|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 7676 |
FusionGeneSummary for CNN2_SSU72 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CNN2_SSU72 | Fusion gene ID: 7676 | Hgene | Tgene | Gene symbol | CNN2 | SSU72 | Gene ID | 1265 | 29101 |
| Gene name | calponin 2 | SSU72 homolog, RNA polymerase II CTD phosphatase | |
| Synonyms | - | HSPC182|PNAS-120 | |
| Cytomap | 19p13.3 | 1p36.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | calponin-2calponin H2, smooth muscleneutral calponin | RNA polymerase II subunit A C-terminal domain phosphatase SSU72CTD phosphatase SSU72 | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q99439 | Q9NP77 | |
| Ensembl transtripts involved in fusion gene | ENST00000263097, ENST00000606983, ENST00000348419, ENST00000565096, ENST00000562958, | ENST00000291386, ENST00000359060, | |
| Fusion gene scores | * DoF score | 8 X 8 X 5=320 | 9 X 7 X 6=378 |
| # samples | 8 | 10 | |
| ** MAII score | log2(8/320*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/378*10)=-1.91838623444635 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CNN2 [Title/Abstract] AND SSU72 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CNN2 | GO:0032970 | regulation of actin filament-based process | 16236705 |
| Hgene | CNN2 | GO:0071260 | cellular response to mechanical stimulus | 16236705 |
| Tgene | SSU72 | GO:0070940 | dephosphorylation of RNA polymerase II C-terminal domain | 20861839 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | DB278470 | CNN2 | chr19 | 1032695 | + | SSU72 | chr1 | 1500298 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000263097 | ENST00000291386 | CNN2 | chr19 | 1032695 | + | SSU72 | chr1 | 1500298 | - |
| In-frame | ENST00000263097 | ENST00000359060 | CNN2 | chr19 | 1032695 | + | SSU72 | chr1 | 1500298 | - |
| 3UTR-3CDS | ENST00000606983 | ENST00000291386 | CNN2 | chr19 | 1032695 | + | SSU72 | chr1 | 1500298 | - |
| 3UTR-3CDS | ENST00000606983 | ENST00000359060 | CNN2 | chr19 | 1032695 | + | SSU72 | chr1 | 1500298 | - |
| Frame-shift | ENST00000348419 | ENST00000291386 | CNN2 | chr19 | 1032695 | + | SSU72 | chr1 | 1500298 | - |
| In-frame | ENST00000348419 | ENST00000359060 | CNN2 | chr19 | 1032695 | + | SSU72 | chr1 | 1500298 | - |
| intron-3CDS | ENST00000565096 | ENST00000291386 | CNN2 | chr19 | 1032695 | + | SSU72 | chr1 | 1500298 | - |
| intron-3CDS | ENST00000565096 | ENST00000359060 | CNN2 | chr19 | 1032695 | + | SSU72 | chr1 | 1500298 | - |
| Frame-shift | ENST00000562958 | ENST00000291386 | CNN2 | chr19 | 1032695 | + | SSU72 | chr1 | 1500298 | - |
| In-frame | ENST00000562958 | ENST00000359060 | CNN2 | chr19 | 1032695 | + | SSU72 | chr1 | 1500298 | - |
Top |
FusionProtFeatures for CNN2_SSU72 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CNN2 | SSU72 |
| Thin filament-associated protein that is implicated inthe regulation and modulation of smooth muscle contraction. It iscapable of binding to actin, calmodulin, troponin C andtropomyosin. The interaction of calponin with actin inhibits theactomyosin Mg-ATPase activity. | Protein phosphatase that catalyzes the dephosphorylationof the C-terminal domain of RNA polymerase II. Plays a role in RNAprocessing and termination. Plays a role in pre-mRNApolyadenylation via its interaction with SYMPK.{ECO:0000269|PubMed:15659578, ECO:0000269|PubMed:20861839,ECO:0000269|PubMed:23070812}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for CNN2_SSU72 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_CNN2_ENST00000263097_chr19_1032695_+_SSU72_ENST00000359060_chr1_1500298_-_3325nt GAAAGAGTGAGAGCCGCCCACGAGCTCTGAGCAGAGAGCCCGCAGGAGTGCCACGTCCCGGCGGCCTCGGCCCCTCCCTGCCTCAGTTTC CCGTGGCATCAAAGGGGGCGAGGGGCCCCTCCAGGCCTCTGGTGACGGGGGTGCTGTGCCCAGGCGGGGGTCCGGGGGCGACCGAGGGGG CTCAGGAAGTCCGCGGCCGCAGGAATTCGGCGCCTCCAGGCCTTATAAGGACATTTGCGCTCCGGGCCAATCAGCGGCGGGGGCGTGGCG CGCGGAGCCCGGCGCGTCCCAACCCCGCGCCAGCCCGGCGGTCCCGTCCCGTCCCGTCCTGTGCGGCCCCGTCCCGCCGCCCGCCCGCCA GCCATGAGCTCCACGCAGTTCAACAAGGGCCCCTCGTACGGGCTGTCGGCCGAGGTCAAGAACCGGCTCCTGTCCAAATATGACCCCCAG AAGGAGGCAGAGCTCCGCACCTGGATCGAGGGACTCACCGGCCTCTCCATCGGCCCCGACTTCCAGAAGGGCCTGAAGGATGGAACTATC TTATGCACACTCATGAACAAGCTACAGCCGGGCTCCGTCCCCAAGATCAACCGCTCCATGCAGAACTGGCACCAGCTAGAAAACCTGTCC AACTTCATCAAGGCCATGGTCAGCTACGGCATGAACCCTGTGGACCTGTTCGAGGCCAACGACCTGTTTGAGAGTGGGAACATGACGCAG GTGCAGGTGTCTCTTCTCGCCCTGGCGGGGAAGCAAACGGGGATTCAGCGTCCGATCCTTTGGAACAGGGACTCACGTGAAGCTTCCAGG ACCAGCTCCCGACAAGCCCAATGTTTATGATTTCAAAACCACATATGACCAGATGTACAATGATCTTCTTAGGAAAGACAAAGAACTGTA TCCCAGCGGGTTGCCCTTTAAAAACCCCCCGTGTGGTCCTCCCTGGAAGGTGTTACGTGTGGCTCGGGCACAGGAGGCGTGTCACCCTGT GCAGTGCACACACTGGCTCCTCTGTCTTTGCGAGAGCTTGGTTTCTATTCCTGGTGCACGTCGGATCGTCCACGGGTTAGTTCCAGTGCC ACCCATGGCAGTAGGCGTGGTGAGGCGCACAGACACGGTGTGGGGTTCACCCTGACGTGGTTCAGCAGAGGGTCGTGACATAGCGTAGAC CAGGGATGCTTAGGTGAGGAGGTGGAACCCACAAAATCCCATTGCTTTTCACACTGCAGGGCTGCCCCGTTATTTCCTTTGCAGGTTGGT GTGCGTGCGTGTGTGCGTGCGTGCCTGATACACATGGAGCCGGGCTGCTTCACACATCTGGTGAGGTCGTTAGAAGGTCAGATAAAGAAG AGGGCGGAGCTTGCTAACCAAGCTGTTAGAAGAAATAATGGGAGAGAACATTCCTTCATTTCAGGAGGACACAGAGCAGGCTAGGTCTGC CGCGAAGACTCCTATAGAGAGAAGAGTATTCTTAAACTAGATTCTGATGGACGCAACACCAGTTGCATAATGGTTATGACAATCAGTGCC CGGGTTTTTGACCAGGCATTTCATGGTCACCCCCACGCTAATGGAAAGTTTCTGGATCTTATTTTGTTATAGTGAGTGATTTGTAGTTTT CAGAACGGAGGCCAGGCCAAACGTATTCCAAATGAAAAGAGAATAGGTGTCAAATGCTAAACCTTTTATCTTCGTGTTGGCACTGTTGCC ATCCCCGCCCTCTCCCGACATCCCCGCCCTTGACCAGCATCTCTGGCCTTGCCCAGCATTGTCTATGTATTGGCACTCTTGCCATCCCCG CCCTTTCCCAGCAGAGTCTCACTGTGTCACCCCGGCTGGAGTGCAGTGGCGAGATCTTGGCTCACTGCAGACTCACTGCAACATCCACCT CCCGGGTTCCAGTGATTCTCCTGCTTCAGCCTCCTGGGTAGCTGGGATTACAGGCACGCGCCACCACACCTGGCTAATTTTTGTATTTTT AGTAGTCACAGGGTTTCACCATGTTGGCCAGGCTGGTCTTAAACTCCTGACTTCAGGTGATCCACCCTCCTCGTCCTCCCAAAGTGCTGG GATTACAGGCGTGAGCCACCATGCTCAGCCCTACTCTTGTATTTTTTTTTTTTTTTTTTTTTGAGATGGAGTCAGAGTCTCACCCTGTTG CCCAAGGTGGAGTGTAGCGGCTTGATCTCAGCTCACTGCAACCTCCCCCTCCCAAGTTCAAGCGATTCTCTGCCTCAGCCTCCCGAATAG CTGGGATTACAGGCATCCGCTGTCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACGGGGGTTTCACCATCTTGACCAAACTGGTCTT GAACTCTTGACCTCGTGATCCAGCTGCCTCGGCCTCTCAGAGTGTTGGGATTACAGGCGTGAGCCACCATGCCTGGCCTCTTGGAATATT TAATAAGCTAAAAAATTCTTATACACAGGTAGATTAATTAGGTAGCCAGGAGTGGCCCCTGAAAGTATGTCTGGCAAAACCTAGAACTGC ATCCTAGCCATCACTGTACCTTCTGCCCTCCCTGCTGTCTCCTCTGCCAGTTACAGTTAAAAGGTTGTGGGTGAGGACGCTGGGCAGAGT CCCAGGCGTCTGCTGTCAGCTCCCCAGCCCGGCCTGCCTGCCGAGCCATCTGGGCGTCCCACGGTGGAGAGTGTGGTGCTTGTGACGCGG TGGTGCTGGGAGCCATCCTGGTGGCAGATGTGGGCTCTCACTGCAAGTCAGTGTAAGTCCCCAGGGACTGTCAGCAGCACGTCCTGCTGC CCCTCTCTCTGCAGAAGCCCTGGTAACCTGCGTTTGGAAAAATCTCTAAGGATTTCTGAGGAGCTGTCAGGCCATGTCCTTGTCCACCCT GTGTGGGGCACGGCTTCGACATGGCTCTGCTCCCGTCGTGGGCTGAGAAGGAGCAGGTGGGGCTGTGCCTTGGAAAGGAGGCCCTCCCGA CATGCCTTTGTGCGAGGTCCCTGTCCATGCTGTCTCCATCCCGGAGCCTTACGGCGATGGGTGGCCACAGAGCCTATTCCAAGAGTCTGG TTTAGGGCTGGGTCTTCCCATCTTCACCTCTGAGTCTTAGGCGATGCGTGACCACGCAGCCCCTTCCAGGAGTCTGGTTTAGGGCTGGGT CTTCCCATCTTCACCTCTGAGTCTTAGGCGGTGCATGACCACGCAGCCCCTTCCCGGAGTCTGGTTTAGGGCTGCGTGCTCAAGAGTCTG >In-frame_CNN2_ENST00000348419_chr19_1032695_+_SSU72_ENST00000359060_chr1_1500298_-_3013nt CCCGTCCCGTCCCGTCCTGTGCGGCCCCGTCCCGCCGCCCGCCCGCCAGCCATGAGCTCCACGCAGTTCAACAAGGGCCCCTCGTACGGG CTGTCGGCCGAGGTCAAGAACCGGCTCCTGTCCAAATATGACCCCCAGAAGGAGGCAGAGCTCCGCACCTGGATCGAGGGACTCACCGGC CTCTCCATCGGCCCCGACTTCCAGAAGGGCCTGAAGGATGGAACTATCTTATGCACACTCATGAACAAGCTACAGCCGGGCTCCGTCCCC AAGATCAACCGCTCCATGCAGAACTGGCACCAGCTAGAAAACCTGTCCAACTTCATCAAGGCCATGGTCAGCTACGGCATGAACCCTGTG GACCTGTTCGAGGCCAACGACCTGTTTGAGAGTGGGAACATGACGCAGGTGCAGGTGTCTCTTCTCGCCCTGGCGGGGAAGCAAACGGGG ATTCAGCGTCCGATCCTTTGGAACAGGGACTCACGTGAAGCTTCCAGGACCAGCTCCCGACAAGCCCAATGTTTATGATTTCAAAACCAC ATATGACCAGATGTACAATGATCTTCTTAGGAAAGACAAAGAACTGTATCCCAGCGGGTTGCCCTTTAAAAACCCCCCGTGTGGTCCTCC CTGGAAGGTGTTACGTGTGGCTCGGGCACAGGAGGCGTGTCACCCTGTGCAGTGCACACACTGGCTCCTCTGTCTTTGCGAGAGCTTGGT TTCTATTCCTGGTGCACGTCGGATCGTCCACGGGTTAGTTCCAGTGCCACCCATGGCAGTAGGCGTGGTGAGGCGCACAGACACGGTGTG GGGTTCACCCTGACGTGGTTCAGCAGAGGGTCGTGACATAGCGTAGACCAGGGATGCTTAGGTGAGGAGGTGGAACCCACAAAATCCCAT TGCTTTTCACACTGCAGGGCTGCCCCGTTATTTCCTTTGCAGGTTGGTGTGCGTGCGTGTGTGCGTGCGTGCCTGATACACATGGAGCCG GGCTGCTTCACACATCTGGTGAGGTCGTTAGAAGGTCAGATAAAGAAGAGGGCGGAGCTTGCTAACCAAGCTGTTAGAAGAAATAATGGG AGAGAACATTCCTTCATTTCAGGAGGACACAGAGCAGGCTAGGTCTGCCGCGAAGACTCCTATAGAGAGAAGAGTATTCTTAAACTAGAT TCTGATGGACGCAACACCAGTTGCATAATGGTTATGACAATCAGTGCCCGGGTTTTTGACCAGGCATTTCATGGTCACCCCCACGCTAAT GGAAAGTTTCTGGATCTTATTTTGTTATAGTGAGTGATTTGTAGTTTTCAGAACGGAGGCCAGGCCAAACGTATTCCAAATGAAAAGAGA ATAGGTGTCAAATGCTAAACCTTTTATCTTCGTGTTGGCACTGTTGCCATCCCCGCCCTCTCCCGACATCCCCGCCCTTGACCAGCATCT CTGGCCTTGCCCAGCATTGTCTATGTATTGGCACTCTTGCCATCCCCGCCCTTTCCCAGCAGAGTCTCACTGTGTCACCCCGGCTGGAGT GCAGTGGCGAGATCTTGGCTCACTGCAGACTCACTGCAACATCCACCTCCCGGGTTCCAGTGATTCTCCTGCTTCAGCCTCCTGGGTAGC TGGGATTACAGGCACGCGCCACCACACCTGGCTAATTTTTGTATTTTTAGTAGTCACAGGGTTTCACCATGTTGGCCAGGCTGGTCTTAA ACTCCTGACTTCAGGTGATCCACCCTCCTCGTCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCATGCTCAGCCCTACTCTTGTAT TTTTTTTTTTTTTTTTTTTTGAGATGGAGTCAGAGTCTCACCCTGTTGCCCAAGGTGGAGTGTAGCGGCTTGATCTCAGCTCACTGCAAC CTCCCCCTCCCAAGTTCAAGCGATTCTCTGCCTCAGCCTCCCGAATAGCTGGGATTACAGGCATCCGCTGTCATGCCTGGCTAATTTTTG TATTTTTAGTAGAGACGGGGGTTTCACCATCTTGACCAAACTGGTCTTGAACTCTTGACCTCGTGATCCAGCTGCCTCGGCCTCTCAGAG TGTTGGGATTACAGGCGTGAGCCACCATGCCTGGCCTCTTGGAATATTTAATAAGCTAAAAAATTCTTATACACAGGTAGATTAATTAGG TAGCCAGGAGTGGCCCCTGAAAGTATGTCTGGCAAAACCTAGAACTGCATCCTAGCCATCACTGTACCTTCTGCCCTCCCTGCTGTCTCC TCTGCCAGTTACAGTTAAAAGGTTGTGGGTGAGGACGCTGGGCAGAGTCCCAGGCGTCTGCTGTCAGCTCCCCAGCCCGGCCTGCCTGCC GAGCCATCTGGGCGTCCCACGGTGGAGAGTGTGGTGCTTGTGACGCGGTGGTGCTGGGAGCCATCCTGGTGGCAGATGTGGGCTCTCACT GCAAGTCAGTGTAAGTCCCCAGGGACTGTCAGCAGCACGTCCTGCTGCCCCTCTCTCTGCAGAAGCCCTGGTAACCTGCGTTTGGAAAAA TCTCTAAGGATTTCTGAGGAGCTGTCAGGCCATGTCCTTGTCCACCCTGTGTGGGGCACGGCTTCGACATGGCTCTGCTCCCGTCGTGGG CTGAGAAGGAGCAGGTGGGGCTGTGCCTTGGAAAGGAGGCCCTCCCGACATGCCTTTGTGCGAGGTCCCTGTCCATGCTGTCTCCATCCC GGAGCCTTACGGCGATGGGTGGCCACAGAGCCTATTCCAAGAGTCTGGTTTAGGGCTGGGTCTTCCCATCTTCACCTCTGAGTCTTAGGC GATGCGTGACCACGCAGCCCCTTCCAGGAGTCTGGTTTAGGGCTGGGTCTTCCCATCTTCACCTCTGAGTCTTAGGCGGTGCATGACCAC GCAGCCCCTTCCCGGAGTCTGGTTTAGGGCTGCGTGCTCAAGAGTCTGGTTTGGGGCTGGGTCTTCCCATCGCCCTGGAGGAGGCTTTTG >In-frame_CNN2_ENST00000562958_chr19_1032695_+_SSU72_ENST00000359060_chr1_1500298_-_2995nt GTGCGGCCCCGTCCCGCCGCCCGCCCGCCAGCCATGAGCTCCACGCAGTTCAACAAGGGCCCCTCGTACGGGCTGTCGGCCGAGGTCAAG AACCGGCTCCTGTCCAAATATGACCCCCAGAAGGAGGCAGAGCTCCGCACCTGGATCGAGGGACTCACCGGCCTCTCCATCGGCCCCGAC TTCCAGAAGGGCCTGAAGGATGGAACTATCTTATGCACACTCATGAACAAGCTACAGCCGGGCTCCGTCCCCAAGATCAACCGCTCCATG CAGAACTGGCACCAGCTAGAAAACCTGTCCAACTTCATCAAGGCCATGGTCAGCTACGGCATGAACCCTGTGGACCTGTTCGAGGCCAAC GACCTGTTTGAGAGTGGGAACATGACGCAGGTGCAGGTGTCTCTTCTCGCCCTGGCGGGGAAGCAAACGGGGATTCAGCGTCCGATCCTT TGGAACAGGGACTCACGTGAAGCTTCCAGGACCAGCTCCCGACAAGCCCAATGTTTATGATTTCAAAACCACATATGACCAGATGTACAA TGATCTTCTTAGGAAAGACAAAGAACTGTATCCCAGCGGGTTGCCCTTTAAAAACCCCCCGTGTGGTCCTCCCTGGAAGGTGTTACGTGT GGCTCGGGCACAGGAGGCGTGTCACCCTGTGCAGTGCACACACTGGCTCCTCTGTCTTTGCGAGAGCTTGGTTTCTATTCCTGGTGCACG TCGGATCGTCCACGGGTTAGTTCCAGTGCCACCCATGGCAGTAGGCGTGGTGAGGCGCACAGACACGGTGTGGGGTTCACCCTGACGTGG TTCAGCAGAGGGTCGTGACATAGCGTAGACCAGGGATGCTTAGGTGAGGAGGTGGAACCCACAAAATCCCATTGCTTTTCACACTGCAGG GCTGCCCCGTTATTTCCTTTGCAGGTTGGTGTGCGTGCGTGTGTGCGTGCGTGCCTGATACACATGGAGCCGGGCTGCTTCACACATCTG GTGAGGTCGTTAGAAGGTCAGATAAAGAAGAGGGCGGAGCTTGCTAACCAAGCTGTTAGAAGAAATAATGGGAGAGAACATTCCTTCATT TCAGGAGGACACAGAGCAGGCTAGGTCTGCCGCGAAGACTCCTATAGAGAGAAGAGTATTCTTAAACTAGATTCTGATGGACGCAACACC AGTTGCATAATGGTTATGACAATCAGTGCCCGGGTTTTTGACCAGGCATTTCATGGTCACCCCCACGCTAATGGAAAGTTTCTGGATCTT ATTTTGTTATAGTGAGTGATTTGTAGTTTTCAGAACGGAGGCCAGGCCAAACGTATTCCAAATGAAAAGAGAATAGGTGTCAAATGCTAA ACCTTTTATCTTCGTGTTGGCACTGTTGCCATCCCCGCCCTCTCCCGACATCCCCGCCCTTGACCAGCATCTCTGGCCTTGCCCAGCATT GTCTATGTATTGGCACTCTTGCCATCCCCGCCCTTTCCCAGCAGAGTCTCACTGTGTCACCCCGGCTGGAGTGCAGTGGCGAGATCTTGG CTCACTGCAGACTCACTGCAACATCCACCTCCCGGGTTCCAGTGATTCTCCTGCTTCAGCCTCCTGGGTAGCTGGGATTACAGGCACGCG CCACCACACCTGGCTAATTTTTGTATTTTTAGTAGTCACAGGGTTTCACCATGTTGGCCAGGCTGGTCTTAAACTCCTGACTTCAGGTGA TCCACCCTCCTCGTCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCATGCTCAGCCCTACTCTTGTATTTTTTTTTTTTTTTTTTT TTGAGATGGAGTCAGAGTCTCACCCTGTTGCCCAAGGTGGAGTGTAGCGGCTTGATCTCAGCTCACTGCAACCTCCCCCTCCCAAGTTCA AGCGATTCTCTGCCTCAGCCTCCCGAATAGCTGGGATTACAGGCATCCGCTGTCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACGG GGGTTTCACCATCTTGACCAAACTGGTCTTGAACTCTTGACCTCGTGATCCAGCTGCCTCGGCCTCTCAGAGTGTTGGGATTACAGGCGT GAGCCACCATGCCTGGCCTCTTGGAATATTTAATAAGCTAAAAAATTCTTATACACAGGTAGATTAATTAGGTAGCCAGGAGTGGCCCCT GAAAGTATGTCTGGCAAAACCTAGAACTGCATCCTAGCCATCACTGTACCTTCTGCCCTCCCTGCTGTCTCCTCTGCCAGTTACAGTTAA AAGGTTGTGGGTGAGGACGCTGGGCAGAGTCCCAGGCGTCTGCTGTCAGCTCCCCAGCCCGGCCTGCCTGCCGAGCCATCTGGGCGTCCC ACGGTGGAGAGTGTGGTGCTTGTGACGCGGTGGTGCTGGGAGCCATCCTGGTGGCAGATGTGGGCTCTCACTGCAAGTCAGTGTAAGTCC CCAGGGACTGTCAGCAGCACGTCCTGCTGCCCCTCTCTCTGCAGAAGCCCTGGTAACCTGCGTTTGGAAAAATCTCTAAGGATTTCTGAG GAGCTGTCAGGCCATGTCCTTGTCCACCCTGTGTGGGGCACGGCTTCGACATGGCTCTGCTCCCGTCGTGGGCTGAGAAGGAGCAGGTGG GGCTGTGCCTTGGAAAGGAGGCCCTCCCGACATGCCTTTGTGCGAGGTCCCTGTCCATGCTGTCTCCATCCCGGAGCCTTACGGCGATGG GTGGCCACAGAGCCTATTCCAAGAGTCTGGTTTAGGGCTGGGTCTTCCCATCTTCACCTCTGAGTCTTAGGCGATGCGTGACCACGCAGC CCCTTCCAGGAGTCTGGTTTAGGGCTGGGTCTTCCCATCTTCACCTCTGAGTCTTAGGCGGTGCATGACCACGCAGCCCCTTCCCGGAGT CTGGTTTAGGGCTGCGTGCTCAAGAGTCTGGTTTGGGGCTGGGTCTTCCCATCGCCCTGGAGGAGGCTTTTGTCTCATCTCATGATTCAC |
Top |
FusionGenePPI for CNN2_SSU72 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CNN2 | ELAVL1, ZYX, HNRNPH2, TPM1, FSCN1, ACTA2, FN1, PAN2, CD81, ERP44, FUBP1, LAGE3, PDCD10, MAT2B, CNN3, ATE1, TRAPPC9, ALAD, ALDH8A1, MTAP, SF1, U2AF2, CDH1, NAGK, HSPA8, TRAPPC4, BRCA1, YAP1, TES | SSU72 | UIMC1, RAD21, STAG2, SMC1A, SMC3, ACAT2, SEC23IP, LACTB2, STXBP2, VCL, KYNU, XPO1, PTGES3, THOP1, UBE2H, NUDCD2, DNPH1, TIPRL, TPI1, PRDX6, SYMPK, MAPK8, MAPK9, POLR2A, NCAPG2, PPP1CB, SKP1, TRIO, UGGT1, FOS, CPSF1, CPSF2, CPSF3, CSTF2, CSTF3, HIST2H2AA4, HNRNPL, CDKN2AIP, ZNF638, NCOA5, PCF11, ELP5, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for CNN2_SSU72 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for CNN2_SSU72 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CNN2 | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|