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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 776

FusionGeneSummary for ADAP1_NOLC1

check button Fusion gene summary
Fusion gene informationFusion gene name: ADAP1_NOLC1
Fusion gene ID: 776
HgeneTgene
Gene symbol

ADAP1

NOLC1

Gene ID

11033

9221

Gene nameArfGAP with dual PH domains 1nucleolar and coiled-body phosphoprotein 1
SynonymsCENTA1|GCS1L|p42IP4NOPP130|NOPP140|NS5ATP13|P130
Cytomap

7p22.3

10q24.32

Type of geneprotein-codingprotein-coding
Descriptionarf-GAP with dual PH domain-containing protein 1centaurin-alphacentaurin-alpha-1cnt-a1putative MAPK-activating protein PM25nucleolar and coiled-body phosphoprotein 1140 kDa nucleolar phosphoproteinHCV NS5A trans-regulated protein 13HCV NS5A-transactivated protein 13hepatitis C virus NS5A-transactivated protein 13nucleolar 130 kDa proteinnucleolar and coiled-body phosphp
Modification date2018052320180523
UniProtAcc

O75689

Q14978

Ensembl transtripts involved in fusion geneENST00000265846, ENST00000449296, 
ENST00000539900, ENST00000463358, 
ENST00000605788, ENST00000405356, 
ENST00000603742, ENST00000488254, 
ENST00000477977, 
Fusion gene scores* DoF score8 X 5 X 7=2803 X 3 X 2=18
# samples 94
** MAII scorelog2(9/280*10)=-1.63742992061529
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ADAP1 [Title/Abstract] AND NOLC1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BM841194ADAP1chr7

994030

-NOLC1chr10

103921312

+
ChiTaRS3.1BM847741ADAP1chr7

994030

-NOLC1chr10

103921312

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000265846ENST00000605788ADAP1chr7

994030

-NOLC1chr10

103921312

+
Frame-shiftENST00000265846ENST00000405356ADAP1chr7

994030

-NOLC1chr10

103921312

+
Frame-shiftENST00000265846ENST00000603742ADAP1chr7

994030

-NOLC1chr10

103921312

+
Frame-shiftENST00000265846ENST00000488254ADAP1chr7

994030

-NOLC1chr10

103921312

+
5CDS-3UTRENST00000265846ENST00000477977ADAP1chr7

994030

-NOLC1chr10

103921312

+
intron-3CDSENST00000449296ENST00000605788ADAP1chr7

994030

-NOLC1chr10

103921312

+
intron-3CDSENST00000449296ENST00000405356ADAP1chr7

994030

-NOLC1chr10

103921312

+
intron-3CDSENST00000449296ENST00000603742ADAP1chr7

994030

-NOLC1chr10

103921312

+
intron-3CDSENST00000449296ENST00000488254ADAP1chr7

994030

-NOLC1chr10

103921312

+
intron-3UTRENST00000449296ENST00000477977ADAP1chr7

994030

-NOLC1chr10

103921312

+
intron-3CDSENST00000539900ENST00000605788ADAP1chr7

994030

-NOLC1chr10

103921312

+
intron-3CDSENST00000539900ENST00000405356ADAP1chr7

994030

-NOLC1chr10

103921312

+
intron-3CDSENST00000539900ENST00000603742ADAP1chr7

994030

-NOLC1chr10

103921312

+
intron-3CDSENST00000539900ENST00000488254ADAP1chr7

994030

-NOLC1chr10

103921312

+
intron-3UTRENST00000539900ENST00000477977ADAP1chr7

994030

-NOLC1chr10

103921312

+
intron-3CDSENST00000463358ENST00000605788ADAP1chr7

994030

-NOLC1chr10

103921312

+
intron-3CDSENST00000463358ENST00000405356ADAP1chr7

994030

-NOLC1chr10

103921312

+
intron-3CDSENST00000463358ENST00000603742ADAP1chr7

994030

-NOLC1chr10

103921312

+
intron-3CDSENST00000463358ENST00000488254ADAP1chr7

994030

-NOLC1chr10

103921312

+
intron-3UTRENST00000463358ENST00000477977ADAP1chr7

994030

-NOLC1chr10

103921312

+

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FusionProtFeatures for ADAP1_NOLC1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ADAP1

O75689

NOLC1

Q14978

GTPase-activating protein for the ADP ribosylationfactor family (Probable). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate(InsP4). {ECO:0000269|PubMed:10448098,ECO:0000303|PubMed:10333475, ECO:0000305}. Nucleolar protein that acts as a regulator of RNApolymerase I by connecting RNA polymerase I with enzymesresponsible for ribosomal processing and modification(PubMed:10567578, PubMed:26399832). Required for neural crestspecification: following monoubiquitination by the BCR(KBTBD8)complex, associates with TCOF1 and acts as a platform to connectRNA polymerase I with enzymes responsible for ribosomal processingand modification, leading to remodel the translational program ofdifferentiating cells in favor of neural crest specification(PubMed:26399832). Involved in nucleologenesis, possibly byplaying a role in the maintenance of the fundamental structure ofthe fibrillar center and dense fibrillar component in thenucleolus (PubMed:9016786). It has intrinsic GTPase and ATPaseactivities (PubMed:9016786). {ECO:0000269|PubMed:10567578,ECO:0000269|PubMed:26399832, ECO:0000269|PubMed:9016786}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ADAP1_NOLC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ADAP1_NOLC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ADAP1PRKCI, PRKCZ, PIK3CA, PRKD1, PRKCE, PSME3, CSNK1A1, NCL, ANP32A, GSK3B, GADD45A, RANBP9, DVL3, GOLGA2, SDCBP2, ARF6NOLC1ARRB2, ARRB1, YWHAZ, COIL, POLR1A, CEBPB, CSNK2B, MME, NOP56, YWHAG, CHD4, SIRT7, CHMP4B, GRK5, APP, FBL, RPS14, RSL1D1, NHP2L1, RPL15, RPL23A, RPL18A, RPL19, RPL6, RPL11, NOP58, RPS6, RPS23, RPL5, RPL4, RPS4X, RRP7A, UTP14A, PTRF, IK, NOP16, GPRC5A, RRS1, G3BP1, SAP18, GTF3C1, PNKP, PAN2, YWHAE, YWHAQ, CD2AP, SPAG9, RABEP2, WWOX, ERG, CSNK2A2, MOV10, NXF1, CUL7, OBSL1, SUZ12, EED, RNF2, CSNK2A1, FAM9A, DENND2D, BRIX1, CDK11A, CEBPZ, DDX56, DHX15, NOP2, PELP1, SRP14, SRRM1, SUB1, SSRP1, WDR36, SCARNA22, SRPK2, CC2D2A, XPO1, ATM, MKNK2, HDAC1, KLC1, KIF11, LLGL2, SUPT5H, TMPO, EZR, MYH13, VPS26A, ING4, POLK, KIF21A, KLC3, CEP170P1, MCM2, CDC5L, OTUB1, DAXX, KBTBD8, TCOF1, POLR1B, DKC1, NHP2, MDM2, CAMKV, PIP4K2A, GRK6, GTF2IRD1, RAB11FIP1, TWISTNB, HOXB9, AP3B1, EAF1, POLD1, CCDC154, MFAP1, COX15, DLD, HEY1, BRCA1, TES


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ADAP1_NOLC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneNOLC1Q14978DB00997DoxorubicinNucleolar and coiled-body phosphoprotein 1 {ECO:0000305}small moleculeapproved|investigational

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RelatedDiseases for ADAP1_NOLC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource