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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 7719

FusionGeneSummary for CNOT2_SLCO1A2

check button Fusion gene summary
Fusion gene informationFusion gene name: CNOT2_SLCO1A2
Fusion gene ID: 7719
HgeneTgene
Gene symbol

CNOT2

SLCO1A2

Gene ID

4848

6579

Gene nameCCR4-NOT transcription complex subunit 2solute carrier organic anion transporter family member 1A2
SynonymsCDC36|HSPC131|NOT2|NOT2HOATP|OATP-A|OATP1A2|SLC21A3
Cytomap

12q15

12p12.1

Type of geneprotein-codingprotein-coding
DescriptionCCR4-NOT transcription complex subunit 2CCR4-associated factor 2negative regulator of transcription 2solute carrier organic anion transporter family member 1A2OATP-1organic anion transporting polypeptide Aorganic anion-transporting polypeptide 1sodium-independent organic anion transportersolute carrier family 21 (organic anion transporter), member 3
Modification date2018052320180523
UniProtAcc

Q9NZN8

P46721

Ensembl transtripts involved in fusion geneENST00000229195, ENST00000418359, 
ENST00000548230, ENST00000551483, 
ENST00000307378, ENST00000537524, 
ENST00000473830, ENST00000452078, 
ENST00000458504, ENST00000390670, 
Fusion gene scores* DoF score26 X 8 X 9=18728 X 6 X 6=288
# samples 258
** MAII scorelog2(25/1872*10)=-2.90458043492132
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/288*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CNOT2 [Title/Abstract] AND SLCO1A2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCNOT2

GO:0000122

negative regulation of transcription by RNA polymerase II

14707134|16712523


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLGGTCGA-TQ-A7RH-01ACNOT2chr12

70672054

+SLCO1A2chr12

21445270

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000229195ENST00000307378CNOT2chr12

70672054

+SLCO1A2chr12

21445270

-
In-frameENST00000229195ENST00000537524CNOT2chr12

70672054

+SLCO1A2chr12

21445270

-
5CDS-intronENST00000229195ENST00000473830CNOT2chr12

70672054

+SLCO1A2chr12

21445270

-
5CDS-intronENST00000229195ENST00000452078CNOT2chr12

70672054

+SLCO1A2chr12

21445270

-
5CDS-intronENST00000229195ENST00000458504CNOT2chr12

70672054

+SLCO1A2chr12

21445270

-
5CDS-intronENST00000229195ENST00000390670CNOT2chr12

70672054

+SLCO1A2chr12

21445270

-
In-frameENST00000418359ENST00000307378CNOT2chr12

70672054

+SLCO1A2chr12

21445270

-
In-frameENST00000418359ENST00000537524CNOT2chr12

70672054

+SLCO1A2chr12

21445270

-
5CDS-intronENST00000418359ENST00000473830CNOT2chr12

70672054

+SLCO1A2chr12

21445270

-
5CDS-intronENST00000418359ENST00000452078CNOT2chr12

70672054

+SLCO1A2chr12

21445270

-
5CDS-intronENST00000418359ENST00000458504CNOT2chr12

70672054

+SLCO1A2chr12

21445270

-
5CDS-intronENST00000418359ENST00000390670CNOT2chr12

70672054

+SLCO1A2chr12

21445270

-
intron-3CDSENST00000548230ENST00000307378CNOT2chr12

70672054

+SLCO1A2chr12

21445270

-
intron-3CDSENST00000548230ENST00000537524CNOT2chr12

70672054

+SLCO1A2chr12

21445270

-
intron-intronENST00000548230ENST00000473830CNOT2chr12

70672054

+SLCO1A2chr12

21445270

-
intron-intronENST00000548230ENST00000452078CNOT2chr12

70672054

+SLCO1A2chr12

21445270

-
intron-intronENST00000548230ENST00000458504CNOT2chr12

70672054

+SLCO1A2chr12

21445270

-
intron-intronENST00000548230ENST00000390670CNOT2chr12

70672054

+SLCO1A2chr12

21445270

-
intron-3CDSENST00000551483ENST00000307378CNOT2chr12

70672054

+SLCO1A2chr12

21445270

-
intron-3CDSENST00000551483ENST00000537524CNOT2chr12

70672054

+SLCO1A2chr12

21445270

-
intron-intronENST00000551483ENST00000473830CNOT2chr12

70672054

+SLCO1A2chr12

21445270

-
intron-intronENST00000551483ENST00000452078CNOT2chr12

70672054

+SLCO1A2chr12

21445270

-
intron-intronENST00000551483ENST00000458504CNOT2chr12

70672054

+SLCO1A2chr12

21445270

-
intron-intronENST00000551483ENST00000390670CNOT2chr12

70672054

+SLCO1A2chr12

21445270

-

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FusionProtFeatures for CNOT2_SLCO1A2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CNOT2

Q9NZN8

SLCO1A2

P46721

Component of the CCR4-NOT complex which is one of themajor cellular mRNA deadenylases and is linked to various cellularprocesses including bulk mRNA degradation, miRNA-mediatedrepression, translational repression during translationalinitiation and general transcription regulation. Additionalcomplex functions may be a consequence of its influence on mRNAexpression. Required for the CCR4-NOT complex structuralintegrity. Can repress transcription and may link the CCR4-NOTcomplex to transcriptional regulation; the repressive function mayspecifically involve the N-Cor repressor complex containing HDAC3,NCOR1 and NCOR2. Involved in the maintenance of emryonic stem (ES)cell identity. {ECO:0000269|PubMed:14707134,ECO:0000269|PubMed:16712523, ECO:0000269|PubMed:21299754,ECO:0000269|PubMed:22367759}. Mediates the Na(+)-independent transport of organicanions such as sulfobromophthalein (BSP) and conjugated(taurocholate) and unconjugated (cholate) bile acids (Bysimilarity). Selectively inhibited by the grapefruit juicecomponent naringin. {ECO:0000250, ECO:0000269|PubMed:17301733}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000307378-1116537_545479671Topological domainCytoplasmic
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000307378-1116572_605479671Topological domainExtracellular
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000307378-1116624_670479671Topological domainCytoplasmic
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000390670-1013537_545477580Topological domainCytoplasmic
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000390670-1013572_605477580Topological domainExtracellular
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000390670-1013624_670477580Topological domainCytoplasmic
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000452078-914537_545479671Topological domainCytoplasmic
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000452078-914572_605479671Topological domainExtracellular
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000452078-914624_670479671Topological domainCytoplasmic
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000307378-1116514_536479671TransmembraneHelical%3B Name%3D10
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000307378-1116546_571479671TransmembraneHelical%3B Name%3D11
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000307378-1116606_623479671TransmembraneHelical%3B Name%3D12
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000390670-1013514_536477580TransmembraneHelical%3B Name%3D10
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000390670-1013546_571477580TransmembraneHelical%3B Name%3D11
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000390670-1013606_623477580TransmembraneHelical%3B Name%3D12
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000452078-914514_536479671TransmembraneHelical%3B Name%3D10
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000452078-914546_571479671TransmembraneHelical%3B Name%3D11
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000452078-914606_623479671TransmembraneHelical%3B Name%3D12

- In-frame and not-retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCNOT2chr12:70672054chr12:21445270ENST00000229195+216437_54016541RegionNote=Repressor domain
HgeneCNOT2chr12:70672054chr12:21445270ENST00000418359+317437_54016541RegionNote=Repressor domain
HgeneCNOT2chr12:70672054chr12:21445270ENST00000551483+17437_540-1385192RegionNote=Repressor domain
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000307378-1116433_488479671DomainKazal-like
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000390670-1013433_488477580DomainKazal-like
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000452078-914433_488479671DomainKazal-like
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000307378-1116112_155479671Topological domainExtracellular
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000307378-1116185_203479671Topological domainCytoplasmic
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000307378-11161_20479671Topological domainCytoplasmic
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000307378-1116225_242479671Topological domainExtracellular
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000307378-1116268_311479671Topological domainCytoplasmic
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000307378-1116334_353479671Topological domainExtracellular
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000307378-1116378_381479671Topological domainCytoplasmic
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000307378-1116406_513479671Topological domainExtracellular
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000307378-111641_59479671Topological domainExtracellular
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000307378-111681_86479671Topological domainCytoplasmic
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000390670-1013112_155477580Topological domainExtracellular
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000390670-1013185_203477580Topological domainCytoplasmic
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000390670-10131_20477580Topological domainCytoplasmic
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000390670-1013225_242477580Topological domainExtracellular
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000390670-1013268_311477580Topological domainCytoplasmic
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000390670-1013334_353477580Topological domainExtracellular
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000390670-1013378_381477580Topological domainCytoplasmic
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000390670-1013406_513477580Topological domainExtracellular
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000390670-101341_59477580Topological domainExtracellular
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000390670-101381_86477580Topological domainCytoplasmic
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000452078-914112_155479671Topological domainExtracellular
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000452078-914185_203479671Topological domainCytoplasmic
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000452078-9141_20479671Topological domainCytoplasmic
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000452078-914225_242479671Topological domainExtracellular
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000452078-914268_311479671Topological domainCytoplasmic
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000452078-914334_353479671Topological domainExtracellular
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000452078-914378_381479671Topological domainCytoplasmic
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000452078-914406_513479671Topological domainExtracellular
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000452078-91441_59479671Topological domainExtracellular
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000452078-91481_86479671Topological domainCytoplasmic
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000307378-1116156_184479671TransmembraneHelical%3B Name%3D4
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000307378-1116204_224479671TransmembraneHelical%3B Name%3D5
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000307378-111621_40479671TransmembraneHelical%3B Name%3D1
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000307378-1116243_267479671TransmembraneHelical%3B Name%3D6
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000307378-1116312_333479671TransmembraneHelical%3B Name%3D7
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000307378-1116354_377479671TransmembraneHelical%3B Name%3D8
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000307378-1116382_405479671TransmembraneHelical%3B Name%3D9
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000307378-111660_80479671TransmembraneHelical%3B Name%3D2
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000307378-111687_111479671TransmembraneHelical%3B Name%3D3
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000390670-1013156_184477580TransmembraneHelical%3B Name%3D4
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000390670-1013204_224477580TransmembraneHelical%3B Name%3D5
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000390670-101321_40477580TransmembraneHelical%3B Name%3D1
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000390670-1013243_267477580TransmembraneHelical%3B Name%3D6
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000390670-1013312_333477580TransmembraneHelical%3B Name%3D7
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000390670-1013354_377477580TransmembraneHelical%3B Name%3D8
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000390670-1013382_405477580TransmembraneHelical%3B Name%3D9
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000390670-101360_80477580TransmembraneHelical%3B Name%3D2
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000390670-101387_111477580TransmembraneHelical%3B Name%3D3
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000452078-914156_184479671TransmembraneHelical%3B Name%3D4
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000452078-914204_224479671TransmembraneHelical%3B Name%3D5
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000452078-91421_40479671TransmembraneHelical%3B Name%3D1
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000452078-914243_267479671TransmembraneHelical%3B Name%3D6
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000452078-914312_333479671TransmembraneHelical%3B Name%3D7
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000452078-914354_377479671TransmembraneHelical%3B Name%3D8
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000452078-914382_405479671TransmembraneHelical%3B Name%3D9
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000452078-91460_80479671TransmembraneHelical%3B Name%3D2
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000452078-91487_111479671TransmembraneHelical%3B Name%3D3


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FusionGeneSequence for CNOT2_SLCO1A2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_CNOT2_ENST00000229195_chr12_70672054_+_SLCO1A2_ENST00000307378_chr12_21445270_-_208aa
MVRTDGHTLSEKRNYQVFQNCSCIQTSGNSSAVLGLCDKGPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLRCMKSEEKSLGVGLHTF
CTRVFAGIPAPIYFGALMDSTCLHWGTLKCGESGACRIYDSTTFRYIYLGLPAALRGSSFVPALIILILLRKCHLPGENASSGTELIETK

>In-frame_CNOT2_ENST00000229195_chr12_70672054_+_SLCO1A2_ENST00000537524_chr12_21445270_-_208aa
MVRTDGHTLSEKRNYQVFQNCSCIQTSGNSSAVLGLCDKGPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLRCMKSEEKSLGVGLHTF
CTRVFAGIPAPIYFGALMDSTCLHWGTLKCGESGACRIYDSTTFRYIYLGLPAALRGSSFVPALIILILLRKCHLPGENASSGTELIETK

>In-frame_CNOT2_ENST00000418359_chr12_70672054_+_SLCO1A2_ENST00000307378_chr12_21445270_-_208aa
MVRTDGHTLSEKRNYQVFQNCSCIQTSGNSSAVLGLCDKGPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLRCMKSEEKSLGVGLHTF
CTRVFAGIPAPIYFGALMDSTCLHWGTLKCGESGACRIYDSTTFRYIYLGLPAALRGSSFVPALIILILLRKCHLPGENASSGTELIETK

>In-frame_CNOT2_ENST00000418359_chr12_70672054_+_SLCO1A2_ENST00000537524_chr12_21445270_-_208aa
MVRTDGHTLSEKRNYQVFQNCSCIQTSGNSSAVLGLCDKGPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLRCMKSEEKSLGVGLHTF
CTRVFAGIPAPIYFGALMDSTCLHWGTLKCGESGACRIYDSTTFRYIYLGLPAALRGSSFVPALIILILLRKCHLPGENASSGTELIETK


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_CNOT2_ENST00000229195_chr12_70672054_+_SLCO1A2_ENST00000307378_chr12_21445270_-_624nt
ATGGTGAGGACTGATGGACATACATTATCTGAGAAAAGAAACTACCAGGTGTTCCAAAATTGCAGCTGTATTCAAACATCAGGAAATTCA
TCTGCAGTTCTTGGGCTGTGCGACAAAGGACCTGACTGTTCCTTGATGCTCCAGTACTTCCTAATCTTGTCAGCGATGAGCAGTTTCATT
TATTCTTTGGCTGCCATACCTGGATATATGGTTCTCTTGAGGTGTATGAAATCTGAAGAGAAGTCCCTTGGTGTGGGATTACATACATTT
TGCACAAGAGTATTTGCTGGCATTCCTGCACCTATATATTTTGGCGCTTTAATGGATTCCACATGTTTACACTGGGGAACTTTGAAATGT
GGTGAGTCAGGGGCATGCAGGATATATGATTCCACCACCTTCAGATACATCTACCTCGGATTGCCGGCAGCACTAAGAGGATCAAGCTTT
GTTCCAGCCTTAATCATCTTAATTCTTTTGAGGAAGTGTCATCTACCTGGTGAAAATGCCTCTTCAGGAACAGAGCTTATAGAGACAAAA

>In-frame_CNOT2_ENST00000229195_chr12_70672054_+_SLCO1A2_ENST00000537524_chr12_21445270_-_624nt
ATGGTGAGGACTGATGGACATACATTATCTGAGAAAAGAAACTACCAGGTGTTCCAAAATTGCAGCTGTATTCAAACATCAGGAAATTCA
TCTGCAGTTCTTGGGCTGTGCGACAAAGGACCTGACTGTTCCTTGATGCTCCAGTACTTCCTAATCTTGTCAGCGATGAGCAGTTTCATT
TATTCTTTGGCTGCCATACCTGGATATATGGTTCTCTTGAGGTGTATGAAATCTGAAGAGAAGTCCCTTGGTGTGGGATTACATACATTT
TGCACAAGAGTATTTGCTGGCATTCCTGCACCTATATATTTTGGCGCTTTAATGGATTCCACATGTTTACACTGGGGAACTTTGAAATGT
GGTGAGTCAGGGGCATGCAGGATATATGATTCCACCACCTTCAGATACATCTACCTCGGATTGCCGGCAGCACTAAGAGGATCAAGCTTT
GTTCCAGCCTTAATCATCTTAATTCTTTTGAGGAAGTGTCATCTACCTGGTGAAAATGCCTCTTCAGGAACAGAGCTTATAGAGACAAAA

>In-frame_CNOT2_ENST00000418359_chr12_70672054_+_SLCO1A2_ENST00000307378_chr12_21445270_-_624nt
ATGGTGAGGACTGATGGACATACATTATCTGAGAAAAGAAACTACCAGGTGTTCCAAAATTGCAGCTGTATTCAAACATCAGGAAATTCA
TCTGCAGTTCTTGGGCTGTGCGACAAAGGACCTGACTGTTCCTTGATGCTCCAGTACTTCCTAATCTTGTCAGCGATGAGCAGTTTCATT
TATTCTTTGGCTGCCATACCTGGATATATGGTTCTCTTGAGGTGTATGAAATCTGAAGAGAAGTCCCTTGGTGTGGGATTACATACATTT
TGCACAAGAGTATTTGCTGGCATTCCTGCACCTATATATTTTGGCGCTTTAATGGATTCCACATGTTTACACTGGGGAACTTTGAAATGT
GGTGAGTCAGGGGCATGCAGGATATATGATTCCACCACCTTCAGATACATCTACCTCGGATTGCCGGCAGCACTAAGAGGATCAAGCTTT
GTTCCAGCCTTAATCATCTTAATTCTTTTGAGGAAGTGTCATCTACCTGGTGAAAATGCCTCTTCAGGAACAGAGCTTATAGAGACAAAA

>In-frame_CNOT2_ENST00000418359_chr12_70672054_+_SLCO1A2_ENST00000537524_chr12_21445270_-_624nt
ATGGTGAGGACTGATGGACATACATTATCTGAGAAAAGAAACTACCAGGTGTTCCAAAATTGCAGCTGTATTCAAACATCAGGAAATTCA
TCTGCAGTTCTTGGGCTGTGCGACAAAGGACCTGACTGTTCCTTGATGCTCCAGTACTTCCTAATCTTGTCAGCGATGAGCAGTTTCATT
TATTCTTTGGCTGCCATACCTGGATATATGGTTCTCTTGAGGTGTATGAAATCTGAAGAGAAGTCCCTTGGTGTGGGATTACATACATTT
TGCACAAGAGTATTTGCTGGCATTCCTGCACCTATATATTTTGGCGCTTTAATGGATTCCACATGTTTACACTGGGGAACTTTGAAATGT
GGTGAGTCAGGGGCATGCAGGATATATGATTCCACCACCTTCAGATACATCTACCTCGGATTGCCGGCAGCACTAAGAGGATCAAGCTTT
GTTCCAGCCTTAATCATCTTAATTCTTTTGAGGAAGTGTCATCTACCTGGTGAAAATGCCTCTTCAGGAACAGAGCTTATAGAGACAAAA


* Fusion transcript sequences (Full-length transcript).
>In-frame_CNOT2_ENST00000229195_chr12_70672054_+_SLCO1A2_ENST00000307378_chr12_21445270_-_6151nt
AACACAAACACAAACACGAACACGAACACGCTCAGCGTCCCCGGGGAGGGCGGACTGAAGCCACCTCACCATTCATCGCCCCTGGACCCC
GCAGTCCCCCTCGGACTCAGGGCCAGAGCCTTCTGCGAAGCAACCTAGCCCCAGGGAAACGGTAGCGGCCGCAGAAGCCCCGCTCTCTGT
AACGGCCGCGGAGGAGCAGCAAGCCTCCCTGTGAGTCGGTGGGAGACAAGACGGAGCGGCGGTAAGGGCGGTAGGGAAGTGAAGCGCCTC
TCTCCACCTTGTTAGAAGCGCGCTGAAAGCGGCCTGCCTACCCACCCCATCGCTGCCGTTTTGCAGTCGTCGCTCCCACCTTCCGCTGCC
GCCTGGAGGGAAGCCGGAGCGACGGGGGTCACGGCGGCGGTCAGAGGGTAAAGGTCTTGCTCCCAGCAGCCTCCGCGGTGGATACGTCGC
CATCTTGGATCCGCGGGACAAGAAAATTCATGCGAGGGAGACGTGGTGGGCGGTCCTTCCTGTGACACGACCCTTGAGTGACAGTTCTAT
TTGATTGCCTCCGGTACTGTGAGGAAAGGACACGACTCTATGGTGAGGACTGATGGACATACATTATCTGAGAAAAGAAACTACCAGGTG
TTCCAAAATTGCAGCTGTATTCAAACATCAGGAAATTCATCTGCAGTTCTTGGGCTGTGCGACAAAGGACCTGACTGTTCCTTGATGCTC
CAGTACTTCCTAATCTTGTCAGCGATGAGCAGTTTCATTTATTCTTTGGCTGCCATACCTGGATATATGGTTCTCTTGAGGTGTATGAAA
TCTGAAGAGAAGTCCCTTGGTGTGGGATTACATACATTTTGCACAAGAGTATTTGCTGGCATTCCTGCACCTATATATTTTGGCGCTTTA
ATGGATTCCACATGTTTACACTGGGGAACTTTGAAATGTGGTGAGTCAGGGGCATGCAGGATATATGATTCCACCACCTTCAGATACATC
TACCTCGGATTGCCGGCAGCACTAAGAGGATCAAGCTTTGTTCCAGCCTTAATCATCTTAATTCTTTTGAGGAAGTGTCATCTACCTGGT
GAAAATGCCTCTTCAGGAACAGAGCTTATAGAGACAAAAGTCAAAGGGAAGGAAAATGAGTGCAAAGATATATACCAAAAGTCCACGGTT
TTGAAAGATGATGAATTGAAAACTAAATTGTAATTGTCCTATTATATTACTTTTTTCAGAATTAGAGAACATGCTGTACAACTTAATTGT
TTTAAAAATCAGTAGAGATATAATAGATAACTTTTTCTTGTCTTTAAGAACCTAAAAAACCTCTTAACTCAAAATAATAAAATGTTCACT
AATGATATTTCTAAGGTATCAGTGACACTTGAGTTTTCCTAGGAGGGACATCAATAACAGCCCCCTAAAGAAGATTCTTAGAGCCAGCTT
TATTTTTATGTTGAAACAGCAATTTCCCTTAATTCATCGAAGTAAGGGTGTACTTCCTACATCTCCTTCTACTAATACTTCTAAAAATTT
TCTGTTATGAAAACCTATTTAATTCCACTAAATTTGTTCTTTGATATTGGAATTATTCAGATGCCTAAATTCTCATTCTGTTATGTGAAG
ATTTAAATATTTTATTCAAGTTTATCGCTTCCATGTGAGAGAAGCCTACATCTTCTTATTCTATTTAGGAATCGTTCTTTAACTCTTCTT
ATTCATTCTAGGCATGACTCCTATATAATAGATTACTCATAAATATACCCTCCTACTTTCAATTTTTTCTTTTCTTTATTACTCATACAT
TTGCTCAATTTGTACAGAATACTGACAAACTTAAGCAGGTTATTAAACATCATGAGGCAAAGATTGTTGGATTTTTTTTCAGTAATTCAA
ATCCAGTGACTAAAGTTTTTCTTACAAACAAGTGTCTGAATCAAAGGATGAAAGGACAATATTATAAAAACTCCAGTTCTTAAAGGCTGT
TTGTAATGTCAGATATTGTCAAAGAACCACTTTCTAAGATTCAGGACTCTTTAGACCGATGTTTATATCACCCATTGTGTCCTAAGGTAG
AACACAAACACTAATTTTCCCAAAATAATCTTAGACAATAGCTTCTGTTATGAAACAGAGGTTAGTAAAGGCTAAGGTACATATTAAAAG
CTAAATCTACTTATATTATTATTTTGTAAATTATGGATAAAATTAAAAATTGAAGGATTTTAGACATAGAAGAGGACTTATTGATTAATA
TAGGGCTTCTGGTAAAAGAGAATAGAATGAACAGACAAATACCTGTTTGTCTACTCCTTACTCTCCTTCCTGTTGAAATGACAGTCAATA
TATAAGAATGACATAAATCCCTAATGGATGAAGAGAATGGAGTAAGGAAGGGTGGGAGAAGTGGGTGTCAATACACTATGGTTATTTATG
TGTACTATAAATGGAGTGAGAGTGTCTGCAGGGATACAACAGAGTGGAGGAAGCTGAAATACAGAATATACCTAGAAGGAGCCTGGAATG
GAAGTGTGAAACTGAGTTGCCAGTTCAAAGTGTGAGTTGGTAGCTGGACAGAAAGCAGGCCAGTTAACTGAAGGACTTTGTACAGATGCT
TTACAGGTTAATATGATTTCCTAAATGATCAGATGCATCATATGAAAAAAGAAAGCAAATGAGAAGAGAAAGGCTGTATAGAACAGGTTT
AGGGGGAAGGATGAAAAGTTAAGTTTCAGTTTCATGAAGTTTGAGACTTCAACTCTGGGCATATAAAAAATAACCAAGGTTCAAACCAAG
ACTGGCTTTGAAACAAGAGAGAGGAACTAAAATCATTGGAAAGGGGGAGTTTAACTTTGATGTAGGTATGACTGCAGCAGTGAGATATCG
TATTAAGATCTGATGACATGAAATTTGGAGCCACTTCCTTTGTGGTGGGAGGAAGTGAGGAGAATGGCCTGGAAACTAAAACAAGGAGAA
GAGACTTACCTATATTCACAGAGCAGCAAGAAAAAGTAAACAGCCACTGCATGAGAAGGTTTCAGGGGAATCAGATTTTGCTGAGTGTGC
GATGGTGAAGAGAATGCTCATTTCTGAACTGGAATCTGAGCTAAAAAGAAGCAAATAGGATATATATGGAAGTTAGACTTATGGAAATTA
GAAGAAGGGGAATGAGAGATAGTTTGGAATTCTGTGGCTATTTAGGTGACTGACATAAATGGGGGCAGAGGACATAATGAGGTTAGTTCT
TACGGATTCAAGGCAGATAGTGTTGGTGAAACAGTGAGTGTCAAAATTAGGCGAGGTGGTGACTGGGCTCCCTGATGACCTCTTGTCGTG
GAGCAAAACTGAATAAGCAAAAACTTACTCAAGCTCCTGAGGCCCATTCATCATCCCTATTGATAGATTTGAGGTGATCTGAGAAAGCTG
AGTCTTGCTTTGTGGACAATTCACCCACTTGAACTCCCTCAATGGAGCATCATAGGCCCAGAGAGACATGGCTATGGACTTAGTACCTTG
GCATCACTTTTATCCCCTCATGGAGGAGATGGCATTTTACTCTGAAAACATAGGGTTCTCCTTTGACACTTCTTGGTGGGAGAAAGCAGG
TCAGAGAAAGTGGGTGTTGGAGTGCTTTGGGATCCCTCATGACCTCTTTTGTTGGTATACATGAAGCCTGGGAGTTTAGTTCTTATTCTG
AGCACTTGTACTACTCTCATGAGGGTAGAGATAATGGCATAGCGGACAGACATGGAGAAGAGAAACAAGAGAACAGGTAGTGAGAAGTCG
AGAGTCAGTAATTTTCTTACTTAATATTGTGGGGATCTTACTTAATACATAAAGTTAATGAAACTAGAAATAGTGGTTTAATATATTACT
TATAATTCAAAAATTAACCTATATTTACAGATGCTTACACAGTTTCTTTGTGAATCCACCTATGGTTTTATTTTAATTAATTTTTTATTG
CAAAGCAATGAAATGTTGCTTTGTGGAGCCAGATAGCATTACAGCAGGTAAATGGGTTTCTGCTAGATCTCCACATTATTGGGGAGATGC
TCGAAGACCTCAGAATATACACACCCTTAAGGTTCAAGGGCTGGGGTTGAGCTCTCCATAAGGAACTTTTCCTCCTCCCAGAAGGGCGAT
CATTGTGTATATAGACATGGAGACAGAACCAGAATGACTTCTGTGGGTGGAAATAGTGCCATCAGAATCATTTATTATTATGAAATAAAT
ATTATTTATCTACATTGAAAAAATACTACTCCTCCTAAAATCATTAACTTTTCCTCAGATGATTTTAAGAAATTTGAGTAATAGCACACG
AAGTGGTAAAGACCCTTAGTCTTTCTGGTATATTAGAAAAGCCTTTTAATCAGTCTCTGGAAGGACACTAGGGATTGCAGCTGAATAAAT
ATATTAAGAATAACAAATCAGTTCAACAAGGAGTAGAGTCTGAAGTGGGATTTTCCGTGGAAATTCTCTTATGTCTGTACTAACAATAAG
AAAGACAAGACAAAGACTAAGTAATTAAAGAAAAGCTCGAAATGTTTTGTAACCAAAAGCTTGAAATGTTATGTAACCAGAATGTTATGT
AACCAGAGCTGTTAGATCAGATACTGGCTGATTCATAGGTGAACGTCCTCTTTGTGGGTCCTCTCATGCATCCCCATTTTCAGAATGTAA
ATAATTTGGCTTTGTAGCCCTTCCAAAAAGGGTACTATCCCACTTCTCCTGGCATAAATCATACATTGACTGAACGTTCACCATCTAAAA
ATCACTCATGCTCCTTGAACCAAGGTGATTATCAGAGACAGCTCCTGGTAGAAGAGGTTGTAGATGTTAAAAGAGTATGATTTCTATATA
AGAAAATATAGAAATTGACAGAATGGTTCTTATTTACTGGGCCTGGAGAATTCCTGTTCTGGCATTCTTAGATCCCTCAAATTTATTACC
AAGGGGAAAAGGAAAAAGAGGCAAGTAGGCAGTAGGGTAAGCTGTTGTTTGCTTGCCAAGGAACTGGAGAGTGCAGGTTTCAAGACACCT
TGAGGAAATTCTCCTGAGCCCTTAGCCAAGAGAAGAGAGCAGAAAATGCTTTTCTGTAGAATCCCAAGAGGCATAAAAGAGGATGAGTAA
CTGGGTCCTGTGCCAAGTTCCCAACCCCTAAGCCTTCCCAACATGGAGAAACTACACCAGTGTTTAAAAGTTTCTAGGTTGGAGGAACAA
ACTTGAGCATCAAGGGCAGATGATTTGTTAACACAGTCCTGTGCAGAGGGCTCCTTCAGAAGGCATCCCCTGTGACCCAAACACAGTGAG
CACCTTCTACTTTCTGGCCTTATGCCATCAATGCATCCAGCTGCAATCTATCCTCAAACCTGGAATCCATCTCTTGACTTCCCAGCCAGA
CCACCTTCCATCCCTTCACTGTGTCCCACCCTGCCCAGAATGCATGCTGTTCTCCCAGAGTCTCATGGAAATAAGGCCTTGCACTGAAAT
AGGCTGTGGGAAACAAAAGGATAAGCAGGTCTGGACCAGTCTGTAATGGTAGCAGGTGAAAACAACTTACGGAAAAACACATGAATTCAT
TAGGAAATAAGGTGACAGATCCCCAGCTGCTGAAGAACTAGAATGTCTATTACACTCATACAATTGATGTTTTATTTTAATACACCAGAG
CTACCACACAAAACTTCCTTCCATGTGAAAGGCTCCAGATAAAATTCTGCCATCCCTCCTCTCCTCATGTCCTCCTGCTCAGACCCACCT
TCATGCCCCTAAACCAATCTGCATCATGCCTGTTTCAGAGAGTCATGGGAAGATGGGCAGTGCCTCCATTGTCACCATTCCCCACACCTC
TGCACACTTCTGCCCCTTCCCCTCTAGACGCCACAACTTCACAGTCTTACTGTTGTAAATATTCCTGCACAGTTAGTAATGATCAAATGA
TCCTGTGGTCAGAGGCCTCTTTGGCAGTGTCTTCTTACCCTTAAGAAAGGTCATGAAATCCAGAAGGGGCAACCTTTCCAGGAGAGCTTT
GGAGTCATTTCTGTGTGAGACACTATTGCATAATCCTGTAAGATTGCTTTTATATTTAAGGAATGATGTTACTTAACAAATGAACAAAAA

>In-frame_CNOT2_ENST00000229195_chr12_70672054_+_SLCO1A2_ENST00000537524_chr12_21445270_-_1292nt
AACACAAACACAAACACGAACACGAACACGCTCAGCGTCCCCGGGGAGGGCGGACTGAAGCCACCTCACCATTCATCGCCCCTGGACCCC
GCAGTCCCCCTCGGACTCAGGGCCAGAGCCTTCTGCGAAGCAACCTAGCCCCAGGGAAACGGTAGCGGCCGCAGAAGCCCCGCTCTCTGT
AACGGCCGCGGAGGAGCAGCAAGCCTCCCTGTGAGTCGGTGGGAGACAAGACGGAGCGGCGGTAAGGGCGGTAGGGAAGTGAAGCGCCTC
TCTCCACCTTGTTAGAAGCGCGCTGAAAGCGGCCTGCCTACCCACCCCATCGCTGCCGTTTTGCAGTCGTCGCTCCCACCTTCCGCTGCC
GCCTGGAGGGAAGCCGGAGCGACGGGGGTCACGGCGGCGGTCAGAGGGTAAAGGTCTTGCTCCCAGCAGCCTCCGCGGTGGATACGTCGC
CATCTTGGATCCGCGGGACAAGAAAATTCATGCGAGGGAGACGTGGTGGGCGGTCCTTCCTGTGACACGACCCTTGAGTGACAGTTCTAT
TTGATTGCCTCCGGTACTGTGAGGAAAGGACACGACTCTATGGTGAGGACTGATGGACATACATTATCTGAGAAAAGAAACTACCAGGTG
TTCCAAAATTGCAGCTGTATTCAAACATCAGGAAATTCATCTGCAGTTCTTGGGCTGTGCGACAAAGGACCTGACTGTTCCTTGATGCTC
CAGTACTTCCTAATCTTGTCAGCGATGAGCAGTTTCATTTATTCTTTGGCTGCCATACCTGGATATATGGTTCTCTTGAGGTGTATGAAA
TCTGAAGAGAAGTCCCTTGGTGTGGGATTACATACATTTTGCACAAGAGTATTTGCTGGCATTCCTGCACCTATATATTTTGGCGCTTTA
ATGGATTCCACATGTTTACACTGGGGAACTTTGAAATGTGGTGAGTCAGGGGCATGCAGGATATATGATTCCACCACCTTCAGATACATC
TACCTCGGATTGCCGGCAGCACTAAGAGGATCAAGCTTTGTTCCAGCCTTAATCATCTTAATTCTTTTGAGGAAGTGTCATCTACCTGGT
GAAAATGCCTCTTCAGGAACAGAGCTTATAGAGACAAAAGTCAAAGGGAAGGAAAATGAGTGCAAAGATATATACCAAAAGTCCACGGTT
TTGAAAGATGATGAATTGAAAACTAAATTGTAATTGTCCTATTATATTACTTTTTTCAGAATTAGAGAACATGCTGTACAACTTAATTGT

>In-frame_CNOT2_ENST00000418359_chr12_70672054_+_SLCO1A2_ENST00000307378_chr12_21445270_-_6023nt
AGCGTCCCCGGGGAGGGCGGACTGAAGCCACCTCACCATTCATCGCCCCTGGACCCCGCAGTCCCCCTCGGACTCAGGGCCAGAGCCTTC
TGCGAAGCAACCTAGCCCCAGGGAAACGGTAGCGGCCGCAGAAGCCCCGCTCTCTGTAACGGCCGCGGAGGAGCAGCAAGCCTCCCTGTG
AGTCGGTGGGAGACAAGACGGAGCGGCGTCGTCGCTCCCACCTTCCGCTGCCGCCTGGAGGGAAGCCGGAGCGACGGGGGTCACGGCGGC
GGTCAGAGGGTAAAGGTCTTGCTCCCAGCAGCCTCCGCGGTGGATACGTCGCCATCTTGGATCCGCGGGACAAGAAAATTCATGCGAGGG
AGACGTGGTGGGCGGTCCTTCCTGTGACACGACCCTTGAGTGACAGTTCTATTTGATTGCCTCCGGTACTGTGAGGAAAGGACACGACTC
TATGGTGAGGACTGATGGACATACATTATCTGAGAAAAGAAACTACCAGGTGTTCCAAAATTGCAGCTGTATTCAAACATCAGGAAATTC
ATCTGCAGTTCTTGGGCTGTGCGACAAAGGACCTGACTGTTCCTTGATGCTCCAGTACTTCCTAATCTTGTCAGCGATGAGCAGTTTCAT
TTATTCTTTGGCTGCCATACCTGGATATATGGTTCTCTTGAGGTGTATGAAATCTGAAGAGAAGTCCCTTGGTGTGGGATTACATACATT
TTGCACAAGAGTATTTGCTGGCATTCCTGCACCTATATATTTTGGCGCTTTAATGGATTCCACATGTTTACACTGGGGAACTTTGAAATG
TGGTGAGTCAGGGGCATGCAGGATATATGATTCCACCACCTTCAGATACATCTACCTCGGATTGCCGGCAGCACTAAGAGGATCAAGCTT
TGTTCCAGCCTTAATCATCTTAATTCTTTTGAGGAAGTGTCATCTACCTGGTGAAAATGCCTCTTCAGGAACAGAGCTTATAGAGACAAA
AGTCAAAGGGAAGGAAAATGAGTGCAAAGATATATACCAAAAGTCCACGGTTTTGAAAGATGATGAATTGAAAACTAAATTGTAATTGTC
CTATTATATTACTTTTTTCAGAATTAGAGAACATGCTGTACAACTTAATTGTTTTAAAAATCAGTAGAGATATAATAGATAACTTTTTCT
TGTCTTTAAGAACCTAAAAAACCTCTTAACTCAAAATAATAAAATGTTCACTAATGATATTTCTAAGGTATCAGTGACACTTGAGTTTTC
CTAGGAGGGACATCAATAACAGCCCCCTAAAGAAGATTCTTAGAGCCAGCTTTATTTTTATGTTGAAACAGCAATTTCCCTTAATTCATC
GAAGTAAGGGTGTACTTCCTACATCTCCTTCTACTAATACTTCTAAAAATTTTCTGTTATGAAAACCTATTTAATTCCACTAAATTTGTT
CTTTGATATTGGAATTATTCAGATGCCTAAATTCTCATTCTGTTATGTGAAGATTTAAATATTTTATTCAAGTTTATCGCTTCCATGTGA
GAGAAGCCTACATCTTCTTATTCTATTTAGGAATCGTTCTTTAACTCTTCTTATTCATTCTAGGCATGACTCCTATATAATAGATTACTC
ATAAATATACCCTCCTACTTTCAATTTTTTCTTTTCTTTATTACTCATACATTTGCTCAATTTGTACAGAATACTGACAAACTTAAGCAG
GTTATTAAACATCATGAGGCAAAGATTGTTGGATTTTTTTTCAGTAATTCAAATCCAGTGACTAAAGTTTTTCTTACAAACAAGTGTCTG
AATCAAAGGATGAAAGGACAATATTATAAAAACTCCAGTTCTTAAAGGCTGTTTGTAATGTCAGATATTGTCAAAGAACCACTTTCTAAG
ATTCAGGACTCTTTAGACCGATGTTTATATCACCCATTGTGTCCTAAGGTAGAACACAAACACTAATTTTCCCAAAATAATCTTAGACAA
TAGCTTCTGTTATGAAACAGAGGTTAGTAAAGGCTAAGGTACATATTAAAAGCTAAATCTACTTATATTATTATTTTGTAAATTATGGAT
AAAATTAAAAATTGAAGGATTTTAGACATAGAAGAGGACTTATTGATTAATATAGGGCTTCTGGTAAAAGAGAATAGAATGAACAGACAA
ATACCTGTTTGTCTACTCCTTACTCTCCTTCCTGTTGAAATGACAGTCAATATATAAGAATGACATAAATCCCTAATGGATGAAGAGAAT
GGAGTAAGGAAGGGTGGGAGAAGTGGGTGTCAATACACTATGGTTATTTATGTGTACTATAAATGGAGTGAGAGTGTCTGCAGGGATACA
ACAGAGTGGAGGAAGCTGAAATACAGAATATACCTAGAAGGAGCCTGGAATGGAAGTGTGAAACTGAGTTGCCAGTTCAAAGTGTGAGTT
GGTAGCTGGACAGAAAGCAGGCCAGTTAACTGAAGGACTTTGTACAGATGCTTTACAGGTTAATATGATTTCCTAAATGATCAGATGCAT
CATATGAAAAAAGAAAGCAAATGAGAAGAGAAAGGCTGTATAGAACAGGTTTAGGGGGAAGGATGAAAAGTTAAGTTTCAGTTTCATGAA
GTTTGAGACTTCAACTCTGGGCATATAAAAAATAACCAAGGTTCAAACCAAGACTGGCTTTGAAACAAGAGAGAGGAACTAAAATCATTG
GAAAGGGGGAGTTTAACTTTGATGTAGGTATGACTGCAGCAGTGAGATATCGTATTAAGATCTGATGACATGAAATTTGGAGCCACTTCC
TTTGTGGTGGGAGGAAGTGAGGAGAATGGCCTGGAAACTAAAACAAGGAGAAGAGACTTACCTATATTCACAGAGCAGCAAGAAAAAGTA
AACAGCCACTGCATGAGAAGGTTTCAGGGGAATCAGATTTTGCTGAGTGTGCGATGGTGAAGAGAATGCTCATTTCTGAACTGGAATCTG
AGCTAAAAAGAAGCAAATAGGATATATATGGAAGTTAGACTTATGGAAATTAGAAGAAGGGGAATGAGAGATAGTTTGGAATTCTGTGGC
TATTTAGGTGACTGACATAAATGGGGGCAGAGGACATAATGAGGTTAGTTCTTACGGATTCAAGGCAGATAGTGTTGGTGAAACAGTGAG
TGTCAAAATTAGGCGAGGTGGTGACTGGGCTCCCTGATGACCTCTTGTCGTGGAGCAAAACTGAATAAGCAAAAACTTACTCAAGCTCCT
GAGGCCCATTCATCATCCCTATTGATAGATTTGAGGTGATCTGAGAAAGCTGAGTCTTGCTTTGTGGACAATTCACCCACTTGAACTCCC
TCAATGGAGCATCATAGGCCCAGAGAGACATGGCTATGGACTTAGTACCTTGGCATCACTTTTATCCCCTCATGGAGGAGATGGCATTTT
ACTCTGAAAACATAGGGTTCTCCTTTGACACTTCTTGGTGGGAGAAAGCAGGTCAGAGAAAGTGGGTGTTGGAGTGCTTTGGGATCCCTC
ATGACCTCTTTTGTTGGTATACATGAAGCCTGGGAGTTTAGTTCTTATTCTGAGCACTTGTACTACTCTCATGAGGGTAGAGATAATGGC
ATAGCGGACAGACATGGAGAAGAGAAACAAGAGAACAGGTAGTGAGAAGTCGAGAGTCAGTAATTTTCTTACTTAATATTGTGGGGATCT
TACTTAATACATAAAGTTAATGAAACTAGAAATAGTGGTTTAATATATTACTTATAATTCAAAAATTAACCTATATTTACAGATGCTTAC
ACAGTTTCTTTGTGAATCCACCTATGGTTTTATTTTAATTAATTTTTTATTGCAAAGCAATGAAATGTTGCTTTGTGGAGCCAGATAGCA
TTACAGCAGGTAAATGGGTTTCTGCTAGATCTCCACATTATTGGGGAGATGCTCGAAGACCTCAGAATATACACACCCTTAAGGTTCAAG
GGCTGGGGTTGAGCTCTCCATAAGGAACTTTTCCTCCTCCCAGAAGGGCGATCATTGTGTATATAGACATGGAGACAGAACCAGAATGAC
TTCTGTGGGTGGAAATAGTGCCATCAGAATCATTTATTATTATGAAATAAATATTATTTATCTACATTGAAAAAATACTACTCCTCCTAA
AATCATTAACTTTTCCTCAGATGATTTTAAGAAATTTGAGTAATAGCACACGAAGTGGTAAAGACCCTTAGTCTTTCTGGTATATTAGAA
AAGCCTTTTAATCAGTCTCTGGAAGGACACTAGGGATTGCAGCTGAATAAATATATTAAGAATAACAAATCAGTTCAACAAGGAGTAGAG
TCTGAAGTGGGATTTTCCGTGGAAATTCTCTTATGTCTGTACTAACAATAAGAAAGACAAGACAAAGACTAAGTAATTAAAGAAAAGCTC
GAAATGTTTTGTAACCAAAAGCTTGAAATGTTATGTAACCAGAATGTTATGTAACCAGAGCTGTTAGATCAGATACTGGCTGATTCATAG
GTGAACGTCCTCTTTGTGGGTCCTCTCATGCATCCCCATTTTCAGAATGTAAATAATTTGGCTTTGTAGCCCTTCCAAAAAGGGTACTAT
CCCACTTCTCCTGGCATAAATCATACATTGACTGAACGTTCACCATCTAAAAATCACTCATGCTCCTTGAACCAAGGTGATTATCAGAGA
CAGCTCCTGGTAGAAGAGGTTGTAGATGTTAAAAGAGTATGATTTCTATATAAGAAAATATAGAAATTGACAGAATGGTTCTTATTTACT
GGGCCTGGAGAATTCCTGTTCTGGCATTCTTAGATCCCTCAAATTTATTACCAAGGGGAAAAGGAAAAAGAGGCAAGTAGGCAGTAGGGT
AAGCTGTTGTTTGCTTGCCAAGGAACTGGAGAGTGCAGGTTTCAAGACACCTTGAGGAAATTCTCCTGAGCCCTTAGCCAAGAGAAGAGA
GCAGAAAATGCTTTTCTGTAGAATCCCAAGAGGCATAAAAGAGGATGAGTAACTGGGTCCTGTGCCAAGTTCCCAACCCCTAAGCCTTCC
CAACATGGAGAAACTACACCAGTGTTTAAAAGTTTCTAGGTTGGAGGAACAAACTTGAGCATCAAGGGCAGATGATTTGTTAACACAGTC
CTGTGCAGAGGGCTCCTTCAGAAGGCATCCCCTGTGACCCAAACACAGTGAGCACCTTCTACTTTCTGGCCTTATGCCATCAATGCATCC
AGCTGCAATCTATCCTCAAACCTGGAATCCATCTCTTGACTTCCCAGCCAGACCACCTTCCATCCCTTCACTGTGTCCCACCCTGCCCAG
AATGCATGCTGTTCTCCCAGAGTCTCATGGAAATAAGGCCTTGCACTGAAATAGGCTGTGGGAAACAAAAGGATAAGCAGGTCTGGACCA
GTCTGTAATGGTAGCAGGTGAAAACAACTTACGGAAAAACACATGAATTCATTAGGAAATAAGGTGACAGATCCCCAGCTGCTGAAGAAC
TAGAATGTCTATTACACTCATACAATTGATGTTTTATTTTAATACACCAGAGCTACCACACAAAACTTCCTTCCATGTGAAAGGCTCCAG
ATAAAATTCTGCCATCCCTCCTCTCCTCATGTCCTCCTGCTCAGACCCACCTTCATGCCCCTAAACCAATCTGCATCATGCCTGTTTCAG
AGAGTCATGGGAAGATGGGCAGTGCCTCCATTGTCACCATTCCCCACACCTCTGCACACTTCTGCCCCTTCCCCTCTAGACGCCACAACT
TCACAGTCTTACTGTTGTAAATATTCCTGCACAGTTAGTAATGATCAAATGATCCTGTGGTCAGAGGCCTCTTTGGCAGTGTCTTCTTAC
CCTTAAGAAAGGTCATGAAATCCAGAAGGGGCAACCTTTCCAGGAGAGCTTTGGAGTCATTTCTGTGTGAGACACTATTGCATAATCCTG

>In-frame_CNOT2_ENST00000418359_chr12_70672054_+_SLCO1A2_ENST00000537524_chr12_21445270_-_1164nt
AGCGTCCCCGGGGAGGGCGGACTGAAGCCACCTCACCATTCATCGCCCCTGGACCCCGCAGTCCCCCTCGGACTCAGGGCCAGAGCCTTC
TGCGAAGCAACCTAGCCCCAGGGAAACGGTAGCGGCCGCAGAAGCCCCGCTCTCTGTAACGGCCGCGGAGGAGCAGCAAGCCTCCCTGTG
AGTCGGTGGGAGACAAGACGGAGCGGCGTCGTCGCTCCCACCTTCCGCTGCCGCCTGGAGGGAAGCCGGAGCGACGGGGGTCACGGCGGC
GGTCAGAGGGTAAAGGTCTTGCTCCCAGCAGCCTCCGCGGTGGATACGTCGCCATCTTGGATCCGCGGGACAAGAAAATTCATGCGAGGG
AGACGTGGTGGGCGGTCCTTCCTGTGACACGACCCTTGAGTGACAGTTCTATTTGATTGCCTCCGGTACTGTGAGGAAAGGACACGACTC
TATGGTGAGGACTGATGGACATACATTATCTGAGAAAAGAAACTACCAGGTGTTCCAAAATTGCAGCTGTATTCAAACATCAGGAAATTC
ATCTGCAGTTCTTGGGCTGTGCGACAAAGGACCTGACTGTTCCTTGATGCTCCAGTACTTCCTAATCTTGTCAGCGATGAGCAGTTTCAT
TTATTCTTTGGCTGCCATACCTGGATATATGGTTCTCTTGAGGTGTATGAAATCTGAAGAGAAGTCCCTTGGTGTGGGATTACATACATT
TTGCACAAGAGTATTTGCTGGCATTCCTGCACCTATATATTTTGGCGCTTTAATGGATTCCACATGTTTACACTGGGGAACTTTGAAATG
TGGTGAGTCAGGGGCATGCAGGATATATGATTCCACCACCTTCAGATACATCTACCTCGGATTGCCGGCAGCACTAAGAGGATCAAGCTT
TGTTCCAGCCTTAATCATCTTAATTCTTTTGAGGAAGTGTCATCTACCTGGTGAAAATGCCTCTTCAGGAACAGAGCTTATAGAGACAAA
AGTCAAAGGGAAGGAAAATGAGTGCAAAGATATATACCAAAAGTCCACGGTTTTGAAAGATGATGAATTGAAAACTAAATTGTAATTGTC


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FusionGenePPI for CNOT2_SLCO1A2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CNOT2CNOT3, CNOT1, DDB1, HDAC3, NCOR2, NCOR1, GPS2, VCP, CNOT6L, CNOT6, NLK, RNF219, CNOT8, MMP7, CAPZA2, CNOT7, WRAP73, AURKA, TNRC6C, TNRC6A, TNRC6B, AGO2, CAPZB, XPO1, CACNA2D1, DDX11, FHL2, EIF6, POLD1, UPF1, RPL12, MRPS12, RQCD1, USP24, LARP1, CNOT10, SS18L2, CNOT11, KANSL3, TMEM165, AKIP1, DDX24, WDR26, LCOR, TNKS1BP1, CNKSR3, RC3H1, NANOS2, TOB1, RIBC1, GADD45B, GPBP1L1, TEX13A, BTRC, KLKB1, GLA, NFKB1SLCO1A2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CNOT2_SLCO1A2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneSLCO1A2P46721DB01045RifampicinSolute carrier organic anion transporter family member 1A2small moleculeapproved

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RelatedDiseases for CNOT2_SLCO1A2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource