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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 7756

FusionGeneSummary for CNRIP1_ZNF638

check button Fusion gene summary
Fusion gene informationFusion gene name: CNRIP1_ZNF638
Fusion gene ID: 7756
HgeneTgene
Gene symbol

CNRIP1

ZNF638

Gene ID

25927

27332

Gene namecannabinoid receptor interacting protein 1zinc finger protein 638
SynonymsC2orf32|CRIP1NP220|ZFML|Zfp638
Cytomap

2p14

2p13.3-p13.2

Type of geneprotein-codingprotein-coding
DescriptionCB1 cannabinoid receptor-interacting protein 1CRIP-1cannabinoid receptor CB1-interacting protein 1zinc finger protein 638CTCL tumor antigen se33-1CTCL-associated antigen se33-1NP220 nuclear proteincutaneous T-cell lymphoma-associated antigen se33-1nuclear protein 220zinc finger matrin-like protein
Modification date2018051920180519
UniProtAcc

Q96F85

Q14966

Ensembl transtripts involved in fusion geneENST00000409559, ENST00000263655, 
ENST00000481714, ENST00000409862, 
ENST00000410075, ENST00000377802, 
ENST00000355812, ENST00000409544, 
ENST00000264447, ENST00000409407, 
Fusion gene scores* DoF score1 X 1 X 1=16 X 5 X 3=90
# samples 16
** MAII scorelog2(1/1*10)=3.32192809488736log2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CNRIP1 [Title/Abstract] AND ZNF638 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLGGTCGA-DU-6410-01ACNRIP1chr2

68544289

-ZNF638chr2

71623271

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000409559ENST00000410075CNRIP1chr2

68544289

-ZNF638chr2

71623271

+
5CDS-intronENST00000409559ENST00000377802CNRIP1chr2

68544289

-ZNF638chr2

71623271

+
5CDS-intronENST00000409559ENST00000355812CNRIP1chr2

68544289

-ZNF638chr2

71623271

+
5CDS-intronENST00000409559ENST00000409544CNRIP1chr2

68544289

-ZNF638chr2

71623271

+
5CDS-intronENST00000409559ENST00000264447CNRIP1chr2

68544289

-ZNF638chr2

71623271

+
5CDS-intronENST00000409559ENST00000409407CNRIP1chr2

68544289

-ZNF638chr2

71623271

+
5CDS-intronENST00000263655ENST00000410075CNRIP1chr2

68544289

-ZNF638chr2

71623271

+
5CDS-intronENST00000263655ENST00000377802CNRIP1chr2

68544289

-ZNF638chr2

71623271

+
5CDS-intronENST00000263655ENST00000355812CNRIP1chr2

68544289

-ZNF638chr2

71623271

+
5CDS-intronENST00000263655ENST00000409544CNRIP1chr2

68544289

-ZNF638chr2

71623271

+
5CDS-intronENST00000263655ENST00000264447CNRIP1chr2

68544289

-ZNF638chr2

71623271

+
5CDS-intronENST00000263655ENST00000409407CNRIP1chr2

68544289

-ZNF638chr2

71623271

+
5UTR-intronENST00000481714ENST00000410075CNRIP1chr2

68544289

-ZNF638chr2

71623271

+
5UTR-intronENST00000481714ENST00000377802CNRIP1chr2

68544289

-ZNF638chr2

71623271

+
5UTR-intronENST00000481714ENST00000355812CNRIP1chr2

68544289

-ZNF638chr2

71623271

+
5UTR-intronENST00000481714ENST00000409544CNRIP1chr2

68544289

-ZNF638chr2

71623271

+
5UTR-intronENST00000481714ENST00000264447CNRIP1chr2

68544289

-ZNF638chr2

71623271

+
5UTR-intronENST00000481714ENST00000409407CNRIP1chr2

68544289

-ZNF638chr2

71623271

+
intron-intronENST00000409862ENST00000410075CNRIP1chr2

68544289

-ZNF638chr2

71623271

+
intron-intronENST00000409862ENST00000377802CNRIP1chr2

68544289

-ZNF638chr2

71623271

+
intron-intronENST00000409862ENST00000355812CNRIP1chr2

68544289

-ZNF638chr2

71623271

+
intron-intronENST00000409862ENST00000409544CNRIP1chr2

68544289

-ZNF638chr2

71623271

+
intron-intronENST00000409862ENST00000264447CNRIP1chr2

68544289

-ZNF638chr2

71623271

+
intron-intronENST00000409862ENST00000409407CNRIP1chr2

68544289

-ZNF638chr2

71623271

+

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FusionProtFeatures for CNRIP1_ZNF638


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CNRIP1

Q96F85

ZNF638

Q14966

Isoform 1 suppresses cannabinoid receptor CNR1-mediatedtonic inhibition of voltage-gated calcium channels. Isoform 2 doesnot have this effect. {ECO:0000269|PubMed:17895407}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CNRIP1_ZNF638


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CNRIP1_ZNF638


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CNRIP1GCH1, BRCA1, KCTD5, CIRH1A, PGLYRP1, RBM18, ZFP41, C20orf203, KCTD2ZNF638WWP1, KIAA1279, CALCOCO2, KRTAP4-12, KRT19, CCDC85B, KRT15, EFEMP2, PLSCR1, HOOK2, SFN, FHL2, SRRM1, ELAVL1, SIRT7, SPP1, CAND1, PURA, YY1, WASL, NELFCD, HECW2, RPA3, RPA2, RPA1, LGR4, PASK, CUL7, OBSL1, EZH2, EED, RNF2, BMI1, LUC7L, SF3A3, IFI16, MED4, HNRNPA1, PPP1CB, PPP1CC, MATR3, MPHOSPH8, SNW1, CDC5L, SSU72, TNFRSF13B, GTF3C2, CLK2, CLEC3A, JPH4, NEUROG3, NOL9, CLK3, BHLHA15, E4F1, APOBEC3D, FEZ1, RBFA, CCDC59, KCTD3, KIF13B, ZBTB21, KSR1, GIGYF1, LRFN1, DENND1A, SH3PXD2A, SRGAP2, EIF4E2, SIPA1L1, LIMA1, MAGI1, TESK2, DCLK1, SRSF12, SYDE1, AGAP1, CDC25B, CDK16, PPM1H, MAST3, RTKN, FAM110B, DENND4C, USP21, ANKRD34A, FAM53C, MAPKAP1, FAM110A, HDAC4, CGN, TBC1D25, NF1, NADK, CBY1, TIAM1, PHLDB2, KIAA1804, RASAL2, GAB2, MELK, PLEKHA7, CAMSAP2, CDC25C, KIF1C, LPIN3, DEPDC1B, GIGYF2, NAV1, MLLT4, DENND4A, PTPN14, STARD13, SH3BP4, PLEKHA5, RPTOR, EDC3, HDAC7, LARP1, RAB3IP, INPP5E, G3BP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CNRIP1_ZNF638


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CNRIP1_ZNF638


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource