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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 777

FusionGeneSummary for ADAP1_SUN1

check button Fusion gene summary
Fusion gene informationFusion gene name: ADAP1_SUN1
Fusion gene ID: 777
HgeneTgene
Gene symbol

ADAP1

SUN1

Gene ID

11033

23353

Gene nameArfGAP with dual PH domains 1Sad1 and UNC84 domain containing 1
SynonymsCENTA1|GCS1L|p42IP4UNC84A
Cytomap

7p22.3

7p22.3

Type of geneprotein-codingprotein-coding
Descriptionarf-GAP with dual PH domain-containing protein 1centaurin-alphacentaurin-alpha-1cnt-a1putative MAPK-activating protein PM25SUN domain-containing protein 1Sad1 unc-84 domain protein 1protein unc-84 homolog Asad1/unc-84 protein-like 1unc-84 homolog A
Modification date2018052320180523
UniProtAcc

O75689

O94901

Ensembl transtripts involved in fusion geneENST00000265846, ENST00000449296, 
ENST00000539900, ENST00000463358, 
ENST00000456758, ENST00000457378, 
ENST00000389574, ENST00000452783, 
ENST00000405266, ENST00000401592, 
ENST00000403868, ENST00000425407, 
ENST00000469755, ENST00000413514, 
Fusion gene scores* DoF score8 X 5 X 7=2802 X 2 X 2=8
# samples 92
** MAII scorelog2(9/280*10)=-1.63742992061529
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: ADAP1 [Title/Abstract] AND SUN1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSUN1

GO:0090286

cytoskeletal anchoring at nuclear membrane

18396275

TgeneSUN1

GO:0090292

nuclear matrix anchoring at nuclear membrane

18396275


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVCESCTCGA-DS-A7WH-01AADAP1chr7

959605

-SUN1chr7

908986

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000265846ENST00000456758ADAP1chr7

959605

-SUN1chr7

908986

+
5CDS-intronENST00000265846ENST00000457378ADAP1chr7

959605

-SUN1chr7

908986

+
5CDS-intronENST00000265846ENST00000389574ADAP1chr7

959605

-SUN1chr7

908986

+
5CDS-intronENST00000265846ENST00000452783ADAP1chr7

959605

-SUN1chr7

908986

+
5CDS-intronENST00000265846ENST00000405266ADAP1chr7

959605

-SUN1chr7

908986

+
5CDS-intronENST00000265846ENST00000401592ADAP1chr7

959605

-SUN1chr7

908986

+
5CDS-intronENST00000265846ENST00000403868ADAP1chr7

959605

-SUN1chr7

908986

+
5CDS-intronENST00000265846ENST00000425407ADAP1chr7

959605

-SUN1chr7

908986

+
5CDS-intronENST00000265846ENST00000469755ADAP1chr7

959605

-SUN1chr7

908986

+
5CDS-intronENST00000265846ENST00000413514ADAP1chr7

959605

-SUN1chr7

908986

+
Frame-shiftENST00000449296ENST00000456758ADAP1chr7

959605

-SUN1chr7

908986

+
5CDS-intronENST00000449296ENST00000457378ADAP1chr7

959605

-SUN1chr7

908986

+
5CDS-intronENST00000449296ENST00000389574ADAP1chr7

959605

-SUN1chr7

908986

+
5CDS-intronENST00000449296ENST00000452783ADAP1chr7

959605

-SUN1chr7

908986

+
5CDS-intronENST00000449296ENST00000405266ADAP1chr7

959605

-SUN1chr7

908986

+
5CDS-intronENST00000449296ENST00000401592ADAP1chr7

959605

-SUN1chr7

908986

+
5CDS-intronENST00000449296ENST00000403868ADAP1chr7

959605

-SUN1chr7

908986

+
5CDS-intronENST00000449296ENST00000425407ADAP1chr7

959605

-SUN1chr7

908986

+
5CDS-intronENST00000449296ENST00000469755ADAP1chr7

959605

-SUN1chr7

908986

+
5CDS-intronENST00000449296ENST00000413514ADAP1chr7

959605

-SUN1chr7

908986

+
Frame-shiftENST00000539900ENST00000456758ADAP1chr7

959605

-SUN1chr7

908986

+
5CDS-intronENST00000539900ENST00000457378ADAP1chr7

959605

-SUN1chr7

908986

+
5CDS-intronENST00000539900ENST00000389574ADAP1chr7

959605

-SUN1chr7

908986

+
5CDS-intronENST00000539900ENST00000452783ADAP1chr7

959605

-SUN1chr7

908986

+
5CDS-intronENST00000539900ENST00000405266ADAP1chr7

959605

-SUN1chr7

908986

+
5CDS-intronENST00000539900ENST00000401592ADAP1chr7

959605

-SUN1chr7

908986

+
5CDS-intronENST00000539900ENST00000403868ADAP1chr7

959605

-SUN1chr7

908986

+
5CDS-intronENST00000539900ENST00000425407ADAP1chr7

959605

-SUN1chr7

908986

+
5CDS-intronENST00000539900ENST00000469755ADAP1chr7

959605

-SUN1chr7

908986

+
5CDS-intronENST00000539900ENST00000413514ADAP1chr7

959605

-SUN1chr7

908986

+
5UTR-3CDSENST00000463358ENST00000456758ADAP1chr7

959605

-SUN1chr7

908986

+
5UTR-intronENST00000463358ENST00000457378ADAP1chr7

959605

-SUN1chr7

908986

+
5UTR-intronENST00000463358ENST00000389574ADAP1chr7

959605

-SUN1chr7

908986

+
5UTR-intronENST00000463358ENST00000452783ADAP1chr7

959605

-SUN1chr7

908986

+
5UTR-intronENST00000463358ENST00000405266ADAP1chr7

959605

-SUN1chr7

908986

+
5UTR-intronENST00000463358ENST00000401592ADAP1chr7

959605

-SUN1chr7

908986

+
5UTR-intronENST00000463358ENST00000403868ADAP1chr7

959605

-SUN1chr7

908986

+
5UTR-intronENST00000463358ENST00000425407ADAP1chr7

959605

-SUN1chr7

908986

+
5UTR-intronENST00000463358ENST00000469755ADAP1chr7

959605

-SUN1chr7

908986

+
5UTR-intronENST00000463358ENST00000413514ADAP1chr7

959605

-SUN1chr7

908986

+

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FusionProtFeatures for ADAP1_SUN1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ADAP1

O75689

SUN1

O94901

GTPase-activating protein for the ADP ribosylationfactor family (Probable). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate(InsP4). {ECO:0000269|PubMed:10448098,ECO:0000303|PubMed:10333475, ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ADAP1_SUN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ADAP1_SUN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ADAP1PRKCI, PRKCZ, PIK3CA, PRKD1, PRKCE, PSME3, CSNK1A1, NCL, ANP32A, GSK3B, GADD45A, RANBP9, DVL3, GOLGA2, SDCBP2, ARF6SUN1SYNE1, SYNE2, FBXO6, OBSL1, ZNF507, TYW5, TRIP6, CLEC12A, TEX264, ZACN, HTR3C, SCARA3, IFI16, TCTN3, TMEM216, CTDNEP1, DPEP1, CAPN6, LRRTM1, MPPE1, ZNRF4, CSGALNACT2, KCNS3, FBXO28, TRIM25, G3BP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ADAP1_SUN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ADAP1_SUN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource