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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 765

FusionGeneSummary for ADAMTSL1_WNT5B

check button Fusion gene summary
Fusion gene informationFusion gene name: ADAMTSL1_WNT5B
Fusion gene ID: 765
HgeneTgene
Gene symbol

ADAMTSL1

WNT5B

Gene ID

92949

81029

Gene nameADAMTS like 1Wnt family member 5B
SynonymsADAMTSL-1|ADAMTSR1|C9orf94|PUNCTIN-
Cytomap

9p22.2-p22.1

12p13.33

Type of geneprotein-codingprotein-coding
DescriptionADAMTS-like protein 1ADAM-TS related protein 1punctin-1protein Wnt-5bWNT-5B proteinwingless-type MMTV integration site family, member 5B
Modification date2018052220180523
UniProtAcc

Q8N6G6

Q9H1J7

Ensembl transtripts involved in fusion geneENST00000380548, ENST00000380545, 
ENST00000327883, ENST00000431052, 
ENST00000380570, ENST00000380566, 
ENST00000276935, ENST00000496521, 
ENST00000537031, ENST00000310594, 
ENST00000397196, ENST00000542408, 
ENST00000545747, 
Fusion gene scores* DoF score2 X 2 X 2=85 X 2 X 3=30
# samples 25
** MAII scorelog2(2/8*10)=1.32192809488736log2(5/30*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ADAMTSL1 [Title/Abstract] AND WNT5B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneWNT5B

GO:0016055

Wnt signaling pathway

15731909

TgeneWNT5B

GO:0030335

positive regulation of cell migration

19486338


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-FR-A7U9-06AADAMTSL1chr9

18474293

+WNT5Bchr12

1740464

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000380548ENST00000537031ADAMTSL1chr9

18474293

+WNT5Bchr12

1740464

+
5CDS-5UTRENST00000380548ENST00000310594ADAMTSL1chr9

18474293

+WNT5Bchr12

1740464

+
5CDS-5UTRENST00000380548ENST00000397196ADAMTSL1chr9

18474293

+WNT5Bchr12

1740464

+
5CDS-intronENST00000380548ENST00000542408ADAMTSL1chr9

18474293

+WNT5Bchr12

1740464

+
5CDS-intronENST00000380548ENST00000545747ADAMTSL1chr9

18474293

+WNT5Bchr12

1740464

+
intron-5UTRENST00000380545ENST00000537031ADAMTSL1chr9

18474293

+WNT5Bchr12

1740464

+
intron-5UTRENST00000380545ENST00000310594ADAMTSL1chr9

18474293

+WNT5Bchr12

1740464

+
intron-5UTRENST00000380545ENST00000397196ADAMTSL1chr9

18474293

+WNT5Bchr12

1740464

+
intron-intronENST00000380545ENST00000542408ADAMTSL1chr9

18474293

+WNT5Bchr12

1740464

+
intron-intronENST00000380545ENST00000545747ADAMTSL1chr9

18474293

+WNT5Bchr12

1740464

+
5CDS-5UTRENST00000327883ENST00000537031ADAMTSL1chr9

18474293

+WNT5Bchr12

1740464

+
5CDS-5UTRENST00000327883ENST00000310594ADAMTSL1chr9

18474293

+WNT5Bchr12

1740464

+
5CDS-5UTRENST00000327883ENST00000397196ADAMTSL1chr9

18474293

+WNT5Bchr12

1740464

+
5CDS-intronENST00000327883ENST00000542408ADAMTSL1chr9

18474293

+WNT5Bchr12

1740464

+
5CDS-intronENST00000327883ENST00000545747ADAMTSL1chr9

18474293

+WNT5Bchr12

1740464

+
5CDS-5UTRENST00000431052ENST00000537031ADAMTSL1chr9

18474293

+WNT5Bchr12

1740464

+
5CDS-5UTRENST00000431052ENST00000310594ADAMTSL1chr9

18474293

+WNT5Bchr12

1740464

+
5CDS-5UTRENST00000431052ENST00000397196ADAMTSL1chr9

18474293

+WNT5Bchr12

1740464

+
5CDS-intronENST00000431052ENST00000542408ADAMTSL1chr9

18474293

+WNT5Bchr12

1740464

+
5CDS-intronENST00000431052ENST00000545747ADAMTSL1chr9

18474293

+WNT5Bchr12

1740464

+
5CDS-5UTRENST00000380570ENST00000537031ADAMTSL1chr9

18474293

+WNT5Bchr12

1740464

+
5CDS-5UTRENST00000380570ENST00000310594ADAMTSL1chr9

18474293

+WNT5Bchr12

1740464

+
5CDS-5UTRENST00000380570ENST00000397196ADAMTSL1chr9

18474293

+WNT5Bchr12

1740464

+
5CDS-intronENST00000380570ENST00000542408ADAMTSL1chr9

18474293

+WNT5Bchr12

1740464

+
5CDS-intronENST00000380570ENST00000545747ADAMTSL1chr9

18474293

+WNT5Bchr12

1740464

+
5CDS-5UTRENST00000380566ENST00000537031ADAMTSL1chr9

18474293

+WNT5Bchr12

1740464

+
5CDS-5UTRENST00000380566ENST00000310594ADAMTSL1chr9

18474293

+WNT5Bchr12

1740464

+
5CDS-5UTRENST00000380566ENST00000397196ADAMTSL1chr9

18474293

+WNT5Bchr12

1740464

+
5CDS-intronENST00000380566ENST00000542408ADAMTSL1chr9

18474293

+WNT5Bchr12

1740464

+
5CDS-intronENST00000380566ENST00000545747ADAMTSL1chr9

18474293

+WNT5Bchr12

1740464

+
5CDS-5UTRENST00000276935ENST00000537031ADAMTSL1chr9

18474293

+WNT5Bchr12

1740464

+
5CDS-5UTRENST00000276935ENST00000310594ADAMTSL1chr9

18474293

+WNT5Bchr12

1740464

+
5CDS-5UTRENST00000276935ENST00000397196ADAMTSL1chr9

18474293

+WNT5Bchr12

1740464

+
5CDS-intronENST00000276935ENST00000542408ADAMTSL1chr9

18474293

+WNT5Bchr12

1740464

+
5CDS-intronENST00000276935ENST00000545747ADAMTSL1chr9

18474293

+WNT5Bchr12

1740464

+
intron-5UTRENST00000496521ENST00000537031ADAMTSL1chr9

18474293

+WNT5Bchr12

1740464

+
intron-5UTRENST00000496521ENST00000310594ADAMTSL1chr9

18474293

+WNT5Bchr12

1740464

+
intron-5UTRENST00000496521ENST00000397196ADAMTSL1chr9

18474293

+WNT5Bchr12

1740464

+
intron-intronENST00000496521ENST00000542408ADAMTSL1chr9

18474293

+WNT5Bchr12

1740464

+
intron-intronENST00000496521ENST00000545747ADAMTSL1chr9

18474293

+WNT5Bchr12

1740464

+

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FusionProtFeatures for ADAMTSL1_WNT5B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ADAMTSL1

Q8N6G6

WNT5B

Q9H1J7

Ligand for members of the frizzled family of seventransmembrane receptors. Probable developmental protein. May be asignaling molecule which affects the development of discreteregions of tissues. Is likely to signal over only few celldiameters (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ADAMTSL1_WNT5B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ADAMTSL1_WNT5B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ADAMTSL1B3GALTL, FHL2, RSPRY1, C2orf44, ACOX1, FBN2, GRNWNT5BAPPBP2, WNT5A, KLRG2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ADAMTSL1_WNT5B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ADAMTSL1_WNT5B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneWNT5BC0010606Adenoid Cystic Carcinoma1CTD_human
TgeneWNT5BC0023267Fibroid Tumor1CTD_human
TgeneWNT5BC0036095Salivary Gland Neoplasms1CTD_human