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Center for Computational Systems Medicine
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FusionGeneSummary

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Fusion gene ID: 7617

FusionGeneSummary for CMTM4_TRIM40

check button Fusion gene summary
Fusion gene informationFusion gene name: CMTM4_TRIM40
Fusion gene ID: 7617
HgeneTgene
Gene symbol

CMTM4

TRIM40

Gene ID

146223

135644

Gene nameCKLF like MARVEL transmembrane domain containing 4tripartite motif containing 40
SynonymsCKLFSF4RNF35
Cytomap

16q21-q22.1

6p22.1

Type of geneprotein-codingprotein-coding
DescriptionCKLF-like MARVEL transmembrane domain-containing protein 4chemokine-like factor super family 4chemokine-like factor superfamily member 4tripartite motif-containing protein 40RING finger protein 35probable E3 NEDD8-protein ligasering finger RNF35
Modification date2018052320180519
UniProtAcc

Q8IZR5

Q6P9F5

Ensembl transtripts involved in fusion geneENST00000330687, ENST00000394106, 
ENST00000563952, 		ENST00000396581, 
ENST00000489892, ENST00000376724, 
ENST00000307859, ENST00000497688, 
ENST00000433713, ENST00000436951, 
ENST00000437563, ENST00000470577, 
ENST00000552119, ENST00000429471, 
ENST00000431397, ENST00000475016, 
ENST00000548672, ENST00000445004, 
ENST00000425845, ENST00000488232, 
ENST00000418267, ENST00000383610, 
ENST00000476094, ENST00000547289, 
ENST00000400651, ENST00000434151, 
ENST00000462556, ENST00000549728, 
ENST00000421981, ENST00000430485, 
ENST00000456884, ENST00000486552, 
Fusion gene scores* DoF score7 X 4 X 5=1403 X 3 X 3=27
# samples 73
** MAII scorelog2(7/140*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CMTM4 [Title/Abstract] AND TRIM40 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTRIM40

GO:0032088

negative regulation of NF-kappaB transcription factor activity

21474709

TgeneTRIM40

GO:0042177

negative regulation of protein catabolic process

21474709

TgeneTRIM40

GO:0045116

protein neddylation

21474709

TgeneTRIM40

GO:1900181

negative regulation of protein localization to nucleus

21474709


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSTADTCGA-R5-A805-01ACMTM4chr16

66730243

-TRIM40chr6

30113771

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000330687ENST00000396581CMTM4chr16

66730243

-TRIM40chr6

30113771

+
5CDS-intronENST00000330687ENST00000489892CMTM4chr16

66730243

-TRIM40chr6

30113771

+
5CDS-intronENST00000330687ENST00000376724CMTM4chr16

66730243

-TRIM40chr6

30113771

+
5CDS-intronENST00000330687ENST00000307859CMTM4chr16

66730243

-TRIM40chr6

30113771

+
5CDS-intronENST00000330687ENST00000497688CMTM4chr16

66730243

-TRIM40chr6

30113771

+
5CDS-intronENST00000330687ENST00000433713CMTM4chr16

66730243

-TRIM40chr6

30113771

+
5CDS-intronENST00000330687ENST00000436951CMTM4chr16

66730243

-TRIM40chr6

30113771

+
5CDS-intronENST00000330687ENST00000437563CMTM4chr16

66730243

-TRIM40chr6

30113771

+
5CDS-intronENST00000330687ENST00000470577CMTM4chr16

66730243

-TRIM40chr6

30113771

+
5CDS-intronENST00000330687ENST00000552119CMTM4chr16

66730243

-TRIM40chr6

30113771

+
5CDS-intronENST00000330687ENST00000429471CMTM4chr16

66730243

-TRIM40chr6

30113771

+
5CDS-intronENST00000330687ENST00000431397CMTM4chr16

66730243

-TRIM40chr6

30113771

+
5CDS-intronENST00000330687ENST00000475016CMTM4chr16

66730243

-TRIM40chr6

30113771

+
5CDS-intronENST00000330687ENST00000548672CMTM4chr16

66730243

-TRIM40chr6

30113771

+
5CDS-intronENST00000330687ENST00000445004CMTM4chr16

66730243

-TRIM40chr6

30113771

+
5CDS-intronENST00000330687ENST00000425845CMTM4chr16

66730243

-TRIM40chr6

30113771

+
5CDS-intronENST00000330687ENST00000488232CMTM4chr16

66730243

-TRIM40chr6

30113771

+
5CDS-intronENST00000330687ENST00000418267CMTM4chr16

66730243

-TRIM40chr6

30113771

+
5CDS-intronENST00000330687ENST00000383610CMTM4chr16

66730243

-TRIM40chr6

30113771

+
5CDS-intronENST00000330687ENST00000476094CMTM4chr16

66730243

-TRIM40chr6

30113771

+
5CDS-intronENST00000330687ENST00000547289CMTM4chr16

66730243

-TRIM40chr6

30113771

+
5CDS-intronENST00000330687ENST00000400651CMTM4chr16

66730243

-TRIM40chr6

30113771

+
5CDS-intronENST00000330687ENST00000434151CMTM4chr16

66730243

-TRIM40chr6

30113771

+
5CDS-intronENST00000330687ENST00000462556CMTM4chr16

66730243

-TRIM40chr6

30113771

+
5CDS-intronENST00000330687ENST00000549728CMTM4chr16

66730243

-TRIM40chr6

30113771

+
5CDS-intronENST00000330687ENST00000421981CMTM4chr16

66730243

-TRIM40chr6

30113771

+
5CDS-intronENST00000330687ENST00000430485CMTM4chr16

66730243

-TRIM40chr6

30113771

+
5CDS-intronENST00000330687ENST00000456884CMTM4chr16

66730243

-TRIM40chr6

30113771

+
5CDS-intronENST00000330687ENST00000486552CMTM4chr16

66730243

-TRIM40chr6

30113771

+
In-frameENST00000394106ENST00000396581CMTM4chr16

66730243

-TRIM40chr6

30113771

+
5CDS-intronENST00000394106ENST00000489892CMTM4chr16

66730243

-TRIM40chr6

30113771

+
5CDS-intronENST00000394106ENST00000376724CMTM4chr16

66730243

-TRIM40chr6

30113771

+
5CDS-intronENST00000394106ENST00000307859CMTM4chr16

66730243

-TRIM40chr6

30113771

+
5CDS-intronENST00000394106ENST00000497688CMTM4chr16

66730243

-TRIM40chr6

30113771

+
5CDS-intronENST00000394106ENST00000433713CMTM4chr16

66730243

-TRIM40chr6

30113771

+
5CDS-intronENST00000394106ENST00000436951CMTM4chr16

66730243

-TRIM40chr6

30113771

+
5CDS-intronENST00000394106ENST00000437563CMTM4chr16

66730243

-TRIM40chr6

30113771

+
5CDS-intronENST00000394106ENST00000470577CMTM4chr16

66730243

-TRIM40chr6

30113771

+
5CDS-intronENST00000394106ENST00000552119CMTM4chr16

66730243

-TRIM40chr6

30113771

+
5CDS-intronENST00000394106ENST00000429471CMTM4chr16

66730243

-TRIM40chr6

30113771

+
5CDS-intronENST00000394106ENST00000431397CMTM4chr16

66730243

-TRIM40chr6

30113771

+
5CDS-intronENST00000394106ENST00000475016CMTM4chr16

66730243

-TRIM40chr6

30113771

+
5CDS-intronENST00000394106ENST00000548672CMTM4chr16

66730243

-TRIM40chr6

30113771

+
5CDS-intronENST00000394106ENST00000445004CMTM4chr16

66730243

-TRIM40chr6

30113771

+
5CDS-intronENST00000394106ENST00000425845CMTM4chr16

66730243

-TRIM40chr6

30113771

+
5CDS-intronENST00000394106ENST00000488232CMTM4chr16

66730243

-TRIM40chr6

30113771

+
5CDS-intronENST00000394106ENST00000418267CMTM4chr16

66730243

-TRIM40chr6

30113771

+
5CDS-intronENST00000394106ENST00000383610CMTM4chr16

66730243

-TRIM40chr6

30113771

+
5CDS-intronENST00000394106ENST00000476094CMTM4chr16

66730243

-TRIM40chr6

30113771

+
5CDS-intronENST00000394106ENST00000547289CMTM4chr16

66730243

-TRIM40chr6

30113771

+
5CDS-intronENST00000394106ENST00000400651CMTM4chr16

66730243

-TRIM40chr6

30113771

+
5CDS-intronENST00000394106ENST00000434151CMTM4chr16

66730243

-TRIM40chr6

30113771

+
5CDS-intronENST00000394106ENST00000462556CMTM4chr16

66730243

-TRIM40chr6

30113771

+
5CDS-intronENST00000394106ENST00000549728CMTM4chr16

66730243

-TRIM40chr6

30113771

+
5CDS-intronENST00000394106ENST00000421981CMTM4chr16

66730243

-TRIM40chr6

30113771

+
5CDS-intronENST00000394106ENST00000430485CMTM4chr16

66730243

-TRIM40chr6

30113771

+
5CDS-intronENST00000394106ENST00000456884CMTM4chr16

66730243

-TRIM40chr6

30113771

+
5CDS-intronENST00000394106ENST00000486552CMTM4chr16

66730243

-TRIM40chr6

30113771

+
intron-3CDSENST00000563952ENST00000396581CMTM4chr16

66730243

-TRIM40chr6

30113771

+
intron-intronENST00000563952ENST00000489892CMTM4chr16

66730243

-TRIM40chr6

30113771

+
intron-intronENST00000563952ENST00000376724CMTM4chr16

66730243

-TRIM40chr6

30113771

+
intron-intronENST00000563952ENST00000307859CMTM4chr16

66730243

-TRIM40chr6

30113771

+
intron-intronENST00000563952ENST00000497688CMTM4chr16

66730243

-TRIM40chr6

30113771

+
intron-intronENST00000563952ENST00000433713CMTM4chr16

66730243

-TRIM40chr6

30113771

+
intron-intronENST00000563952ENST00000436951CMTM4chr16

66730243

-TRIM40chr6

30113771

+
intron-intronENST00000563952ENST00000437563CMTM4chr16

66730243

-TRIM40chr6

30113771

+
intron-intronENST00000563952ENST00000470577CMTM4chr16

66730243

-TRIM40chr6

30113771

+
intron-intronENST00000563952ENST00000552119CMTM4chr16

66730243

-TRIM40chr6

30113771

+
intron-intronENST00000563952ENST00000429471CMTM4chr16

66730243

-TRIM40chr6

30113771

+
intron-intronENST00000563952ENST00000431397CMTM4chr16

66730243

-TRIM40chr6

30113771

+
intron-intronENST00000563952ENST00000475016CMTM4chr16

66730243

-TRIM40chr6

30113771

+
intron-intronENST00000563952ENST00000548672CMTM4chr16

66730243

-TRIM40chr6

30113771

+
intron-intronENST00000563952ENST00000445004CMTM4chr16

66730243

-TRIM40chr6

30113771

+
intron-intronENST00000563952ENST00000425845CMTM4chr16

66730243

-TRIM40chr6

30113771

+
intron-intronENST00000563952ENST00000488232CMTM4chr16

66730243

-TRIM40chr6

30113771

+
intron-intronENST00000563952ENST00000418267CMTM4chr16

66730243

-TRIM40chr6

30113771

+
intron-intronENST00000563952ENST00000383610CMTM4chr16

66730243

-TRIM40chr6

30113771

+
intron-intronENST00000563952ENST00000476094CMTM4chr16

66730243

-TRIM40chr6

30113771

+
intron-intronENST00000563952ENST00000547289CMTM4chr16

66730243

-TRIM40chr6

30113771

+
intron-intronENST00000563952ENST00000400651CMTM4chr16

66730243

-TRIM40chr6

30113771

+
intron-intronENST00000563952ENST00000434151CMTM4chr16

66730243

-TRIM40chr6

30113771

+
intron-intronENST00000563952ENST00000462556CMTM4chr16

66730243

-TRIM40chr6

30113771

+
intron-intronENST00000563952ENST00000549728CMTM4chr16

66730243

-TRIM40chr6

30113771

+
intron-intronENST00000563952ENST00000421981CMTM4chr16

66730243

-TRIM40chr6

30113771

+
intron-intronENST00000563952ENST00000430485CMTM4chr16

66730243

-TRIM40chr6

30113771

+
intron-intronENST00000563952ENST00000456884CMTM4chr16

66730243

-TRIM40chr6

30113771

+
intron-intronENST00000563952ENST00000486552CMTM4chr16

66730243

-TRIM40chr6

30113771

+

Top

FusionProtFeatures for CMTM4_TRIM40


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CMTM4

Q8IZR5

TRIM40

Q6P9F5

Acts as a backup for CMTM6 to regulate plasma membraneexpression of PD-L1/CD274, an immune inhibitory ligand criticalfor immune tolerance to self and antitumor immunity. May protectPD-L1/CD274 from being polyubiquitinated and targeted fordegradation. {ECO:0000269|PubMed:28813410}. May function as an E3 ubiquitin-protein ligase of theNEDD8 conjugation pathway. Promotes neddylation of IKBKG/NEMO,stabilizing NFKBIA, and inhibiting of NF-kappaB nucleartranslocation and activity. {ECO:0000269|PubMed:21474709}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTRIM40chr16:66730243chr6:30113771ENST00000383610+06107_159-129259Coiled coilOntology_term=ECO:0000255
TgeneTRIM40chr16:66730243chr6:30113771ENST00000400651+05107_159-9230Coiled coilOntology_term=ECO:0000255
TgeneTRIM40chr16:66730243chr6:30113771ENST00000421981+05107_159-9230Coiled coilOntology_term=ECO:0000255
TgeneTRIM40chr16:66730243chr6:30113771ENST00000429471+05107_159-9230Coiled coilOntology_term=ECO:0000255
TgeneTRIM40chr16:66730243chr6:30113771ENST00000433713+06107_159-122259Coiled coilOntology_term=ECO:0000255
TgeneTRIM40chr16:66730243chr6:30113771ENST00000434151+06107_159-129259Coiled coilOntology_term=ECO:0000255
TgeneTRIM40chr16:66730243chr6:30113771ENST00000436951+05107_159-9230Coiled coilOntology_term=ECO:0000255
TgeneTRIM40chr16:66730243chr6:30113771ENST00000437563+06107_159-129259Coiled coilOntology_term=ECO:0000255
TgeneTRIM40chr16:66730243chr6:30113771ENST00000547289+05107_159-102259Coiled coilOntology_term=ECO:0000255
TgeneTRIM40chr16:66730243chr6:30113771ENST00000549728+05107_159-102259Coiled coilOntology_term=ECO:0000255
TgeneTRIM40chr16:66730243chr6:30113771ENST00000552119+05107_159-102259Coiled coilOntology_term=ECO:0000255
TgeneTRIM40chr16:66730243chr6:30113771ENST00000383610+0614_56-129259Zinc fingerRING-type
TgeneTRIM40chr16:66730243chr6:30113771ENST00000383610+0666_107-129259Zinc fingerB box-type
TgeneTRIM40chr16:66730243chr6:30113771ENST00000400651+0514_56-9230Zinc fingerRING-type
TgeneTRIM40chr16:66730243chr6:30113771ENST00000400651+0566_107-9230Zinc fingerB box-type
TgeneTRIM40chr16:66730243chr6:30113771ENST00000421981+0514_56-9230Zinc fingerRING-type
TgeneTRIM40chr16:66730243chr6:30113771ENST00000421981+0566_107-9230Zinc fingerB box-type
TgeneTRIM40chr16:66730243chr6:30113771ENST00000429471+0514_56-9230Zinc fingerRING-type
TgeneTRIM40chr16:66730243chr6:30113771ENST00000429471+0566_107-9230Zinc fingerB box-type
TgeneTRIM40chr16:66730243chr6:30113771ENST00000433713+0614_56-122259Zinc fingerRING-type
TgeneTRIM40chr16:66730243chr6:30113771ENST00000433713+0666_107-122259Zinc fingerB box-type
TgeneTRIM40chr16:66730243chr6:30113771ENST00000434151+0614_56-129259Zinc fingerRING-type
TgeneTRIM40chr16:66730243chr6:30113771ENST00000434151+0666_107-129259Zinc fingerB box-type
TgeneTRIM40chr16:66730243chr6:30113771ENST00000436951+0514_56-9230Zinc fingerRING-type
TgeneTRIM40chr16:66730243chr6:30113771ENST00000436951+0566_107-9230Zinc fingerB box-type
TgeneTRIM40chr16:66730243chr6:30113771ENST00000437563+0614_56-129259Zinc fingerRING-type
TgeneTRIM40chr16:66730243chr6:30113771ENST00000437563+0666_107-129259Zinc fingerB box-type
TgeneTRIM40chr16:66730243chr6:30113771ENST00000547289+0514_56-102259Zinc fingerRING-type
TgeneTRIM40chr16:66730243chr6:30113771ENST00000547289+0566_107-102259Zinc fingerB box-type
TgeneTRIM40chr16:66730243chr6:30113771ENST00000549728+0514_56-102259Zinc fingerRING-type
TgeneTRIM40chr16:66730243chr6:30113771ENST00000549728+0566_107-102259Zinc fingerB box-type
TgeneTRIM40chr16:66730243chr6:30113771ENST00000552119+0514_56-102259Zinc fingerRING-type
TgeneTRIM40chr16:66730243chr6:30113771ENST00000552119+0566_107-102259Zinc fingerB box-type

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCMTM4chr16:66730243chr6:30113771ENST00000330687-1549_17662235DomainMARVEL
HgeneCMTM4chr16:66730243chr6:30113771ENST00000394106-1449_17662209DomainMARVEL
HgeneCMTM4chr16:66730243chr6:30113771ENST00000563952-1449_176-61180DomainMARVEL
HgeneCMTM4chr16:66730243chr6:30113771ENST00000330687-15123_14362235TransmembraneHelical
HgeneCMTM4chr16:66730243chr6:30113771ENST00000330687-15151_17162235TransmembraneHelical
HgeneCMTM4chr16:66730243chr6:30113771ENST00000330687-1559_7962235TransmembraneHelical
HgeneCMTM4chr16:66730243chr6:30113771ENST00000330687-1585_10562235TransmembraneHelical
HgeneCMTM4chr16:66730243chr6:30113771ENST00000394106-14123_14362209TransmembraneHelical
HgeneCMTM4chr16:66730243chr6:30113771ENST00000394106-14151_17162209TransmembraneHelical
HgeneCMTM4chr16:66730243chr6:30113771ENST00000394106-1459_7962209TransmembraneHelical
HgeneCMTM4chr16:66730243chr6:30113771ENST00000394106-1485_10562209TransmembraneHelical
HgeneCMTM4chr16:66730243chr6:30113771ENST00000563952-14123_143-61180TransmembraneHelical
HgeneCMTM4chr16:66730243chr6:30113771ENST00000563952-14151_171-61180TransmembraneHelical
HgeneCMTM4chr16:66730243chr6:30113771ENST00000563952-1459_79-61180TransmembraneHelical
HgeneCMTM4chr16:66730243chr6:30113771ENST00000563952-1485_105-61180TransmembraneHelical
TgeneTRIM40chr16:66730243chr6:30113771ENST00000307859+05107_159115230Coiled coilOntology_term=ECO:0000255
TgeneTRIM40chr16:66730243chr6:30113771ENST00000376724+05107_159115259Coiled coilOntology_term=ECO:0000255
TgeneTRIM40chr16:66730243chr6:30113771ENST00000396581+16107_159115259Coiled coilOntology_term=ECO:0000255
TgeneTRIM40chr16:66730243chr6:30113771ENST00000307859+0514_56115230Zinc fingerRING-type
TgeneTRIM40chr16:66730243chr6:30113771ENST00000307859+0566_107115230Zinc fingerB box-type
TgeneTRIM40chr16:66730243chr6:30113771ENST00000376724+0514_56115259Zinc fingerRING-type
TgeneTRIM40chr16:66730243chr6:30113771ENST00000376724+0566_107115259Zinc fingerB box-type
TgeneTRIM40chr16:66730243chr6:30113771ENST00000396581+1614_56115259Zinc fingerRING-type
TgeneTRIM40chr16:66730243chr6:30113771ENST00000396581+1666_107115259Zinc fingerB box-type


Top

FusionGeneSequence for CMTM4_TRIM40


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_CMTM4_ENST00000330687_chr16_66730243_-_TRIM40_ENST00000396581_chr6_30113771_+_206aa
MRSGEELDGFEGEASSTSMISGASSPYQPTTEPVSQRRGLAGLRCDPDYLRGALGRLKVAQVERLNRRSRKLRKDIAELQRLKAQQEKKL
QALQFQVDHGNHRLEAGPESQHQTREQLGALPQQWLGQLEHMPAEAARILDISRAVTQLRSLVIDLERTAKELDTNTLKNAGDLLNRSAP

>In-frame_CMTM4_ENST00000394106_chr16_66730243_-_TRIM40_ENST00000396581_chr6_30113771_+_206aa
MRSGEELDGFEGEASSTSMISGASSPYQPTTEPVSQRRGLAGLRCDPDYLRGALGRLKVAQVERLNRRSRKLRKDIAELQRLKAQQEKKL
QALQFQVDHGNHRLEAGPESQHQTREQLGALPQQWLGQLEHMPAEAARILDISRAVTQLRSLVIDLERTAKELDTNTLKNAGDLLNRSAP


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_CMTM4_ENST00000330687_chr16_66730243_-_TRIM40_ENST00000396581_chr6_30113771_+_618nt
ATGCGGAGCGGCGAGGAGCTGGACGGCTTCGAGGGCGAGGCCTCGAGCACCTCCATGATCTCGGGCGCCAGCAGCCCGTACCAGCCCACC
ACCGAGCCGGTGAGCCAGCGCCGCGGGCTGGCCGGCCTGCGCTGCGACCCCGACTACCTGCGCGGCGCGCTCGGCCGCCTCAAGGTCGCC
CAAGTGGAACGACTCAATCGCCGGAGCAGGAAGCTCAGAAAGGACATTGCAGAACTTCAGCGGCTCAAGGCTCAGCAGGAGAAGAAACTG
CAGGCTCTGCAGTTTCAGGTAGACCACGGGAACCACAGGCTGGAGGCTGGGCCGGAGAGCCAGCACCAAACCAGGGAACAGCTGGGTGCC
CTCCCTCAGCAGTGGCTGGGCCAGCTGGAGCACATGCCAGCAGAAGCGGCCAGAATCCTTGACATCTCCAGGGCAGTAACACAGCTCAGA
AGCCTGGTCATTGATCTGGAAAGGACGGCCAAGGAATTAGACACCAACACACTGAAGAATGCTGGTGACTTACTGAACAGGAGTGCTCCA

>In-frame_CMTM4_ENST00000394106_chr16_66730243_-_TRIM40_ENST00000396581_chr6_30113771_+_618nt
ATGCGGAGCGGCGAGGAGCTGGACGGCTTCGAGGGCGAGGCCTCGAGCACCTCCATGATCTCGGGCGCCAGCAGCCCGTACCAGCCCACC
ACCGAGCCGGTGAGCCAGCGCCGCGGGCTGGCCGGCCTGCGCTGCGACCCCGACTACCTGCGCGGCGCGCTCGGCCGCCTCAAGGTCGCC
CAAGTGGAACGACTCAATCGCCGGAGCAGGAAGCTCAGAAAGGACATTGCAGAACTTCAGCGGCTCAAGGCTCAGCAGGAGAAGAAACTG
CAGGCTCTGCAGTTTCAGGTAGACCACGGGAACCACAGGCTGGAGGCTGGGCCGGAGAGCCAGCACCAAACCAGGGAACAGCTGGGTGCC
CTCCCTCAGCAGTGGCTGGGCCAGCTGGAGCACATGCCAGCAGAAGCGGCCAGAATCCTTGACATCTCCAGGGCAGTAACACAGCTCAGA
AGCCTGGTCATTGATCTGGAAAGGACGGCCAAGGAATTAGACACCAACACACTGAAGAATGCTGGTGACTTACTGAACAGGAGTGCTCCA


* Fusion transcript sequences (Full-length transcript).
>In-frame_CMTM4_ENST00000330687_chr16_66730243_-_TRIM40_ENST00000396581_chr6_30113771_+_1723nt
AGCGGACCGAGCCGCAGCCGCAGCCGGGCGGCGGGCGAGAGGCGGCGGCGGCGGGCGGGCCGCGGGCAGTCAGTCGGGCGGCGGCGGCGG
CGGCGGCGGCGGCGATGCGGCGGCCCCGCTGAGTCCGCCCGCTCCTGGCGCCGGGAGCCAGCCGCGCGAGGCGGCCCGGGCCGGGCGGCA
GCATGCGGAGCGGCGAGGAGCTGGACGGCTTCGAGGGCGAGGCCTCGAGCACCTCCATGATCTCGGGCGCCAGCAGCCCGTACCAGCCCA
CCACCGAGCCGGTGAGCCAGCGCCGCGGGCTGGCCGGCCTGCGCTGCGACCCCGACTACCTGCGCGGCGCGCTCGGCCGCCTCAAGGTCG
CCCAAGTGGAACGACTCAATCGCCGGAGCAGGAAGCTCAGAAAGGACATTGCAGAACTTCAGCGGCTCAAGGCTCAGCAGGAGAAGAAAC
TGCAGGCTCTGCAGTTTCAGGTAGACCACGGGAACCACAGGCTGGAGGCTGGGCCGGAGAGCCAGCACCAAACCAGGGAACAGCTGGGTG
CCCTCCCTCAGCAGTGGCTGGGCCAGCTGGAGCACATGCCAGCAGAAGCGGCCAGAATCCTTGACATCTCCAGGGCAGTAACACAGCTCA
GAAGCCTGGTCATTGATCTGGAAAGGACGGCCAAGGAATTAGACACCAACACACTGAAGAATGCTGGTGACTTACTGAACAGGAGTGCTC
CACAGAAATTAGAGGTTATTTATCCCCAGTTGGAGAAAGGAGTCAGTGAATTGCTTCTTCAGCCCCCTCAGAAGCTCTGACCTGTTCATC
CCTGGGACACCTCACTTCAGGCTCACCTCAGCCTCCTCTCTCTCCTTCCTCCAACCTGTCCAGGCCCCCACTGGGTCTACCCAGTGCATC
TTCGGGCCTGCCAGCTCCTGAACATGTCACCATTTCTTCATGTCCACAGTCATCACCTGATGCCTGACCCTCTGACTCTTGGACGATAGC
CAGCCTCCTTCCAGGACAGGCTCATGCTTGGGGCTGCCACTGTGGAGGTCGGGGCCCATGGTCTCCAGGAGCATTTGTGAAATCTCCATT
TTGCCTGTAAACTGATGGTAGTGCCCATCTCTCACAATCTCATTCAAATAGGATCCTCCAGGCCTCTGAATGGCCCGAGCTCATCAGCAG
TGACACCACCTCACATGTGGAGCCCAGCTGAGTTCCTGCAGTACTTGTTGTCTGTACCACTCACCTGGCACTTATTTATTATTGTTGTGG
AAGACAGACTCAAAGACAGCCTCCCTTCATGATCCTCACCTCTTGGAATTCATGCCCTTGTTTGGTCCCCTCCCCTTGAGTGTAAGTGGG
ATCTGTGACTTGCTTCTAATGAATGGAATAAGGCAAAGGTGATAGGGTGTCACTCTGGCAACTGTGTTGCATTGTATAGAACTCCTCCTT
GCTGGCCCACCCTTTTAGAGCCCCTCCTAGGAGCCAAGAGCAGCTTCCAGCCAACAACAAGCAGAGGCCCTCAGTCTTGTGGCTGCAAGA
ACCTGAATTCTGCCAACAACCCGAGTGAGCTTGGAAGCAGATTCTTCCCCAACTGAGCCGGATAAGAACCTAGTCCAGCCAACACCTTGA
TTATAGTCTTGTGAGTACCTAAGCTGAGGACCCAGTGAAGCTGTGCCAAAATTTCCCACCCACAGAAACAGTGTGACAATAAATGTGTGT

>In-frame_CMTM4_ENST00000394106_chr16_66730243_-_TRIM40_ENST00000396581_chr6_30113771_+_1723nt
AGCGGACCGAGCCGCAGCCGCAGCCGGGCGGCGGGCGAGAGGCGGCGGCGGCGGGCGGGCCGCGGGCAGTCAGTCGGGCGGCGGCGGCGG
CGGCGGCGGCGGCGATGCGGCGGCCCCGCTGAGTCCGCCCGCTCCTGGCGCCGGGAGCCAGCCGCGCGAGGCGGCCCGGGCCGGGCGGCA
GCATGCGGAGCGGCGAGGAGCTGGACGGCTTCGAGGGCGAGGCCTCGAGCACCTCCATGATCTCGGGCGCCAGCAGCCCGTACCAGCCCA
CCACCGAGCCGGTGAGCCAGCGCCGCGGGCTGGCCGGCCTGCGCTGCGACCCCGACTACCTGCGCGGCGCGCTCGGCCGCCTCAAGGTCG
CCCAAGTGGAACGACTCAATCGCCGGAGCAGGAAGCTCAGAAAGGACATTGCAGAACTTCAGCGGCTCAAGGCTCAGCAGGAGAAGAAAC
TGCAGGCTCTGCAGTTTCAGGTAGACCACGGGAACCACAGGCTGGAGGCTGGGCCGGAGAGCCAGCACCAAACCAGGGAACAGCTGGGTG
CCCTCCCTCAGCAGTGGCTGGGCCAGCTGGAGCACATGCCAGCAGAAGCGGCCAGAATCCTTGACATCTCCAGGGCAGTAACACAGCTCA
GAAGCCTGGTCATTGATCTGGAAAGGACGGCCAAGGAATTAGACACCAACACACTGAAGAATGCTGGTGACTTACTGAACAGGAGTGCTC
CACAGAAATTAGAGGTTATTTATCCCCAGTTGGAGAAAGGAGTCAGTGAATTGCTTCTTCAGCCCCCTCAGAAGCTCTGACCTGTTCATC
CCTGGGACACCTCACTTCAGGCTCACCTCAGCCTCCTCTCTCTCCTTCCTCCAACCTGTCCAGGCCCCCACTGGGTCTACCCAGTGCATC
TTCGGGCCTGCCAGCTCCTGAACATGTCACCATTTCTTCATGTCCACAGTCATCACCTGATGCCTGACCCTCTGACTCTTGGACGATAGC
CAGCCTCCTTCCAGGACAGGCTCATGCTTGGGGCTGCCACTGTGGAGGTCGGGGCCCATGGTCTCCAGGAGCATTTGTGAAATCTCCATT
TTGCCTGTAAACTGATGGTAGTGCCCATCTCTCACAATCTCATTCAAATAGGATCCTCCAGGCCTCTGAATGGCCCGAGCTCATCAGCAG
TGACACCACCTCACATGTGGAGCCCAGCTGAGTTCCTGCAGTACTTGTTGTCTGTACCACTCACCTGGCACTTATTTATTATTGTTGTGG
AAGACAGACTCAAAGACAGCCTCCCTTCATGATCCTCACCTCTTGGAATTCATGCCCTTGTTTGGTCCCCTCCCCTTGAGTGTAAGTGGG
ATCTGTGACTTGCTTCTAATGAATGGAATAAGGCAAAGGTGATAGGGTGTCACTCTGGCAACTGTGTTGCATTGTATAGAACTCCTCCTT
GCTGGCCCACCCTTTTAGAGCCCCTCCTAGGAGCCAAGAGCAGCTTCCAGCCAACAACAAGCAGAGGCCCTCAGTCTTGTGGCTGCAAGA
ACCTGAATTCTGCCAACAACCCGAGTGAGCTTGGAAGCAGATTCTTCCCCAACTGAGCCGGATAAGAACCTAGTCCAGCCAACACCTTGA
TTATAGTCTTGTGAGTACCTAAGCTGAGGACCCAGTGAAGCTGTGCCAAAATTTCCCACCCACAGAAACAGTGTGACAATAAATGTGTGT


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FusionGenePPI for CMTM4_TRIM40


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CMTM4MRPL2, APPL1, TMEM171, PTGER3, MANSC1, LPAR1, VIPR2, SLC7A1, SPPL2B, MPPE1, TRIM25TRIM40CHUK, IKBKB, IKBKG, APP, LGR4


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CMTM4_TRIM40


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CMTM4_TRIM40


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource