FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 7605

FusionGeneSummary for CMSS1_CRYBG3

check button Fusion gene summary
Fusion gene informationFusion gene name: CMSS1_CRYBG3
Fusion gene ID: 7605
HgeneTgene
Gene symbol

CMSS1

CRYBG3

Gene ID

84319

131544

Gene namecms1 ribosomal small subunit homolog (yeast)crystallin beta-gamma domain containing 3
SynonymsC3orf26DKFZp667G2110|vlAKAP
Cytomap

3q12.1

3q11.2

Type of geneprotein-codingprotein-coding
Descriptionprotein CMSS1very large A-kinase anchor proteinbeta-gamma crystallin domain containing 3beta/gamma crystallin domain-containing protein 3
Modification date2018051920180519
UniProtAcc

Q9BQ75

Q68DQ2

Ensembl transtripts involved in fusion geneENST00000421999, ENST00000496116, 
ENST00000489081, 
ENST00000182096, 
ENST00000485253, ENST00000419587, 
ENST00000389622, 
Fusion gene scores* DoF score5 X 2 X 4=402 X 2 X 2=8
# samples 62
** MAII scorelog2(6/40*10)=0.584962500721156
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/8*10)=1.32192809488736
Context

PubMed: CMSS1 [Title/Abstract] AND CRYBG3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBLCATCGA-DK-A2I6-01ACMSS1chr3

99536887

+CRYBG3chr3

97562039

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000421999ENST00000182096CMSS1chr3

99536887

+CRYBG3chr3

97562039

+
5CDS-intronENST00000421999ENST00000485253CMSS1chr3

99536887

+CRYBG3chr3

97562039

+
5CDS-intronENST00000421999ENST00000419587CMSS1chr3

99536887

+CRYBG3chr3

97562039

+
5CDS-intronENST00000421999ENST00000389622CMSS1chr3

99536887

+CRYBG3chr3

97562039

+
3UTR-intronENST00000496116ENST00000182096CMSS1chr3

99536887

+CRYBG3chr3

97562039

+
3UTR-intronENST00000496116ENST00000485253CMSS1chr3

99536887

+CRYBG3chr3

97562039

+
3UTR-intronENST00000496116ENST00000419587CMSS1chr3

99536887

+CRYBG3chr3

97562039

+
3UTR-intronENST00000496116ENST00000389622CMSS1chr3

99536887

+CRYBG3chr3

97562039

+
intron-intronENST00000489081ENST00000182096CMSS1chr3

99536887

+CRYBG3chr3

97562039

+
intron-intronENST00000489081ENST00000485253CMSS1chr3

99536887

+CRYBG3chr3

97562039

+
intron-intronENST00000489081ENST00000419587CMSS1chr3

99536887

+CRYBG3chr3

97562039

+
intron-intronENST00000489081ENST00000389622CMSS1chr3

99536887

+CRYBG3chr3

97562039

+

Top

FusionProtFeatures for CMSS1_CRYBG3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CMSS1

Q9BQ75

CRYBG3

Q68DQ2


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for CMSS1_CRYBG3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for CMSS1_CRYBG3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CMSS1SART3, CAND1, S1PR1, GYG1, EGFR, PCDH7, PSME3, MRGBP, MDM2, PEX19, SPANXN3, RPL10, NES, CBX8, FOXI2, FOXL2, FOXS1, PTP4A1, HIST1H1E, HIST1H1T, ACSBG2, FOXA1, TRIM25CRYBG3TSSK1B, MLF1, PRKAR2B, FGFR1OP, POC1A, SSH3, NPAS1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for CMSS1_CRYBG3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for CMSS1_CRYBG3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource