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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 7645

FusionGeneSummary for CNBP_USP6

check button Fusion gene summary
Fusion gene informationFusion gene name: CNBP_USP6
Fusion gene ID: 7645
HgeneTgene
Gene symbol

CNBP

USP6

Gene ID

7555

9098

Gene nameCCHC-type zinc finger nucleic acid binding proteinubiquitin specific peptidase 6
SynonymsCNBP1|DM2|PROMM|RNF163|ZCCHC22|ZNF9HRP1|TRE17|TRE2|TRESMCR|Tre-2|USP6-short
Cytomap

3q21.3

17p13.2

Type of geneprotein-codingprotein-coding
Descriptioncellular nucleic acid-binding proteinerythroid differentiation-relatedsterol regulatory element-binding proteinzinc finger protein 273zinc finger protein 9 (a cellular retroviral nucleic acid binding protein)ubiquitin carboxyl-terminal hydrolase 6TBC1D3 and USP32 fusiondeubiquitinating enzyme 6hyperpolymorphic gene 1proto-oncogene TRE-2ubiquitin specific peptidase 6 (Tre-2 oncogene)ubiquitin specific protease 6 (Tre-2 oncogene)ubiquitin thioesterase 6
Modification date2018051920180523
UniProtAcc

P62633

P35125

Ensembl transtripts involved in fusion geneENST00000502976, ENST00000422453, 
ENST00000451728, ENST00000446936, 
ENST00000500450, ENST00000504813, 
ENST00000441626, 
ENST00000332776, 
ENST00000574788, ENST00000304328, 
ENST00000250066, ENST00000572429, 
Fusion gene scores* DoF score4 X 3 X 3=366 X 5 X 1=30
# samples 512
** MAII scorelog2(5/36*10)=0.473931188332412
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(12/30*10)=2
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CNBP [Title/Abstract] AND USP6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCNBP

GO:0000122

negative regulation of transcription by RNA polymerase II

23774591

TgeneUSP6

GO:0016579

protein deubiquitination

16127172

TgeneUSP6

GO:0060627

regulation of vesicle-mediated transport

15509780


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AY624557CNBPchr3

128902618

-USP6chr17

5033229

+
ChiTaRS3.1AY624556CNBPchr3

128902618

-USP6chr17

5033660

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-5UTRENST00000502976ENST00000332776CNBPchr3

128902618

-USP6chr17

5033229

+
5UTR-5UTRENST00000502976ENST00000574788CNBPchr3

128902618

-USP6chr17

5033229

+
5UTR-5UTRENST00000502976ENST00000304328CNBPchr3

128902618

-USP6chr17

5033229

+
5UTR-5UTRENST00000502976ENST00000250066CNBPchr3

128902618

-USP6chr17

5033229

+
5UTR-intronENST00000502976ENST00000572429CNBPchr3

128902618

-USP6chr17

5033229

+
5UTR-5UTRENST00000422453ENST00000332776CNBPchr3

128902618

-USP6chr17

5033229

+
5UTR-5UTRENST00000422453ENST00000574788CNBPchr3

128902618

-USP6chr17

5033229

+
5UTR-5UTRENST00000422453ENST00000304328CNBPchr3

128902618

-USP6chr17

5033229

+
5UTR-5UTRENST00000422453ENST00000250066CNBPchr3

128902618

-USP6chr17

5033229

+
5UTR-intronENST00000422453ENST00000572429CNBPchr3

128902618

-USP6chr17

5033229

+
5UTR-5UTRENST00000451728ENST00000332776CNBPchr3

128902618

-USP6chr17

5033229

+
5UTR-5UTRENST00000451728ENST00000574788CNBPchr3

128902618

-USP6chr17

5033229

+
5UTR-5UTRENST00000451728ENST00000304328CNBPchr3

128902618

-USP6chr17

5033229

+
5UTR-5UTRENST00000451728ENST00000250066CNBPchr3

128902618

-USP6chr17

5033229

+
5UTR-intronENST00000451728ENST00000572429CNBPchr3

128902618

-USP6chr17

5033229

+
5UTR-5UTRENST00000446936ENST00000332776CNBPchr3

128902618

-USP6chr17

5033229

+
5UTR-5UTRENST00000446936ENST00000574788CNBPchr3

128902618

-USP6chr17

5033229

+
5UTR-5UTRENST00000446936ENST00000304328CNBPchr3

128902618

-USP6chr17

5033229

+
5UTR-5UTRENST00000446936ENST00000250066CNBPchr3

128902618

-USP6chr17

5033229

+
5UTR-intronENST00000446936ENST00000572429CNBPchr3

128902618

-USP6chr17

5033229

+
5UTR-5UTRENST00000500450ENST00000332776CNBPchr3

128902618

-USP6chr17

5033229

+
5UTR-5UTRENST00000500450ENST00000574788CNBPchr3

128902618

-USP6chr17

5033229

+
5UTR-5UTRENST00000500450ENST00000304328CNBPchr3

128902618

-USP6chr17

5033229

+
5UTR-5UTRENST00000500450ENST00000250066CNBPchr3

128902618

-USP6chr17

5033229

+
5UTR-intronENST00000500450ENST00000572429CNBPchr3

128902618

-USP6chr17

5033229

+
5UTR-5UTRENST00000504813ENST00000332776CNBPchr3

128902618

-USP6chr17

5033229

+
5UTR-5UTRENST00000504813ENST00000574788CNBPchr3

128902618

-USP6chr17

5033229

+
5UTR-5UTRENST00000504813ENST00000304328CNBPchr3

128902618

-USP6chr17

5033229

+
5UTR-5UTRENST00000504813ENST00000250066CNBPchr3

128902618

-USP6chr17

5033229

+
5UTR-intronENST00000504813ENST00000572429CNBPchr3

128902618

-USP6chr17

5033229

+
5UTR-5UTRENST00000441626ENST00000332776CNBPchr3

128902618

-USP6chr17

5033229

+
5UTR-5UTRENST00000441626ENST00000574788CNBPchr3

128902618

-USP6chr17

5033229

+
5UTR-5UTRENST00000441626ENST00000304328CNBPchr3

128902618

-USP6chr17

5033229

+
5UTR-5UTRENST00000441626ENST00000250066CNBPchr3

128902618

-USP6chr17

5033229

+
5UTR-intronENST00000441626ENST00000572429CNBPchr3

128902618

-USP6chr17

5033229

+
5UTR-5UTRENST00000502976ENST00000332776CNBPchr3

128902618

-USP6chr17

5033660

+
5UTR-5UTRENST00000502976ENST00000574788CNBPchr3

128902618

-USP6chr17

5033660

+
5UTR-5UTRENST00000502976ENST00000304328CNBPchr3

128902618

-USP6chr17

5033660

+
5UTR-5UTRENST00000502976ENST00000250066CNBPchr3

128902618

-USP6chr17

5033660

+
5UTR-intronENST00000502976ENST00000572429CNBPchr3

128902618

-USP6chr17

5033660

+
5UTR-5UTRENST00000422453ENST00000332776CNBPchr3

128902618

-USP6chr17

5033660

+
5UTR-5UTRENST00000422453ENST00000574788CNBPchr3

128902618

-USP6chr17

5033660

+
5UTR-5UTRENST00000422453ENST00000304328CNBPchr3

128902618

-USP6chr17

5033660

+
5UTR-5UTRENST00000422453ENST00000250066CNBPchr3

128902618

-USP6chr17

5033660

+
5UTR-intronENST00000422453ENST00000572429CNBPchr3

128902618

-USP6chr17

5033660

+
5UTR-5UTRENST00000451728ENST00000332776CNBPchr3

128902618

-USP6chr17

5033660

+
5UTR-5UTRENST00000451728ENST00000574788CNBPchr3

128902618

-USP6chr17

5033660

+
5UTR-5UTRENST00000451728ENST00000304328CNBPchr3

128902618

-USP6chr17

5033660

+
5UTR-5UTRENST00000451728ENST00000250066CNBPchr3

128902618

-USP6chr17

5033660

+
5UTR-intronENST00000451728ENST00000572429CNBPchr3

128902618

-USP6chr17

5033660

+
5UTR-5UTRENST00000446936ENST00000332776CNBPchr3

128902618

-USP6chr17

5033660

+
5UTR-5UTRENST00000446936ENST00000574788CNBPchr3

128902618

-USP6chr17

5033660

+
5UTR-5UTRENST00000446936ENST00000304328CNBPchr3

128902618

-USP6chr17

5033660

+
5UTR-5UTRENST00000446936ENST00000250066CNBPchr3

128902618

-USP6chr17

5033660

+
5UTR-intronENST00000446936ENST00000572429CNBPchr3

128902618

-USP6chr17

5033660

+
5UTR-5UTRENST00000500450ENST00000332776CNBPchr3

128902618

-USP6chr17

5033660

+
5UTR-5UTRENST00000500450ENST00000574788CNBPchr3

128902618

-USP6chr17

5033660

+
5UTR-5UTRENST00000500450ENST00000304328CNBPchr3

128902618

-USP6chr17

5033660

+
5UTR-5UTRENST00000500450ENST00000250066CNBPchr3

128902618

-USP6chr17

5033660

+
5UTR-intronENST00000500450ENST00000572429CNBPchr3

128902618

-USP6chr17

5033660

+
5UTR-5UTRENST00000504813ENST00000332776CNBPchr3

128902618

-USP6chr17

5033660

+
5UTR-5UTRENST00000504813ENST00000574788CNBPchr3

128902618

-USP6chr17

5033660

+
5UTR-5UTRENST00000504813ENST00000304328CNBPchr3

128902618

-USP6chr17

5033660

+
5UTR-5UTRENST00000504813ENST00000250066CNBPchr3

128902618

-USP6chr17

5033660

+
5UTR-intronENST00000504813ENST00000572429CNBPchr3

128902618

-USP6chr17

5033660

+
5UTR-5UTRENST00000441626ENST00000332776CNBPchr3

128902618

-USP6chr17

5033660

+
5UTR-5UTRENST00000441626ENST00000574788CNBPchr3

128902618

-USP6chr17

5033660

+
5UTR-5UTRENST00000441626ENST00000304328CNBPchr3

128902618

-USP6chr17

5033660

+
5UTR-5UTRENST00000441626ENST00000250066CNBPchr3

128902618

-USP6chr17

5033660

+
5UTR-intronENST00000441626ENST00000572429CNBPchr3

128902618

-USP6chr17

5033660

+

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FusionProtFeatures for CNBP_USP6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CNBP

P62633

USP6

P35125

Deubiquitinase with an ATP-independent isopeptidaseactivity, cleaving at the C-terminus of the ubiquitin moiety.Catalyzes its own deubiquitination. In vitro, isoform 2, but notisoform 3, shows deubiquitinating activity. Promotes plasmamembrane localization of ARF6 and selectively regulates ARF6-dependent endocytic protein trafficking. Is able to initiatetumorigenesis by inducing the production of matrixmetalloproteinases following NF-kappa-B activation.{ECO:0000269|PubMed:15509780, ECO:0000269|PubMed:16127172,ECO:0000269|PubMed:20418905}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CNBP_USP6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CNBP_USP6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CNBPIGF2BP1, RPL3, HNRNPC, PURA, RPS3A, DHX9, HNRNPAB, RPL34, IGF2BP3, BRIX1, RPL23A, RBMX, HNRNPR, RPL31, RPL35A, RPS16, APOBEC3C, RPA3, RPL36, RPS19, ERH, EBNA1BP2, HNRNPUL1, SYNCRIP, HNRNPA3, RSL1D1, DAP3, FKTN, MYH4, ZWINT, KCND3, VCAM1, ITGA4, PAN2, MAPK14, BZW2, DFFA, EIF6, FERMT2, HSPA9, PFAS, EZH2, SUZ12, RNF2, BMI1, CDK2, MARK3, WEE1, CADM1, HK2, NMD3, PABPC3, PABPC4, CASP8, HIST1H3E, EGFR, TRIM56, HIST1H1A, NLE1, ZNF275, ITGB3BP, RPL18, RPF2, RPL26L1, DDX31, RPLP0, RPL27, GTPBP4, RPLP2, GNL2, ZC3HAV1, RPF1, RPL4, RPL10A, RPL18A, KIAA0020, ZNF689, STAU1, RPL32, RPS8, CENPN, RPL37A, PAK1IP1, RPL13, RPL14, RRS1, RPL15, CENPU, ZNF184, WHSC1, ZNF800, RPL12, GLYR1, RPS6, RSL24D1, RRP8, RPL6, TTF1, ZFP62, ZNF512, DDX27, REPIN1, RPLP1, ZNF48, RPL30, RPL7, RPS13, RPL8, C8orf33, NSA2, RBM34, ZSCAN25, DDX24, SURF6, FTSJ3, NIP7, RPL11, DKC1, RPL5, PPAN-P2RY11, NOL12, NOP56, POP1, NOP2, DHX30, DDX21, FCF1, RPL7A, MAK16, RPL13A, RBM28, RPL7L1, LLPH, PAPD5, ABT1, ZNF771, GLTSCR2, CCDC137, NR3C1, ARUSP6USP32, CALM2, RAC1, CDC42, RAB33B, ARF6, MYL2, ANKRD44, ATXN7L3, APP, MDFI, EXOSC8, KRAS, JUN


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CNBP_USP6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CNBP_USP6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource