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Fusion gene ID: 7834 |
FusionGeneSummary for COG6_MAPK8 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: COG6_MAPK8 | Fusion gene ID: 7834 | Hgene | Tgene | Gene symbol | COG6 | MAPK8 | Gene ID | 57511 | 5599 |
| Gene name | component of oligomeric golgi complex 6 | mitogen-activated protein kinase 8 | |
| Synonyms | CDG2L|COD2|SHNS | JNK|JNK-46|JNK1|JNK1A2|JNK21B1/2|PRKM8|SAPK1|SAPK1c | |
| Cytomap | 13q14.11 | 10q11.22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | conserved oligomeric Golgi complex subunit 6COG complex subunit 6complexed with Dor1p 2conserved oligomeric Golgi complex protein 6testicular tissue protein Li 41 | mitogen-activated protein kinase 8JUN N-terminal kinaseMAP kinase 8c-Jun N-terminal kinase 1mitogen-activated protein kinase 8 isoform JNK1 alpha1mitogen-activated protein kinase 8 isoform JNK1 beta2stress-activated protein kinase 1stress-activated | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | Q9Y2V7 | P45983 | |
| Ensembl transtripts involved in fusion gene | ENST00000416691, ENST00000455146, ENST00000465775, | ENST00000374189, ENST00000374182, ENST00000360332, ENST00000374174, ENST00000395611, ENST00000459755, | |
| Fusion gene scores | * DoF score | 6 X 5 X 5=150 | 3 X 2 X 3=18 |
| # samples | 6 | 3 | |
| ** MAII score | log2(6/150*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: COG6 [Title/Abstract] AND MAPK8 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | MAPK8 | GO:0006468 | protein phosphorylation | 21856198 |
| Tgene | MAPK8 | GO:0007254 | JNK cascade | 8654373 |
| Tgene | MAPK8 | GO:0007258 | JUN phosphorylation | 14967141|21095239 |
| Tgene | MAPK8 | GO:0009411 | response to UV | 14967141 |
| Tgene | MAPK8 | GO:0018105 | peptidyl-serine phosphorylation | 15850461|20027304|21095239 |
| Tgene | MAPK8 | GO:0018107 | peptidyl-threonine phosphorylation | 21095239 |
| Tgene | MAPK8 | GO:0032091 | negative regulation of protein binding | 21095239 |
| Tgene | MAPK8 | GO:0032880 | regulation of protein localization | 20027304 |
| Tgene | MAPK8 | GO:0034198 | cellular response to amino acid starvation | 11096076 |
| Tgene | MAPK8 | GO:0043066 | negative regulation of apoptotic process | 14967141|21095239 |
| Tgene | MAPK8 | GO:0051403 | stress-activated MAPK cascade | 11096076 |
| Tgene | MAPK8 | GO:0071222 | cellular response to lipopolysaccharide | 23776175 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-C8-A26V-01A | COG6 | chr13 | 40235018 | + | MAPK8 | chr10 | 49639236 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000416691 | ENST00000374189 | COG6 | chr13 | 40235018 | + | MAPK8 | chr10 | 49639236 | + |
| Frame-shift | ENST00000416691 | ENST00000374182 | COG6 | chr13 | 40235018 | + | MAPK8 | chr10 | 49639236 | + |
| Frame-shift | ENST00000416691 | ENST00000360332 | COG6 | chr13 | 40235018 | + | MAPK8 | chr10 | 49639236 | + |
| 5CDS-intron | ENST00000416691 | ENST00000374174 | COG6 | chr13 | 40235018 | + | MAPK8 | chr10 | 49639236 | + |
| 5CDS-intron | ENST00000416691 | ENST00000395611 | COG6 | chr13 | 40235018 | + | MAPK8 | chr10 | 49639236 | + |
| 5CDS-3UTR | ENST00000416691 | ENST00000459755 | COG6 | chr13 | 40235018 | + | MAPK8 | chr10 | 49639236 | + |
| Frame-shift | ENST00000455146 | ENST00000374189 | COG6 | chr13 | 40235018 | + | MAPK8 | chr10 | 49639236 | + |
| Frame-shift | ENST00000455146 | ENST00000374182 | COG6 | chr13 | 40235018 | + | MAPK8 | chr10 | 49639236 | + |
| Frame-shift | ENST00000455146 | ENST00000360332 | COG6 | chr13 | 40235018 | + | MAPK8 | chr10 | 49639236 | + |
| 5CDS-intron | ENST00000455146 | ENST00000374174 | COG6 | chr13 | 40235018 | + | MAPK8 | chr10 | 49639236 | + |
| 5CDS-intron | ENST00000455146 | ENST00000395611 | COG6 | chr13 | 40235018 | + | MAPK8 | chr10 | 49639236 | + |
| 5CDS-3UTR | ENST00000455146 | ENST00000459755 | COG6 | chr13 | 40235018 | + | MAPK8 | chr10 | 49639236 | + |
| intron-3CDS | ENST00000465775 | ENST00000374189 | COG6 | chr13 | 40235018 | + | MAPK8 | chr10 | 49639236 | + |
| intron-3CDS | ENST00000465775 | ENST00000374182 | COG6 | chr13 | 40235018 | + | MAPK8 | chr10 | 49639236 | + |
| intron-3CDS | ENST00000465775 | ENST00000360332 | COG6 | chr13 | 40235018 | + | MAPK8 | chr10 | 49639236 | + |
| intron-intron | ENST00000465775 | ENST00000374174 | COG6 | chr13 | 40235018 | + | MAPK8 | chr10 | 49639236 | + |
| intron-intron | ENST00000465775 | ENST00000395611 | COG6 | chr13 | 40235018 | + | MAPK8 | chr10 | 49639236 | + |
| intron-3UTR | ENST00000465775 | ENST00000459755 | COG6 | chr13 | 40235018 | + | MAPK8 | chr10 | 49639236 | + |
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FusionProtFeatures for COG6_MAPK8 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| COG6 | MAPK8 |
| Required for normal Golgi function. {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for COG6_MAPK8 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for COG6_MAPK8 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| COG6 | COG3, ATXN7, COG1, COG7, COG5, COG8, COG2, COG4, EGFR, TRAPPC13, PARP16, VSIG2, CD68, DTNBP1, IFT57, SCN2B, C10orf76, PTAR1, PKN1, ATP7A, KLC2, KIF5A, POC1A, NAV1, HAUS1, KLC4, POC1B, SASS6, RNF20, TRAF6, EXOC7, KIF5B, KLC1, COMMD8, BLOC1S2, DTNA, ATP6V1D, CCHCR1, KIF5C, RNF40, DTNB, SNTB2, TBC1D2B, ABI1, EXOC5, FCGRT, BICD2, C9orf16, NUP88, PKD2, EXOC1, AMOTL1, SYCE3, CENPF, CCDC22, SNAPIN, NPY2R, NCKAP1, SPAG5, STX6, CCDC53, VSIG1, STX12 | MAPK8 | IRS1, DUSP10, TNFRSF10B, FADD, FASLG, BID, EZR, RHOA, ARHGDIA, FAS, MSN, CASP10, CASP8, TNFRSF1A, JUN, SPIB, SPI1, SH3BP5, MAP3K1, IKBKAP, PRKD1, ATF2, SPAG9, MAP2K4, CRK, BCAR1, SNCG, SNCA, JUND, SH2D3A, MAPK8IP1, MAPK8IP3, PAX2, PRKDC, TP53, REL, JUNB, DUSP16, ETV1, DUSP4, ELK1, DUSP1, MAP2K7, GSTP1, MYC, MAP3K2, PDPK1, NR4A1, CEBPA, CDKN1A, SIRT1, H2AFX, HDAC9, HDAC1, TFCP2, NFATC2, NFE2, PIAS2, ZNF605, DUSP8, FAM193B, BMPR2, PNRC1, HSPA8, CCDC88C, ZNF219, RBM15, SCAND1, STAT3, KRT8, NCOA3, CBL, FZR1, ITCH, RAD18, FLNB, RPTOR, MTOR, MAP3K7, TRAF2, MAP3K4, SP1, MAPK8, BCL2, MAP2K1, MAP2K2, CTNNB1, STAB2, CDKN1B, APP, HSF1, GORASP2, WDR62, DCP1A, IRF3, AIMP1, ELK4, BCL2L11, BMF, JKAMP, MAPKAP1, NFATC4, NFATC3, VRK2, CASP3, PKMYT1, SERPINB3, SERPINB4, CDKN2A, CDKN2C, RB1, ATF7, WWOX, MAPT, APLP2, GEMIN5, HIVEP1, CAMP, SSU72, SCOC, GARS, GFPT1, MKNK2, GUCY1A3, HSD17B4, ID2, RAF1, RPLP2, RPS6KB1, GANAB, C11orf57, MAPK9, NFE2L2, YWHAZ, EP300, EGFR, AKT1, CCT2, CCT3, CCT4, CCT6A, CCT8, NUP98, TCP1, TKT, SUN2, ATE1, KCNAB3, PPM1B, ANXA7, BCL7A, BLMH, CTSC, CSNK2A2, PSMD2, SF1, HIST2H2AA3, TJP2, COG2, PHLPP1, CRTC3, TAF1D, C2orf44, PRR3, STK11IP, RABL3, CDC42, BCL2L1, SMAD3, GPS1, GPS2, HRAS, MBP, VANGL2, LAMP3, MAPK14, BANP |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for COG6_MAPK8 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for COG6_MAPK8 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | COG6 | C3553230 | CONGENITAL DISORDER OF GLYCOSYLATION, TYPE IIl | 1 | ORPHANET;UNIPROT |
| Tgene | MAPK8 | C0011570 | Mental Depression | 2 | PSYGENET |
| Tgene | MAPK8 | C0011581 | Depressive disorder | 2 | PSYGENET |
| Tgene | MAPK8 | C0007621 | Neoplastic Cell Transformation | 1 | CTD_human |
| Tgene | MAPK8 | C0011615 | Dermatitis, Atopic | 1 | CTD_human |
| Tgene | MAPK8 | C0020429 | Hyperalgesia | 1 | CTD_human |
| Tgene | MAPK8 | C0032927 | Precancerous Conditions | 1 | CTD_human |
| Tgene | MAPK8 | C0035126 | Reperfusion Injury | 1 | CTD_human |
| Tgene | MAPK8 | C0036341 | Schizophrenia | 1 | PSYGENET |
| Tgene | MAPK8 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
| Tgene | MAPK8 | C0040997 | Trigeminal Neuralgia | 1 | CTD_human |
| Tgene | MAPK8 | C0162557 | Liver Failure, Acute | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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