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Fusion gene ID: 7768 |
FusionGeneSummary for CNTLN_RFX3 |
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Fusion gene information | Fusion gene name: CNTLN_RFX3 | Fusion gene ID: 7768 | Hgene | Tgene | Gene symbol | CNTLN | RFX3 | Gene ID | 54875 | 5991 |
Gene name | centlein | regulatory factor X3 | |
Synonyms | C9orf101|C9orf39|bA340N12.1 | - | |
Cytomap | 9p22.2 | 9p24.2 | |
Type of gene | protein-coding | protein-coding | |
Description | centleincentlein, centrosomal proteincentrosomal protein | transcription factor RFX3DNA binding protein RFX3regulatory factor X, 3 (influences HLA class II expression) | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q9NXG0 | P48380 | |
Ensembl transtripts involved in fusion gene | ENST00000380647, ENST00000262360, ENST00000425824, ENST00000380641, ENST00000484374, | ENST00000382004, ENST00000358730, ENST00000302303, ENST00000381984, | |
Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 3 X 3 X 2=18 |
# samples | 4 | 2 | |
** MAII score | log2(4/27*10)=0.567040592723894 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/18*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: CNTLN [Title/Abstract] AND RFX3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | RFX3 | GO:0045892 | negative regulation of transcription, DNA-templated | 12411430 |
Tgene | RFX3 | GO:0045893 | positive regulation of transcription, DNA-templated | 20148032 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | KIRC | TCGA-B0-4696-01A | CNTLN | chr9 | 17226285 | + | RFX3 | chr9 | 3248185 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shit | ENST00000380647 | ENST00000382004 | CNTLN | chr9 | 17226285 | + | RFX3 | chr9 | 3248185 | - |
Frame-shit | ENST00000380647 | ENST00000358730 | CNTLN | chr9 | 17226285 | + | RFX3 | chr9 | 3248185 | - |
Frame-shit | ENST00000380647 | ENST00000302303 | CNTLN | chr9 | 17226285 | + | RFX3 | chr9 | 3248185 | - |
5CDS-intron | ENST00000380647 | ENST00000381984 | CNTLN | chr9 | 17226285 | + | RFX3 | chr9 | 3248185 | - |
Frame-shit | ENST00000262360 | ENST00000382004 | CNTLN | chr9 | 17226285 | + | RFX3 | chr9 | 3248185 | - |
Frame-shit | ENST00000262360 | ENST00000358730 | CNTLN | chr9 | 17226285 | + | RFX3 | chr9 | 3248185 | - |
Frame-shit | ENST00000262360 | ENST00000302303 | CNTLN | chr9 | 17226285 | + | RFX3 | chr9 | 3248185 | - |
5CDS-intron | ENST00000262360 | ENST00000381984 | CNTLN | chr9 | 17226285 | + | RFX3 | chr9 | 3248185 | - |
Frame-shit | ENST00000425824 | ENST00000382004 | CNTLN | chr9 | 17226285 | + | RFX3 | chr9 | 3248185 | - |
Frame-shit | ENST00000425824 | ENST00000358730 | CNTLN | chr9 | 17226285 | + | RFX3 | chr9 | 3248185 | - |
Frame-shit | ENST00000425824 | ENST00000302303 | CNTLN | chr9 | 17226285 | + | RFX3 | chr9 | 3248185 | - |
5CDS-intron | ENST00000425824 | ENST00000381984 | CNTLN | chr9 | 17226285 | + | RFX3 | chr9 | 3248185 | - |
Frame-shit | ENST00000380641 | ENST00000382004 | CNTLN | chr9 | 17226285 | + | RFX3 | chr9 | 3248185 | - |
Frame-shit | ENST00000380641 | ENST00000358730 | CNTLN | chr9 | 17226285 | + | RFX3 | chr9 | 3248185 | - |
Frame-shit | ENST00000380641 | ENST00000302303 | CNTLN | chr9 | 17226285 | + | RFX3 | chr9 | 3248185 | - |
5CDS-intron | ENST00000380641 | ENST00000381984 | CNTLN | chr9 | 17226285 | + | RFX3 | chr9 | 3248185 | - |
intron-3CDS | ENST00000484374 | ENST00000382004 | CNTLN | chr9 | 17226285 | + | RFX3 | chr9 | 3248185 | - |
intron-3CDS | ENST00000484374 | ENST00000358730 | CNTLN | chr9 | 17226285 | + | RFX3 | chr9 | 3248185 | - |
intron-3CDS | ENST00000484374 | ENST00000302303 | CNTLN | chr9 | 17226285 | + | RFX3 | chr9 | 3248185 | - |
intron-intron | ENST00000484374 | ENST00000381984 | CNTLN | chr9 | 17226285 | + | RFX3 | chr9 | 3248185 | - |
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FusionProtFeatures for CNTLN_RFX3 |
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Hgene | Tgene |
CNTLN | RFX3 |
Required for centrosome cohesion and recruitment ofCEP68 to centrosomes. {ECO:0000269|PubMed:24554434}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CNTLN_RFX3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CNTLN_RFX3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CNTLN | SP1, BRCA1, HDAC6, TPM1, C9orf41, PRSS12, GOPC | RFX3 | TRAF2, RFX6, RFX4, BIN1, CREB1, EWSR1, IRF6, PKNOX1, SOX2, FHL2, FHL3, TRIP6, SEC63, PABPC5, FOXJ1, FOXJ2, FOXN3, FAM188A, IGSF8, RFX1, HDAC1, XYLT2, RTCB, MTA2, PTOV1, DDX1, TBC1D32, VPS45, TAF6L, MBD2, CDK20, ACAD9, HDAC2, TMED4, CFAP20, PLK1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CNTLN_RFX3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CNTLN_RFX3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | RFX3 | C0037274 | Dermatologic disorders | 1 | CTD_human |
Tgene | RFX3 | C0311375 | Arsenic Poisoning | 1 | CTD_human |