FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 7704

FusionGeneSummary for CNOT2_AHSG

check button Fusion gene summary
Fusion gene informationFusion gene name: CNOT2_AHSG
Fusion gene ID: 7704
HgeneTgene
Gene symbol

CNOT2

AHSG

Gene ID

4848

197

Gene nameCCR4-NOT transcription complex subunit 2alpha 2-HS glycoprotein
SynonymsCDC36|HSPC131|NOT2|NOT2HA2HS|AHS|APMR1|FETUA|HSGA
Cytomap

12q15

3q27.3

Type of geneprotein-codingprotein-coding
DescriptionCCR4-NOT transcription complex subunit 2CCR4-associated factor 2negative regulator of transcription 2alpha-2-HS-glycoproteinalpha-2-Z-globulinba-alpha-2-glycoproteinfetuin-A
Modification date2018052320180523
UniProtAcc

Q9NZN8

P02765

Ensembl transtripts involved in fusion geneENST00000229195, ENST00000418359, 
ENST00000548230, ENST00000551483, 
ENST00000411641, ENST00000273784, 
Fusion gene scores* DoF score26 X 8 X 9=18722 X 2 X 2=8
# samples 252
** MAII scorelog2(25/1872*10)=-2.90458043492132
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: CNOT2 [Title/Abstract] AND AHSG [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCNOT2

GO:0000122

negative regulation of transcription by RNA polymerase II

14707134|16712523

TgeneAHSG

GO:0006953

acute-phase response

12153747

TgeneAHSG

GO:0050766

positive regulation of phagocytosis

12725640


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AF130057CNOT2chr12

70715461

-AHSGchr3

186338832

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000229195ENST00000411641CNOT2chr12

70715461

-AHSGchr3

186338832

+
intron-3UTRENST00000229195ENST00000273784CNOT2chr12

70715461

-AHSGchr3

186338832

+
intron-3UTRENST00000418359ENST00000411641CNOT2chr12

70715461

-AHSGchr3

186338832

+
intron-3UTRENST00000418359ENST00000273784CNOT2chr12

70715461

-AHSGchr3

186338832

+
intron-3UTRENST00000548230ENST00000411641CNOT2chr12

70715461

-AHSGchr3

186338832

+
intron-3UTRENST00000548230ENST00000273784CNOT2chr12

70715461

-AHSGchr3

186338832

+
intron-3UTRENST00000551483ENST00000411641CNOT2chr12

70715461

-AHSGchr3

186338832

+
intron-3UTRENST00000551483ENST00000273784CNOT2chr12

70715461

-AHSGchr3

186338832

+

Top

FusionProtFeatures for CNOT2_AHSG


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CNOT2

Q9NZN8

AHSG

P02765

Component of the CCR4-NOT complex which is one of themajor cellular mRNA deadenylases and is linked to various cellularprocesses including bulk mRNA degradation, miRNA-mediatedrepression, translational repression during translationalinitiation and general transcription regulation. Additionalcomplex functions may be a consequence of its influence on mRNAexpression. Required for the CCR4-NOT complex structuralintegrity. Can repress transcription and may link the CCR4-NOTcomplex to transcriptional regulation; the repressive function mayspecifically involve the N-Cor repressor complex containing HDAC3,NCOR1 and NCOR2. Involved in the maintenance of emryonic stem (ES)cell identity. {ECO:0000269|PubMed:14707134,ECO:0000269|PubMed:16712523, ECO:0000269|PubMed:21299754,ECO:0000269|PubMed:22367759}. Promotes endocytosis, possesses opsonic properties andinfluences the mineral phase of bone. Shows affinity for calciumand barium ions.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for CNOT2_AHSG


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for CNOT2_AHSG


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for CNOT2_AHSG


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneAHSGP02765DB01593ZincAlpha-2-HS-glycoproteinsmall moleculeapproved|investigational

Top

RelatedDiseases for CNOT2_AHSG


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneAHSGC0006663Calcinosis1CTD_human