	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 7682

FusionGeneSummary for CNN3_CNN3

Fusion gene summary

Fusion gene information	Fusion gene name: CNN3_CNN3
	Fusion gene ID: 7682
		Hgene	Tgene
	Gene symbol	CNN3	CNN3
	Gene ID	1266	1266
	Gene name	calponin 3	calponin 3
	Synonyms	-	-
	Cytomap	1p21.3	1p21.3
	Type of gene	protein-coding	protein-coding
	Description	calponin-3calponin 3, acidiccalponin, acidic isoformdJ639P13.2.2 (acidic calponin 3)	calponin-3calponin 3, acidiccalponin, acidic isoformdJ639P13.2.2 (acidic calponin 3)
	Modification date	20180522	20180522
	UniProtAcc	Q15417	Q15417
	Ensembl transtripts involved in fusion gene	ENST00000370206, ENST00000538964, ENST00000394202, ENST00000545882, ENST00000487539,	ENST00000370206, ENST00000538964, ENST00000394202, ENST00000545882, ENST00000487539,
Fusion gene scores	* DoF score	3 X 4 X 5=60	2 X 4 X 2=16
	# samples	8	5
	** MAII score	log2(8/60*10)=0.415037499278844 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(5/16*10)=1.64385618977472 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: CNN3 [Title/Abstract] AND CNN3 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			AI247480	CNN3	chr1	95373277	+	CNN3	chr1	95371888	+
ChiTaRS3.1			AA677082	CNN3	chr1	95373277	+	CNN3	chr1	95371888	+
ChiTaRS3.1			BF340377	CNN3	chr1	95362836	+	CNN3	chr1	95362794	-
ChiTaRS3.1			AA640449	CNN3	chr1	95365008	-	CNN3	chr1	95364933	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000370206	ENST00000370206	CNN3	chr1	95373277	+	CNN3	chr1	95371888	+
intron-intron	ENST00000370206	ENST00000538964	CNN3	chr1	95373277	+	CNN3	chr1	95371888	+
intron-intron	ENST00000370206	ENST00000394202	CNN3	chr1	95373277	+	CNN3	chr1	95371888	+
intron-intron	ENST00000370206	ENST00000545882	CNN3	chr1	95373277	+	CNN3	chr1	95371888	+
intron-intron	ENST00000370206	ENST00000487539	CNN3	chr1	95373277	+	CNN3	chr1	95371888	+
intron-intron	ENST00000538964	ENST00000370206	CNN3	chr1	95373277	+	CNN3	chr1	95371888	+
intron-intron	ENST00000538964	ENST00000538964	CNN3	chr1	95373277	+	CNN3	chr1	95371888	+
intron-intron	ENST00000538964	ENST00000394202	CNN3	chr1	95373277	+	CNN3	chr1	95371888	+
intron-intron	ENST00000538964	ENST00000545882	CNN3	chr1	95373277	+	CNN3	chr1	95371888	+
intron-intron	ENST00000538964	ENST00000487539	CNN3	chr1	95373277	+	CNN3	chr1	95371888	+
intron-intron	ENST00000394202	ENST00000370206	CNN3	chr1	95373277	+	CNN3	chr1	95371888	+
intron-intron	ENST00000394202	ENST00000538964	CNN3	chr1	95373277	+	CNN3	chr1	95371888	+
intron-intron	ENST00000394202	ENST00000394202	CNN3	chr1	95373277	+	CNN3	chr1	95371888	+
intron-intron	ENST00000394202	ENST00000545882	CNN3	chr1	95373277	+	CNN3	chr1	95371888	+
intron-intron	ENST00000394202	ENST00000487539	CNN3	chr1	95373277	+	CNN3	chr1	95371888	+
intron-intron	ENST00000545882	ENST00000370206	CNN3	chr1	95373277	+	CNN3	chr1	95371888	+
intron-intron	ENST00000545882	ENST00000538964	CNN3	chr1	95373277	+	CNN3	chr1	95371888	+
intron-intron	ENST00000545882	ENST00000394202	CNN3	chr1	95373277	+	CNN3	chr1	95371888	+
intron-intron	ENST00000545882	ENST00000545882	CNN3	chr1	95373277	+	CNN3	chr1	95371888	+
intron-intron	ENST00000545882	ENST00000487539	CNN3	chr1	95373277	+	CNN3	chr1	95371888	+
intron-intron	ENST00000487539	ENST00000370206	CNN3	chr1	95373277	+	CNN3	chr1	95371888	+
intron-intron	ENST00000487539	ENST00000538964	CNN3	chr1	95373277	+	CNN3	chr1	95371888	+
intron-intron	ENST00000487539	ENST00000394202	CNN3	chr1	95373277	+	CNN3	chr1	95371888	+
intron-intron	ENST00000487539	ENST00000545882	CNN3	chr1	95373277	+	CNN3	chr1	95371888	+
intron-intron	ENST00000487539	ENST00000487539	CNN3	chr1	95373277	+	CNN3	chr1	95371888	+
intron-3UTR	ENST00000370206	ENST00000370206	CNN3	chr1	95362836	+	CNN3	chr1	95362794	-
intron-3UTR	ENST00000370206	ENST00000538964	CNN3	chr1	95362836	+	CNN3	chr1	95362794	-
intron-intron	ENST00000370206	ENST00000394202	CNN3	chr1	95362836	+	CNN3	chr1	95362794	-
intron-intron	ENST00000370206	ENST00000545882	CNN3	chr1	95362836	+	CNN3	chr1	95362794	-
intron-intron	ENST00000370206	ENST00000487539	CNN3	chr1	95362836	+	CNN3	chr1	95362794	-
intron-3UTR	ENST00000538964	ENST00000370206	CNN3	chr1	95362836	+	CNN3	chr1	95362794	-
intron-3UTR	ENST00000538964	ENST00000538964	CNN3	chr1	95362836	+	CNN3	chr1	95362794	-
intron-intron	ENST00000538964	ENST00000394202	CNN3	chr1	95362836	+	CNN3	chr1	95362794	-
intron-intron	ENST00000538964	ENST00000545882	CNN3	chr1	95362836	+	CNN3	chr1	95362794	-
intron-intron	ENST00000538964	ENST00000487539	CNN3	chr1	95362836	+	CNN3	chr1	95362794	-
intron-3UTR	ENST00000394202	ENST00000370206	CNN3	chr1	95362836	+	CNN3	chr1	95362794	-
intron-3UTR	ENST00000394202	ENST00000538964	CNN3	chr1	95362836	+	CNN3	chr1	95362794	-
intron-intron	ENST00000394202	ENST00000394202	CNN3	chr1	95362836	+	CNN3	chr1	95362794	-
intron-intron	ENST00000394202	ENST00000545882	CNN3	chr1	95362836	+	CNN3	chr1	95362794	-
intron-intron	ENST00000394202	ENST00000487539	CNN3	chr1	95362836	+	CNN3	chr1	95362794	-
intron-3UTR	ENST00000545882	ENST00000370206	CNN3	chr1	95362836	+	CNN3	chr1	95362794	-
intron-3UTR	ENST00000545882	ENST00000538964	CNN3	chr1	95362836	+	CNN3	chr1	95362794	-
intron-intron	ENST00000545882	ENST00000394202	CNN3	chr1	95362836	+	CNN3	chr1	95362794	-
intron-intron	ENST00000545882	ENST00000545882	CNN3	chr1	95362836	+	CNN3	chr1	95362794	-
intron-intron	ENST00000545882	ENST00000487539	CNN3	chr1	95362836	+	CNN3	chr1	95362794	-
intron-3UTR	ENST00000487539	ENST00000370206	CNN3	chr1	95362836	+	CNN3	chr1	95362794	-
intron-3UTR	ENST00000487539	ENST00000538964	CNN3	chr1	95362836	+	CNN3	chr1	95362794	-
intron-intron	ENST00000487539	ENST00000394202	CNN3	chr1	95362836	+	CNN3	chr1	95362794	-
intron-intron	ENST00000487539	ENST00000545882	CNN3	chr1	95362836	+	CNN3	chr1	95362794	-
intron-intron	ENST00000487539	ENST00000487539	CNN3	chr1	95362836	+	CNN3	chr1	95362794	-
intron-3CDS	ENST00000370206	ENST00000370206	CNN3	chr1	95365008	-	CNN3	chr1	95364933	+
intron-3CDS	ENST00000370206	ENST00000538964	CNN3	chr1	95365008	-	CNN3	chr1	95364933	+
intron-3CDS	ENST00000370206	ENST00000394202	CNN3	chr1	95365008	-	CNN3	chr1	95364933	+
intron-3CDS	ENST00000370206	ENST00000545882	CNN3	chr1	95365008	-	CNN3	chr1	95364933	+
intron-5UTR	ENST00000370206	ENST00000487539	CNN3	chr1	95365008	-	CNN3	chr1	95364933	+
intron-3CDS	ENST00000538964	ENST00000370206	CNN3	chr1	95365008	-	CNN3	chr1	95364933	+
intron-3CDS	ENST00000538964	ENST00000538964	CNN3	chr1	95365008	-	CNN3	chr1	95364933	+
intron-3CDS	ENST00000538964	ENST00000394202	CNN3	chr1	95365008	-	CNN3	chr1	95364933	+
intron-3CDS	ENST00000538964	ENST00000545882	CNN3	chr1	95365008	-	CNN3	chr1	95364933	+
intron-5UTR	ENST00000538964	ENST00000487539	CNN3	chr1	95365008	-	CNN3	chr1	95364933	+
intron-3CDS	ENST00000394202	ENST00000370206	CNN3	chr1	95365008	-	CNN3	chr1	95364933	+
intron-3CDS	ENST00000394202	ENST00000538964	CNN3	chr1	95365008	-	CNN3	chr1	95364933	+
intron-3CDS	ENST00000394202	ENST00000394202	CNN3	chr1	95365008	-	CNN3	chr1	95364933	+
intron-3CDS	ENST00000394202	ENST00000545882	CNN3	chr1	95365008	-	CNN3	chr1	95364933	+
intron-5UTR	ENST00000394202	ENST00000487539	CNN3	chr1	95365008	-	CNN3	chr1	95364933	+
intron-3CDS	ENST00000545882	ENST00000370206	CNN3	chr1	95365008	-	CNN3	chr1	95364933	+
intron-3CDS	ENST00000545882	ENST00000538964	CNN3	chr1	95365008	-	CNN3	chr1	95364933	+
intron-3CDS	ENST00000545882	ENST00000394202	CNN3	chr1	95365008	-	CNN3	chr1	95364933	+
intron-3CDS	ENST00000545882	ENST00000545882	CNN3	chr1	95365008	-	CNN3	chr1	95364933	+
intron-5UTR	ENST00000545882	ENST00000487539	CNN3	chr1	95365008	-	CNN3	chr1	95364933	+
intron-3CDS	ENST00000487539	ENST00000370206	CNN3	chr1	95365008	-	CNN3	chr1	95364933	+
intron-3CDS	ENST00000487539	ENST00000538964	CNN3	chr1	95365008	-	CNN3	chr1	95364933	+
intron-3CDS	ENST00000487539	ENST00000394202	CNN3	chr1	95365008	-	CNN3	chr1	95364933	+
intron-3CDS	ENST00000487539	ENST00000545882	CNN3	chr1	95365008	-	CNN3	chr1	95364933	+
intron-5UTR	ENST00000487539	ENST00000487539	CNN3	chr1	95365008	-	CNN3	chr1	95364933	+

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FusionProtFeatures for CNN3_CNN3

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CNN3 Q15417	CNN3 Q15417
Thin filament-associated protein that is implicated inthe regulation and modulation of smooth muscle contraction. It iscapable of binding to actin, calmodulin, troponin C andtropomyosin. The interaction of calponin with actin inhibits theactomyosin Mg-ATPase activity.	Thin filament-associated protein that is implicated inthe regulation and modulation of smooth muscle contraction. It iscapable of binding to actin, calmodulin, troponin C andtropomyosin. The interaction of calponin with actin inhibits theactomyosin Mg-ATPase activity.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for CNN3_CNN3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CNN3_CNN3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for CNN3_CNN3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for CNN3_CNN3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	CNN3	C0024667	Animal Mammary Neoplasms	1	CTD_human
Hgene	CNN3	C0024668	Mammary Neoplasms, Experimental	1	CTD_human
Hgene	CNN3	C0033578	Prostatic Neoplasms	1	CTD_human
Tgene	CNN3	C0024667	Animal Mammary Neoplasms	1	CTD_human
Tgene	CNN3	C0024668	Mammary Neoplasms, Experimental	1	CTD_human
Tgene	CNN3	C0033578	Prostatic Neoplasms	1	CTD_human

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Fusion gene ID: 7682

FusionGeneSummary for CNN3_CNN3

FusionProtFeatures for CNN3_CNN3

FusionGeneSequence for CNN3_CNN3

FusionGenePPI for CNN3_CNN3

RelatedDrugs for CNN3_CNN3

RelatedDiseases for CNN3_CNN3