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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 7795

FusionGeneSummary for COASY_DTD1

check button Fusion gene summary
Fusion gene informationFusion gene name: COASY_DTD1
Fusion gene ID: 7795
HgeneTgene
Gene symbol

COASY

DTD1

Gene ID

80347

92675

Gene nameCoenzyme A synthaseD-tyrosyl-tRNA deacylase 1
SynonymsDPCK|NBIA6|NBP|PPAT|UKR1|pOV-2C20orf88|DTD|DUE-B|DUEB|HARS2|pqn-68
Cytomap

17q21.2

20p11.23

Type of geneprotein-codingprotein-coding
Descriptionbifunctional coenzyme A synthaseCoA synthasebifunctional phosphopantetheine adenylyl transferase/dephospho CoA kinasenucleotide binding proteinphosphopantetheine adenylyltransferase / dephosphocoenzyme A kinaseD-aminoacyl-tRNA deacylase 1D-tyrosyl-tRNA deacylase 1 homologD-tyrosyl-tRNA(Tyr) deacylase 1DNA-unwinding element-binding protein Bgly-tRNA(Ala) deacylasehistidyl-tRNA synthase-relatedhistidyl-tRNA synthetase 2
Modification date2018052320180523
UniProtAcc

Q13057

Q8TEA8

Ensembl transtripts involved in fusion geneENST00000588757, ENST00000420359, 
ENST00000449624, ENST00000421097, 
ENST00000590958, ENST00000393818, 
ENST00000377452, ENST00000494921, 
Fusion gene scores* DoF score4 X 5 X 2=4012 X 5 X 8=480
# samples 613
** MAII scorelog2(6/40*10)=0.584962500721156
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(13/480*10)=-1.88452278258006
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: COASY [Title/Abstract] AND DTD1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCOASY

GO:0015937

coenzyme A biosynthetic process

11923312


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE252620COASYchr17

40716570

-DTD1chr20

18576749

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000588757ENST00000377452COASYchr17

40716570

-DTD1chr20

18576749

+
intron-3UTRENST00000588757ENST00000494921COASYchr17

40716570

-DTD1chr20

18576749

+
Frame-shitENST00000420359ENST00000377452COASYchr17

40716570

-DTD1chr20

18576749

+
5CDS-3UTRENST00000420359ENST00000494921COASYchr17

40716570

-DTD1chr20

18576749

+
Frame-shitENST00000449624ENST00000377452COASYchr17

40716570

-DTD1chr20

18576749

+
5CDS-3UTRENST00000449624ENST00000494921COASYchr17

40716570

-DTD1chr20

18576749

+
Frame-shitENST00000421097ENST00000377452COASYchr17

40716570

-DTD1chr20

18576749

+
5CDS-3UTRENST00000421097ENST00000494921COASYchr17

40716570

-DTD1chr20

18576749

+
Frame-shitENST00000590958ENST00000377452COASYchr17

40716570

-DTD1chr20

18576749

+
5CDS-3UTRENST00000590958ENST00000494921COASYchr17

40716570

-DTD1chr20

18576749

+
Frame-shitENST00000393818ENST00000377452COASYchr17

40716570

-DTD1chr20

18576749

+
5CDS-3UTRENST00000393818ENST00000494921COASYchr17

40716570

-DTD1chr20

18576749

+

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FusionProtFeatures for COASY_DTD1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
COASY

Q13057

DTD1

Q8TEA8

Bifunctional enzyme that catalyzes the fourth and fifthsequential steps of CoA biosynthetic pathway. The fourth reactionis catalyzed by the phosphopantetheine adenylyltransferase, codedby the coaD domain; the fifth reaction is catalyzed by thedephospho-CoA kinase, coded by the coaE domain. May act as a pointof CoA biosynthesis regulation. {ECO:0000269|PubMed:11923312}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for COASY_DTD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for COASY_DTD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for COASY_DTD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for COASY_DTD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCOASYC3810230NEURODEGENERATION WITH BRAIN IRON ACCUMULATION 61ORPHANET;UNIPROT