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Fusion gene ID: 7667 |
FusionGeneSummary for CNN1_CCT5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CNN1_CCT5 | Fusion gene ID: 7667 | Hgene | Tgene | Gene symbol | CNN1 | CCT5 | Gene ID | 1264 | 22948 |
| Gene name | calponin 1 | chaperonin containing TCP1 subunit 5 | |
| Synonyms | HEL-S-14|SMCC|Sm-Calp | CCT-epsilon|CCTE|HEL-S-69|PNAS-102|TCP-1-epsilon | |
| Cytomap | 19p13.2 | 5p15.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | calponin-1basic calponincalponin 1, basic, smooth musclecalponin H1, smooth musclecalponins, basicepididymis secretory protein Li 14 | T-complex protein 1 subunit epsilonchaperonin containing TCP1, subunit 5 (epsilon)epididymis secretory protein Li 69 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | P51911 | P48643 | |
| Ensembl transtripts involved in fusion gene | ENST00000252456, ENST00000592923, ENST00000535659, ENST00000588468, ENST00000544952, | ENST00000280326, ENST00000503026, ENST00000515390, ENST00000515676, ENST00000506600, | |
| Fusion gene scores | * DoF score | 6 X 4 X 3=72 | 49 X 6 X 16=4704 |
| # samples | 6 | 53 | |
| ** MAII score | log2(6/72*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(53/4704*10)=-3.1498237953858 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CNN1 [Title/Abstract] AND CCT5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-EJ-5521-01A | CNN1 | chr19 | 11661138 | + | CCT5 | chr5 | 10250033 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000252456 | ENST00000280326 | CNN1 | chr19 | 11661138 | + | CCT5 | chr5 | 10250033 | + |
| 5CDS-intron | ENST00000252456 | ENST00000503026 | CNN1 | chr19 | 11661138 | + | CCT5 | chr5 | 10250033 | + |
| 5CDS-intron | ENST00000252456 | ENST00000515390 | CNN1 | chr19 | 11661138 | + | CCT5 | chr5 | 10250033 | + |
| 5CDS-intron | ENST00000252456 | ENST00000515676 | CNN1 | chr19 | 11661138 | + | CCT5 | chr5 | 10250033 | + |
| 5CDS-intron | ENST00000252456 | ENST00000506600 | CNN1 | chr19 | 11661138 | + | CCT5 | chr5 | 10250033 | + |
| Frame-shift | ENST00000592923 | ENST00000280326 | CNN1 | chr19 | 11661138 | + | CCT5 | chr5 | 10250033 | + |
| 5CDS-intron | ENST00000592923 | ENST00000503026 | CNN1 | chr19 | 11661138 | + | CCT5 | chr5 | 10250033 | + |
| 5CDS-intron | ENST00000592923 | ENST00000515390 | CNN1 | chr19 | 11661138 | + | CCT5 | chr5 | 10250033 | + |
| 5CDS-intron | ENST00000592923 | ENST00000515676 | CNN1 | chr19 | 11661138 | + | CCT5 | chr5 | 10250033 | + |
| 5CDS-intron | ENST00000592923 | ENST00000506600 | CNN1 | chr19 | 11661138 | + | CCT5 | chr5 | 10250033 | + |
| intron-3CDS | ENST00000535659 | ENST00000280326 | CNN1 | chr19 | 11661138 | + | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000535659 | ENST00000503026 | CNN1 | chr19 | 11661138 | + | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000535659 | ENST00000515390 | CNN1 | chr19 | 11661138 | + | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000535659 | ENST00000515676 | CNN1 | chr19 | 11661138 | + | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000535659 | ENST00000506600 | CNN1 | chr19 | 11661138 | + | CCT5 | chr5 | 10250033 | + |
| intron-3CDS | ENST00000588468 | ENST00000280326 | CNN1 | chr19 | 11661138 | + | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000588468 | ENST00000503026 | CNN1 | chr19 | 11661138 | + | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000588468 | ENST00000515390 | CNN1 | chr19 | 11661138 | + | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000588468 | ENST00000515676 | CNN1 | chr19 | 11661138 | + | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000588468 | ENST00000506600 | CNN1 | chr19 | 11661138 | + | CCT5 | chr5 | 10250033 | + |
| intron-3CDS | ENST00000544952 | ENST00000280326 | CNN1 | chr19 | 11661138 | + | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000544952 | ENST00000503026 | CNN1 | chr19 | 11661138 | + | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000544952 | ENST00000515390 | CNN1 | chr19 | 11661138 | + | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000544952 | ENST00000515676 | CNN1 | chr19 | 11661138 | + | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000544952 | ENST00000506600 | CNN1 | chr19 | 11661138 | + | CCT5 | chr5 | 10250033 | + |
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FusionProtFeatures for CNN1_CCT5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CNN1 | CCT5 |
| Thin filament-associated protein that is implicated inthe regulation and modulation of smooth muscle contraction. It iscapable of binding to actin, calmodulin, troponin C andtropomyosin. The interaction of calponin with actin inhibits theactomyosin Mg-ATPase activity (By similarity). {ECO:0000250}. | Molecular chaperone; assists the folding of proteinsupon ATP hydrolysis. As part of the BBS/CCT complex may play arole in the assembly of BBSome, a complex involved in ciliogenesisregulating transports vesicles to the cilia. Known to play a role,in vitro, in the folding of actin and tubulin.{ECO:0000269|PubMed:20080638}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | CNN1 | chr19:11661138 | chr5:10250033 | ENST00000252456 | + | 7 | 7 | 28_131 | 474 | 298 | Domain | Calponin-homology (CH) |
| Hgene | CNN1 | chr19:11661138 | chr5:10250033 | ENST00000252456 | + | 7 | 7 | 164_189 | 474 | 298 | Repeat | Note=Calponin-like 1 |
| Hgene | CNN1 | chr19:11661138 | chr5:10250033 | ENST00000252456 | + | 7 | 7 | 204_229 | 474 | 298 | Repeat | Note=Calponin-like 2 |
| Hgene | CNN1 | chr19:11661138 | chr5:10250033 | ENST00000252456 | + | 7 | 7 | 243_268 | 474 | 298 | Repeat | Note=Calponin-like 3 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CNN1_CCT5 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_CNN1_ENST00000252456_chr19_11661138_+_CCT5_ENST00000280326_chr5_10250033_+_1156aa MSSAHFNRGPAYGLSAEVKNKLAQKYDHQREQELREWIEGVTGRRIGNNFMDGLKDGIILCEFINKLQPGSVKKINESTQNWHQLENIGN FIKAITKYGVKPHDIFEANDLFENTNHTQVQSTLLALASMAKTKGNKVNVGVKYAEKQERKFEPGKLREGRNIIGLQMGTNKFASQQGMT AYGTRRHLYDPKLGTDQPLDQATISLQMGTNKGASQAGMTAPGTKRQIFEPGLGMEHCDTLNVSLQMGSNKGASQRGMTVYGLPRQVYDP KYCLTPEYPELGEPAHNHHAHNYYNSAXGHKAFPVFPPREAAAALGWTQPGPADPLSLHGILQPLXNSTSTGLEFGESRLAGGPLGGRGP SALXCYRVQHRAGCPQQRPKDALSNAIPAVPPLPHKWVPPGPEAPPAKPPEPRLGLPPPHSRSGSKLHAQRPSGHTRFGLQRLAYYVDVT VAFVMRALSFFSISLEHNKWLXNLKKKKNRKWVLPSSRSRSAKKXRNSALSQXIPPWDPLSRNYQWXRFKKXQIQSALDLCVLRFPLSVF KPPPPRLPGXXKFPKAADSRRYCLAXNXSQXKHKSRASCAARAQAFGPSREREVHSRFRSGLRRLGGSNSGCCTMASMGTLAFDEYGRPF LIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSMMDVDHQIAKLMVELSKSQDDEIGDGT TGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVAIEHLDKISDSVLVDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAVLTV ADMERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAILTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFE EMIQQIKETGANLAICQWGFDDEANHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKDKMLVIEQ CKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEADKCPTLEQYAMRAFADALEVIPMALSENS |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_CNN1_ENST00000252456_chr19_11661138_+_CCT5_ENST00000280326_chr5_10250033_+_3468nt ATGTCCTCTGCTCACTTCAACCGAGGCCCTGCCTACGGGCTGTCAGCCGAGGTTAAGAACAAGCTGGCCCAGAAGTATGACCACCAGCGG GAGCAGGAGCTGAGAGAGTGGATCGAGGGGGTGACAGGCCGTCGCATCGGCAACAACTTCATGGACGGCCTCAAAGATGGCATCATTCTT TGCGAATTCATCAATAAGCTGCAGCCAGGCTCCGTGAAGAAGATCAATGAGTCAACCCAAAATTGGCACCAGCTGGAGAACATCGGCAAC TTCATCAAGGCCATCACCAAGTATGGGGTGAAGCCCCACGACATTTTTGAGGCCAACGACCTGTTTGAGAACACCAACCATACACAGGTG CAGTCCACCCTCCTGGCTTTGGCCAGCATGGCGAAGACGAAAGGAAACAAGGTGAACGTGGGAGTGAAGTACGCAGAGAAGCAGGAGCGG AAATTCGAGCCGGGGAAGCTAAGAGAAGGGCGGAACATCATTGGGCTGCAGATGGGCACCAACAAGTTTGCCAGCCAGCAGGGCATGACG GCCTATGGCACCCGGCGCCACCTCTACGACCCCAAGCTGGGCACAGACCAGCCTCTGGACCAGGCGACCATCAGCCTGCAGATGGGCACC AACAAAGGAGCCAGCCAGGCTGGCATGACTGCGCCAGGGACCAAGCGGCAGATCTTCGAGCCGGGGCTGGGCATGGAGCACTGCGACACG CTCAATGTCAGCCTGCAGATGGGCAGCAACAAGGGCGCCTCGCAGCGGGGCATGACGGTGTATGGGCTGCCACGCCAGGTCTACGACCCC AAGTACTGTCTGACTCCCGAGTACCCAGAGCTGGGTGAGCCCGCCCACAACCACCACGCACACAACTACTACAATTCCGCCTAGGGCCAC AAGGCCTTCCCTGTTTTCCCCCCAAGGGAGGCTGCTGCTGCTCTTGGCTGGACCCAGCCAGGCCCAGCCGACCCCCTCTCCCTGCATGGC ATCCTCCAGCCCCTGTAGAACTCAACCTCTACAGGGTTAGAGTTTGGAGAGAGCAGACTGGCGGGGGGCCCATTGGGGGGAAGGGGACCC TCCGCTCTGTAGTGCTACAGGGTCCAACATAGAGCCGGGTGTCCCCAACAGCGCCCAAAGGACGCACTGAGCAACGCTATTCCAGCTGTC CCCCCACTCCCTCACAAGTGGGTACCCCCAGGACCAGAAGCTCCCCCAGCAAAGCCCCCAGAGCCCAGGCTCGGCCTGCCCCCACCCCAT TCCCGCAGTGGGAGCAAACTGCATGCCCAGAGACCCAGCGGACACACGCGGTTTGGTTTGCAGCGACTGGCATACTATGTGGATGTGACA GTGGCGTTTGTAATGAGAGCACTTTCTTTTTTTTCTATTTCACTGGAGCACAATAAATGGCTGTAAAATCTCAAAAAAAAAAAAAACCGG AAATGGGTCCTACCATCTTCTCGGAGCCGGAGTGCGAAGAAATAAAGAAATAGTGCTTTAAGTCAATGAATTCCTCCTTGGGACCCACTA TCGAGAAACTATCAGTGGTAACGTTTTAAAAAATGACAAATTCAATCTGCTCTTGACTTGTGTGTCCTAAGATTTCCACTAAGTGTCTTC AAACCTCCCCCTCCCCGGCTTCCTGGATAATAGAAGTTCCCGAAGGCCGCCGATTCCAGAAGATACTGTCTGGCGTGAAATTAGTCTCAG TAGAAACATAAGTCCCGCGCGTCTTGTGCTGCGCGTGCGCAAGCTTTTGGGCCCTCCCGAGAAAGGGAAGTGCATTCTCGCTTCCGTAGC GGTCTCCGCCGGTTGGGGGGAAGTAATTCCGGTTGTTGCACCATGGCGTCCATGGGGACCCTCGCCTTCGATGAATATGGGCGCCCTTTC CTCATCATCAAGGATCAGGACCGCAAGTCCCGTCTTATGGGACTTGAGGCCCTCAAGTCTCATATAATGGCAGCAAAGGCTGTAGCAAAT ACAATGAGAACATCACTTGGACCAAATGGGCTTGATAAGATGATGGTGGATAAGGATGGAGATGTGACTGTAACTAATGATGGGGCCACC ATCTTAAGCATGATGGATGTTGATCATCAGATTGCCAAGCTGATGGTGGAACTGTCCAAGTCTCAGGATGATGAAATTGGAGATGGAACC ACAGGAGTGGTTGTCCTGGCTGGTGCCTTGTTAGAAGAAGCGGAGCAATTGCTAGACCGAGGCATTCACCCAATCAGAATAGCCGATGGC TATGAGCAGGCTGCTCGTGTTGCTATTGAACACCTGGACAAGATCAGCGATAGCGTCCTTGTTGACATAAAGGACACCGAACCCCTGATT CAGACAGCAAAAACCACGCTGGGCTCCAAAGTGGTCAACAGTTGTCACCGACAGATGGCTGAGATTGCTGTGAATGCCGTCCTCACTGTA GCAGATATGGAGCGGAGAGACGTTGACTTTGAGCTTATCAAAGTAGAAGGCAAAGTGGGCGGCAGGCTGGAGGACACTAAACTGATTAAG GGCGTGATTGTGGACAAGGATTTCAGTCACCCACAGATGCCAAAAAAAGTGGAAGATGCGAAGATTGCAATTCTCACATGTCCATTTGAA CCACCCAAACCAAAAACAAAGCATAAGCTGGATGTGACCTCTGTCGAAGATTATAAAGCCCTTCAGAAATACGAAAAGGAGAAATTTGAA GAGATGATTCAACAAATTAAAGAGACTGGTGCTAACCTAGCAATTTGTCAGTGGGGCTTTGATGATGAAGCAAATCACTTACTTCTTCAG AACAACTTGCCTGCGGTTCGCTGGGTAGGAGGACCTGAAATTGAGCTGATTGCCATCGCAACAGGAGGGCGGATCGTCCCCAGGTTCTCA GAGCTCACAGCCGAGAAGCTGGGCTTTGCTGGTCTTGTACAGGAGATCTCATTTGGGACAACTAAGGATAAAATGCTGGTCATCGAGCAG TGTAAGAACTCCAGAGCTGTAACCATTTTTATTAGAGGAGGAAATAAGATGATCATTGAGGAGGCGAAACGATCCCTTCACGATGCTTTG TGTGTCATCCGGAACCTCATCCGCGATAATCGTGTGGTGTATGGAGGAGGGGCTGCTGAGATATCCTGTGCCCTGGCAGTTAGCCAAGAG GCGGATAAGTGCCCCACCTTAGAACAGTATGCCATGAGAGCGTTTGCCGACGCACTGGAGGTCATCCCCATGGCCCTCTCTGAAAACAGT GGCATGAATCCCATCCAGACTATGACCGAAGTCCGAGCCAGACAGGTGAAGGAGATGAACCCTGCTCTTGGCATCGACTGTTTGCACAAG GGGACAAATGATATGAAGCAACAGCATGTCATAGAAACCTTGATTGGCAAAAAGCAACAGATATCTCTTGCAACACAAATGGTTAGAATG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_CNN1_ENST00000252456_chr19_11661138_+_CCT5_ENST00000280326_chr5_10250033_+_5308nt GGGAGGGGAAGGCAGCTGAGGTTGTGGGGGGAGGTGCCCCGCCCCTTGGCAGGCCCCTACAGCCAATGGAACGGCCCTGGAAGAGACCCG GGTCGCCTCCGGAGCTTCAAAAACATGTGAGGAGGGAAGAGTGTGCAGACGGAACTTCAGCCGCTGCCTCTGTTCTCAGCGTCAGTGCCG CCACTGCCCCCGCCAGAGCCCACCGGCCAGCATGTCCTCTGCTCACTTCAACCGAGGCCCTGCCTACGGGCTGTCAGCCGAGGTTAAGAA CAAGCTGGCCCAGAAGTATGACCACCAGCGGGAGCAGGAGCTGAGAGAGTGGATCGAGGGGGTGACAGGCCGTCGCATCGGCAACAACTT CATGGACGGCCTCAAAGATGGCATCATTCTTTGCGAATTCATCAATAAGCTGCAGCCAGGCTCCGTGAAGAAGATCAATGAGTCAACCCA AAATTGGCACCAGCTGGAGAACATCGGCAACTTCATCAAGGCCATCACCAAGTATGGGGTGAAGCCCCACGACATTTTTGAGGCCAACGA CCTGTTTGAGAACACCAACCATACACAGGTGCAGTCCACCCTCCTGGCTTTGGCCAGCATGGCGAAGACGAAAGGAAACAAGGTGAACGT GGGAGTGAAGTACGCAGAGAAGCAGGAGCGGAAATTCGAGCCGGGGAAGCTAAGAGAAGGGCGGAACATCATTGGGCTGCAGATGGGCAC CAACAAGTTTGCCAGCCAGCAGGGCATGACGGCCTATGGCACCCGGCGCCACCTCTACGACCCCAAGCTGGGCACAGACCAGCCTCTGGA CCAGGCGACCATCAGCCTGCAGATGGGCACCAACAAAGGAGCCAGCCAGGCTGGCATGACTGCGCCAGGGACCAAGCGGCAGATCTTCGA GCCGGGGCTGGGCATGGAGCACTGCGACACGCTCAATGTCAGCCTGCAGATGGGCAGCAACAAGGGCGCCTCGCAGCGGGGCATGACGGT GTATGGGCTGCCACGCCAGGTCTACGACCCCAAGTACTGTCTGACTCCCGAGTACCCAGAGCTGGGTGAGCCCGCCCACAACCACCACGC ACACAACTACTACAATTCCGCCTAGGGCCACAAGGCCTTCCCTGTTTTCCCCCCAAGGGAGGCTGCTGCTGCTCTTGGCTGGACCCAGCC AGGCCCAGCCGACCCCCTCTCCCTGCATGGCATCCTCCAGCCCCTGTAGAACTCAACCTCTACAGGGTTAGAGTTTGGAGAGAGCAGACT GGCGGGGGGCCCATTGGGGGGAAGGGGACCCTCCGCTCTGTAGTGCTACAGGGTCCAACATAGAGCCGGGTGTCCCCAACAGCGCCCAAA GGACGCACTGAGCAACGCTATTCCAGCTGTCCCCCCACTCCCTCACAAGTGGGTACCCCCAGGACCAGAAGCTCCCCCAGCAAAGCCCCC AGAGCCCAGGCTCGGCCTGCCCCCACCCCATTCCCGCAGTGGGAGCAAACTGCATGCCCAGAGACCCAGCGGACACACGCGGTTTGGTTT GCAGCGACTGGCATACTATGTGGATGTGACAGTGGCGTTTGTAATGAGAGCACTTTCTTTTTTTTCTATTTCACTGGAGCACAATAAATG GCTGTAAAATCTCAAAAAAAAAAAAAACCGGAAATGGGTCCTACCATCTTCTCGGAGCCGGAGTGCGAAGAAATAAAGAAATAGTGCTTT AAGTCAATGAATTCCTCCTTGGGACCCACTATCGAGAAACTATCAGTGGTAACGTTTTAAAAAATGACAAATTCAATCTGCTCTTGACTT GTGTGTCCTAAGATTTCCACTAAGTGTCTTCAAACCTCCCCCTCCCCGGCTTCCTGGATAATAGAAGTTCCCGAAGGCCGCCGATTCCAG AAGATACTGTCTGGCGTGAAATTAGTCTCAGTAGAAACATAAGTCCCGCGCGTCTTGTGCTGCGCGTGCGCAAGCTTTTGGGCCCTCCCG AGAAAGGGAAGTGCATTCTCGCTTCCGTAGCGGTCTCCGCCGGTTGGGGGGAAGTAATTCCGGTTGTTGCACCATGGCGTCCATGGGGAC CCTCGCCTTCGATGAATATGGGCGCCCTTTCCTCATCATCAAGGATCAGGACCGCAAGTCCCGTCTTATGGGACTTGAGGCCCTCAAGTC TCATATAATGGCAGCAAAGGCTGTAGCAAATACAATGAGAACATCACTTGGACCAAATGGGCTTGATAAGATGATGGTGGATAAGGATGG AGATGTGACTGTAACTAATGATGGGGCCACCATCTTAAGCATGATGGATGTTGATCATCAGATTGCCAAGCTGATGGTGGAACTGTCCAA GTCTCAGGATGATGAAATTGGAGATGGAACCACAGGAGTGGTTGTCCTGGCTGGTGCCTTGTTAGAAGAAGCGGAGCAATTGCTAGACCG AGGCATTCACCCAATCAGAATAGCCGATGGCTATGAGCAGGCTGCTCGTGTTGCTATTGAACACCTGGACAAGATCAGCGATAGCGTCCT TGTTGACATAAAGGACACCGAACCCCTGATTCAGACAGCAAAAACCACGCTGGGCTCCAAAGTGGTCAACAGTTGTCACCGACAGATGGC TGAGATTGCTGTGAATGCCGTCCTCACTGTAGCAGATATGGAGCGGAGAGACGTTGACTTTGAGCTTATCAAAGTAGAAGGCAAAGTGGG CGGCAGGCTGGAGGACACTAAACTGATTAAGGGCGTGATTGTGGACAAGGATTTCAGTCACCCACAGATGCCAAAAAAAGTGGAAGATGC GAAGATTGCAATTCTCACATGTCCATTTGAACCACCCAAACCAAAAACAAAGCATAAGCTGGATGTGACCTCTGTCGAAGATTATAAAGC CCTTCAGAAATACGAAAAGGAGAAATTTGAAGAGATGATTCAACAAATTAAAGAGACTGGTGCTAACCTAGCAATTTGTCAGTGGGGCTT TGATGATGAAGCAAATCACTTACTTCTTCAGAACAACTTGCCTGCGGTTCGCTGGGTAGGAGGACCTGAAATTGAGCTGATTGCCATCGC AACAGGAGGGCGGATCGTCCCCAGGTTCTCAGAGCTCACAGCCGAGAAGCTGGGCTTTGCTGGTCTTGTACAGGAGATCTCATTTGGGAC AACTAAGGATAAAATGCTGGTCATCGAGCAGTGTAAGAACTCCAGAGCTGTAACCATTTTTATTAGAGGAGGAAATAAGATGATCATTGA GGAGGCGAAACGATCCCTTCACGATGCTTTGTGTGTCATCCGGAACCTCATCCGCGATAATCGTGTGGTGTATGGAGGAGGGGCTGCTGA GATATCCTGTGCCCTGGCAGTTAGCCAAGAGGCGGATAAGTGCCCCACCTTAGAACAGTATGCCATGAGAGCGTTTGCCGACGCACTGGA GGTCATCCCCATGGCCCTCTCTGAAAACAGTGGCATGAATCCCATCCAGACTATGACCGAAGTCCGAGCCAGACAGGTGAAGGAGATGAA CCCTGCTCTTGGCATCGACTGTTTGCACAAGGGGACAAATGATATGAAGCAACAGCATGTCATAGAAACCTTGATTGGCAAAAAGCAACA GATATCTCTTGCAACACAAATGGTTAGAATGATTTTGAAGATTGATGACATTCGTAAGCCTGGAGAATCTGAAGAATGAAGACATTGAGA AAACTATGTAGCAAGATCCACTTCTGTGATTAAGTAAATGGATGTCTCGTGATGCATCTACAGTTATTTATTGTTACATCCTTTTCCAGA CACTGTAGATGCTATAATAAAAATAGCTGTTTGGTAACCATAGTTTCACTTGTTCAAAGCTGTGTAATCGTGGGGGTACCATCTCAACTG CTTTTGTATTCATTGTATTAAAAGAATCTGTTTAAACAACCTTTATCTTCTCTTCGGGTTTAAGAAACGTTTATTGTAACAGTAATTAAA TGCTGCCTTAATTGAAGGGGTTTGGGTGGATTTTTTTTTCTCAAAATAAGCTGTAGGGACTATTTTAACAGCTTAAACAGGAGCTCTCAA GATGCACTTTCATATTGAGAGGAATATGGGCTTGATCCTCTTCCTATCTAAATGGGTGGGCCATTTGATTGTAGAGGGTCCACCACAGAA TTATGGGATGCCTTAAGTGCTGTTACTAGGTTGCTCACAGCCTAACCTGGCGTGTTGTTTAGGGCTGATGGAGACCCATGTGAGCCTTTG CTTTCCTCTGGCCCCGGCCCCACCCTGAACACAGCTCATACACAGAATCAGGACCAGCATGTGCAGAGCTGGCCACCAGCACAGGCTTAG GGCAGTTCAGAACCCACTTGTTTCCCTATCAGAGGGACACAGTGAAGTGGAGGTTAAAGTAAATTACAGGAAATAAGGGAGAAATCTTGC AGTTACCATGTTCAGATAGAGTGACTGAAATTAATTGTACTTACTAAAGTATTAACTAGCTAACAGTGATGGGCCAAGACGCTCCGAGAA CTCTACCGGGATTGTCTGTTCTGACAACCCAGTGAGGCAGATACACTTTCTTACTGCTCACATCTTACAGGTGAGTACTCATAATTGGCC AGCATCTCACCACCAGCAAGTAGTAGGGCCAGGTCAATCCCAGGCAGTCTGACCCCAGAGTGGCCCAGCTCATCCCCTACTCTGTTATTT GCTTGTTAATGATTCTCTAGATTTTCTAAAATAATGTTTCTTAGCATTGTGATGATAAAGCTCATGATGAACTTTATCACTAGTTATGCC ACCTTAACTAGTCAGATTTCCTAGAATTAGGAAATGGTGACTCTTGTCTAAATTTGGTTAAGTGATGAATTTGGGTTACCGTCTCATGTG AACCTGGAGATTCACCAGTCTTAACTTTTGGGTCATTGTGTTTTCTCTACATTCATGCATTGGATGTTTTGCTAAATAACTCCTGTGGAT TTAGGAATGTGTGCTAATAGCAATCTTCCTAATTTTCATGTTTATATGGAACTATGCAGTTGAGTATTGAAAGCTTTAAACTGAGTTTAT TTACAAGGACTGAGTCTAGCCTACAGAGAACATACAGCAGCCTTCTTTGGACCACAGTCTTATCCGAGGGGTCTGTGGTTGTATCAGAAG AGCCACTAAACCAATCCCCCTTTCCAAAATTGAACCTCACAGACGTTCCTGTTTTTTGTGATTGAGAAACTGGTCAATGAACAGGAAGAC |
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FusionGenePPI for CNN1_CCT5 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CNN1 | TPM1, ACTA1, CALM1, MYO1A, TNNC1, DNMBP, TUBB, ADRB2, MTHFD1, MTHFD1L, MYEOV, RNF150 | CCT5 | XRN1, THEG, SSSCA1, HDAC3, ACTB, TBC1D17, IKBKAP, IMMT, TP53, PPP4C, CTTNBP2, MOB4, PPP2CA, STK24, STRN, STRN3, TRAF3IP3, PPP2CB, PPP2R2C, IGBP1, TCP1, ACTA2, ACTA1, GPN1, HNRNPH1, RPAP2, RPAP3, CDK9, RFWD2, SRRM2, SRRM1, WDR82, H2AFX, UBC, MYC, PPP2R2A, PPP2R2B, PPP2R2D, PPP2R4, AGO4, HDAC5, PCK1, VHL, SIRT7, FBXO25, CUL3, CUL4A, CDK2, GNB5, GNB1, RGS7, PDCL, GRB2, PACRG, CCT2, CCT3, CCT8, CCT6A, CCT4, CCT7, CCT6B, AHCYL1, IARS, TARS, PSMA6, PSMB1, VCP, SSR1, XPO1, SLU7, TXNL1, SRSF2, ATXN2, TRIM28, FN1, VCAM1, ATF2, PEX14, NOS2, FAM86B2, METTL21B, ITGA4, PAN2, HDAC6, FBXW4, TERT, FBXO6, CDK5, ILK, CDC20, LGALS3BP, NEDD1, TUBG1, HUWE1, FUS, CUL7, OBSL1, RNF2, SIRT6, IKBKE, IRAK1, SGK2, TSSK6, TYK2, WDR76, POC1A, PEX7, RPS6KB2, DCAF7, UNK, ACTR2, AHNAK, HSPE1, PIN4, STUB1, NTRK1, BTRC, B9D1, MKS1, CETN2, CDK1, DDB2, HDAC1, PDK3, NSMAF, NIPSNAP1, PRPF4, BUB3, WRAP53, RFWD3, KIF21A, SEH1L, KBTBD7, TUBA1C, ARMC6, GAN, CRY2, ALKBH3, MCM2, SNW1, CDC5L, TTC27, NLE1, CDC73, CRBN, PPM1J, KLHDC8A, DNAI2, HCFC2, WDR77, DCAF11, KDM4B, KLHL33, KLHDC2, TXNDC9, WDR86, TBL1Y, DCAF8, THOC3, WDTC1, GANAB, ODF1, DCAF5, SEC31B, TSSC1, WDR83, CYLD, WDR92, TRIM25, MCPH1, HEY1, BRCA1, YAP1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CNN1_CCT5 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CNN1_CCT5 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | CCT5 | C0019693 | HIV Infections | 1 | CTD_human |
| Tgene | CCT5 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| Tgene | CCT5 | C1850395 | Neuropathy, Hereditary Sensory, with Spastic Paraplegia, Autosomal Recessive | 1 | CTD_human;ORPHANET;UNIPROT |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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