FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 7630

FusionGeneSummary for CMTM8_RPN1

check button Fusion gene summary
Fusion gene informationFusion gene name: CMTM8_RPN1
Fusion gene ID: 7630
HgeneTgene
Gene symbol

CMTM8

RPN1

Gene ID

152189

6184

Gene nameCKLF like MARVEL transmembrane domain containing 8ribophorin I
SynonymsCKLFSF8|CKLFSF8-V2OST1|RBPH1
Cytomap

3p22.3

3q21.3

Type of geneprotein-codingprotein-coding
DescriptionCKLF-like MARVEL transmembrane domain-containing protein 8chemokine-like factor superfamily member 8dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1RPN-Idolichyl-diphosphooligosaccharide-protein glycosyltransferase 67 kDa subunitoligosaccharyltransferase 1 homologoligosaccharyltransferase complex subunit (non-catalytic)ribop
Modification date2018052320180523
UniProtAcc

Q8IZV2

P04843

Ensembl transtripts involved in fusion geneENST00000458535, ENST00000307526, 
ENST00000296255, ENST00000497289, 
ENST00000490166, 
Fusion gene scores* DoF score6 X 1 X 4=247 X 5 X 5=175
# samples 67
** MAII scorelog2(6/24*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(7/175*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CMTM8 [Title/Abstract] AND RPN1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-W3-AA1R-06ACMTM8chr3

32280611

+RPN1chr3

128345675

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000458535ENST00000296255CMTM8chr3

32280611

+RPN1chr3

128345675

-
Frame-shiftENST00000458535ENST00000497289CMTM8chr3

32280611

+RPN1chr3

128345675

-
5CDS-5UTRENST00000458535ENST00000490166CMTM8chr3

32280611

+RPN1chr3

128345675

-
Frame-shiftENST00000307526ENST00000296255CMTM8chr3

32280611

+RPN1chr3

128345675

-
Frame-shiftENST00000307526ENST00000497289CMTM8chr3

32280611

+RPN1chr3

128345675

-
5CDS-5UTRENST00000307526ENST00000490166CMTM8chr3

32280611

+RPN1chr3

128345675

-

Top

FusionProtFeatures for CMTM8_RPN1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CMTM8

Q8IZV2

RPN1

P04843

Essential subunit of the N-oligosaccharyl transferase(OST) complex which catalyzes the transfer of a high mannoseoligosaccharide from a lipid-linked oligosaccharide donor to anasparagine residue within an Asn-X-Ser/Thr consensus motif innascent polypeptide chains. {ECO:0000250|UniProtKB:E2RQ08,ECO:0000250|UniProtKB:Q9GMB0, ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for CMTM8_RPN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for CMTM8_RPN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CMTM8TRIM25RPN1GSTK1, USP49, SLX4IP, ERBB3, FOXRED2, SEL1L, RNF185, MYC, HDAC5, INSIG2, CDK9, NELFB, ELAVL1, OS9, FBXO25, CUL3, COPS5, UBQLN4, NHS, HSPA5, FBXO6, STT3B, RPN2, SSR3, RPSA, TECR, ILF3, SLC25A5, VDAC2, SYNCRIP, SND1, ESR1, ECT2, VCP, FN1, VCAM1, ATF2, UBL4A, MMS19, OST4, CLN3, CLN5, ADRB2, EGFR, ASB5, ASB11, LGR4, STAU1, SGTA, UBQLN1, EED, RNF2, BMI1, ILK, SCCPDH, RPS6KB2, ATP5C1, CANX, CCDC47, CLGN, CYC1, IDH3A, COX2, NDUFA12, NDUFB8, PC, PPIB, RAB2A, RPL35, ABCB7, ACADM, AFG3L2, ATAD3A, ATAD3B, ATP1A1, ATP5A1, ATP5L, ATP6V0D1, ATP6V1A, BCAP29, CCT3, CCT6A, CCT7, CCT8, CDC5L, CLTC, DDOST, DDX39A, DDX39B, EIF2S1, EIF3M, HNRNPU, HSD17B12, HSP90B1, IPO5, IPO9, KDSR, MTCH1, MTCH2, NDUFB9, NOMO1, NOMO2, PDIA6, PKM, PPP2R1A, PPP2R1B, PRPF19, PSMC1, PSMC2, PSMC3, PSMC5, RAB1A, RAB1B, RAB5A, RAB5B, RAB5C, RDH13, SCAMP2, SLC25A3, SSR2, SUCLG2, TCP1, TMCO1, UQCRC2, VDAC1, VDAC3, SSR1, SSR4, TUFM, NTRK1, SCARNA22, BAG6, TCTN2, TCTN3, EVC2, TCTN1, TMEM67, TUBG1, TMEM63B, TUBA1C, CRY2, MCM2, U2AF2, RC3H1, UBC, TMEM258, CDC73, DERL1, ZNF746, NCDN, COX15, DLST, PDHA1, SDHA, EDEM3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for CMTM8_RPN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for CMTM8_RPN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource