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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 7697

FusionGeneSummary for CNOT1_PHKB

check button Fusion gene summary
Fusion gene informationFusion gene name: CNOT1_PHKB
Fusion gene ID: 7697
HgeneTgene
Gene symbol

CNOT1

PHKB

Gene ID

23019

5257

Gene nameCCR4-NOT transcription complex subunit 1phosphorylase kinase regulatory subunit beta
SynonymsAD-005|CDC39|NOT1|NOT1H-
Cytomap

16q21

16q12.1

Type of geneprotein-codingprotein-coding
DescriptionCCR4-NOT transcription complex subunit 1CCR4-associated factor 1NOT1 (negative regulator of transcription 1, yeast) homologadrenal gland protein AD-005negative regulator of transcription subunit 1 homologphosphorylase b kinase regulatory subunit betaphosphorylase kinase beta-subunitphosphorylase kinase subunit betaphosphorylase kinase, beta
Modification date2018052320180523
UniProtAcc

A5YKK6

Q93100

Ensembl transtripts involved in fusion geneENST00000317147, ENST00000569240, 
ENST00000441024, ENST00000569732, 
ENST00000245138, 		ENST00000566044, 
ENST00000455779, ENST00000299167, 
ENST00000323584, ENST00000567402, 
Fusion gene scores* DoF score14 X 9 X 10=12604 X 4 X 4=64
# samples 154
** MAII scorelog2(15/1260*10)=-3.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CNOT1 [Title/Abstract] AND PHKB [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCNOT1

GO:0000122

negative regulation of transcription by RNA polymerase II

16778766

HgeneCNOT1

GO:0010606

positive regulation of cytoplasmic mRNA processing body assembly

21976065

HgeneCNOT1

GO:0017148

negative regulation of translation

24736845

HgeneCNOT1

GO:0033147

negative regulation of intracellular estrogen receptor signaling pathway

16778766

HgeneCNOT1

GO:0035195

gene silencing by miRNA

23172285|24768540

HgeneCNOT1

GO:0048387

negative regulation of retinoic acid receptor signaling pathway

16778766

HgeneCNOT1

GO:0060213

positive regulation of nuclear-transcribed mRNA poly(A) tail shortening

23644599


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDKIRCTCGA-CJ-4923-01ACNOT1chr16

58585493

-PHKBchr16

47596309

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000317147ENST00000566044CNOT1chr16

58585493

-PHKBchr16

47596309

+
5CDS-intronENST00000317147ENST00000455779CNOT1chr16

58585493

-PHKBchr16

47596309

+
5CDS-intronENST00000317147ENST00000299167CNOT1chr16

58585493

-PHKBchr16

47596309

+
5CDS-intronENST00000317147ENST00000323584CNOT1chr16

58585493

-PHKBchr16

47596309

+
5CDS-intronENST00000317147ENST00000567402CNOT1chr16

58585493

-PHKBchr16

47596309

+
5CDS-intronENST00000569240ENST00000566044CNOT1chr16

58585493

-PHKBchr16

47596309

+
5CDS-intronENST00000569240ENST00000455779CNOT1chr16

58585493

-PHKBchr16

47596309

+
5CDS-intronENST00000569240ENST00000299167CNOT1chr16

58585493

-PHKBchr16

47596309

+
5CDS-intronENST00000569240ENST00000323584CNOT1chr16

58585493

-PHKBchr16

47596309

+
5CDS-intronENST00000569240ENST00000567402CNOT1chr16

58585493

-PHKBchr16

47596309

+
5CDS-intronENST00000441024ENST00000566044CNOT1chr16

58585493

-PHKBchr16

47596309

+
5CDS-intronENST00000441024ENST00000455779CNOT1chr16

58585493

-PHKBchr16

47596309

+
5CDS-intronENST00000441024ENST00000299167CNOT1chr16

58585493

-PHKBchr16

47596309

+
5CDS-intronENST00000441024ENST00000323584CNOT1chr16

58585493

-PHKBchr16

47596309

+
5CDS-intronENST00000441024ENST00000567402CNOT1chr16

58585493

-PHKBchr16

47596309

+
intron-intronENST00000569732ENST00000566044CNOT1chr16

58585493

-PHKBchr16

47596309

+
intron-intronENST00000569732ENST00000455779CNOT1chr16

58585493

-PHKBchr16

47596309

+
intron-intronENST00000569732ENST00000299167CNOT1chr16

58585493

-PHKBchr16

47596309

+
intron-intronENST00000569732ENST00000323584CNOT1chr16

58585493

-PHKBchr16

47596309

+
intron-intronENST00000569732ENST00000567402CNOT1chr16

58585493

-PHKBchr16

47596309

+
5UTR-intronENST00000245138ENST00000566044CNOT1chr16

58585493

-PHKBchr16

47596309

+
5UTR-intronENST00000245138ENST00000455779CNOT1chr16

58585493

-PHKBchr16

47596309

+
5UTR-intronENST00000245138ENST00000299167CNOT1chr16

58585493

-PHKBchr16

47596309

+
5UTR-intronENST00000245138ENST00000323584CNOT1chr16

58585493

-PHKBchr16

47596309

+
5UTR-intronENST00000245138ENST00000567402CNOT1chr16

58585493

-PHKBchr16

47596309

+

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FusionProtFeatures for CNOT1_PHKB


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CNOT1

A5YKK6

PHKB

Q93100

Phosphorylase b kinase catalyzes the phosphorylation ofserine in certain substrates, including troponin I. The beta chainacts as a regulatory unit and modulates the activity of theholoenzyme in response to phosphorylation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CNOT1_PHKB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CNOT1_PHKB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CNOT1CNOT8, BTG2, CNOT2, CNOT4, USP22, GTF2A1, SIRT7, GRB2, CNOT3, RQCD1, NOTCH1, EPAS1, ALB, FN1, CNOT6L, CNOT6, PEX14, PPP6R1, CCAR2, KRT18, POLR1C, LGR4, RNF219, FBXW11, TNRC6A, TNRC6C, RXRA, CCDC8, NANOS1, NANOS2, NANOS3, TRIM74, CT55, MMP7, CAPZA2, CNOT7, SCN2B, TNRC6B, AGO2, NTRK1, KRAS, IFI16, BTRC, MED4, SSX2IP, CEP152, CNTROB, NINL, CENPJ, XPO1, ABCF1, ATRX, CAPZA1, CAPZB, FHL2, RPS27, SDCBP, UBTF, TOB1, TOB2, BTG3, NUPL2, REEP5, BAG6, CNOT10, IBTK, SND1, AFF4, AURKAIP1, PI4K2A, CNOT11, GPBP1L1, INTS5, TNKS1BP1, RAVER1, DDX6, SNW1, CDC5L, MEX3C, RC3H1, EYA2, TEX13A, RIBC1, GADD45B, IZUMO1, TRIM25, G3BP1, BRCA1PHKBC20orf27, HNRNPC, UBE3A, RAVER1, BRAF, DCP2, AURKB, TP53, CAMK2B, CALM1, DOK4, MPPED1, CORO1B, CORO1C, NTRK1, MED23, HERC2, PHKG2, PTPRT, EYA2, VBP1, TULP3, LGALS3BP


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CNOT1_PHKB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CNOT1_PHKB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePHKBC0543514Glycogen Storage Disease IXB1CTD_human;ORPHANET;UNIPROT