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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 7737

FusionGeneSummary for CNOT6_TSPAN8

check button Fusion gene summary
Fusion gene informationFusion gene name: CNOT6_TSPAN8
Fusion gene ID: 7737
HgeneTgene
Gene symbol

CNOT6

TSPAN8

Gene ID

57472

7103

Gene nameCCR4-NOT transcription complex subunit 6tetraspanin 8
SynonymsCCR4|Ccr4aCO-029|TM4SF3
Cytomap

5q35.3

12q21.1

Type of geneprotein-codingprotein-coding
DescriptionCCR4-NOT transcription complex subunit 6carbon catabolite repression 4 proteincarbon catabolite repressor protein 4 homologcytoplasmic deadenylasetetraspanin-8transmembrane 4 superfamily member 3tspan-8tumor-associated antigen CO-029
Modification date2018052220180523
UniProtAcc

Q9ULM6

P19075

Ensembl transtripts involved in fusion geneENST00000261951, ENST00000393356, 
ENST00000502447, 		ENST00000393330, 
ENST00000247829, ENST00000546561, 
ENST00000552128, ENST00000552786, 
Fusion gene scores* DoF score3 X 4 X 2=2427 X 7 X 11=2079
# samples 225
** MAII scorelog2(2/24*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(25/2079*10)=-3.05588975819628
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CNOT6 [Title/Abstract] AND TSPAN8 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCNOT6

GO:0043928

exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay

20065043

HgeneCNOT6

GO:2000327

positive regulation of ligand-dependent nuclear receptor transcription coactivator activity

18180299


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-3B-A9HS-01ACNOT6chr5

179980471

+TSPAN8chr12

71551567

-
TCGALDSARCTCGA-3B-A9HS-01ACNOT6chr5

179977117

+TSPAN8chr12

71551567

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000261951ENST00000393330CNOT6chr5

179980471

+TSPAN8chr12

71551567

-
5CDS-5UTRENST00000261951ENST00000247829CNOT6chr5

179980471

+TSPAN8chr12

71551567

-
5CDS-5UTRENST00000261951ENST00000546561CNOT6chr5

179980471

+TSPAN8chr12

71551567

-
5CDS-intronENST00000261951ENST00000552128CNOT6chr5

179980471

+TSPAN8chr12

71551567

-
5CDS-5UTRENST00000261951ENST00000552786CNOT6chr5

179980471

+TSPAN8chr12

71551567

-
5CDS-5UTRENST00000393356ENST00000393330CNOT6chr5

179980471

+TSPAN8chr12

71551567

-
5CDS-5UTRENST00000393356ENST00000247829CNOT6chr5

179980471

+TSPAN8chr12

71551567

-
5CDS-5UTRENST00000393356ENST00000546561CNOT6chr5

179980471

+TSPAN8chr12

71551567

-
5CDS-intronENST00000393356ENST00000552128CNOT6chr5

179980471

+TSPAN8chr12

71551567

-
5CDS-5UTRENST00000393356ENST00000552786CNOT6chr5

179980471

+TSPAN8chr12

71551567

-
intron-5UTRENST00000502447ENST00000393330CNOT6chr5

179980471

+TSPAN8chr12

71551567

-
intron-5UTRENST00000502447ENST00000247829CNOT6chr5

179980471

+TSPAN8chr12

71551567

-
intron-5UTRENST00000502447ENST00000546561CNOT6chr5

179980471

+TSPAN8chr12

71551567

-
intron-intronENST00000502447ENST00000552128CNOT6chr5

179980471

+TSPAN8chr12

71551567

-
intron-5UTRENST00000502447ENST00000552786CNOT6chr5

179980471

+TSPAN8chr12

71551567

-
5CDS-5UTRENST00000261951ENST00000393330CNOT6chr5

179977117

+TSPAN8chr12

71551567

-
5CDS-5UTRENST00000261951ENST00000247829CNOT6chr5

179977117

+TSPAN8chr12

71551567

-
5CDS-5UTRENST00000261951ENST00000546561CNOT6chr5

179977117

+TSPAN8chr12

71551567

-
5CDS-intronENST00000261951ENST00000552128CNOT6chr5

179977117

+TSPAN8chr12

71551567

-
5CDS-5UTRENST00000261951ENST00000552786CNOT6chr5

179977117

+TSPAN8chr12

71551567

-
5CDS-5UTRENST00000393356ENST00000393330CNOT6chr5

179977117

+TSPAN8chr12

71551567

-
5CDS-5UTRENST00000393356ENST00000247829CNOT6chr5

179977117

+TSPAN8chr12

71551567

-
5CDS-5UTRENST00000393356ENST00000546561CNOT6chr5

179977117

+TSPAN8chr12

71551567

-
5CDS-intronENST00000393356ENST00000552128CNOT6chr5

179977117

+TSPAN8chr12

71551567

-
5CDS-5UTRENST00000393356ENST00000552786CNOT6chr5

179977117

+TSPAN8chr12

71551567

-
3UTR-5UTRENST00000502447ENST00000393330CNOT6chr5

179977117

+TSPAN8chr12

71551567

-
3UTR-5UTRENST00000502447ENST00000247829CNOT6chr5

179977117

+TSPAN8chr12

71551567

-
3UTR-5UTRENST00000502447ENST00000546561CNOT6chr5

179977117

+TSPAN8chr12

71551567

-
3UTR-intronENST00000502447ENST00000552128CNOT6chr5

179977117

+TSPAN8chr12

71551567

-
3UTR-5UTRENST00000502447ENST00000552786CNOT6chr5

179977117

+TSPAN8chr12

71551567

-

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FusionProtFeatures for CNOT6_TSPAN8


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CNOT6

Q9ULM6

TSPAN8

P19075

Poly(A) nuclease with 3'-5' RNase activity. Catalyticcomponent of the CCR4-NOT complex which is one of the majorcellular mRNA deadenylases and is linked to various cellularprocesses including bulk mRNA degradation, miRNA-mediatedrepression, translational repression during translationalinitiation and general transcription regulation. Additionalcomplex functions may be a consequence of its influence on mRNAexpression. Involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in thecytoplasm. In the presence of ZNF335, enhances ligand-dependenttranscriptional activity of nuclear hormone receptors, includingRARA. The increase of ligand-dependent ESR1-mediated transcriptionis much smaller, if any. Mediates cell proliferation and cellsurvival and prevents cellular senescence.{ECO:0000269|PubMed:11889047, ECO:0000269|PubMed:18180299,ECO:0000269|PubMed:20065043, ECO:0000269|PubMed:21233283}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CNOT6_TSPAN8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CNOT6_TSPAN8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CNOT6ELAVL1, PABPC1, HSP90AA1, CNOT1, CNOT2, CNOT3, CHAF1A, RQCD1, TNKS1BP1, CNOT10, CNOT7, TNRC6C, ZMAT3, MMP7, CAPZA2, TNRC6A, TNRC6B, AGO2, ATXN3, ZFP36, ZFP36L1, NANOS2, TOB1, CNOT11, RIBC1, TEX13A, GADD45B, IZUMO1, CNOT6L, NFKB1, GLATSPAN8


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CNOT6_TSPAN8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CNOT6_TSPAN8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTSPAN8C0005586Bipolar Disorder1PSYGENET
TgeneTSPAN8C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneTSPAN8C0035222Respiratory Distress Syndrome, Adult1CTD_human
TgeneTSPAN8C0036341Schizophrenia1PSYGENET
TgeneTSPAN8C0525045Mood Disorders1PSYGENET