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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 7754

FusionGeneSummary for CNP_NIPAL3

check button Fusion gene summary
Fusion gene informationFusion gene name: CNP_NIPAL3
Fusion gene ID: 7754
HgeneTgene
Gene symbol

CNP

NIPAL3

Gene ID

1267

57185

Gene name2',3'-cyclic nucleotide 3' phosphodiesteraseNIPA like domain containing 3
SynonymsCNP1DJ462O23.2|NPAL3
Cytomap

17q21.2

1p36.11

Type of geneprotein-codingprotein-coding
Description2',3'-cyclic-nucleotide 3'-phosphodiesterase2', 3' cyclic nucleotide 3' phosphohydrolaseCNPaseNIPA-like protein 3
Modification date2018052320180523
UniProtAcc

P09543

Q6P499

Ensembl transtripts involved in fusion geneENST00000393892, ENST00000472031, 
ENST00000591072, ENST00000592446, 
ENST00000393888, 		ENST00000374399, 
ENST00000003912, ENST00000358028, 
ENST00000339255, ENST00000428131, 
ENST00000488155, 
Fusion gene scores* DoF score4 X 4 X 2=325 X 5 X 3=75
# samples 45
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CNP [Title/Abstract] AND NIPAL3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA935868CNPchr17

40128491

-NIPAL3chr1

24792795

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000393892ENST00000374399CNPchr17

40128491

-NIPAL3chr1

24792795

+
3UTR-intronENST00000393892ENST00000003912CNPchr17

40128491

-NIPAL3chr1

24792795

+
3UTR-intronENST00000393892ENST00000358028CNPchr17

40128491

-NIPAL3chr1

24792795

+
3UTR-intronENST00000393892ENST00000339255CNPchr17

40128491

-NIPAL3chr1

24792795

+
3UTR-intronENST00000393892ENST00000428131CNPchr17

40128491

-NIPAL3chr1

24792795

+
3UTR-intronENST00000393892ENST00000488155CNPchr17

40128491

-NIPAL3chr1

24792795

+
intron-intronENST00000472031ENST00000374399CNPchr17

40128491

-NIPAL3chr1

24792795

+
intron-intronENST00000472031ENST00000003912CNPchr17

40128491

-NIPAL3chr1

24792795

+
intron-intronENST00000472031ENST00000358028CNPchr17

40128491

-NIPAL3chr1

24792795

+
intron-intronENST00000472031ENST00000339255CNPchr17

40128491

-NIPAL3chr1

24792795

+
intron-intronENST00000472031ENST00000428131CNPchr17

40128491

-NIPAL3chr1

24792795

+
intron-intronENST00000472031ENST00000488155CNPchr17

40128491

-NIPAL3chr1

24792795

+
intron-intronENST00000591072ENST00000374399CNPchr17

40128491

-NIPAL3chr1

24792795

+
intron-intronENST00000591072ENST00000003912CNPchr17

40128491

-NIPAL3chr1

24792795

+
intron-intronENST00000591072ENST00000358028CNPchr17

40128491

-NIPAL3chr1

24792795

+
intron-intronENST00000591072ENST00000339255CNPchr17

40128491

-NIPAL3chr1

24792795

+
intron-intronENST00000591072ENST00000428131CNPchr17

40128491

-NIPAL3chr1

24792795

+
intron-intronENST00000591072ENST00000488155CNPchr17

40128491

-NIPAL3chr1

24792795

+
intron-intronENST00000592446ENST00000374399CNPchr17

40128491

-NIPAL3chr1

24792795

+
intron-intronENST00000592446ENST00000003912CNPchr17

40128491

-NIPAL3chr1

24792795

+
intron-intronENST00000592446ENST00000358028CNPchr17

40128491

-NIPAL3chr1

24792795

+
intron-intronENST00000592446ENST00000339255CNPchr17

40128491

-NIPAL3chr1

24792795

+
intron-intronENST00000592446ENST00000428131CNPchr17

40128491

-NIPAL3chr1

24792795

+
intron-intronENST00000592446ENST00000488155CNPchr17

40128491

-NIPAL3chr1

24792795

+
intron-intronENST00000393888ENST00000374399CNPchr17

40128491

-NIPAL3chr1

24792795

+
intron-intronENST00000393888ENST00000003912CNPchr17

40128491

-NIPAL3chr1

24792795

+
intron-intronENST00000393888ENST00000358028CNPchr17

40128491

-NIPAL3chr1

24792795

+
intron-intronENST00000393888ENST00000339255CNPchr17

40128491

-NIPAL3chr1

24792795

+
intron-intronENST00000393888ENST00000428131CNPchr17

40128491

-NIPAL3chr1

24792795

+
intron-intronENST00000393888ENST00000488155CNPchr17

40128491

-NIPAL3chr1

24792795

+

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FusionProtFeatures for CNP_NIPAL3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CNP

P09543

NIPAL3

Q6P499

May participate in RNA metabolism in the myelinatingcell, CNP is the third most abundant protein in central nervoussystem myelin. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CNP_NIPAL3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CNP_NIPAL3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CNP_NIPAL3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CNP_NIPAL3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCNPC0036341Schizophrenia5PSYGENET
HgeneCNPC0023893Liver Cirrhosis, Experimental1CTD_human
HgeneCNPC0033975Psychotic Disorders1PSYGENET
HgeneCNPC0041696Unipolar Depression1PSYGENET
HgeneCNPC1269683Major Depressive Disorder1PSYGENET
TgeneNIPAL3C0033578Prostatic Neoplasms1CTD_human