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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 7597

FusionGeneSummary for CMIP_TPX2

check button Fusion gene summary
Fusion gene informationFusion gene name: CMIP_TPX2
Fusion gene ID: 7597
HgeneTgene
Gene symbol

CMIP

TPX2

Gene ID

80790

22974

Gene namec-Maf inducing proteinTPX2, microtubule nucleation factor
SynonymsTCMIPC20orf1|C20orf2|DIL-2|DIL2|FLS353|GD:C20orf1|HCA519|HCTP4|REPP86|p100
Cytomap

16q23.2-q23.3

20q11.21

Type of geneprotein-codingprotein-coding
DescriptionC-Maf-inducing proteintc-Miptargeting protein for Xklp2TPX2, microtubule-associated protein homologTPX2, microtubule-associated, homologdifferentially expressed in cancerous and non-cancerous lung cells 2differentially expressed in lung cellshepatocellular carcinoma-associated
Modification date2018051920180519
UniProtAcc

Q8IY22

Q9ULW0

Ensembl transtripts involved in fusion geneENST00000537098, ENST00000539778, 
ENST00000566513, ENST00000398040, 
ENST00000340513, ENST00000300403, 
Fusion gene scores* DoF score9 X 7 X 4=2526 X 6 X 5=180
# samples 106
** MAII scorelog2(10/252*10)=-1.33342373372519
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/180*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CMIP [Title/Abstract] AND TPX2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTPX2

GO:0032147

activation of protein kinase activity

14580337|19801554

TgeneTPX2

GO:0090307

mitotic spindle assembly

26165940


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF932217CMIPchr16

81598907

+TPX2chr20

30389116

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000537098ENST00000340513CMIPchr16

81598907

+TPX2chr20

30389116

+
intron-3UTRENST00000537098ENST00000300403CMIPchr16

81598907

+TPX2chr20

30389116

+
intron-3UTRENST00000539778ENST00000340513CMIPchr16

81598907

+TPX2chr20

30389116

+
intron-3UTRENST00000539778ENST00000300403CMIPchr16

81598907

+TPX2chr20

30389116

+
intron-3UTRENST00000566513ENST00000340513CMIPchr16

81598907

+TPX2chr20

30389116

+
intron-3UTRENST00000566513ENST00000300403CMIPchr16

81598907

+TPX2chr20

30389116

+
intron-3UTRENST00000398040ENST00000340513CMIPchr16

81598907

+TPX2chr20

30389116

+
intron-3UTRENST00000398040ENST00000300403CMIPchr16

81598907

+TPX2chr20

30389116

+

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FusionProtFeatures for CMIP_TPX2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CMIP

Q8IY22

TPX2

Q9ULW0

Plays a role in T-cell signaling pathway. Isoform 2 mayplay a role in T-helper 2 (Th2) signaling pathway and seems torepresent the first proximal signaling protein that links T-cellreceptor-mediated signal to the activation of c-Maf Th2 specificfactor. {ECO:0000269|PubMed:12939343,ECO:0000269|PubMed:15128042}. Spindle assembly factor required for normal assembly ofmitotic spindles. Required for normal assembly of microtubulesduring apoptosis. Required for chromatin and/or kinetochoredependent microtubule nucleation. Mediates AURKA localization tospindle microtubules (PubMed:18663142, PubMed:19208764). ActivatesAURKA by promoting its autophosphorylation at 'Thr-288' andprotects this residue against dephosphorylation (PubMed:18663142,PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interactswith importin-alpha, liberating TPX2 from importin-alpha, allowingTPX2 to activates AURKA kinase and stimulates local microtubulenucleation (PubMed:26165940). {ECO:0000269|PubMed:18663142,ECO:0000269|PubMed:19208764, ECO:0000269|PubMed:26165940}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CMIP_TPX2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CMIP_TPX2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CMIP_TPX2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CMIP_TPX2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource