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Fusion gene ID: 7708 |
FusionGeneSummary for CNOT2_CRADD |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CNOT2_CRADD | Fusion gene ID: 7708 | Hgene | Tgene | Gene symbol | CNOT2 | CRADD | Gene ID | 4848 | 8738 |
| Gene name | CCR4-NOT transcription complex subunit 2 | CASP2 and RIPK1 domain containing adaptor with death domain | |
| Synonyms | CDC36|HSPC131|NOT2|NOT2H | MRT34|RAIDD | |
| Cytomap | 12q15 | 12q22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | CCR4-NOT transcription complex subunit 2CCR4-associated factor 2negative regulator of transcription 2 | death domain-containing protein CRADDCRADD/LYZ fusionRIP-associated ICH1/CED3-homologous protein with death domaincaspase and RIP adaptor with death domaindeath adaptor molecule RAIDDdeath domain containing protein CRADD | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9NZN8 | P78560 | |
| Ensembl transtripts involved in fusion gene | ENST00000229195, ENST00000418359, ENST00000548230, ENST00000551483, | ENST00000552983, ENST00000332896, ENST00000552033, ENST00000548483, ENST00000542893, ENST00000541813, ENST00000548330, | |
| Fusion gene scores | * DoF score | 26 X 8 X 9=1872 | 4 X 3 X 4=48 |
| # samples | 25 | 5 | |
| ** MAII score | log2(25/1872*10)=-2.90458043492132 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/48*10)=0.0588936890535686 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: CNOT2 [Title/Abstract] AND CRADD [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CNOT2 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 14707134|16712523 |
| Tgene | CRADD | GO:0043065 | positive regulation of apoptotic process | 11821383 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SARC | TCGA-DX-A1L3-01A | CNOT2 | chr12 | 70637260 | + | CRADD | chr12 | 94243746 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-intron | ENST00000229195 | ENST00000552983 | CNOT2 | chr12 | 70637260 | + | CRADD | chr12 | 94243746 | + |
| 5UTR-intron | ENST00000229195 | ENST00000332896 | CNOT2 | chr12 | 70637260 | + | CRADD | chr12 | 94243746 | + |
| 5UTR-intron | ENST00000229195 | ENST00000552033 | CNOT2 | chr12 | 70637260 | + | CRADD | chr12 | 94243746 | + |
| 5UTR-intron | ENST00000229195 | ENST00000548483 | CNOT2 | chr12 | 70637260 | + | CRADD | chr12 | 94243746 | + |
| 5UTR-intron | ENST00000229195 | ENST00000542893 | CNOT2 | chr12 | 70637260 | + | CRADD | chr12 | 94243746 | + |
| 5UTR-intron | ENST00000229195 | ENST00000541813 | CNOT2 | chr12 | 70637260 | + | CRADD | chr12 | 94243746 | + |
| 5UTR-3UTR | ENST00000229195 | ENST00000548330 | CNOT2 | chr12 | 70637260 | + | CRADD | chr12 | 94243746 | + |
| 5UTR-intron | ENST00000418359 | ENST00000552983 | CNOT2 | chr12 | 70637260 | + | CRADD | chr12 | 94243746 | + |
| 5UTR-intron | ENST00000418359 | ENST00000332896 | CNOT2 | chr12 | 70637260 | + | CRADD | chr12 | 94243746 | + |
| 5UTR-intron | ENST00000418359 | ENST00000552033 | CNOT2 | chr12 | 70637260 | + | CRADD | chr12 | 94243746 | + |
| 5UTR-intron | ENST00000418359 | ENST00000548483 | CNOT2 | chr12 | 70637260 | + | CRADD | chr12 | 94243746 | + |
| 5UTR-intron | ENST00000418359 | ENST00000542893 | CNOT2 | chr12 | 70637260 | + | CRADD | chr12 | 94243746 | + |
| 5UTR-intron | ENST00000418359 | ENST00000541813 | CNOT2 | chr12 | 70637260 | + | CRADD | chr12 | 94243746 | + |
| 5UTR-3UTR | ENST00000418359 | ENST00000548330 | CNOT2 | chr12 | 70637260 | + | CRADD | chr12 | 94243746 | + |
| intron-intron | ENST00000548230 | ENST00000552983 | CNOT2 | chr12 | 70637260 | + | CRADD | chr12 | 94243746 | + |
| intron-intron | ENST00000548230 | ENST00000332896 | CNOT2 | chr12 | 70637260 | + | CRADD | chr12 | 94243746 | + |
| intron-intron | ENST00000548230 | ENST00000552033 | CNOT2 | chr12 | 70637260 | + | CRADD | chr12 | 94243746 | + |
| intron-intron | ENST00000548230 | ENST00000548483 | CNOT2 | chr12 | 70637260 | + | CRADD | chr12 | 94243746 | + |
| intron-intron | ENST00000548230 | ENST00000542893 | CNOT2 | chr12 | 70637260 | + | CRADD | chr12 | 94243746 | + |
| intron-intron | ENST00000548230 | ENST00000541813 | CNOT2 | chr12 | 70637260 | + | CRADD | chr12 | 94243746 | + |
| intron-3UTR | ENST00000548230 | ENST00000548330 | CNOT2 | chr12 | 70637260 | + | CRADD | chr12 | 94243746 | + |
| intron-intron | ENST00000551483 | ENST00000552983 | CNOT2 | chr12 | 70637260 | + | CRADD | chr12 | 94243746 | + |
| intron-intron | ENST00000551483 | ENST00000332896 | CNOT2 | chr12 | 70637260 | + | CRADD | chr12 | 94243746 | + |
| intron-intron | ENST00000551483 | ENST00000552033 | CNOT2 | chr12 | 70637260 | + | CRADD | chr12 | 94243746 | + |
| intron-intron | ENST00000551483 | ENST00000548483 | CNOT2 | chr12 | 70637260 | + | CRADD | chr12 | 94243746 | + |
| intron-intron | ENST00000551483 | ENST00000542893 | CNOT2 | chr12 | 70637260 | + | CRADD | chr12 | 94243746 | + |
| intron-intron | ENST00000551483 | ENST00000541813 | CNOT2 | chr12 | 70637260 | + | CRADD | chr12 | 94243746 | + |
| intron-3UTR | ENST00000551483 | ENST00000548330 | CNOT2 | chr12 | 70637260 | + | CRADD | chr12 | 94243746 | + |
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FusionProtFeatures for CNOT2_CRADD |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CNOT2 | CRADD |
| Component of the CCR4-NOT complex which is one of themajor cellular mRNA deadenylases and is linked to various cellularprocesses including bulk mRNA degradation, miRNA-mediatedrepression, translational repression during translationalinitiation and general transcription regulation. Additionalcomplex functions may be a consequence of its influence on mRNAexpression. Required for the CCR4-NOT complex structuralintegrity. Can repress transcription and may link the CCR4-NOTcomplex to transcriptional regulation; the repressive function mayspecifically involve the N-Cor repressor complex containing HDAC3,NCOR1 and NCOR2. Involved in the maintenance of emryonic stem (ES)cell identity. {ECO:0000269|PubMed:14707134,ECO:0000269|PubMed:16712523, ECO:0000269|PubMed:21299754,ECO:0000269|PubMed:22367759}. | Apoptotic adaptor molecule specific for caspase-2 andFASL/TNF receptor-interacting protein RIP. In the presence of RIPand TRADD, CRADD recruits caspase-2 to the TNFR-1 signallingcomplex. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CNOT2_CRADD |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CNOT2_CRADD |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CNOT2 | CNOT3, CNOT1, DDB1, HDAC3, NCOR2, NCOR1, GPS2, VCP, CNOT6L, CNOT6, NLK, RNF219, CNOT8, MMP7, CAPZA2, CNOT7, WRAP73, AURKA, TNRC6C, TNRC6A, TNRC6B, AGO2, CAPZB, XPO1, CACNA2D1, DDX11, FHL2, EIF6, POLD1, UPF1, RPL12, MRPS12, RQCD1, USP24, LARP1, CNOT10, SS18L2, CNOT11, KANSL3, TMEM165, AKIP1, DDX24, WDR26, LCOR, TNKS1BP1, CNKSR3, RC3H1, NANOS2, TOB1, RIBC1, GADD45B, GPBP1L1, TEX13A, BTRC, KLKB1, GLA, NFKB1 | CRADD | CASP2, PIDD1, C14orf1, EEF1A1, CCSER2, LRIF1, RIPK1, TNFRSF1A, MYC, APP, IL9R, KPNA1, VTN, SLC35A3, DCXR, CRYAB, KCTD9, APPL2, TRIM54, BBS5 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CNOT2_CRADD |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CNOT2_CRADD |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | CRADD | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
| Tgene | CRADD | C3281044 | MENTAL RETARDATION, AUTOSOMAL RECESSIVE 34 | 1 | UNIPROT |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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