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Fusion gene ID: 776 |
FusionGeneSummary for ADAP1_NOLC1 |
Fusion gene summary |
Fusion gene information | Fusion gene name: ADAP1_NOLC1 | Fusion gene ID: 776 | Hgene | Tgene | Gene symbol | ADAP1 | NOLC1 | Gene ID | 11033 | 9221 |
Gene name | ArfGAP with dual PH domains 1 | nucleolar and coiled-body phosphoprotein 1 | |
Synonyms | CENTA1|GCS1L|p42IP4 | NOPP130|NOPP140|NS5ATP13|P130 | |
Cytomap | 7p22.3 | 10q24.32 | |
Type of gene | protein-coding | protein-coding | |
Description | arf-GAP with dual PH domain-containing protein 1centaurin-alphacentaurin-alpha-1cnt-a1putative MAPK-activating protein PM25 | nucleolar and coiled-body phosphoprotein 1140 kDa nucleolar phosphoproteinHCV NS5A trans-regulated protein 13HCV NS5A-transactivated protein 13hepatitis C virus NS5A-transactivated protein 13nucleolar 130 kDa proteinnucleolar and coiled-body phosphp | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | O75689 | Q14978 | |
Ensembl transtripts involved in fusion gene | ENST00000265846, ENST00000449296, ENST00000539900, ENST00000463358, | ENST00000605788, ENST00000405356, ENST00000603742, ENST00000488254, ENST00000477977, | |
Fusion gene scores | * DoF score | 8 X 5 X 7=280 | 3 X 3 X 2=18 |
# samples | 9 | 4 | |
** MAII score | log2(9/280*10)=-1.63742992061529 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ADAP1 [Title/Abstract] AND NOLC1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BM841194 | ADAP1 | chr7 | 994030 | - | NOLC1 | chr10 | 103921312 | + | ||
ChiTaRS3.1 | BM847741 | ADAP1 | chr7 | 994030 | - | NOLC1 | chr10 | 103921312 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000265846 | ENST00000605788 | ADAP1 | chr7 | 994030 | - | NOLC1 | chr10 | 103921312 | + |
Frame-shift | ENST00000265846 | ENST00000405356 | ADAP1 | chr7 | 994030 | - | NOLC1 | chr10 | 103921312 | + |
Frame-shift | ENST00000265846 | ENST00000603742 | ADAP1 | chr7 | 994030 | - | NOLC1 | chr10 | 103921312 | + |
Frame-shift | ENST00000265846 | ENST00000488254 | ADAP1 | chr7 | 994030 | - | NOLC1 | chr10 | 103921312 | + |
5CDS-3UTR | ENST00000265846 | ENST00000477977 | ADAP1 | chr7 | 994030 | - | NOLC1 | chr10 | 103921312 | + |
intron-3CDS | ENST00000449296 | ENST00000605788 | ADAP1 | chr7 | 994030 | - | NOLC1 | chr10 | 103921312 | + |
intron-3CDS | ENST00000449296 | ENST00000405356 | ADAP1 | chr7 | 994030 | - | NOLC1 | chr10 | 103921312 | + |
intron-3CDS | ENST00000449296 | ENST00000603742 | ADAP1 | chr7 | 994030 | - | NOLC1 | chr10 | 103921312 | + |
intron-3CDS | ENST00000449296 | ENST00000488254 | ADAP1 | chr7 | 994030 | - | NOLC1 | chr10 | 103921312 | + |
intron-3UTR | ENST00000449296 | ENST00000477977 | ADAP1 | chr7 | 994030 | - | NOLC1 | chr10 | 103921312 | + |
intron-3CDS | ENST00000539900 | ENST00000605788 | ADAP1 | chr7 | 994030 | - | NOLC1 | chr10 | 103921312 | + |
intron-3CDS | ENST00000539900 | ENST00000405356 | ADAP1 | chr7 | 994030 | - | NOLC1 | chr10 | 103921312 | + |
intron-3CDS | ENST00000539900 | ENST00000603742 | ADAP1 | chr7 | 994030 | - | NOLC1 | chr10 | 103921312 | + |
intron-3CDS | ENST00000539900 | ENST00000488254 | ADAP1 | chr7 | 994030 | - | NOLC1 | chr10 | 103921312 | + |
intron-3UTR | ENST00000539900 | ENST00000477977 | ADAP1 | chr7 | 994030 | - | NOLC1 | chr10 | 103921312 | + |
intron-3CDS | ENST00000463358 | ENST00000605788 | ADAP1 | chr7 | 994030 | - | NOLC1 | chr10 | 103921312 | + |
intron-3CDS | ENST00000463358 | ENST00000405356 | ADAP1 | chr7 | 994030 | - | NOLC1 | chr10 | 103921312 | + |
intron-3CDS | ENST00000463358 | ENST00000603742 | ADAP1 | chr7 | 994030 | - | NOLC1 | chr10 | 103921312 | + |
intron-3CDS | ENST00000463358 | ENST00000488254 | ADAP1 | chr7 | 994030 | - | NOLC1 | chr10 | 103921312 | + |
intron-3UTR | ENST00000463358 | ENST00000477977 | ADAP1 | chr7 | 994030 | - | NOLC1 | chr10 | 103921312 | + |
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FusionProtFeatures for ADAP1_NOLC1 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
ADAP1 | NOLC1 |
GTPase-activating protein for the ADP ribosylationfactor family (Probable). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate(InsP4). {ECO:0000269|PubMed:10448098,ECO:0000303|PubMed:10333475, ECO:0000305}. | Nucleolar protein that acts as a regulator of RNApolymerase I by connecting RNA polymerase I with enzymesresponsible for ribosomal processing and modification(PubMed:10567578, PubMed:26399832). Required for neural crestspecification: following monoubiquitination by the BCR(KBTBD8)complex, associates with TCOF1 and acts as a platform to connectRNA polymerase I with enzymes responsible for ribosomal processingand modification, leading to remodel the translational program ofdifferentiating cells in favor of neural crest specification(PubMed:26399832). Involved in nucleologenesis, possibly byplaying a role in the maintenance of the fundamental structure ofthe fibrillar center and dense fibrillar component in thenucleolus (PubMed:9016786). It has intrinsic GTPase and ATPaseactivities (PubMed:9016786). {ECO:0000269|PubMed:10567578,ECO:0000269|PubMed:26399832, ECO:0000269|PubMed:9016786}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ADAP1_NOLC1 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ADAP1_NOLC1 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ADAP1 | PRKCI, PRKCZ, PIK3CA, PRKD1, PRKCE, PSME3, CSNK1A1, NCL, ANP32A, GSK3B, GADD45A, RANBP9, DVL3, GOLGA2, SDCBP2, ARF6 | NOLC1 | ARRB2, ARRB1, YWHAZ, COIL, POLR1A, CEBPB, CSNK2B, MME, NOP56, YWHAG, CHD4, SIRT7, CHMP4B, GRK5, APP, FBL, RPS14, RSL1D1, NHP2L1, RPL15, RPL23A, RPL18A, RPL19, RPL6, RPL11, NOP58, RPS6, RPS23, RPL5, RPL4, RPS4X, RRP7A, UTP14A, PTRF, IK, NOP16, GPRC5A, RRS1, G3BP1, SAP18, GTF3C1, PNKP, PAN2, YWHAE, YWHAQ, CD2AP, SPAG9, RABEP2, WWOX, ERG, CSNK2A2, MOV10, NXF1, CUL7, OBSL1, SUZ12, EED, RNF2, CSNK2A1, FAM9A, DENND2D, BRIX1, CDK11A, CEBPZ, DDX56, DHX15, NOP2, PELP1, SRP14, SRRM1, SUB1, SSRP1, WDR36, SCARNA22, SRPK2, CC2D2A, XPO1, ATM, MKNK2, HDAC1, KLC1, KIF11, LLGL2, SUPT5H, TMPO, EZR, MYH13, VPS26A, ING4, POLK, KIF21A, KLC3, CEP170P1, MCM2, CDC5L, OTUB1, DAXX, KBTBD8, TCOF1, POLR1B, DKC1, NHP2, MDM2, CAMKV, PIP4K2A, GRK6, GTF2IRD1, RAB11FIP1, TWISTNB, HOXB9, AP3B1, EAF1, POLD1, CCDC154, MFAP1, COX15, DLD, HEY1, BRCA1, TES |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ADAP1_NOLC1 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | NOLC1 | Q14978 | DB00997 | Doxorubicin | Nucleolar and coiled-body phosphoprotein 1 {ECO:0000305} | small molecule | approved|investigational |
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RelatedDiseases for ADAP1_NOLC1 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |