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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 7766

FusionGeneSummary for CNTLN_CNTLN

check button Fusion gene summary
Fusion gene informationFusion gene name: CNTLN_CNTLN
Fusion gene ID: 7766
HgeneTgene
Gene symbol

CNTLN

CNTLN

Gene ID

54875

54875

Gene namecentleincentlein
SynonymsC9orf101|C9orf39|bA340N12.1C9orf101|C9orf39|bA340N12.1
Cytomap

9p22.2

9p22.2

Type of geneprotein-codingprotein-coding
Descriptioncentleincentlein, centrosomal proteincentrosomal proteincentleincentlein, centrosomal proteincentrosomal protein
Modification date2018051920180519
UniProtAcc

Q9NXG0

Q9NXG0

Ensembl transtripts involved in fusion geneENST00000380647, ENST00000262360, 
ENST00000425824, ENST00000380641, 
ENST00000484374, 
ENST00000380647, 
ENST00000262360, ENST00000425824, 
ENST00000380641, ENST00000484374, 
Fusion gene scores* DoF score3 X 3 X 3=274 X 4 X 4=64
# samples 45
** MAII scorelog2(4/27*10)=0.567040592723894
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(5/64*10)=-0.356143810225275
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CNTLN [Title/Abstract] AND CNTLN [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BX109042CNTLNchr9

17168620

+CNTLNchr9

17167501

+
ChiTaRS3.1AA280904CNTLNchr9

17168620

+CNTLNchr9

17167501

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000380647ENST00000380647CNTLNchr9

17168620

+CNTLNchr9

17167501

+
intron-intronENST00000380647ENST00000262360CNTLNchr9

17168620

+CNTLNchr9

17167501

+
intron-intronENST00000380647ENST00000425824CNTLNchr9

17168620

+CNTLNchr9

17167501

+
intron-intronENST00000380647ENST00000380641CNTLNchr9

17168620

+CNTLNchr9

17167501

+
intron-3UTRENST00000380647ENST00000484374CNTLNchr9

17168620

+CNTLNchr9

17167501

+
intron-intronENST00000262360ENST00000380647CNTLNchr9

17168620

+CNTLNchr9

17167501

+
intron-intronENST00000262360ENST00000262360CNTLNchr9

17168620

+CNTLNchr9

17167501

+
intron-intronENST00000262360ENST00000425824CNTLNchr9

17168620

+CNTLNchr9

17167501

+
intron-intronENST00000262360ENST00000380641CNTLNchr9

17168620

+CNTLNchr9

17167501

+
intron-3UTRENST00000262360ENST00000484374CNTLNchr9

17168620

+CNTLNchr9

17167501

+
intron-intronENST00000425824ENST00000380647CNTLNchr9

17168620

+CNTLNchr9

17167501

+
intron-intronENST00000425824ENST00000262360CNTLNchr9

17168620

+CNTLNchr9

17167501

+
intron-intronENST00000425824ENST00000425824CNTLNchr9

17168620

+CNTLNchr9

17167501

+
intron-intronENST00000425824ENST00000380641CNTLNchr9

17168620

+CNTLNchr9

17167501

+
intron-3UTRENST00000425824ENST00000484374CNTLNchr9

17168620

+CNTLNchr9

17167501

+
intron-intronENST00000380641ENST00000380647CNTLNchr9

17168620

+CNTLNchr9

17167501

+
intron-intronENST00000380641ENST00000262360CNTLNchr9

17168620

+CNTLNchr9

17167501

+
intron-intronENST00000380641ENST00000425824CNTLNchr9

17168620

+CNTLNchr9

17167501

+
intron-intronENST00000380641ENST00000380641CNTLNchr9

17168620

+CNTLNchr9

17167501

+
intron-3UTRENST00000380641ENST00000484374CNTLNchr9

17168620

+CNTLNchr9

17167501

+
intron-intronENST00000484374ENST00000380647CNTLNchr9

17168620

+CNTLNchr9

17167501

+
intron-intronENST00000484374ENST00000262360CNTLNchr9

17168620

+CNTLNchr9

17167501

+
intron-intronENST00000484374ENST00000425824CNTLNchr9

17168620

+CNTLNchr9

17167501

+
intron-intronENST00000484374ENST00000380641CNTLNchr9

17168620

+CNTLNchr9

17167501

+
intron-3UTRENST00000484374ENST00000484374CNTLNchr9

17168620

+CNTLNchr9

17167501

+

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FusionProtFeatures for CNTLN_CNTLN


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CNTLN

Q9NXG0

CNTLN

Q9NXG0

Required for centrosome cohesion and recruitment ofCEP68 to centrosomes. {ECO:0000269|PubMed:24554434}. Required for centrosome cohesion and recruitment ofCEP68 to centrosomes. {ECO:0000269|PubMed:24554434}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CNTLN_CNTLN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CNTLN_CNTLN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CNTLN_CNTLN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CNTLN_CNTLN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource