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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 7786

FusionGeneSummary for COA1_FAM222B

check button Fusion gene summary
Fusion gene informationFusion gene name: COA1_FAM222B
Fusion gene ID: 7786
HgeneTgene
Gene symbol

COA1

FAM222B

Gene ID

55744

55731

Gene namecytochrome c oxidase assembly factor 1 homologfamily with sequence similarity 222 member B
SynonymsC7orf44|MITRAC15C17orf63
Cytomap

7p13

17q11.2

Type of geneprotein-codingprotein-coding
Descriptioncytochrome c oxidase assembly factor 1 homologcytochrome c oxidase assembly protein 1 homologmitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 15 kDaprotein FAM222Buncharacterized protein C17orf63
Modification date2018051920180519
UniProtAcc

Q9GZY4

Q8WU58

Ensembl transtripts involved in fusion geneENST00000488813, ENST00000395879, 
ENST00000395880, ENST00000310564, 
ENST00000223336, 
ENST00000341217, 
ENST00000581407, ENST00000582266, 
ENST00000452648, ENST00000582059, 
ENST00000583953, ENST00000577682, 
ENST00000583522, ENST00000581381, 
Fusion gene scores* DoF score8 X 4 X 5=16011 X 8 X 4=352
# samples 912
** MAII scorelog2(9/160*10)=-0.830074998557688
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(12/352*10)=-1.55254102302878
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: COA1 [Title/Abstract] AND FAM222B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE162477COA1chr7

43759482

+FAM222Bchr17

27136112

-
ChiTaRS3.1BE161179COA1chr7

43759482

+FAM222Bchr17

27136112

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000488813ENST00000341217COA1chr7

43759482

+FAM222Bchr17

27136112

-
intron-intronENST00000488813ENST00000581407COA1chr7

43759482

+FAM222Bchr17

27136112

-
intron-intronENST00000488813ENST00000582266COA1chr7

43759482

+FAM222Bchr17

27136112

-
intron-intronENST00000488813ENST00000452648COA1chr7

43759482

+FAM222Bchr17

27136112

-
intron-intronENST00000488813ENST00000582059COA1chr7

43759482

+FAM222Bchr17

27136112

-
intron-intronENST00000488813ENST00000583953COA1chr7

43759482

+FAM222Bchr17

27136112

-
intron-intronENST00000488813ENST00000577682COA1chr7

43759482

+FAM222Bchr17

27136112

-
intron-intronENST00000488813ENST00000583522COA1chr7

43759482

+FAM222Bchr17

27136112

-
intron-intronENST00000488813ENST00000581381COA1chr7

43759482

+FAM222Bchr17

27136112

-
intron-intronENST00000395879ENST00000341217COA1chr7

43759482

+FAM222Bchr17

27136112

-
intron-intronENST00000395879ENST00000581407COA1chr7

43759482

+FAM222Bchr17

27136112

-
intron-intronENST00000395879ENST00000582266COA1chr7

43759482

+FAM222Bchr17

27136112

-
intron-intronENST00000395879ENST00000452648COA1chr7

43759482

+FAM222Bchr17

27136112

-
intron-intronENST00000395879ENST00000582059COA1chr7

43759482

+FAM222Bchr17

27136112

-
intron-intronENST00000395879ENST00000583953COA1chr7

43759482

+FAM222Bchr17

27136112

-
intron-intronENST00000395879ENST00000577682COA1chr7

43759482

+FAM222Bchr17

27136112

-
intron-intronENST00000395879ENST00000583522COA1chr7

43759482

+FAM222Bchr17

27136112

-
intron-intronENST00000395879ENST00000581381COA1chr7

43759482

+FAM222Bchr17

27136112

-
intron-intronENST00000395880ENST00000341217COA1chr7

43759482

+FAM222Bchr17

27136112

-
intron-intronENST00000395880ENST00000581407COA1chr7

43759482

+FAM222Bchr17

27136112

-
intron-intronENST00000395880ENST00000582266COA1chr7

43759482

+FAM222Bchr17

27136112

-
intron-intronENST00000395880ENST00000452648COA1chr7

43759482

+FAM222Bchr17

27136112

-
intron-intronENST00000395880ENST00000582059COA1chr7

43759482

+FAM222Bchr17

27136112

-
intron-intronENST00000395880ENST00000583953COA1chr7

43759482

+FAM222Bchr17

27136112

-
intron-intronENST00000395880ENST00000577682COA1chr7

43759482

+FAM222Bchr17

27136112

-
intron-intronENST00000395880ENST00000583522COA1chr7

43759482

+FAM222Bchr17

27136112

-
intron-intronENST00000395880ENST00000581381COA1chr7

43759482

+FAM222Bchr17

27136112

-
intron-intronENST00000310564ENST00000341217COA1chr7

43759482

+FAM222Bchr17

27136112

-
intron-intronENST00000310564ENST00000581407COA1chr7

43759482

+FAM222Bchr17

27136112

-
intron-intronENST00000310564ENST00000582266COA1chr7

43759482

+FAM222Bchr17

27136112

-
intron-intronENST00000310564ENST00000452648COA1chr7

43759482

+FAM222Bchr17

27136112

-
intron-intronENST00000310564ENST00000582059COA1chr7

43759482

+FAM222Bchr17

27136112

-
intron-intronENST00000310564ENST00000583953COA1chr7

43759482

+FAM222Bchr17

27136112

-
intron-intronENST00000310564ENST00000577682COA1chr7

43759482

+FAM222Bchr17

27136112

-
intron-intronENST00000310564ENST00000583522COA1chr7

43759482

+FAM222Bchr17

27136112

-
intron-intronENST00000310564ENST00000581381COA1chr7

43759482

+FAM222Bchr17

27136112

-
intron-intronENST00000223336ENST00000341217COA1chr7

43759482

+FAM222Bchr17

27136112

-
intron-intronENST00000223336ENST00000581407COA1chr7

43759482

+FAM222Bchr17

27136112

-
intron-intronENST00000223336ENST00000582266COA1chr7

43759482

+FAM222Bchr17

27136112

-
intron-intronENST00000223336ENST00000452648COA1chr7

43759482

+FAM222Bchr17

27136112

-
intron-intronENST00000223336ENST00000582059COA1chr7

43759482

+FAM222Bchr17

27136112

-
intron-intronENST00000223336ENST00000583953COA1chr7

43759482

+FAM222Bchr17

27136112

-
intron-intronENST00000223336ENST00000577682COA1chr7

43759482

+FAM222Bchr17

27136112

-
intron-intronENST00000223336ENST00000583522COA1chr7

43759482

+FAM222Bchr17

27136112

-
intron-intronENST00000223336ENST00000581381COA1chr7

43759482

+FAM222Bchr17

27136112

-

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FusionProtFeatures for COA1_FAM222B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
COA1

Q9GZY4

FAM222B

Q8WU58

Component of the MITRAC (mitochondrial translationregulation assembly intermediate of cytochrome c oxidase complex)complex, that regulates cytochrome c oxidase assembly. MITRACcomplexes regulate both translation of mitochondrial encodedcomponents and assembly of nuclear-encoded components imported inmitochondrion. Required for assembly of mitochondrial respiratorychain complex I and complex IV. {ECO:0000269|PubMed:23260140}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for COA1_FAM222B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for COA1_FAM222B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for COA1_FAM222B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for COA1_FAM222B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource