAATACATTCATAAATTTCTTGATCAAAGCTAGGTCAAAGTTACATTCATTTTA ATTTTGGTACATATCCATAAATTCTCCATAAAAGTAGGACCAACTTACATTACCACCAATAGTGTATGTGAGCCTTATTTTTATGTATGA TAGGACTTTTTTTAGTCCAAATGTTCCTATAGATTTTCTGGGTTTTTTTTTTTTTTTTGTCCTTGGAAGAATAACCTTCCTTCCACCAAG TCCAAGAACCTGAGATTTTTAATCATTAGGTTTTAGATTTCCTTTAGCAGCAGAGACTGACTTGCTGTATAGAGGGAAGTCAAGTAGTGA CTAACTCACTATATGTCAAACACATCATTACTCTTCTCTTTTCCTACTTTACATGTAATGGTTGCGAGGACCAACTTTCAAATGAGCTAA CTTGGGTGAGACGTTCACTAAAGTACCAAGCACAATACAAATGCATCTTCGAGTTCTTTGGGCCTCACTTTCCCTATCTGAATAATAAGG ATAGTAATCCCTTGCCTTTTCTCAAACCAGTTCAACTCAGCAAACACTTCCTGAGCACCTGCTACATGCCAGGCAAAATGTGAAATTTGC ATGCTATGAGGCTAAATGGTACTGATTCTCAAAACAAGGAGCTCATAGTCTAAAACCATTTTTCTTTCTTTTTTTTCCCCCTAAACAACC TCTTAAAGGGGTAAGAAGTTAGGGGGTTGTTTATTAAGAACCCCTGAAGAGCAACCCTTTACCACTCTCTTAAATTTGAAAAATTCCAAA ATAATATTAACACCTCTTGACTAGAAAAGGAAAAAAAAGGAACATGCCGTATGAAGAGCCTCTCCAATAATAAATGCAAAGCAGCTGTCA AAATATAGAGTCAAGTGATACTTTCATAAAGTGTTTGCACAATTAGAAAATGTTATCCTTTTTCTCGGGAGAAATGGGACATTTTTATTT TCTCTGCTAAGTGAAATGCAACTTTTTGAAGAATCAACACGCTTGACATTTTTACAATGTACATAAAGAACTGAACTATTATTAAAACAA CTTACACACTCCATTGCTTATAACTTTTGAGAGAATGAAAAGAACCTTAAACAGAATGTGCCTGTGGAGCTTCGCTTTAGAAATGAAATA CCCAAGGTGTTTTAACTACAACTGTCTACATGTAATAGTGTGTCTGCATAATGACTTTGTAAATATTAACTGCAATTCTGTATTTGCTTT >In-frame_COG6_ENST00000455146_chr13_40235018_+_STXBP4_ENST00000405898_chr17_53108529_+_1863nt GTGGTCCCTGCCTGGCTGAGGTGGCAGCAGGGGGCGGGACGCGCAGCGCTATGGCAGAGGGCAGCGGGGAAGTGGTCGCAGTGTCTGCGA CCGGGGCTGCCAACGGCCTCAACAATGGGGCAGGCGGGACCTCGGCGACGACCTGCAACCCGCTGTCGCGCAAGCTGCATAAGATCCTGG AGACGCGGCTGGACAACGACAAGGAGATGTTAGAAGCTCTCAAGGCACTTTCAACCTTTTTTGTTGAAAATAGTCTGCGGACTCGAAGAA ATTTACGTGGAGATATTGAACGTAAAAGTTTAGCCATCAATGAAGAATTTGTAAGCATTTTCAAGGAAGTGAAGGAGGAACTTGAAAGCA TAAGCGAAGATGTTCAAGCAATGAGCAACTGTTGTCAAGATATGACAAGTCGCCTACAGGCTCTAAATTATCTTGGTATTCAGCCCACAA AGGAACAACACCAAGCCCTGAGACAGCAAGTACAAGCAGACTCAAAAGGGACAGTGTCTTTTGGAGATTTTGTCCAGGTTGCCAGAAACT TGTTTTGCTTGCAGTTGGATGAAGTAAATGTTGGTGCACATGAAATTTCCAATATATTAGATTCACAGCTTCTTCCTTGTGATTCTTCAG AAGCAGATGAAATGGAAAGGCTCAAGTGTGAAAGAGATGATGCCTTGAAAGAAGTAAATACACTTAAGTGGCCAGGGCAGAATTAGATGA AGAGCCAATAAAGCAAGTCGTGGCAATTTTGGATCCTGTGAGTTCTTTGGGAAATACATTTTTTTTCATGTGCAGGGCTATTCTTAAGGG ACATCATGTTTTGCTAACGTAATTTGGAATTAATATTATTTTAGAGAGGAAAAAAACACACATATCCCAAATATACTGTAACATTTTTCT TCTCTTTTTTTGTTTGTTTGGTTTTTTGATTCTTGTTTTTGTTTTGTGTTTTTGAGACAGGGTCGCACTCTGTCGCCCAGGCTGGAGTGC AATACTGCAATCACGTCTCACTGCAGCCTCAACCTCCTGGGTTCAAGTGATTCTCCCACCTCAACCTCCCAAGTAACTGGGACAACATGT CCATGCCACCATGCTCAACTAATTTTTTTTTAAATTTTTATTTTGTAGAGATGGTGTCTCACTATTTTGTTCAGACTGGTCTCAAACACC TGGGCTCAAATGACCCACCTACCTCAGCCTCTCAAAGTGCTGGGATTACAGGTGTGAGCCACCATGTCTGGCCTTGATTCTCTTTATGTG GTTTCATTCTGTTTTTAGAAGAATATTACATTTAAATTATATCCTAATTTTTATAGAAAGCTATATTTTCCAAATCTTTAGGAAAAGCAA CATAACTACTTGATTTACCACTAATTCGTCATAGGCACATATTTTTAAAATTATTTTATTAAATAAGGTATAGTATATTGATAATTATTT AATTTTTATTAAATAGAAAATATTTACACCAAAAGGAAAGAAAATTTGTTTTGCTACCTTAGTTTTTATAATCTCAACCTCTAGAGGAAG CCATTGTTGCAAATATATTATTTATCTTTTCATAGATTTTTCTCTACACAGAAAATTATATTTTTTAAAAATAGGCAGGGCATGATGGCT GACACCTTTAATCGCAGTACTTTGGGAGGCTGAGGCAAGAGGATTACTTGAGCTCAGGAGTTTAACATCAGCCTGGGCAACATAGCAGGA CCCCATCTCTACTATTTAAAACATAAAAACAAAAATAAATAAATATATGTATATGTGGGGACAGGGAGTATGTGAGAAATTTCTGTACTT >In-frame_COG6_ENST00000455146_chr13_40235018_+_STXBP4_ENST00000434978_chr17_53108529_+_2364nt GTGGTCCCTGCCTGGCTGAGGTGGCAGCAGGGGGCGGGACGCGCAGCGCTATGGCAGAGGGCAGCGGGGAAGTGGTCGCAGTGTCTGCGA CCGGGGCTGCCAACGGCCTCAACAATGGGGCAGGCGGGACCTCGGCGACGACCTGCAACCCGCTGTCGCGCAAGCTGCATAAGATCCTGG AGACGCGGCTGGACAACGACAAGGAGATGTTAGAAGCTCTCAAGGCACTTTCAACCTTTTTTGTTGAAAATAGTCTGCGGACTCGAAGAA ATTTACGTGGAGATATTGAACGTAAAAGTTTAGCCATCAATGAAGAATTTGTAAGCATTTTCAAGGAAGTGAAGGAGGAACTTGAAAGCA TAAGCGAAGATGTTCAAGCAATGAGCAACTGTTGTCAAGATATGACAAGTCGCCTACAGGCTCTAAATTATCTTGGTATTCAGCCCACAA AGGAACAACACCAAGCCCTGAGACAGCAAGTACAAGCAGACTCAAAAGGGACAGTGTCTTTTGGAGATTTTGTCCAGGTTGCCAGAAACT TGTTTTGCTTGCAGTTGGATGAAGTAAATGTTGGTGCACATGAAATTTCCAATATATTAGATTCACAGCTTCTTCCTTGTGATTCTTCAG AAGCAGATGAAATGGAAAGGCTCAAGTGTGAAAGAGATGATGCCTTGAAAGAAGTAAATACACTTAAGGAAGCCAAAGCTGTAGTTGAAG AAACAAGAGCCCTGCGTAGTCGGATTCATCTTGCTGAAGCTGCTCAGAGACAGGCACATGGAATGGAAATGGACTATGAAGAAGTGATCC GTCTGTTAGAGGCCAAGATTACAGAGCTAAAGGCTCAGCTTGCTGATTATTCTGACCAAAATAAAGAAAGTGTTCAGGATTTAAAAAAGA GAATCATGGTACTCGACTGCCAATTACGAAAATCAGAAATGGCTCGAAAAACTTTTGAGGCATCCACTGAAAAGCTTCTTCATTTTGTAG AGGCTATTCAAGAAGTATTTTCTGATAATTCTACTCCTTTATCAAATTTAAGTGAAAGAAGAGCTGTGTTAGCTTCTCAGACTTCCCTCA CACCACTGGGAAGGAATGGACGTAGCATCCCAGCAACGCTGGCGCTTGAATCTAAGGAACTTGTTAAATCTGTTCGTGCCTTACTTGATA TGGATTGTTTACCTTATGGGTGGGAGGAAGCTTACACAGCAGATGGAATCAAGTACTTCATCAATCATGTAACACAGACTACATCCTGGA TCCATCCCGTGATGAGTGTCCTGAATCTATCTCGCTCAGAGGAGAATGAAGAGGATTGCTCTAGAGAACTCCCCAACCAGAAAAGTTGAT GGTTTTCCTTAGGAAGTGGAGCTACATGGATGATGTGAGCAGAGACGCATAACATCCAATTCTGAGATGAAACAGTCTAAAATAGGAGTA AAGCATGCACTACTTGTTGAAGTGTGAAATGGAGACTCTGGACTTTGGGTATTTTTGTAAAACTTTTGATATTTCTGTATACATTTAAAA AATCAATTGCCACTACAGTAGTTCCTTAAGAATAATCTAGTTATATTTTTTGAAATCACATATAATTAGACTTTATAATATATATACTTT TTCATATATAATTAGATCTTTCTTTGTAATTTCATATGTAGTTCTTCATAGGGTCTCAGATACAATGGTTTTTATAATTGACATATTGAA AAAGTATATGAACATAATGAAACACCTCATTTATTTGATAATTCACTAATGTTTTATATTCATATATTAGGAAAGTGAACTTAGCAAGCT TTTTGGAATTTAAGGATCACATTTAGACATCTCATGGGCTGATGAATACAGCTGGTATCTTTGTGGAGCTTTCTAATTTACAAAATGCTT TGTAGACCCCATTGTCTTTAAACCATACAACATGCCCGTGAAGCTGATCTGGTGGGTATGTTTATTCTTGGTTTTCAGTAGGGAAATAGC AGTTCAGAGAGAGGAAGCTCTCTGTCCCAGCACCGAGACTCACTCCTAAGTCTTCTGATTCCATGAGCAGTCCCCCTTCCCCCATACCCT GCTGTCTCCACGGAGGGAGGTCACAGCCCATCACGCAGGACACTGTGATTGTGTTGATGCAGCTGGCTCCACAGCTGTGCATTCCACAGA GATTCAGAAGGCACCTCTTCGGTCAAACATGGCCCCTCTATAACCCCACTATTCTTCTCCTATAAACCCTTCCCCCTTCTCTGCACCCAA GCCTTCGCCAAGTAGGCGCACTCTTTGTGATATTGTTTCAGCAGACTTCTTTCAGCAGCTCGTGTTTTTCTAAAGTGAAAGGCATGGTTT >In-frame_COG6_ENST00000455146_chr13_40235018_+_STXBP4_ENST00000398391_chr17_53108529_+_1863nt GTGGTCCCTGCCTGGCTGAGGTGGCAGCAGGGGGCGGGACGCGCAGCGCTATGGCAGAGGGCAGCGGGGAAGTGGTCGCAGTGTCTGCGA CCGGGGCTGCCAACGGCCTCAACAATGGGGCAGGCGGGACCTCGGCGACGACCTGCAACCCGCTGTCGCGCAAGCTGCATAAGATCCTGG AGACGCGGCTGGACAACGACAAGGAGATGTTAGAAGCTCTCAAGGCACTTTCAACCTTTTTTGTTGAAAATAGTCTGCGGACTCGAAGAA ATTTACGTGGAGATATTGAACGTAAAAGTTTAGCCATCAATGAAGAATTTGTAAGCATTTTCAAGGAAGTGAAGGAGGAACTTGAAAGCA TAAGCGAAGATGTTCAAGCAATGAGCAACTGTTGTCAAGATATGACAAGTCGCCTACAGGCTCTAAATTATCTTGGTATTCAGCCCACAA AGGAACAACACCAAGCCCTGAGACAGCAAGTACAAGCAGACTCAAAAGGGACAGTGTCTTTTGGAGATTTTGTCCAGGTTGCCAGAAACT TGTTTTGCTTGCAGTTGGATGAAGTAAATGTTGGTGCACATGAAATTTCCAATATATTAGATTCACAGCTTCTTCCTTGTGATTCTTCAG AAGCAGATGAAATGGAAAGGCTCAAGTGTGAAAGAGATGATGCCTTGAAAGAAGTAAATACACTTAAGTGGCCAGGGCAGAATTAGATGA AGAGCCAATAAAGCAAGTCGTGGCAATTTTGGATCCTGTGAGTTCTTTGGGAAATACATTTTTTTTCATGTGCAGGGCTATTCTTAAGGG ACATCATGTTTTGCTAACGTAATTTGGAATTAATATTATTTTAGAGAGGAAAAAAACACACATATCCCAAATATACTGTAACATTTTTCT TCTCTTTTTTTGTTTGTTTGGTTTTTTGATTCTTGTTTTTGTTTTGTGTTTTTGAGACAGGGTCGCACTCTGTCGCCCAGGCTGGAGTGC AATACTGCAATCACGTCTCACTGCAGCCTCAACCTCCTGGGTTCAAGTGATTCTCCCACCTCAACCTCCCAAGTAACTGGGACAACATGT CCATGCCACCATGCTCAACTAATTTTTTTTTAAATTTTTATTTTGTAGAGATGGTGTCTCACTATTTTGTTCAGACTGGTCTCAAACACC TGGGCTCAAATGACCCACCTACCTCAGCCTCTCAAAGTGCTGGGATTACAGGTGTGAGCCACCATGTCTGGCCTTGATTCTCTTTATGTG GTTTCATTCTGTTTTTAGAAGAATATTACATTTAAATTATATCCTAATTTTTATAGAAAGCTATATTTTCCAAATCTTTAGGAAAAGCAA CATAACTACTTGATTTACCACTAATTCGTCATAGGCACATATTTTTAAAATTATTTTATTAAATAAGGTATAGTATATTGATAATTATTT AATTTTTATTAAATAGAAAATATTTACACCAAAAGGAAAGAAAATTTGTTTTGCTACCTTAGTTTTTATAATCTCAACCTCTAGAGGAAG CCATTGTTGCAAATATATTATTTATCTTTTCATAGATTTTTCTCTACACAGAAAATTATATTTTTTAAAAATAGGCAGGGCATGATGGCT GACACCTTTAATCGCAGTACTTTGGGAGGCTGAGGCAAGAGGATTACTTGAGCTCAGGAGTTTAACATCAGCCTGGGCAACATAGCAGGA CCCCATCTCTACTATTTAAAACATAAAAACAAAAATAAATAAATATATGTATATGTGGGGACAGGGAGTATGTGAGAAATTTCTGTACTT 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FusionGenePPI for COG6_STXBP4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| COG6 | COG3, ATXN7, COG1, COG7, COG5, COG8, COG2, COG4, EGFR, TRAPPC13, PARP16, VSIG2, CD68, DTNBP1, IFT57, SCN2B, C10orf76, PTAR1, PKN1, ATP7A, KLC2, KIF5A, POC1A, NAV1, HAUS1, KLC4, POC1B, SASS6, RNF20, TRAF6, EXOC7, KIF5B, KLC1, COMMD8, BLOC1S2, DTNA, ATP6V1D, CCHCR1, KIF5C, RNF40, DTNB, SNTB2, TBC1D2B, ABI1, EXOC5, FCGRT, BICD2, C9orf16, NUP88, PKD2, EXOC1, AMOTL1, SYCE3, CENPF, CCDC22, SNAPIN, NPY2R, NCKAP1, SPAG5, STX6, CCDC53, VSIG1, STX12 | STXBP4 | ATN1, LATS2, KLHL42, PRRG4, TMEM171, C20orf195, SUSD6, MBIP, FAM189A2, VPS28, LDLRAD4, TP53, OFD1, CNTROB, CEP128, PTPN13, ERP44, PTPN14, WDTC1, CDR2, ARRDC3, RGS2, CCDC120, PLK1, PMF1, MPP5, PTPN21 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for COG6_STXBP4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for COG6_STXBP4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | COG6 | C3553230 | CONGENITAL DISORDER OF GLYCOSYLATION, TYPE IIl | 1 | ORPHANET;UNIPROT |
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