FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 7625

FusionGeneSummary for CMTM7_METTL2B

check button Fusion gene summary
Fusion gene informationFusion gene name: CMTM7_METTL2B
Fusion gene ID: 7625
HgeneTgene
Gene symbol

CMTM7

METTL2B

Gene ID

112616

55798

Gene nameCKLF like MARVEL transmembrane domain containing 7methyltransferase like 2B
SynonymsCKLFSF7METL|METTL2|METTL2A|PSENIP1
Cytomap

3p22.3

7q32.1

Type of geneprotein-codingprotein-coding
DescriptionCKLF-like MARVEL transmembrane domain-containing protein 7chemokine-like factor super family 7chemokine-like factor super family member 7 variant 2chemokine-like factor superfamily 7chemokine-like factor superfamily member 7methyltransferase-like protein 2B
Modification date2018052320180523
UniProtAcc

Q96FZ5

Q6P1Q9

Ensembl transtripts involved in fusion geneENST00000334983, ENST00000349718, 
ENST00000262432, ENST00000480046, 
ENST00000473488, 
Fusion gene scores* DoF score7 X 4 X 5=1403 X 3 X 3=27
# samples 73
** MAII scorelog2(7/140*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CMTM7 [Title/Abstract] AND METTL2B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-24-1549-01ACMTM7chr3

32433557

+METTL2Bchr7

128119212

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000334983ENST00000262432CMTM7chr3

32433557

+METTL2Bchr7

128119212

+
Frame-shiftENST00000334983ENST00000480046CMTM7chr3

32433557

+METTL2Bchr7

128119212

+
5CDS-intronENST00000334983ENST00000473488CMTM7chr3

32433557

+METTL2Bchr7

128119212

+
Frame-shiftENST00000349718ENST00000262432CMTM7chr3

32433557

+METTL2Bchr7

128119212

+
Frame-shiftENST00000349718ENST00000480046CMTM7chr3

32433557

+METTL2Bchr7

128119212

+
5CDS-intronENST00000349718ENST00000473488CMTM7chr3

32433557

+METTL2Bchr7

128119212

+

Top

FusionProtFeatures for CMTM7_METTL2B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CMTM7

Q96FZ5

METTL2B

Q6P1Q9

Probable S-adenosyl-L-methionine-dependentmethyltransferase that mediates 3-methylcytidine modification ofsome tRNAs. {ECO:0000269|PubMed:21518805}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for CMTM7_METTL2B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for CMTM7_METTL2B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CMTM7LMNAMETTL2BAPP, MAPK3, CENPU, METTL2A, NAT16, TPM3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for CMTM7_METTL2B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for CMTM7_METTL2B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource