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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 7834

FusionGeneSummary for COG6_MAPK8

check button Fusion gene summary
Fusion gene informationFusion gene name: COG6_MAPK8
Fusion gene ID: 7834
HgeneTgene
Gene symbol

COG6

MAPK8

Gene ID

57511

5599

Gene namecomponent of oligomeric golgi complex 6mitogen-activated protein kinase 8
SynonymsCDG2L|COD2|SHNSJNK|JNK-46|JNK1|JNK1A2|JNK21B1/2|PRKM8|SAPK1|SAPK1c
Cytomap

13q14.11

10q11.22

Type of geneprotein-codingprotein-coding
Descriptionconserved oligomeric Golgi complex subunit 6COG complex subunit 6complexed with Dor1p 2conserved oligomeric Golgi complex protein 6testicular tissue protein Li 41mitogen-activated protein kinase 8JUN N-terminal kinaseMAP kinase 8c-Jun N-terminal kinase 1mitogen-activated protein kinase 8 isoform JNK1 alpha1mitogen-activated protein kinase 8 isoform JNK1 beta2stress-activated protein kinase 1stress-activated
Modification date2018052320180527
UniProtAcc

Q9Y2V7

P45983

Ensembl transtripts involved in fusion geneENST00000416691, ENST00000455146, 
ENST00000465775, 
ENST00000374189, 
ENST00000374182, ENST00000360332, 
ENST00000374174, ENST00000395611, 
ENST00000459755, 
Fusion gene scores* DoF score6 X 5 X 5=1503 X 2 X 3=18
# samples 63
** MAII scorelog2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: COG6 [Title/Abstract] AND MAPK8 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMAPK8

GO:0006468

protein phosphorylation

21856198

TgeneMAPK8

GO:0007254

JNK cascade

8654373

TgeneMAPK8

GO:0007258

JUN phosphorylation

14967141|21095239

TgeneMAPK8

GO:0009411

response to UV

14967141

TgeneMAPK8

GO:0018105

peptidyl-serine phosphorylation

15850461|20027304|21095239

TgeneMAPK8

GO:0018107

peptidyl-threonine phosphorylation

21095239

TgeneMAPK8

GO:0032091

negative regulation of protein binding

21095239

TgeneMAPK8

GO:0032880

regulation of protein localization

20027304

TgeneMAPK8

GO:0034198

cellular response to amino acid starvation

11096076

TgeneMAPK8

GO:0043066

negative regulation of apoptotic process

14967141|21095239

TgeneMAPK8

GO:0051403

stress-activated MAPK cascade

11096076

TgeneMAPK8

GO:0071222

cellular response to lipopolysaccharide

23776175


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-C8-A26V-01ACOG6chr13

40235018

+MAPK8chr10

49639236

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000416691ENST00000374189COG6chr13

40235018

+MAPK8chr10

49639236

+
Frame-shitENST00000416691ENST00000374182COG6chr13

40235018

+MAPK8chr10

49639236

+
Frame-shitENST00000416691ENST00000360332COG6chr13

40235018

+MAPK8chr10

49639236

+
5CDS-intronENST00000416691ENST00000374174COG6chr13

40235018

+MAPK8chr10

49639236

+
5CDS-intronENST00000416691ENST00000395611COG6chr13

40235018

+MAPK8chr10

49639236

+
5CDS-3UTRENST00000416691ENST00000459755COG6chr13

40235018

+MAPK8chr10

49639236

+
Frame-shitENST00000455146ENST00000374189COG6chr13

40235018

+MAPK8chr10

49639236

+
Frame-shitENST00000455146ENST00000374182COG6chr13

40235018

+MAPK8chr10

49639236

+
Frame-shitENST00000455146ENST00000360332COG6chr13

40235018

+MAPK8chr10

49639236

+
5CDS-intronENST00000455146ENST00000374174COG6chr13

40235018

+MAPK8chr10

49639236

+
5CDS-intronENST00000455146ENST00000395611COG6chr13

40235018

+MAPK8chr10

49639236

+
5CDS-3UTRENST00000455146ENST00000459755COG6chr13

40235018

+MAPK8chr10

49639236

+
intron-3CDSENST00000465775ENST00000374189COG6chr13

40235018

+MAPK8chr10

49639236

+
intron-3CDSENST00000465775ENST00000374182COG6chr13

40235018

+MAPK8chr10

49639236

+
intron-3CDSENST00000465775ENST00000360332COG6chr13

40235018

+MAPK8chr10

49639236

+
intron-intronENST00000465775ENST00000374174COG6chr13

40235018

+MAPK8chr10

49639236

+
intron-intronENST00000465775ENST00000395611COG6chr13

40235018

+MAPK8chr10

49639236

+
intron-3UTRENST00000465775ENST00000459755COG6chr13

40235018

+MAPK8chr10

49639236

+

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FusionProtFeatures for COG6_MAPK8


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
COG6

Q9Y2V7

MAPK8

P45983

Required for normal Golgi function. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for COG6_MAPK8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for COG6_MAPK8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
COG6COG3, ATXN7, COG1, COG7, COG5, COG8, COG2, COG4, EGFR, TRAPPC13, PARP16, VSIG2, CD68, DTNBP1, IFT57, SCN2B, C10orf76, PTAR1, PKN1, ATP7A, KLC2, KIF5A, POC1A, NAV1, HAUS1, KLC4, POC1B, SASS6, RNF20, TRAF6, EXOC7, KIF5B, KLC1, COMMD8, BLOC1S2, DTNA, ATP6V1D, CCHCR1, KIF5C, RNF40, DTNB, SNTB2, TBC1D2B, ABI1, EXOC5, FCGRT, BICD2, C9orf16, NUP88, PKD2, EXOC1, AMOTL1, SYCE3, CENPF, CCDC22, SNAPIN, NPY2R, NCKAP1, SPAG5, STX6, CCDC53, VSIG1, STX12MAPK8IRS1, DUSP10, TNFRSF10B, FADD, FASLG, BID, EZR, RHOA, ARHGDIA, FAS, MSN, CASP10, CASP8, TNFRSF1A, JUN, SPIB, SPI1, SH3BP5, MAP3K1, IKBKAP, PRKD1, ATF2, SPAG9, MAP2K4, CRK, BCAR1, SNCG, SNCA, JUND, SH2D3A, MAPK8IP1, MAPK8IP3, PAX2, PRKDC, TP53, REL, JUNB, DUSP16, ETV1, DUSP4, ELK1, DUSP1, MAP2K7, GSTP1, MYC, MAP3K2, PDPK1, NR4A1, CEBPA, CDKN1A, SIRT1, H2AFX, HDAC9, HDAC1, TFCP2, NFATC2, NFE2, PIAS2, ZNF605, DUSP8, FAM193B, BMPR2, PNRC1, HSPA8, CCDC88C, ZNF219, RBM15, SCAND1, STAT3, KRT8, NCOA3, CBL, FZR1, ITCH, RAD18, FLNB, RPTOR, MTOR, MAP3K7, TRAF2, MAP3K4, SP1, MAPK8, BCL2, MAP2K1, MAP2K2, CTNNB1, STAB2, CDKN1B, APP, HSF1, GORASP2, WDR62, DCP1A, IRF3, AIMP1, ELK4, BCL2L11, BMF, JKAMP, MAPKAP1, NFATC4, NFATC3, VRK2, CASP3, PKMYT1, SERPINB3, SERPINB4, CDKN2A, CDKN2C, RB1, ATF7, WWOX, MAPT, APLP2, GEMIN5, HIVEP1, CAMP, SSU72, SCOC, GARS, GFPT1, MKNK2, GUCY1A3, HSD17B4, ID2, RAF1, RPLP2, RPS6KB1, GANAB, C11orf57, MAPK9, NFE2L2, YWHAZ, EP300, EGFR, AKT1, CCT2, CCT3, CCT4, CCT6A, CCT8, NUP98, TCP1, TKT, SUN2, ATE1, KCNAB3, PPM1B, ANXA7, BCL7A, BLMH, CTSC, CSNK2A2, PSMD2, SF1, HIST2H2AA3, TJP2, COG2, PHLPP1, CRTC3, TAF1D, C2orf44, PRR3, STK11IP, RABL3, CDC42, BCL2L1, SMAD3, GPS1, GPS2, HRAS, MBP, VANGL2, LAMP3, MAPK14, BANP


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for COG6_MAPK8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for COG6_MAPK8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCOG6C3553230CONGENITAL DISORDER OF GLYCOSYLATION, TYPE IIl1ORPHANET;UNIPROT
TgeneMAPK8C0011570Mental Depression2PSYGENET
TgeneMAPK8C0011581Depressive disorder2PSYGENET
TgeneMAPK8C0007621Neoplastic Cell Transformation1CTD_human
TgeneMAPK8C0011615Dermatitis, Atopic1CTD_human
TgeneMAPK8C0020429Hyperalgesia1CTD_human
TgeneMAPK8C0032927Precancerous Conditions1CTD_human
TgeneMAPK8C0035126Reperfusion Injury1CTD_human
TgeneMAPK8C0036341Schizophrenia1PSYGENET
TgeneMAPK8C0038356Stomach Neoplasms1CTD_human
TgeneMAPK8C0040997Trigeminal Neuralgia1CTD_human
TgeneMAPK8C0162557Liver Failure, Acute1CTD_human