FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 7687

FusionGeneSummary for CNNM3_CNNM3

check button Fusion gene summary
Fusion gene informationFusion gene name: CNNM3_CNNM3
Fusion gene ID: 7687
HgeneTgene
Gene symbol

CNNM3

CNNM3

Gene ID

26505

26505

Gene namecyclin and CBS domain divalent metal cation transport mediator 3cyclin and CBS domain divalent metal cation transport mediator 3
SynonymsACDP3ACDP3
Cytomap

2q11.2

2q11.2

Type of geneprotein-codingprotein-coding
Descriptionmetal transporter CNNM3ancient conserved domain protein 3ancient conserved domain-containing protein 3cyclin-M3metal transporter CNNM3ancient conserved domain protein 3ancient conserved domain-containing protein 3cyclin-M3
Modification date2018052220180522
UniProtAcc

Q8NE01

Q8NE01

Ensembl transtripts involved in fusion geneENST00000377060, ENST00000305510, 
ENST00000480035, 		ENST00000377060, 
ENST00000305510, ENST00000480035, 
Fusion gene scores* DoF score1 X 2 X 1=22 X 3 X 1=6
# samples 23
** MAII scorelog2(2/2*10)=3.32192809488736log2(3/6*10)=2.32192809488736
Context

PubMed: CNNM3 [Title/Abstract] AND CNNM3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA229290CNNM3chr2

97499141

+CNNM3chr2

97499259

-
ChiTaRS3.1AA229402CNNM3chr2

97499259

+CNNM3chr2

97499141

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000377060ENST00000377060CNNM3chr2

97499141

+CNNM3chr2

97499259

-
3UTR-3UTRENST00000377060ENST00000305510CNNM3chr2

97499141

+CNNM3chr2

97499259

-
3UTR-intronENST00000377060ENST00000480035CNNM3chr2

97499141

+CNNM3chr2

97499259

-
3UTR-3UTRENST00000305510ENST00000377060CNNM3chr2

97499141

+CNNM3chr2

97499259

-
3UTR-3UTRENST00000305510ENST00000305510CNNM3chr2

97499141

+CNNM3chr2

97499259

-
3UTR-intronENST00000305510ENST00000480035CNNM3chr2

97499141

+CNNM3chr2

97499259

-
intron-3UTRENST00000480035ENST00000377060CNNM3chr2

97499141

+CNNM3chr2

97499259

-
intron-3UTRENST00000480035ENST00000305510CNNM3chr2

97499141

+CNNM3chr2

97499259

-
intron-intronENST00000480035ENST00000480035CNNM3chr2

97499141

+CNNM3chr2

97499259

-
3UTR-3UTRENST00000377060ENST00000377060CNNM3chr2

97499259

+CNNM3chr2

97499141

-
3UTR-3UTRENST00000377060ENST00000305510CNNM3chr2

97499259

+CNNM3chr2

97499141

-
3UTR-intronENST00000377060ENST00000480035CNNM3chr2

97499259

+CNNM3chr2

97499141

-
3UTR-3UTRENST00000305510ENST00000377060CNNM3chr2

97499259

+CNNM3chr2

97499141

-
3UTR-3UTRENST00000305510ENST00000305510CNNM3chr2

97499259

+CNNM3chr2

97499141

-
3UTR-intronENST00000305510ENST00000480035CNNM3chr2

97499259

+CNNM3chr2

97499141

-
intron-3UTRENST00000480035ENST00000377060CNNM3chr2

97499259

+CNNM3chr2

97499141

-
intron-3UTRENST00000480035ENST00000305510CNNM3chr2

97499259

+CNNM3chr2

97499141

-
intron-intronENST00000480035ENST00000480035CNNM3chr2

97499259

+CNNM3chr2

97499141

-

Top

FusionProtFeatures for CNNM3_CNNM3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CNNM3

Q8NE01

CNNM3

Q8NE01

Probable metal transporter. {ECO:0000250}. Probable metal transporter. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for CNNM3_CNNM3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for CNNM3_CNNM3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for CNNM3_CNNM3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for CNNM3_CNNM3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource