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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 7818

FusionGeneSummary for COG4_MFI2

check button Fusion gene summary
Fusion gene informationFusion gene name: COG4_MFI2
Fusion gene ID: 7818
HgeneTgene
Gene symbol

COG4

MFI2

Gene ID

25839

4241

Gene namecomponent of oligomeric golgi complex 4melanotransferrin
SynonymsCDG2J|COD1CD228|MAP97|MFI2|MTF1|MTf
Cytomap

16q22.1

3q29

Type of geneprotein-codingprotein-coding
Descriptionconserved oligomeric Golgi complex subunit 4COG complex subunit 4complexed with Dor1pconserved oligomeric Golgi complex protein 4melanotransferrinantigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5melanoma-associated antigen p97membrane-bound transferrin-like protein
Modification date2018052320180523
UniProtAcc

Q9H9E3

Ensembl transtripts involved in fusion geneENST00000323786, ENST00000393612, 
ENST00000564653, 
ENST00000296350, 
ENST00000296351, 
Fusion gene scores* DoF score6 X 7 X 5=2103 X 3 X 3=27
# samples 83
** MAII scorelog2(8/210*10)=-1.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: COG4 [Title/Abstract] AND MFI2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMFI2

GO:0010756

positive regulation of plasminogen activation

16713448

TgeneMFI2

GO:0090091

positive regulation of extracellular matrix disassembly

16713448

TgeneMFI2

GO:1900025

negative regulation of substrate adhesion-dependent cell spreading

16713448


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCECTCGA-PG-A5BC-01ACOG4chr16

70534861

-MFI2chr3

196753630

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000323786ENST00000296350COG4chr16

70534861

-MFI2chr3

196753630

-
Frame-shiftENST00000323786ENST00000296351COG4chr16

70534861

-MFI2chr3

196753630

-
intron-3CDSENST00000393612ENST00000296350COG4chr16

70534861

-MFI2chr3

196753630

-
intron-3CDSENST00000393612ENST00000296351COG4chr16

70534861

-MFI2chr3

196753630

-
intron-3CDSENST00000564653ENST00000296350COG4chr16

70534861

-MFI2chr3

196753630

-
intron-3CDSENST00000564653ENST00000296351COG4chr16

70534861

-MFI2chr3

196753630

-

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FusionProtFeatures for COG4_MFI2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
COG4

Q9H9E3

MFI2

Required for normal Golgi function. Plays a role inSNARE-pin assembly and Golgi-to-ER retrograde transport via itsinteraction with SCFD1. {ECO:0000269|PubMed:19536132}. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for COG4_MFI2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for COG4_MFI2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
COG4COG1, COG2, COG5, COG7, COG3, APC, SEPT2, CUL4B, COG8, RPS20, VCP, COG6, EGFR, BSG, CD274, VSIG2, CA14, TEKT4, SCN2B, NTRK1, HDAC1, PDK1, SMEK1, CCDC40, PSMC5, TMCO3, NUP54, CCDC59, COMMD8, VSIG1, OPRM1, SIGLECL1, RAB30, MTNR1BMFI2PDIA3, HPGDS, NOTCH2NL, TAZ, ICOS


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for COG4_MFI2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for COG4_MFI2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCOG4C0032927Precancerous Conditions1CTD_human
HgeneCOG4C3150736CONGENITAL DISORDER OF GLYCOSYLATION, TYPE IIj1CTD_human;ORPHANET;UNIPROT