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Fusion gene ID: 7646 |
FusionGeneSummary for CNDP2_ALKBH5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CNDP2_ALKBH5 | Fusion gene ID: 7646 | Hgene | Tgene | Gene symbol | CNDP2 | ALKBH5 | Gene ID | 55748 | 54890 |
| Gene name | carnosine dipeptidase 2 | alkB homolog 5, RNA demethylase | |
| Synonyms | CN2|CPGL|HEL-S-13|HsT2298|PEPA | ABH5|OFOXD|OFOXD1 | |
| Cytomap | 18q22.3 | 17p11.2|17p11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cytosolic non-specific dipeptidaseCNDP dipeptidase 2 (metallopeptidase M20 family)carnosinase-2carnosine dipeptidase IIcytosolic nonspecific dipeptidaseepididymis secretory protein Li 13glutamate carboxypeptidase-like protein 1peptidase A | RNA demethylase ALKBH5AlkB family member 5, RNA demethylasealkB, alkylation repair homolog 5alkylated DNA repair protein alkB homolog 5alpha-ketoglutarate-dependent dioxygenase alkB homolog 5oxoglutarate and iron-dependent oxygenase domain containing | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q96KP4 | Q6P6C2 | |
| Ensembl transtripts involved in fusion gene | ENST00000324262, ENST00000579847, ENST00000580229, ENST00000324301, | ENST00000541285, ENST00000399138, | |
| Fusion gene scores | * DoF score | 6 X 6 X 2=72 | 8 X 5 X 5=200 |
| # samples | 7 | 7 | |
| ** MAII score | log2(7/72*10)=-0.0406419844973459 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/200*10)=-1.51457317282976 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CNDP2 [Title/Abstract] AND ALKBH5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ALKBH5 | GO:0001666 | response to hypoxia | 21264265 |
| Tgene | ALKBH5 | GO:0035553 | oxidative single-stranded RNA demethylation | 23177736 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AI906669 | CNDP2 | chr18 | 72187366 | + | ALKBH5 | chr17 | 18112581 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3UTR | ENST00000324262 | ENST00000541285 | CNDP2 | chr18 | 72187366 | + | ALKBH5 | chr17 | 18112581 | - |
| 3UTR-3UTR | ENST00000324262 | ENST00000399138 | CNDP2 | chr18 | 72187366 | + | ALKBH5 | chr17 | 18112581 | - |
| 3UTR-3UTR | ENST00000579847 | ENST00000541285 | CNDP2 | chr18 | 72187366 | + | ALKBH5 | chr17 | 18112581 | - |
| 3UTR-3UTR | ENST00000579847 | ENST00000399138 | CNDP2 | chr18 | 72187366 | + | ALKBH5 | chr17 | 18112581 | - |
| intron-3UTR | ENST00000580229 | ENST00000541285 | CNDP2 | chr18 | 72187366 | + | ALKBH5 | chr17 | 18112581 | - |
| intron-3UTR | ENST00000580229 | ENST00000399138 | CNDP2 | chr18 | 72187366 | + | ALKBH5 | chr17 | 18112581 | - |
| 3UTR-3UTR | ENST00000324301 | ENST00000541285 | CNDP2 | chr18 | 72187366 | + | ALKBH5 | chr17 | 18112581 | - |
| 3UTR-3UTR | ENST00000324301 | ENST00000399138 | CNDP2 | chr18 | 72187366 | + | ALKBH5 | chr17 | 18112581 | - |
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FusionProtFeatures for CNDP2_ALKBH5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CNDP2 | ALKBH5 |
| Hydrolyzes a variety of dipeptides including L-carnosinebut has a strong preference for Cys-Gly (PubMed:19346245). Acts asa functional tumor suppressor in gastric cancer via activation ofthe mitogen-activated protein kinase (MAPK) pathway. An elevatedlevel of CNDP2 activates the p38 and JNK MAPK pathways to inducecell apoptosis, and a lower level of CNDP2 activates the ERK MAPKpathway to promote cell proliferation (PubMed:24395568). Isoform 2may play a role as tumor suppressor in hepatocellular carcinoma(HCC) cells (PubMed:17121880). Catalyzes the production of N-lactoyl-amino acids from lactate and amino acids by reverseproteolysis (PubMed:25964343). {ECO:0000269|PubMed:17121880,ECO:0000269|PubMed:19346245, ECO:0000269|PubMed:24395568,ECO:0000269|PubMed:25964343}. | Dioxygenase that demethylates RNA by oxidativedemethylation: specifically demethylates N(6)-methyladenosine(m6A) RNA, the most prevalent internal modification of messengerRNA (mRNA) in higher eukaryotes (PubMed:23177736, PubMed:24778178,PubMed:24616105, PubMed:24489119). Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro)(PubMed:24616105). Requires molecular oxygen, alpha-ketoglutarateand iron (PubMed:21264265, PubMed:23177736, PubMed:24778178,PubMed:24616105, PubMed:24489119). Demethylation of m6A mRNAaffects mRNA processing and export (PubMed:23177736). Required forspermatogenesis (By similarity). {ECO:0000250|UniProtKB:Q3TSG4,ECO:0000269|PubMed:21264265, ECO:0000269|PubMed:23177736,ECO:0000269|PubMed:24489119, ECO:0000269|PubMed:24616105,ECO:0000269|PubMed:24778178}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CNDP2_ALKBH5 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CNDP2_ALKBH5 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CNDP2_ALKBH5 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CNDP2_ALKBH5 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CNDP2 | C0011881 | Diabetic Nephropathy | 1 | CTD_human |
| Hgene | CNDP2 | C0015695 | Fatty Liver | 1 | CTD_human |
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